LOCUS       NM_023727               3723 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus retinal degeneration 3 (Rd3), transcript variant 1,
            mRNA.
ACCESSION   NM_023727
VERSION     NM_023727.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3723)
  AUTHORS   Chen,Y., Brauer,A.U. and Koch,K.W.
  TITLE     Retinal degeneration protein 3 controls membrane guanylate cyclase
            activities in brain tissue
  JOURNAL   Front Mol Neurosci 15, 1076430 (2022)
   PUBMED   36618828
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3723)
  AUTHORS   Peshenko,I.V., Olshevskaya,E.V. and Dizhoor,A.M.
  TITLE     Retinal degeneration-3 protein attenuates photoreceptor
            degeneration in transgenic mice expressing dominant mutation of
            human retinal guanylyl cyclase
  JOURNAL   J Biol Chem 297 (4), 101201 (2021)
   PUBMED   34537244
  REMARK    GeneRIF: Retinal degeneration-3 protein attenuates photoreceptor
            degeneration in transgenic mice expressing dominant mutation of
            human retinal guanylyl cyclase.
REFERENCE   3  (bases 1 to 3723)
  AUTHORS   Dizhoor,A.M., Olshevskaya,E.V. and Peshenko,I.V.
  TITLE     Retinal degeneration-3 protein promotes photoreceptor survival by
            suppressing activation of guanylyl cyclase rather than accelerating
            GMP recycling
  JOURNAL   J Biol Chem 296, 100362 (2021)
   PUBMED   33539922
  REMARK    GeneRIF: Retinal degeneration-3 protein promotes photoreceptor
            survival by suppressing activation of guanylyl cyclase rather than
            accelerating GMP recycling.
REFERENCE   4  (bases 1 to 3723)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3723)
  AUTHORS   Plana-Bonamaiso,A., Lopez-Begines,S., Andilla,J., Fidalgo,M.J.,
            Loza-Alvarez,P., Estanyol,J.M., Villa,P. and Mendez,A.
  TITLE     GCAP neuronal calcium sensor proteins mediate photoreceptor cell
            death in the rd3 mouse model of LCA12 congenital blindness by
            involving endoplasmic reticulum stress
  JOURNAL   Cell Death Dis 11 (1), 62 (2020)
   PUBMED   31980596
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3723)
  AUTHORS   Tomarev,S.I., Zinovieva,R.D., Chang,B. and Hawes,N.L.
  TITLE     Characterization of the mouse Prox1 gene
  JOURNAL   Biochem Biophys Res Commun 248 (3), 684-689 (1998)
   PUBMED   9703987
REFERENCE   7  (bases 1 to 3723)
  AUTHORS   Pieke-Dahl,S., Ohlemiller,K.K., McGee,J., Walsh,E.J. and
            Kimberling,W.J.
  TITLE     Hearing loss in the RBF/DnJ mouse, a proposed animal model of Usher
            syndrome type IIa
  JOURNAL   Hear Res 112 (1-2), 1-12 (1997)
   PUBMED   9367224
REFERENCE   8  (bases 1 to 3723)
  AUTHORS   Heckenlively,J.R., Chang,B., Erway,L.C., Peng,C., Hawes,N.L.,
            Hageman,G.S. and Roderick,T.H.
  TITLE     Mouse model for Usher syndrome: linkage mapping suggests homology
            to Usher type I reported at human chromosome 11p15
  JOURNAL   Proc Natl Acad Sci U S A 92 (24), 11100-11104 (1995)
   PUBMED   7479945
REFERENCE   9  (bases 1 to 3723)
  AUTHORS   Chang,B., Heckenlively,J.R., Hawes,N.L. and Roderick,T.H.
  TITLE     New mouse primary retinal degeneration (rd-3)
  JOURNAL   Genomics 16 (1), 45-49 (1993)
   PUBMED   8486383
REFERENCE   10 (bases 1 to 3723)
  AUTHORS   Bell,J.R., Noveen,A., Liu,Y.H., Ma,L., Dobias,S., Kundu,R., Luo,W.,
            Xia,Y., Lusis,A.J., Snead,M.L. et al.
  TITLE     Genomic structure, chromosomal location, and evolution of the mouse
            Hox 8 gene
  JOURNAL   Genomics 16 (1), 123-131 (1993)
   PUBMED   8098007
  REMARK    Erratum:[Genomics. 1993 Sep;17(3):800. PMID: 7902329]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC182412.2, AK045045.1, AK014383.2 and BB009603.2.
            
            [WARNING] On Mar 28, 2024 this sequence was replaced by
            NM_023727.5.
            
            On Dec 18, 2014 this sequence version replaced NM_023727.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014383.2, BC103778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC182412.2         24104-24122         c
            20-1355             AK045045.1         2-1337
            1356-2908           AK014383.2         1204-2756
            2909-2929           BB009603.2         2-22                c
            2930-3723           AK014383.2         2778-3571
FEATURES             Location/Qualifiers
     source          1..3723
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 97.09 cM"
     gene            1..3723
                     /gene="Rd3"
                     /gene_synonym="3322402L07Rik; rd-3"
                     /note="retinal degeneration 3"
                     /db_xref="GeneID:74023"
                     /db_xref="MGI:MGI:1921273"
     exon            1..340
                     /gene="Rd3"
                     /gene_synonym="3322402L07Rik; rd-3"
                     /inference="alignment:Splign:2.1.0"
     exon            341..652
                     /gene="Rd3"
                     /gene_synonym="3322402L07Rik; rd-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..944
                     /gene="Rd3"
                     /gene_synonym="3322402L07Rik; rd-3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein RD3; retinal degeneration protein 3"
                     /codon_start=1
                     /product="protein RD3 isoform 1"
                     /protein_id="NP_076216.3"
                     /db_xref="CCDS:CCDS15626.3"
                     /db_xref="GeneID:74023"
                     /db_xref="MGI:MGI:1921273"
                     /translation="MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQ
                     RERRSAVRKICTGVDYSWLANTPRPTYDISPGERLQLEDVCAKIHPSYCGPAILRFRQ
                     LLAEREPEVQEVARLFRSVLQEALEKMKQEEEAHKLTRQWSLRPRGSLSSFKTRARIA
                     PFASDIRTISEDVERDAPPPPRTWSMPEFRAPQAD"
     exon            653..3723
                     /gene="Rd3"
                     /gene_synonym="3322402L07Rik; rd-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catgacaacc gatgctggcc tgcctccagg ttctgcaggg agctgtgtct cagctctggg
       61 gacctacaca tactccacaa acaccagccc agctgggtcc ctcctccagt tggtgcctcc
      121 agtacaactt ctcaaagagg aagagcagaa agcacaggag gcagccagca gtggaagagg
      181 cagagggcgg ccgaggatgg agctcactct tcaactcctg ccagtttgcc gctcaacttt
      241 ctactttccc tagaaaagat caaggctctc ttctcctaga gtgtgaagca gaaagcagga
      301 cccctacagt gatagtggcc ctgaaggagg tggacctaag aagagtctgg ggggccatgt
      361 ccctcatccc gtggctccgg tggaacgaca cccctccccg gctctcggcc cggaccccgg
      421 ccgagatggt gctggagacg ctcatgatgg agctggctgg gcagatgaga gaggtggagc
      481 gacaacagag ggagcgtcgc agcgcagtca ggaagatctg cactggtgtg gactacagct
      541 ggttggcaaa cacgcccagg cccacctatg acatcagccc tggtgagcgg ctgcagttgg
      601 aggatgtatg tgccaagatc cacccatcct actgtgggcc tgccatcctc aggttcaggc
      661 agctgctggc tgaacgagag cccgaggtgc aggaggtggc gcggctgttc cgctccgtgt
      721 tgcaggaggc cctggagaag atgaagcagg aggaggaggc ccataagctg acacgtcagt
      781 ggagcttgag gccccgcggc agcctgtcgt ccttcaagac ccgcgctcgc atcgcaccct
      841 ttgccagtga catccgaacc atctcggagg atgtggagcg cgatgcgcca cccccgccgc
      901 gcacctggag catgccggag ttcagggcgc cccaggccga ctgaccaccc agggcaatca
      961 ccctcaggag gaataacggg ctggtgactc tgtcactagc gccggaacct ccccacctac
     1021 cccaaccagg agacccatca agcaacactg ctagaccacg gagccaacta cccagtgagc
     1081 acacctgctt ggatacctgg gcagagtcag gacttgagcc ctgtttctcc gcaaaaaggt
     1141 ctccacttcc cagcctgaca cagacacaag gcccacatac tcatcccaat ttccgggatg
     1201 ccccattcac cctatccatt catggcacct ttactggtga ccagatgaca ttcactgcag
     1261 gggacccaca gcctcaggcc cagggcagct ggtggggccc acagaagact gttcaaccca
     1321 ctcttcagct agtgagtgaa aaaaggaagt cttccaagag tctctgcttt tgccttaact
     1381 ctgatccctc tgatgtggca ttgttcttgc ctctgagtcc ttgaatgctg gactatgata
     1441 gggtgggacc aatgtctaca tctccatcca ctggggccga ggctgctgtc tgagaaaggt
     1501 ggctaggggt aggcaggatg atcataactc ccatcctgcg atgtcatcat atggaacatg
     1561 gccagtccag agtcagggct tggaggcctg cgaacctgct gctgaagtct agggatcctt
     1621 ctgttcacac ctgctctcca gcttccctag gaagtacctg agcaaagcag tccagggtag
     1681 tctcctgcag cctcatgctc tgatggtcta tgagtggatg tcccccacct caatctgggg
     1741 tagaagtaag gttcagggca agcaaagagt gtccccagca cccagtgcat gtgaacctta
     1801 tagtccaaat aaaatgcaat gggagaaaaa tcactaggta ctgcatatag tctggctcaa
     1861 tgggaagtct gctctcctgc cctccccgcc cctcctcctt caaggcaggg tctcactatt
     1921 ttggctgctt cagcctcttg agtgctgagt ctactgcaca gatattcttt ttgaatgatg
     1981 tggctttggg ttgcttcact gggatctgga taatgatcgg atggcacatt cctcttaccc
     2041 atcgctgcca ggatgaagga gctgactggc tcattagtat aatctcttct aaacaaaaac
     2101 attttaaaca tatcttctac tggaagatac tgagaagttc actcagttgc caaactttgg
     2161 atagaggttc aaagttgtag tcgaccctcg actaccagtc aatgtaggta cctcgaaagg
     2221 ggttctgaga attaaaggac agggatgaaa gaaaaatggt gctaagacaa agttctgatc
     2281 aaggttcaat tttattgcaa agcagcaggc ttataaaggc aaaagccata agcccaaccc
     2341 ctagatgtga ctgatgacgt agatcacctc atgctgactg ccaatggcat aggtttccat
     2401 ttctcagaac aggtttctct tatcagggca aaacgagaat tcccaactct ggaggggaaa
     2461 ttccacctgc gaaggcaaaa acagctgatg cggcaacccc tctctgcagg tcagggcaga
     2521 gcctccacac aaagtgacct gtgttgtgat gggggtttgc tttgattcaa tgggtttgtg
     2581 ggtgctttga atgtgacacc aagaacaaat gggaaaggct ttgaaacaaa cagttccaca
     2641 gttgggagga aatgttgagt gaagcagagc ttgccaagcc tcctgcctga ggcccttgtg
     2701 gggcttgatt tgcctagagg gaggttccga ggatcctcag gggaggacta ctgattgctg
     2761 atttcttctt ccaggtctct ctgttctcct caaacaaaag gaaaacctga ggtagtgagc
     2821 ttgctcttgc atgacaggca gctgctactg ctgtccctgc caacctcctc agtactcttc
     2881 tgctttgtcc caccttagct gtgatgctaa ctaaagcctg tgagggtctc aggtcctgta
     2941 agactcaggg ctaacagagg tgtctgctga ggggctggcg ttggctggag gggaggggga
     3001 gcccccccca tcccccccgc tgagccgcag ctggcgcagc atcctagttc tggtgcttct
     3061 tacttggtat gagaactttt aagttctaga aagtaaaggg agccttaatg cttattaatt
     3121 cttaataata ttaatttcat ttttgtttca tgttttaatt tctcaaccca aaattttggc
     3181 ggatacttta atatgaatct cagatatgtt tcttcatgcc tgaatacttc agtgtgctct
     3241 gcaaaagaga acatcccaga agttggggat atctatctgt ctgtctgtct gtcatctacc
     3301 tatctagggt ggcatacatc tttagcccca gagtttggga ggcagaggca tgaagatctc
     3361 tgagttcgag gttagtgtag tctacagcat gagttccaag atagccaggg ctacgcaaag
     3421 aaaccctgtc ttgaaacaca aacacacagc tgttctgcta gtaaaaatct acacaaactt
     3481 tcatattatc taatacctag tccctgctga aatgacccaa attcttccca acatatgact
     3541 ccttgcattt tgtttctgag agtgagggtc tcatcaaatc tcatacatcc acacatcaat
     3601 cagaaaatta tgatttgttt atgctcaatc acatagtgct ctataattct acaatggaag
     3661 attgtttatg gagtatcatg ttgataaaca gtaaattaat aaattgtggc catttgataa
     3721 aat
//
