LOCUS       NM_001346740            4064 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus REST corepressor 3 (Rcor3), transcript variant 6,
            mRNA.
ACCESSION   NM_001346740 XM_006497241
VERSION     NM_001346740.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4064)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4064)
  AUTHORS   Upadhyay,G., Chowdhury,A.H., Vaidyanathan,B., Kim,D. and Saleque,S.
  TITLE     Antagonistic actions of Rcor proteins regulate LSD1 activity and
            cellular differentiation
  JOURNAL   Proc Natl Acad Sci U S A 111 (22), 8071-8076 (2014)
   PUBMED   24843136
  REMARK    GeneRIF: In mature erythroid cells, a strong upsurge in Rcor3 and a
            sharp decline in Rcor1 levels counteract LSD1/Rcor1/2-mediated
            differentiation.
REFERENCE   3  (bases 1 to 4064)
  AUTHORS   Yao,H., Goldman,D.C., Nechiporuk,T., Kawane,S., McWeeney,S.K.,
            Tyner,J.W., Fan,G., Kerenyi,M.A., Orkin,S.H., Fleming,W.H. and
            Mandel,G.
  TITLE     Corepressor Rcor1 is essential for murine erythropoiesis
  JOURNAL   Blood 123 (20), 3175-3184 (2014)
   PUBMED   24652990
REFERENCE   4  (bases 1 to 4064)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 4064)
  AUTHORS   Saleque,S., Kim,J., Rooke,H.M. and Orkin,S.H.
  TITLE     Epigenetic regulation of hematopoietic differentiation by Gfi-1 and
            Gfi-1b is mediated by the cofactors CoREST and LSD1
  JOURNAL   Mol Cell 27 (4), 562-572 (2007)
   PUBMED   17707228
REFERENCE   6  (bases 1 to 4064)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            LO018690.1, AC182250.12 and AC175315.3.
            
            On Mar 29, 2022 this sequence version replaced NM_001346740.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.174685.1,
                                           SRR7345562.3199643.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               LO018690.1         44562-44860         c
            300-356             LO018690.1         44259-44315         c
            357-434             AC182250.12        37321-37398         c
            435-487             AC182250.12        34914-34966         c
            488-649             AC182250.12        32804-32965         c
            650-774             AC182250.12        31181-31305         c
            775-853             AC182250.12        30477-30555         c
            854-1072            AC182250.12        26853-27071         c
            1073-1150           AC182250.12        23207-23284         c
            1151-1208           AC182250.12        15582-15639         c
            1209-1450           AC175315.3         5059-5300
            1451-4064           AC175315.3         5771-8384
FEATURES             Location/Qualifiers
     source          1..4064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 97.23 cM"
     gene            1..4064
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /note="REST corepressor 3"
                     /db_xref="GeneID:214742"
                     /db_xref="MGI:MGI:2441920"
     exon            1..299
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1795
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /note="isoform f is encoded by transcript variant 6"
                     /codon_start=1
                     /product="REST corepressor 3 isoform f"
                     /protein_id="NP_001333669.1"
                     /db_xref="CCDS:CCDS83667.1"
                     /db_xref="GeneID:214742"
                     /db_xref="MGI:MGI:2441920"
                     /translation="MPGMMEKGPELLGKSRSANGGAKSPAGGGGSSANGGLHFSEPES
                     GCSSDDEHGDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEY
                     IAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFH
                     GKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEE
                     AHPMDGNDSDYDPKKEAKREGNADQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKG
                     MYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFK
                     PPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFN
                     LEEVLQEWEAEQGTQASNADASALGEETQSASKVPSGKSTDEEAEAQTPQAPRTLGPS
                     PPAPSSTPTPTVPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPTLNQPP
                     PPLIRPANSMPPRLNPRPVLTTVGGQQPPSLIGIQTDSQPSLH"
     exon            300..356
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            357..434
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            435..487
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            488..649
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            650..774
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            775..853
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1072
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1150
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1208
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1450
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..4064
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3818..3823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3835
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /note="major polyA site"
     regulatory      4029..4034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4064
                     /gene="Rcor3"
                     /gene_synonym="4921514E24Rik; C730034D20Rik;
                     E130101E15Rik"
ORIGIN      
        1 gtggggcgac tgcgctacgg ctcgaccggg gcggtgatgg cggctccata ttaacacctc
       61 ctcctcctcc tccgcgctcc cgcccgcgcc cgccagccgt ctcccccttc cctgacgcca
      121 cctctccccc tcctctacca tgcccggcat gatggagaaa gggcccgagt tactggggaa
      181 gagccgatcg gccaacggcg gcgccaagag cccggcggga ggcggcggct cctcggccaa
      241 cggcgggctg cacttctcgg agcccgagag cggctgcagc agcgacgacg agcacgggga
      301 tgttgggatg agagtcggag ctgaatacca agctcggatc cctgaattcg atccaggtgc
      361 taccaagtac acagataaag acaatggagg catgcttgtg tggtctcctt atcacagtat
      421 cccagatgcc aaattggatg aatatatcgc cattgcaaaa gagaaacatg gctacaatgt
      481 tgaacaggcg cttggcatgt tgttctggca taaacacaac attgagaagt cccttgcgga
      541 cctccctaac ttcacgccct ttccggatga gtggacagtg gaagacaaag tcctgtttga
      601 acaagccttt agttttcatg ggaagagctt tcacaggatt cagcaaatgc ttccagataa
      661 gacaattgca agtcttgtaa agtattacta ttcttggaaa aaaactcgct caaggacaag
      721 tttgatggat cgccaggctc gtaaactagc caatagacac aatcagggtg acagtgatga
      781 tgacgtagaa gaagctcacc ccatggatgg aaacgacagt gactacgacc caaagaaaga
      841 agccaaaaga gagggtaacg ctgaccagcc ggtccaaacc agcaagatcg gcctgggccg
      901 gagagagtac cagagtctgc agcaccgcca ccactctcag cgctccaagt gccgccctcc
      961 taagggcatg tatctaaccc aggaggacgt ggtggctgtc tcctgcagcc ccaacgcagc
     1021 caacaccatc ctgaggcaac tggacatgga gctgatctct ctcaagcgcc aggttcagaa
     1081 tgctaagcaa gtaaacagtg cacttaagca gaaaatggaa ggtggaattg aagagttcaa
     1141 accgcctgag tcaaatcaga aaattaatgc ccgttggacc acagaggagc agcttctagc
     1201 agtgcaaggt gtccgcaaat atggtaaaga ttttcaagct attgcagatg taattggcaa
     1261 caagactgtt ggccaagtga agaacttctt tgtaaactac aggcgtcggt ttaacttaga
     1321 ggaggtattg caggagtggg aagcagaaca aggaacccag gcttctaatg ctgatgcttc
     1381 tgctttaggg gaggagacac aaagtgcttc taaggtgccg tcagggaaga gcactgacga
     1441 agaagcggag gcacagaccc cacaggctcc tcggactctg ggtccatcac ctcctgcccc
     1501 atcatccact ccaacaccaa cagtccccat tgccactctg aaccagcctc caccacttct
     1561 tcgtccaaca ctgcctgccg cccctgctct tcaccgacaa cctcctccac tccagcagca
     1621 ggctcggttc atccagcccc ggccaactct caatcagcct cctccacctc tcattcgccc
     1681 tgctaactcc atgccacccc gcctaaaccc aagaccagtg ttgaccacgg ttggcggtca
     1741 gcagccacct tcactcattg ggattcagac agattcacag ccttcactgc actaattacg
     1801 ctggacaaag gctcacctat cattgtacca gtgctcatct gactgatcca aacaaggcaa
     1861 actagtcctt cctgtggcgg gggtctagcc taagagggtg cgcacacacg ggaagtgtgg
     1921 cggtggacta gtgtaagtgg tgtgacacag caggaggcct ctgtttggcc tcctttctag
     1981 tgcccactgt gatctcatgg gaagaaaagt attctgtcta ccaaggggtt ttcgttcatt
     2041 tttactgtat ttattttgtt gaggtttctt ttttcctgcc tcttcatact caaaactgtt
     2101 agtacaaaaa tattgactta ggaattgtaa aaaaaacaaa acaaaaacaa aacaaaaaca
     2161 aaacaaaaaa aaaactcctt aagttcctta aggatgttta tctttctgct tttttcttta
     2221 atttaaattt tttaaaagac actttcctat gttaggagtg caagataaat agcctgcatt
     2281 tcagattttg atatgttcat atttaagaaa ttatagcttc atatcccttt tttcaaaata
     2341 tgttgctttt tttctaaagg aattttagta tattccttta aaagaaagca attaaatcaa
     2401 ttgcaaagca attatatgaa accacaaaga atgtattgaa cctgctaatc ctttaacata
     2461 gtttggggtc ctagtgcaaa gtccttgttt aaaggtcatt gaccctgtta tctatcagta
     2521 atagaggttt ggaatcactc acatgcagaa aaaggactta aaatttggtg agatataatg
     2581 ttttttaagt tctttgaaaa tattaatttt gaaaaaagaa gtttctaaat gctatttgct
     2641 tttagctagt atctgcctat gttgggaatt tagaacaatt ttcagttatg tagagatggt
     2701 ggttatggaa acatttattt acagtttatc ttctgaactt aaagttcata ctcactaaga
     2761 ggatctgtgt ttgatacaaa gagtgtttgg tttggtttgg tttttttttt ttttccttgc
     2821 taaatctctg ttgaacatct gaatacattt gtatgatcct ttcaaccaac ctgagcttgt
     2881 ggtttgattt agggctaagt catcggcatc acaagatgag ctcattgtgt tgttgcaata
     2941 attgtgccgt tagctaacgt actgagatcg tttttatgaa gaaacagagg cttaaggcct
     3001 ttttattcca atgcaaagtc attagcaccc acaaagaata ttttactatg gcggagtttc
     3061 aacagcgtgt tactgacagc tttgatagaa tgacttcata tgggaagcat ggcttgctgt
     3121 agagggacac ttgctagggc cgcaggctgc ccacatcaga ggggtcatgt ttccttaagt
     3181 actggaaaaa aataatccct ttatgggctc tccagcccat tggtcaattt taattttcag
     3241 ctttcccttc aaaaggaccc tctattctga tgtgattgaa agtggcttgc agaaaaggcc
     3301 cttttttttt ttctcatcag atcaccttaa tagtttatgc cccgtataaa atgtaactga
     3361 tctaaaaata ataatagaga atttatactt atttttactt taaaagccat ggaagacggt
     3421 tatgtatctt aaactgtcta gagcattttt gaaagcactt gtcttgtgta cgtgcatatt
     3481 ataccgtgac agctttcatc gtcttgtctc tcgtcagtag acctgcagta cagtctgtgg
     3541 gagatgtcag tcaagttgtt cagcaccagc atctgtccag atgttcagta tctgtggctt
     3601 aggtgctgta tctgagggat gtgttgcaat tttctttaca aacactagag cacacagtag
     3661 aagaatagta gtttcattag taatatgaca catgtatata gtgagatgtc ttcattgtgt
     3721 gctttgcata ttttgtaaat attttgcacg tcattatttt ccttttttgt ttgagcagtg
     3781 tttggcctgg aagagtaata tgcttgctgc ttaaaggatt aaagatttaa aggtgtccat
     3841 gtcttctatt tttatataac ctcatattgt atgagaattt aggacctctc actgtgaaat
     3901 tctaagtact ggtttatata tatatatata aagcaaagcc tagaaatttc ttaatgacca
     3961 tttttgttaa ttctgaagtt atcttttttg agagatctac accaaagtgt ttttataaca
     4021 taactaaaaa taaatcacat tgttgctact actgttaaaa ttaa
//
