LOCUS       NM_054048               2299 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus REST corepressor 2 (Rcor2), transcript variant 2,
            mRNA.
ACCESSION   NM_054048 XM_006526552
VERSION     NM_054048.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2299)
  AUTHORS   Rummukainen,P., Tarkkonen,K., Al Majidi,R., Puolakkainen,T.,
            Nieminen-Pihala,V., Valensisi,C., Saastamoinen,L., Hawkins,D.,
            Heino,T.J., Ivaska,K.K. and Kiviranta,R.
  TITLE     The complex role of Rcor2: Regulates mesenchymal stromal cell
            differentiation in vitro but is dispensable in vivo
  JOURNAL   Bone 187, 117180 (2024)
   PUBMED   38944098
REFERENCE   2  (bases 1 to 2299)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2299)
  AUTHORS   Hoye,M.L., Calviello,L., Poff,A.J., Ejimogu,N.E., Newman,C.R.,
            Montgomery,M.D., Ou,J., Floor,S.N. and Silver,D.L.
  TITLE     Aberrant cortical development is driven by impaired cell cycle and
            translational control in a DDX3X syndrome model
  JOURNAL   Elife 11, e78203 (2022)
   PUBMED   35762573
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2299)
  AUTHORS   Pei,L., Zhang,H., Zhang,M., Wang,Y. and Wei,K.
  TITLE     Rcor2 Is Required for Somatic Differentiation and Represses
            Germline Cell Fate
  JOURNAL   Stem Cells Int 2022, 5283615 (2022)
   PUBMED   35345626
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2299)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2299)
  AUTHORS   Wang,J., Scully,K., Zhu,X., Cai,L., Zhang,J., Prefontaine,G.G.,
            Krones,A., Ohgi,K.A., Zhu,P., Garcia-Bassets,I., Liu,F., Taylor,H.,
            Lozach,J., Jayes,F.L., Korach,K.S., Glass,C.K., Fu,X.D. and
            Rosenfeld,M.G.
  TITLE     Opposing LSD1 complexes function in developmental gene activation
            and repression programmes
  JOURNAL   Nature 446 (7138), 882-887 (2007)
   PUBMED   17392792
REFERENCE   7  (bases 1 to 2299)
  AUTHORS   Ballas,N., Grunseich,C., Lu,D.D., Speh,J.C. and Mandel,G.
  TITLE     REST and its corepressors mediate plasticity of neuronal gene
            chromatin throughout neurogenesis
  JOURNAL   Cell 121 (4), 645-657 (2005)
   PUBMED   15907476
REFERENCE   8  (bases 1 to 2299)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 2299)
  AUTHORS   Tontsch,S., Zach,O. and Bauer,H.C.
  TITLE     Identification and localization of M-CoREST (1A13), a mouse
            homologue of the human transcriptional co-repressor CoREST, in the
            developing mouse CNS
  JOURNAL   Mech Dev 108 (1-2), 165-169 (2001)
   PUBMED   11578870
REFERENCE   10 (bases 1 to 2299)
  AUTHORS   Grimes,J.A., Nielsen,S.J., Battaglioli,E., Miska,E.A., Speh,J.C.,
            Berry,D.L., Atouf,F., Holdener,B.C., Mandel,G. and Kouzarides,T.
  TITLE     The co-repressor mSin3A is a functional component of the
            REST-CoREST repressor complex
  JOURNAL   J Biol Chem 275 (13), 9461-9467 (2000)
   PUBMED   10734093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY198423.1, AK052295.1 and BC055719.1.
            
            On or before Feb 27, 2016 this sequence version replaced
            XM_006526552.2, NM_054048.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052295.1, SRR7652917.871514.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY198423.1         2-11
            11-2281             AK052295.1         2-2272
            2282-2299           BC055719.1         2440-2457
FEATURES             Location/Qualifiers
     source          1..2299
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.32 cM"
     gene            1..2299
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /note="REST corepressor 2"
                     /db_xref="GeneID:104383"
                     /db_xref="MGI:MGI:1859854"
     exon            1..31
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            32..269
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1714
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /note="co-repressor of Rest; REST co-repressor 2;
                     RE1-silencing transcription factor (REST) co-repressor 1"
                     /codon_start=1
                     /product="REST corepressor 2"
                     /protein_id="NP_473389.2"
                     /db_xref="CCDS:CCDS29522.2"
                     /db_xref="GeneID:104383"
                     /db_xref="MGI:MGI:1859854"
                     /translation="MPSVMEKPSAGSGILSRSRAKTAPNGGQPHSEDDSSEEEHSHDS
                     MIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGY
                     NIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQM
                     LPDKVIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGAVSEGEPD
                     TGDPKREPLPSRPLNARPGPGKKEVQISQYRHHPLRTRRRPPKGMYLSPEGLTAVSGS
                     PDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTT
                     DEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDG
                     APAAPVPTEEARRGAPVPATALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPP
                     PLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPP
                     PTLVGAPLEPPAPSL"
     exon            270..326
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..407
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..460
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..622
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..747
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..817
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1033
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1111
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1169
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1399
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..2282
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2261..2266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /note="hexamer: AATAAA"
     polyA_site      2282
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcagctc acaggcttcg agctgctgcc gcctcagtgg cgacccctcc aggccgggcc
       61 aggcgcagca ctcgaggcaa gcgcggcaag ctcctgcgct ctccaaagga tcccgtgccc
      121 ctcggggctg ccgggtaggg taatgccctc agtaatggag aagcccagtg cgggctccgg
      181 gatcttgtcc cgaagtcggg ccaagacggc acccaacggc ggacagccac actcggagga
      241 tgacagcagc gaggaggagc actctcatga cagcatgatc cgagttggaa ccaattacca
      301 agcagtaatt ccggagtgca agcctgagag ccctgcacgc tatagcaaca aggagctgaa
      361 gggaatgctg gtgtggtccc ccaaccactg tgtatcagat gccaaacttg acaagtacat
      421 tgcaatggcc aaggagaagc atggctataa cattgagcag gcactcggca tgcttctgtg
      481 gcataaacac gatgtggaga aatcactggc tgacctagcc aacttcactc ccttccctga
      541 tgagtggacg gtggaggaca aggtgctgtt tgaacaggcc tttgggttcc atggcaagtg
      601 cttccagcgg atccagcaga tgctccctga caaggtgatt cccagcctgg tgaagtatta
      661 ctactcttgg aagaagaccc gaagtcgaac tagtgtgatg gacaggcagg ccaggcggct
      721 gggtggccgc aaggacaaag aagacagtga tgaactagaa gagggacgag gagctgtgag
      781 tgagggggaa ccggatactg gagaccccaa gcgagagcct ctgccatcca gacctctgaa
      841 tgcacggcct ggtcctggga agaaggaggt tcagatatct cagtatcgcc accacccact
      901 tcgaactcgg agacgtccgc ccaagggcat gtacctgagt cctgaaggcc tcactgcagt
      961 atcgggaagc ccagacctcg ctaacctcac actccgaggt cttgactcac agctcatctc
     1021 tcttaagcgc caggtccaga gcatgaagca gaccaatagc agcctccgcc aagcactgga
     1081 gggcggcatt gaccctctcc gcccccctga ggctaatacc aagttcaact cccgctggac
     1141 cactgatgag caacttctag ctgttcaagc tattcgtaga tacggcaaag actttggggc
     1201 tattgcagag gtgattggga acaagactct gacccaagtg aagaccttct ttgtgagcta
     1261 tcgtcgccgc ttcaacctgg aagaggtgct gcaggaatgg gaggctgagc aggatggggc
     1321 ccccgcagct ccggtcccca cggaagaggc caggcgaggg gctcctgtac cagccacagc
     1381 cctagaagaa gatgatgagg tccagattac atctgtctca acatcagtac cccgatcagt
     1441 accccctgca ccgcccccac ctccaccgcc cacctcgctt tcccagccac ccccgctgct
     1501 gaggccacct ctgcccacag ctcccacatt gctccgccag ccgcctcccc tgcagcaggg
     1561 ccgcttcctg cagcctcggc tggcccccaa ccagcctcca ccaccgctca tccgccctgc
     1621 cctggctgcc tctcgccaca gtgcccgccc tggtcctcag cctccaccta ccctggttgg
     1681 agctcctttg gagccccctg caccctcact ttgagcctga atcctccatt gcccagaggc
     1741 tcctgaaccc ctttggctgg atctctctgg cagcactaag gacagaaggg actagggctc
     1801 ttgccaggtc tttcaaatac ccaaagctgc cagttggcac agcttggacc tgtgggttct
     1861 gcatgtgttc ctggcagctg agcttgtaaa cccccagcca ggggctagat ctcagggcct
     1921 gcagggactc ttgcttcctg gctgtgactg gaatggctgc ctccttgcct gcctgcctgc
     1981 agagggcttg gcctctgggc ctaccctttg tgtgggggta atgactttag cctgggggat
     2041 gggggagagg acaggatgtt agctggcctc attcaccttt ccttcttttt agcaataagt
     2101 caggtgcagt ggaaggggat tggggtgggg atggcagaaa tctggtggga agaatgttgg
     2161 gtagctgtga ggagacccac tttgtccacc cccaaaagtt tggagaaaga agggttgggg
     2221 acttacacag acatgggttt atttttcaac atttttaaaa aataaatgca accttgaatg
     2281 taaaaaaaaa aaaaaaaaa
//
