LOCUS       NM_001320554            2840 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus REST corepressor 2 (Rcor2), transcript variant 1,
            mRNA.
ACCESSION   NM_001320554
VERSION     NM_001320554.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2840)
  AUTHORS   Rummukainen,P., Tarkkonen,K., Al Majidi,R., Puolakkainen,T.,
            Nieminen-Pihala,V., Valensisi,C., Saastamoinen,L., Hawkins,D.,
            Heino,T.J., Ivaska,K.K. and Kiviranta,R.
  TITLE     The complex role of Rcor2: Regulates mesenchymal stromal cell
            differentiation in vitro but is dispensable in vivo
  JOURNAL   Bone 187, 117180 (2024)
   PUBMED   38944098
REFERENCE   2  (bases 1 to 2840)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2840)
  AUTHORS   Hoye,M.L., Calviello,L., Poff,A.J., Ejimogu,N.E., Newman,C.R.,
            Montgomery,M.D., Ou,J., Floor,S.N. and Silver,D.L.
  TITLE     Aberrant cortical development is driven by impaired cell cycle and
            translational control in a DDX3X syndrome model
  JOURNAL   Elife 11, e78203 (2022)
   PUBMED   35762573
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2840)
  AUTHORS   Pei,L., Zhang,H., Zhang,M., Wang,Y. and Wei,K.
  TITLE     Rcor2 Is Required for Somatic Differentiation and Represses
            Germline Cell Fate
  JOURNAL   Stem Cells Int 2022, 5283615 (2022)
   PUBMED   35345626
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2840)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2840)
  AUTHORS   Wang,J., Scully,K., Zhu,X., Cai,L., Zhang,J., Prefontaine,G.G.,
            Krones,A., Ohgi,K.A., Zhu,P., Garcia-Bassets,I., Liu,F., Taylor,H.,
            Lozach,J., Jayes,F.L., Korach,K.S., Glass,C.K., Fu,X.D. and
            Rosenfeld,M.G.
  TITLE     Opposing LSD1 complexes function in developmental gene activation
            and repression programmes
  JOURNAL   Nature 446 (7138), 882-887 (2007)
   PUBMED   17392792
REFERENCE   7  (bases 1 to 2840)
  AUTHORS   Ballas,N., Grunseich,C., Lu,D.D., Speh,J.C. and Mandel,G.
  TITLE     REST and its corepressors mediate plasticity of neuronal gene
            chromatin throughout neurogenesis
  JOURNAL   Cell 121 (4), 645-657 (2005)
   PUBMED   15907476
REFERENCE   8  (bases 1 to 2840)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 2840)
  AUTHORS   Tontsch,S., Zach,O. and Bauer,H.C.
  TITLE     Identification and localization of M-CoREST (1A13), a mouse
            homologue of the human transcriptional co-repressor CoREST, in the
            developing mouse CNS
  JOURNAL   Mech Dev 108 (1-2), 165-169 (2001)
   PUBMED   11578870
REFERENCE   10 (bases 1 to 2840)
  AUTHORS   Grimes,J.A., Nielsen,S.J., Battaglioli,E., Miska,E.A., Speh,J.C.,
            Berry,D.L., Atouf,F., Holdener,B.C., Mandel,G. and Kouzarides,T.
  TITLE     The co-repressor mSin3A is a functional component of the
            REST-CoREST repressor complex
  JOURNAL   J Biol Chem 275 (13), 9461-9467 (2000)
   PUBMED   10734093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ165194.1 and BC055719.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055719.1, SRR7345562.2211066.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               CJ165194.1         1-383
            384-2840            BC055719.1         1-2457
FEATURES             Location/Qualifiers
     source          1..2840
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.32 cM"
     gene            1..2840
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /note="REST corepressor 2"
                     /db_xref="GeneID:104383"
                     /db_xref="MGI:MGI:1859854"
     exon            1..810
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     CDS             684..2255
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /note="co-repressor of Rest; REST co-repressor 2;
                     RE1-silencing transcription factor (REST) co-repressor 1"
                     /codon_start=1
                     /product="REST corepressor 2"
                     /protein_id="NP_001307483.1"
                     /db_xref="CCDS:CCDS29522.2"
                     /db_xref="GeneID:104383"
                     /db_xref="MGI:MGI:1859854"
                     /translation="MPSVMEKPSAGSGILSRSRAKTAPNGGQPHSEDDSSEEEHSHDS
                     MIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGY
                     NIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQM
                     LPDKVIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGAVSEGEPD
                     TGDPKREPLPSRPLNARPGPGKKEVQISQYRHHPLRTRRRPPKGMYLSPEGLTAVSGS
                     PDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTT
                     DEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDG
                     APAAPVPTEEARRGAPVPATALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPP
                     PLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPP
                     PTLVGAPLEPPAPSL"
     exon            811..867
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..948
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1001
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1163
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1288
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1358
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1574
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1652
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1710
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1940
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2823
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2802..2807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /note="hexamer: AATAAA"
     polyA_site      2823
                     /gene="Rcor2"
                     /gene_synonym="1A13; CoREST; Rcor; Rcor1"
                     /note="major polyA site"
ORIGIN      
        1 attgtgtgcg cgaggagcga gcggcggcgg agagcgggcg agcgagcggc ggtagcgcga
       61 gcgcggcggg gcgagcgagc gcgccgggga gggtgcgagg cggcgcccgc ggctgcgctc
      121 cgcccgcctc ccggcaactc tgctccagcg ccgcacgccg tgcgcgccgt cctgccgccg
      181 gggctccagc cggctggcgt ggttgccgtg gggtcgggtc gggcagggtt acctccgttg
      241 gggatcgggg catcctcagc gcagccgagg ggcgcggagt cagctgcggc ggccactgcg
      301 cggtagccct tgctggccaa acagcgtggg caggcgcgcg gcgcggctcc ggggctcccc
      361 gagggcaacg cgccccgact ctccccgggg gagaaccagc cccgaggggc gcacggagcg
      421 agcgtgcccc cggccgcgcc gtctcccccg tacccccact tcacaaactt ttctgccgtc
      481 ctcgcccgtg ggggtcgcag tgagcgttag ggctgccctc cggggccccg acctcccgga
      541 ccctagccac gctgacctcc tgcctctcgt agcctcagtg gcgacccctc caggccgggc
      601 caggcgcagc actcgaggca agcgcggcaa gctcctgcgc tctccaaagg atcccgtgcc
      661 cctcggggct gccgggtagg gtaatgccct cagtaatgga gaagcccagt gcgggctccg
      721 ggatcttgtc ccgaagtcgg gccaagacgg cacccaacgg cggacagcca cactcggagg
      781 atgacagcag cgaggaggag cactctcatg acagcatgat ccgagttgga accaattacc
      841 aagcagtaat tccggagtgc aagcctgaga gccctgcacg ctatagcaac aaggagctga
      901 agggaatgct ggtgtggtcc cccaaccact gtgtatcaga tgccaaactt gacaagtaca
      961 ttgcaatggc caaggagaag catggctata acattgagca ggcactcggc atgcttctgt
     1021 ggcataaaca cgatgtggag aaatcactgg ctgacctagc caacttcact cccttccctg
     1081 atgagtggac ggtggaggac aaggtgctgt ttgaacaggc ctttgggttc catggcaagt
     1141 gcttccagcg gatccagcag atgctccctg acaaggtgat tcccagcctg gtgaagtatt
     1201 actactcttg gaagaagacc cgaagtcgaa ctagtgtgat ggacaggcag gccaggcggc
     1261 tgggtggccg caaggacaaa gaagacagtg atgaactaga agagggacga ggagctgtga
     1321 gtgaggggga accggatact ggagacccca agcgagagcc tctgccatcc agacctctga
     1381 atgcacggcc tggtcctggg aagaaggagg ttcagatatc tcagtatcgc caccacccac
     1441 ttcgaactcg gagacgtccg cccaagggca tgtacctgag tcctgaaggc ctcactgcag
     1501 tatcgggaag cccagacctc gctaacctca cactccgagg tcttgactca cagctcatct
     1561 ctcttaagcg ccaggtccag agcatgaagc agaccaatag cagcctccgc caagcactgg
     1621 agggcggcat tgaccctctc cgcccccctg aggctaatac caagttcaac tcccgctgga
     1681 ccactgatga gcaacttcta gctgttcaag ctattcgtag atacggcaaa gactttgggg
     1741 ctattgcaga ggtgattggg aacaagactc tgacccaagt gaagaccttc tttgtgagct
     1801 atcgtcgccg cttcaacctg gaagaggtgc tgcaggaatg ggaggctgag caggatgggg
     1861 cccccgcagc tccggtcccc acggaagagg ccaggcgagg ggctcctgta ccagccacag
     1921 ccctagaaga agatgatgag gtccagatta catctgtctc aacatcagta ccccgatcag
     1981 taccccctgc accgccccca cctccaccgc ccacctcgct ttcccagcca cccccgctgc
     2041 tgaggccacc tctgcccaca gctcccacat tgctccgcca gccgcctccc ctgcagcagg
     2101 gccgcttcct gcagcctcgg ctggccccca accagcctcc accaccgctc atccgccctg
     2161 ccctggctgc ctctcgccac agtgcccgcc ctggtcctca gcctccacct accctggttg
     2221 gagctccttt ggagccccct gcaccctcac tttgagcctg aatcctccat tgcccagagg
     2281 ctcctgaacc cctttggctg gatctctctg gcagcactaa ggacagaagg gactagggct
     2341 cttgccaggt ctttcaaata cccaaagctg ccagttggca cagcttggac ctgtgggttc
     2401 tgcatgtgtt cctggcagct gagcttgtaa acccccagcc aggggctaga tctcagggcc
     2461 tgcagggact cttgcttcct ggctgtgact ggaatggctg cctccttgcc tgcctgcctg
     2521 cagagggctt ggcctctggg cctacccttt gtgtgggggt aatgacttta gcctggggga
     2581 tgggggagag gacaggatgt tagctggcct cattcacctt tccttctttt tagcaataag
     2641 tcaggtgcag tggaagggga ttggggtggg gatggcagaa atctggtggg aagaatgttg
     2701 ggtagctgtg aggagaccca ctttgtccac ccccaaaagt ttggagaaag aagggttggg
     2761 gacttacaca gacatgggtt tatttttcaa catttttaaa aaataaatgc aaccttgaat
     2821 gtaaaaaaaa aaaaaaaaaa
//
