LOCUS       NM_198023               5669 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus REST corepressor 1 (Rcor1), mRNA.
ACCESSION   NM_198023 XM_006515760 XM_127140
VERSION     NM_198023.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5669)
  AUTHORS   Ramirez,M., Badayeva,Y., Yeung,J., Wu,J., Abdalla-Wyse,A., Yang,E.,
            Trost,B., Scherer,S.W. and Goldowitz,D.
  CONSRTM   FANTOM 5 Consortium
  TITLE     Temporal analysis of enhancers during mouse cerebellar development
            reveals dynamic and novel regulatory functions
  JOURNAL   Elife 11, e74207 (2022)
   PUBMED   35942939
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5669)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5669)
  AUTHORS   Xiong,Y., Wang,L., Di Giorgio,E., Akimova,T., Beier,U.H., Han,R.,
            Trevisanut,M., Kalin,J.H., Cole,P.A. and Hancock,W.W.
  TITLE     Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and
            promotes antitumor immunity
  JOURNAL   J Clin Invest 130 (4), 1830-1842 (2020)
   PUBMED   31917688
  REMARK    GeneRIF: Inhibiting the coregulator CoREST impairs Foxp3+ Treg
            function and promotes antitumor immunity.
REFERENCE   4  (bases 1 to 5669)
  AUTHORS   Zhang,C., Leng,F., Saxena,L., Hoang,N., Yu,J., Alejo,S., Lee,L.,
            Qi,D., Lu,F., Sun,H. and Zhang,H.
  TITLE     Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and
            CRL4DCAF5 ubiquitin ligase
  JOURNAL   J Biol Chem 294 (2), 476-489 (2019)
   PUBMED   30442713
REFERENCE   5  (bases 1 to 5669)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5669)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   7  (bases 1 to 5669)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 5669)
  AUTHORS   Grimes,J.A., Nielsen,S.J., Battaglioli,E., Miska,E.A., Speh,J.C.,
            Berry,D.L., Atouf,F., Holdener,B.C., Mandel,G. and Kouzarides,T.
  TITLE     The co-repressor mSin3A is a functional component of the
            REST-CoREST repressor complex
  JOURNAL   J Biol Chem 275 (13), 9461-9467 (2000)
   PUBMED   10734093
REFERENCE   9  (bases 1 to 5669)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 5669)
  AUTHORS   Lan,Y., Jiang,R., Shawber,C., Weinmaster,G. and Gridley,T.
  TITLE     The Jagged2 gene maps to chromosome 12 and is a candidate for the
            lgl and sm mutations
  JOURNAL   Mamm Genome 8 (11), 875-876 (1997)
   PUBMED   9341252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153152.5 and AC122023.3.
            
            On or before Mar 7, 2019 this sequence version replaced
            XM_006515760.3, NM_198023.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042731.1, SRR7652917.393784.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-522               AC153152.5         61617-62138         c
            523-582             AC153152.5         61484-61543         c
            583-666             AC153152.5         19698-19781         c
            667-719             AC153152.5         8372-8424           c
            720-881             AC153152.5         3889-4050           c
            882-1000            AC153152.5         1467-1585           c
            1001-1079           AC122023.3         147574-147652       c
            1080-1274           AC122023.3         145477-145671       c
            1275-1352           AC122023.3         140633-140710       c
            1353-1410           AC122023.3         140371-140428       c
            1411-1640           AC122023.3         139272-139501       c
            1641-5669           AC122023.3         133380-137408       c
FEATURES             Location/Qualifiers
     source          1..5669
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 60.93 cM"
     gene            1..5669
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /note="REST corepressor 1"
                     /db_xref="GeneID:217864"
                     /db_xref="MGI:MGI:106340"
     exon            1..522
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1682
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /codon_start=1
                     /product="REST corepressor 1"
                     /protein_id="NP_932140.2"
                     /db_xref="CCDS:CCDS49179.2"
                     /db_xref="GeneID:217864"
                     /db_xref="MGI:MGI:106340"
                     /translation="MPAMVEKGPEVSGKRRGRNTAASAASAAASAASAAASAAASAGT
                     ASASAAAAASAAAAPNNGQNKSLAAAAPNGNSGSNSWEEGSSGSSSDEEHGGGGMRVG
                     PQYQAAVPDFDPAKLARRSQERDNLGMLVWSPNQSLSEAKLDEYIAIAKEKHGYNMEQ
                     ALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDK
                     SIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEETNGSNPVDIEIDPNKE
                     SKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQ
                     LDMELVSIKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAI
                     RKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKDETNGPANQK
                     PVKSPESSIKIPEEEDEAASVLDVRYASAS"
     exon            523..582
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..666
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..719
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..881
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1000
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1079
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1274
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1352
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1410
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1640
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..5669
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5642..5647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /note="hexamer: AATAAA"
     polyA_site      5663
                     /gene="Rcor1"
                     /gene_synonym="5730409O11; 6720480E22Rik; D12Wsu95e;
                     mKIAA0071; Rocr1"
                     /note="major polyA site"
ORIGIN      
        1 agagccagcg aagtgcgggc ggcgatgaga gccaaagttg cgctccgttc ggcatcgggg
       61 gcttgaggcg gctcgttgct ccgcccgtct gggcctcctc tagccccaac tcccgccagc
      121 ggatcccgcg cgctcgcccg cccggcccgg cgcccacctg cgccccctgc ccgcggcccg
      181 ccgcccgcgc ctcgcgagcc ggggtccccg tcactttggc ccggccccgg gccccgccga
      241 tgccggccat ggtggagaag ggccccgagg tctcagggaa gcggcgaggg aggaacacgg
      301 cggcctccgc agcctcggcc gccgcctcgg ccgcctcggc cgccgcctca gccgccgcct
      361 cggccggcac cgcctccgcc tcggccgccg ccgccgcctc ggccgccgcc gcccccaata
      421 atggccagaa taaaagtttg gcggcggcgg ctcccaacgg gaacagcggc agcaactcct
      481 gggaggaagg cagctcgggc tcgtccagcg acgaggagca cggtggcggt ggcatgcggg
      541 tgggacccca gtaccaagcg gcggtgcccg acttcgatcc tgccaaactg gcaaggcgca
      601 gtcaagaacg agacaatctt ggcatgttgg tctggtcacc taatcagagt ctttctgaag
      661 caaaactgga cgagtacatc gctatcgcca aagagaagca cgggtacaac atggagcagg
      721 ctcttgggat gctcttttgg cataagcata atattgaaaa atcattggcc gacttgccca
      781 acttcacccc ctttccagat gagtggactg tagaagacaa agtcttattt gagcaagcct
      841 ttagttttca tgggaaaact tttcatagga tccagcaaat gcttcctgat aaatccatag
      901 caagtttggt gaagttttac tactcttgga agaaaactag aactaaaaca agtgtgatgg
      961 atcgccatgc tcggaaacag aagcgggagc gggaggaaag tgaggatgaa ctggaagaaa
     1021 caaacggcag taatcccgtt gacattgaga ttgacccaaa caaggaaagc aaaaaggagg
     1081 tgccccctac agagacagtt cctcaggtca aaaaagaaaa gcacagcaca caagctaaaa
     1141 atagagcaaa aaggaaacct ccgaaaggca tgtttctttc tcaagaagat gtggaggctg
     1201 tgtctgctaa tgctactgct gcgaccacgg tgctgagaca gctggacatg gagctggtct
     1261 ccatcaaacg acagattcag aacatcaagc agacgaacag tgctcttaaa gagaagcttg
     1321 atggtgggat agagccttac cgactcccag aggttattca aaaatgcaac gctcgctgga
     1381 caacggaaga gcagcttctc gccgtacaag ccattaggaa atatgggcga gattttcagg
     1441 cgatctcaga tgtgattggg aacaagtcag ttgttcaggt gaaaaacttt tttgtaaatt
     1501 atcgacgccg cttcaacata gatgaagttt tacaagaatg ggaagcagaa catgggaaag
     1561 acgagaccaa tggacctgct aaccagaaac ctgtcaagtc cccagaaagc tccatcaaga
     1621 tcccggagga ggaagatgag gctgcttctg tcctcgacgt aagatacgca tctgcctcat
     1681 gaaaactgtt ggtagctttg aacacttggt atggacgaca cgttatccag gtatcaggta
     1741 ttacaagaca tcacctagcc atctgcatca catctctgtg gacaagcagc tattaccaaa
     1801 aaaggcatac acttccagtc ccgtgctaca tctgccttaa ttctttgctc gttcctccat
     1861 gttggcacga cttcccagag agctccgttg catctcattc tgcctaaggg ctgggggacc
     1921 cacggcctgc acacctccct cgagtctggg acctaccctc cagttggctc ccccccgagc
     1981 cccaacaatg gcagctctcc caatcaacag cttcagaaca ggtagtcttg aaaggcccag
     2041 ctctgttcct gcatggcctg cagtttctac tttgtgcata gtgtaattct cagaaggcct
     2101 agtagacctt ctagaaaaag tctccccttc tctcctgggg cagccaccta agtaaaatca
     2161 tgcttctttg gaaatcacaa gcccttcagc agaccacatc gtcaccttta tcatacaagc
     2221 ttcctgatac aactcctgtt tccctaagag aggacagtta tggctgtaga tcaggtggct
     2281 tctctcccct ttctctctcc cctaactctt tcccttttct cctttccaag tggtaaaagc
     2341 tcatttgcag caactgtcct tgggcactgt agcctcatgg gaacgtggac ctcagtgctt
     2401 tctgccttca gccttcagca ttgtaatccc aggatgaggg tgcacccatc tcttcttgat
     2461 ccccagctgc caccatcatc cccagctccg agagatttgg ttcctatcat tgtacctggt
     2521 gcttgtacat ttggaattgg tgccttctcc ttctggcaac catgttatca atcccttttc
     2581 tgtttaagtg tcttacttaa agtttattgc ttgccaaaga tgccatcatt gaggtgtagc
     2641 agatggggag ggtgtctgca ggtttgagtg cagactttaa atgtcaggtc agctcaggaa
     2701 aggagaagag agaagctagg gatggtttcc tagacgctgc acaccagtag ctctcatcct
     2761 cttggcgtgc ctggccattg tatgtcactc catgtgtcct tttgtgtcat ttgtgtactg
     2821 gtgtgatcac acaaacacta tatcctgtct cttagcagca gataggacag ataagtaatg
     2881 gatgtgtttg ttgcttagtg agaccaagat gaaaagaaac aacctagagt ggtggcaatg
     2941 ccatttgttt ggactgggaa caagcaaggg ttgctaataa atgttctgag acttcagaat
     3001 cacttttgct ctcttaccag actgtgggcc tgaagggcct gaggagcagc cggctgggct
     3061 gtgtcctagc atccatggcc acttgagact gcactaacca tgtggaaata tcttttgttg
     3121 ttgttttaat attttttctg ctttcaatac caaaaaggaa aaaaaaaaaa gtagatgctt
     3181 taaggtattt aaggtatgaa tggagttctg aagaatttaa aatatgcaat taaaattcga
     3241 tgttttgact cctaagcacc ttcccccctc cccttttttt aagttagctg attttctctt
     3301 tagaaagagg ttcagctggg gataggatgt atattcttct tgagaagtct ggagaaaggt
     3361 cattccaagg tcaagtgcag agggactttg tccatcctgt ctcacaccgg cccattgatg
     3421 aggaagagtc atagagatga gtcagaggca cggcccgtgg tcccacccag gaacccaggg
     3481 acccagggac ccagggaccg gtaacagagt aacactagta acttcttttg tgcttttatc
     3541 ataaacctgc tgtgtagctg aaggggaagg caagcacagg atgaagttag cctccgctct
     3601 gcgtgtgact cacagggaca ctgaggcaca agataaaacc ctgctcacct agcgtgtttg
     3661 catgcccttc cctccagtga gcagagcagc gctgtgctac agggtggctg ctgccgtggt
     3721 tttctccgtc tgccggtggc tctgtgtctg tctttgtgcc caggctactt tgcttgagat
     3781 gtgttccccc tcagcagtgt tgagacttgg tgatcatctc ggatggtgtg gcaggcagag
     3841 cggctgtgcc aggcaccagg cttgttctgt ctttctcttg gttgtgagcg tggcgtggta
     3901 tctagccatg aagagtccgg tgtcgggcgg tatggttatg accagagcag ctgatcttcc
     3961 ctttcctcca aggaagagag gcgcgcatgc cgttctcact tggcagaggg gcgagagtgg
     4021 gctctgcctg gctgctgctg ctgctgctgg aatagtctcc atgttttaaa cttttcatga
     4081 cacagtccac agtgatataa gtccaagaaa ctgcttagct ttcaaagccg agggctctgg
     4141 tctggactgt gactgttaca gtcaagagtt aggtgcatca gcaggttagg tttggaacat
     4201 gacacctgct tccgatggaa tgtcacttaa gctttgggtt cttaaaaatt atcaatgtga
     4261 atgtcataat tatatatttt tgtgggaaaa tcttctaaat ataagttatt gtgcaaaata
     4321 tagtatcatg gacacaaata atagtctaag gtttagttta gagatcccta aagatataaa
     4381 ctgtattgca tatgcattaa aagtttgttt tatttaattt tctgtgaaca tgtaaagtgt
     4441 taggtaattc ttttccctta tccacgtaag cacctgttac ttgaatattg tgttgaccgg
     4501 ccagcggcag tgatcaatgc tgtactctag ctctttcctc agaggccctg gcctcggccg
     4561 tgctggtcag atgagtgttg gcacacagtg ggtgctgtgt cagaggttca caacagaggg
     4621 tcacagcaca cccactgcct ctttgtttat ttgtcaaaac agcttcctaa agaaggtttc
     4681 agagagtttt tgtaagacct tcccaatggt ggttacaaac cttaatcaaa aacacagaag
     4741 gtgacaaagc ttactgtggt gggctcatga agcaggagtc ctgttagaca gtttcccagc
     4801 gctgcctctg agtgagctca gtgacacttt aattcagctc cgcccacttc gtctttctca
     4861 ctatgagatg tactattggt ataattgcac accaaaaata agccaaacag tgcattacac
     4921 taactggatc cctgctttca tggaagcaaa ggaaagacac gtctcacgtc tctgtcctgt
     4981 ttgtacacct agtgacccag gattcaagtt tttagtatca agtaaacttc gcctcagact
     5041 gactaaggca gctgtaggtc atctgagtct aatgctcgtg tgcaatgccc ttcccgcctc
     5101 tcccgggtct ttgcagcttc tcctcactgt agtaaagcac aattgcagga gcgtccgtca
     5161 cggctcagaa ggagtcagta gtctatgcat gttgtaagat aatgagtgtt tacagtcgcc
     5221 ttctctaaag tgagcattta tactggagtg ggtagcattc cattatgtag acttcaaact
     5281 ttgctaagtg ctttttagat tgcttaaaaa tttttcaaga ttttaaaaga tgtataaggt
     5341 taagtttgca aatataacgg aaatgctgta tatcttttga agtgataaaa tccatgttaa
     5401 aattttaaag aaaatatgtt gtaataatgc tgttgtaagt aatatttcca tgtctctctg
     5461 cttgttttct agttcagcac agtcattgtg gtgaatgtcc atagcattat aatcgcttag
     5521 ccattgaatt ataatatttg ttagtggaga ttgggaaatt tatttgtgaa attctgcaga
     5581 attcattttt ctatttccaa tatttgctga agttaaataa aaattttcaa gccattgatg
     5641 taataaaata cgaaacaaaa caacgtaat
//
