LOCUS       NM_009037               3063 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus reticulocalbin 1 (Rcn1), mRNA.
ACCESSION   NM_009037
VERSION     NM_009037.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3063)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3063)
  AUTHORS   Deng,S., Pan,Y., An,N., Chen,F., Chen,H., Wang,H., Xu,X., Liu,R.,
            Yang,L., Wang,X., Du,X. and Zhang,Q.
  TITLE     Downregulation of RCN1 promotes pyroptosis in acute myeloid
            leukemia cells
  JOURNAL   Mol Oncol 17 (12), 2584-2602 (2023)
   PUBMED   37746742
  REMARK    GeneRIF: Downregulation of RCN1 promotes pyroptosis in acute
            myeloid leukemia cells.
REFERENCE   3  (bases 1 to 3063)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3063)
  AUTHORS   Wilkerson,B.A., Zebroski,H.L., Finkbeiner,C.R., Chitsazan,A.D.,
            Beach,K.E., Sen,N., Zhang,R.C. and Bermingham-McDonogh,O.
  TITLE     Novel cell types and developmental lineages revealed by single-cell
            RNA-seq analysis of the mouse crista ampullaris
  JOURNAL   Elife 10, e60108 (2021)
   PUBMED   34003106
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3063)
  AUTHORS   Jin,J., Li,Y., Ren,J., Man Lam,S., Zhang,Y., Hou,Y., Zhang,X.,
            Xu,R., Shui,G. and Ma,R.Z.
  TITLE     Neonatal Respiratory Failure with Retarded Perinatal Lung
            Maturation in Mice Caused by Reticulocalbin 3 Disruption
  JOURNAL   Am J Respir Cell Mol Biol 54 (3), 410-423 (2016)
   PUBMED   26252542
REFERENCE   6  (bases 1 to 3063)
  AUTHORS   Kent,J., Lee,M., Schedl,A., Boyle,S., Fantes,J., Powell,M.,
            Rushmere,N., Abbott,C., van Heyningen,V. and Bickmore,W.A.
  TITLE     The reticulocalbin gene maps to the WAGR region in human and to the
            Small eye Harwell deletion in mouse
  JOURNAL   Genomics 42 (2), 260-267 (1997)
   PUBMED   9192846
REFERENCE   7  (bases 1 to 3063)
  AUTHORS   Ozawa,M.
  TITLE     Structure of the gene encoding mouse reticulocalbin, a novel
            endoplasmic reticulum-resident Ca(2+)-binding protein with multiple
            EF-hand motifs
  JOURNAL   J Biochem 118 (1), 154-160 (1995)
   PUBMED   8537305
REFERENCE   8  (bases 1 to 3063)
  AUTHORS   Ozawa,M.
  TITLE     Cloning of a human homologue of mouse reticulocalbin reveals
            conservation of structural domains in the novel endoplasmic
            reticulum resident Ca(2+)-binding protein with multiple EF-hand
            motifs
  JOURNAL   J Biochem 117 (5), 1113-1119 (1995)
   PUBMED   8586628
REFERENCE   9  (bases 1 to 3063)
  AUTHORS   Merrick,B.A., Patterson,R.M., Witcher,L.L., He,C. and Selkirk,J.K.
  TITLE     Separation and sequencing of familiar and novel murine proteins
            using preparative two-dimensional gel electrophoresis
  JOURNAL   Electrophoresis 15 (5), 735-745 (1994)
   PUBMED   7523108
REFERENCE   10 (bases 1 to 3063)
  AUTHORS   Ozawa,M. and Muramatsu,T.
  TITLE     Reticulocalbin, a novel endoplasmic reticulum resident
            Ca(2+)-binding protein with multiple EF-hand motifs and a
            carboxyl-terminal HDEL sequence
  JOURNAL   J Biol Chem 268 (1), 699-705 (1993)
   PUBMED   8416973
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB612908.1, AK133971.1 and AK017494.1.
            
            On Mar 4, 2006 this sequence version replaced NM_009037.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133971.1, SRR1660817.147638.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BB612908.1         338-387
            51-176              AK133971.1         1-126
            177-2082            AK017494.1         84-1989
            2083-3063           AK133971.1         2033-3013
FEATURES             Location/Qualifiers
     source          1..3063
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 55.18 cM"
     gene            1..3063
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /note="reticulocalbin 1"
                     /db_xref="GeneID:19672"
                     /db_xref="MGI:MGI:104559"
     exon            1..350
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1092
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /codon_start=1
                     /product="reticulocalbin-1 precursor"
                     /protein_id="NP_033063.1"
                     /db_xref="CCDS:CCDS16498.1"
                     /db_xref="GeneID:19672"
                     /db_xref="MGI:MGI:104559"
                     /translation="MARGGRLGLALGLLLALVLALRAKPTVRKERVVRPDSELGERPP
                     EDNQSFQYDHEAFLGKEDSKTFDQLSPDESKERLGKIVDRIDSDGDGLVTTEELKLWI
                     KRVQKRYIYDNVAKVWKDYDRDKDEKISWEEYKQATYGYYLGNPAEFHDSSDHHTFKK
                     MLPRDERRFKASDLDGDLTATREEFTAFLHPEEFEHMKEIVVLETLEDIDKNGDGFVD
                     QDEYIADMFSHEDNGPEPDWVLSEREQFNDFRDLNKDGKLDKDEIRHWILPQDYDHAQ
                     AEARHLVYESDKNKDEMLTKEEILDNWNMFVGSQATNYGEDLTKNHDEL"
     exon            351..544
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            545..723
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            724..784
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            785..984
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            985..3063
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /note="hexamer: AATAAA"
     polyA_site      2083
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /note="major polyA site"
     regulatory      3040..3045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /note="hexamer: AATAAA"
     polyA_site      3063
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
ORIGIN      
        1 gtggggcggc ccgagcctcc tcgagccagc cgggcgcgcc cctcgctggg gaggggacag
       61 cggcagcggc gctgtgagcc cccactgccc cgcagcctcc ctttgctcgc gaccatggcg
      121 cgcggtggcc gcttgggact cgccctgggg ctgctgctgg cgctggtgct ggcgctgcgg
      181 gccaagccca cggtgcgcaa ggagcgcgtg gttcggccgg actcagagct gggcgagcgg
      241 ccgcccgagg acaaccagag cttccagtac gatcatgagg ccttcctggg caaggaggac
      301 tccaagacct tcgatcagct aagcccggac gagagcaagg agaggctggg gaaaattgtg
      361 gatcgaattg acagtgatgg tgatggcctt gttactactg aggagctgaa actttggatc
      421 aaacgggtac agaaaagata catctatgat aatgtcgcta aagtctggaa ggattatgat
      481 agggacaaag acgaaaagat ctcctgggaa gaatacaagc aggccaccta tggctactac
      541 ctgggaaacc ccgctgaatt ccatgatagt tctgatcacc acacctttaa aaagatgctg
      601 ccacgagatg agaggaggtt taaggcttca gaccttgacg gcgacctgac agctactcgg
      661 gaggagttca ctgcctttct gcacccagag gagtttgaac atatgaagga gattgtagtc
      721 ctggaaaccc tggaggacat cgacaagaac ggggatggtt ttgtggacca ggatgagtac
      781 atcgcggaca tgttttccca cgaggacaat ggccctgagc cagactgggt tttgtctgaa
      841 cgggagcagt tcaacgactt ccgagatctg aacaaggatg ggaagctgga caaggatgag
      901 attcgccact ggatcctccc tcaggactac gaccatgcgc aggccgaggc ccggcatctg
      961 gtgtacgagt cagacaaaaa caaggacgag atgctgacca aggaggagat tctggacaac
     1021 tggaacatgt ttgtgggaag ccaagctacc aactacgggg aagacctgac caaaaatcat
     1081 gatgaacttt gaaagacact ggttctggtg tggccaactg tcgcaggctg tctgcaggtg
     1141 tagtgggtga ttgctatagt tgtcaagggt atagcagttg tgtcccttaa cagtgggatt
     1201 atacctcaga ttggggttaa aaattatttt tcactccata tttactggga aataaccatc
     1261 attatttatt ccagtaggat ttcccgtgaa gcacattaaa ctcctggcaa attgcagtcc
     1321 tctgagggga tacattgcta cagcatgatt tttctagact cctctccccc acttaactca
     1381 ttaatgggga agagaccatg aaagggctct gtaactcaag gtgggtgggt gggacactgt
     1441 acagagtaac cgctgtgtat ttgaactatt aaattttggg gtttttagtt gccactgtta
     1501 aacggtggtg aaggtaaagg ctgaaggaat caatttgtat tgtccttgga gcaggcatgg
     1561 tatttcaaat cttctatact tggagctgtc ttgtaaatgg tatataaact tttgtgcgtt
     1621 ttcctgtata gacctgctaa tgtgcacaat aaacccacat cctggggttt ttgttttgtt
     1681 tttaacacta agaagcaatc aaaaaaagat aatgtgaaca aaaacggaat tttagggata
     1741 ggaaaaagat ggatgctagg tatttgaaaa actgtatgac catggtcaac accttaatat
     1801 acttgagaat tttttttaca tgttaatgag gtgggtctgt ttttttaaat agtgaatgga
     1861 aatgcagtcc ctccctggct gtgaggctag ggatcagatg tagtggattt attatttgtt
     1921 gagtcctgaa tctctgagcc tgcttctagc acagcttatg ccaaggaaac agggcaaggt
     1981 gaacatctca gccattgacc aaactagctg gagtaacact tacaggtgaa attccaccct
     2041 gtagatggga ggaaagtgaa taaaggatgc ctttgaggat ctatccatgt gtcttgtggt
     2101 gtttgactcc atagcaagtg tggtttcttc ctctggaatc aaacaatcaa aagagtccgt
     2161 ggtccagatc ggaatggact cagtaattac tgacaagttc agaatacatg tgtagttgct
     2221 gatttcatcc ctctggactt cacgcccttc tctgcagtta gagaactcaa agtcgtgttt
     2281 tcacagtagt cctgagacat ttaactggaa aattcaggtc ttagcattgc ctgtggagcc
     2341 tgcctaacag gatgtggctc tgcttccctt ctgagaactg cctacctctt tactcactct
     2401 tcttttgtct ccacctcttc ccaccccttt acctcgtcct ccaccctcac tgactttgtt
     2461 gctaagatga actccttggg tgagatagaa acaatgtcct aatgagaaac caaagtacag
     2521 tgacactgag tccacgctga ggaagtagag agcttcctgg gcttgtgtac agagcatggg
     2581 tgatggacaa gaacatggtg gataccaacg ccgccatgca gcaaagtctt tacccagcct
     2641 ggactgactg tgcggcttcc tcgaatccag agaccaagcc ccaaggccac actgtactgc
     2701 ctggttttgt atgtcatctt gccacaagct ggagttatca gagaggaagg agtcttagtt
     2761 caggaaatgc ttccatgaga tccagctgga aggcattttc tcaattagtg atcaatgggg
     2821 ggagagtctg gccctctgtg gcccgctgtg ggtgtgccac ccctgggttg gtggtcctgg
     2881 gttctataag tacccaggct gagcaaggca cagggagcaa gctagtaagc agcatccacc
     2941 gtggtttctg cttcagcccc tgcatctagg atcctgctgt gtttgagatc ttgtcctgac
     3001 ttccttcagt aatgaacagc agtatggaaa tgtaagccaa ataaaccctt tctgcccacc
     3061 ttg
//
