LOCUS       NM_001368712            1443 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus Ras converting CAAX endopeptidase 1 (Rce1), transcript
            variant 1, mRNA.
ACCESSION   NM_001368712
VERSION     NM_001368712.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Karlsson,C., Akula,M.K., Staffas,A., Cisowski,J., Sayin,V.I.,
            Ibrahim,M.X., Lindahl,P. and Bergo,M.O.
  TITLE     Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia
            by downregulating GADD45b
  JOURNAL   Leukemia 35 (2), 606-609 (2021)
   PUBMED   32398789
  REMARK    GeneRIF: Knockout of the RAS endoprotease RCE1 accelerates myeloid
            leukemia by downregulating GADD45b.
REFERENCE   2  (bases 1 to 1443)
  AUTHORS   Yao,H., Chen,X., Kashif,M., Wang,T., Ibrahim,M.X., Tuksammel,E.,
            Revechon,G., Eriksson,M., Wiel,C. and Bergo,M.O.
  TITLE     Targeting RAS-converting enzyme 1 overcomes senescence and improves
            progeria-like phenotypes of ZMPSTE24 deficiency
  JOURNAL   Aging Cell 19 (8), e13200 (2020)
   PUBMED   32910507
REFERENCE   3  (bases 1 to 1443)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1443)
  AUTHORS   Jaworski,J., Govender,U., McFarlane,C., de la Vega,M., Greene,M.K.,
            Rawlings,N.D., Johnston,J.A., Scott,C.J. and Burrows,J.F.
  TITLE     A novel RCE1 isoform is required for H-Ras plasma membrane
            localization and is regulated by USP17
  JOURNAL   Biochem J 457 (2), 289-300 (2014)
   PUBMED   24134311
REFERENCE   5  (bases 1 to 1443)
  AUTHORS   Christiansen,J.R., Kolandaivelu,S., Bergo,M.O. and Ramamurthy,V.
  TITLE     RAS-converting enzyme 1-mediated endoproteolysis is required for
            trafficking of rod phosphodiesterase 6 to photoreceptor outer
            segments
  JOURNAL   Proc Natl Acad Sci U S A 108 (21), 8862-8866 (2011)
   PUBMED   21555557
  REMARK    GeneRIF: RCE1 is essential for the intracellular trafficking of
            PDE6 and survival of photoreceptor cells.
REFERENCE   6  (bases 1 to 1443)
  AUTHORS   Aiyagari,A.L., Taylor,B.R., Aurora,V., Young,S.G. and Shannon,K.M.
  TITLE     Hematologic effects of inactivating the Ras processing enzyme Rce1
  JOURNAL   Blood 101 (6), 2250-2252 (2003)
   PUBMED   12433685
REFERENCE   7  (bases 1 to 1443)
  AUTHORS   Bergo,M.O., Gavino,B., Ross,J., Schmidt,W.K., Hong,C.,
            Kendall,L.V., Mohr,A., Meta,M., Genant,H., Jiang,Y., Wisner,E.R.,
            Van Bruggen,N., Carano,R.A., Michaelis,S., Griffey,S.M. and
            Young,S.G.
  TITLE     Zmpste24 deficiency in mice causes spontaneous bone fractures,
            muscle weakness, and a prelamin A processing defect
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13049-13054 (2002)
   PUBMED   12235369
REFERENCE   8  (bases 1 to 1443)
  AUTHORS   Bergo,M.O., Ambroziak,P., Gregory,C., George,A., Otto,J.C., Kim,E.,
            Nagase,H., Casey,P.J., Balmain,A. and Young,S.G.
  TITLE     Absence of the CAAX endoprotease Rce1: effects on cell growth and
            transformation
  JOURNAL   Mol Cell Biol 22 (1), 171-181 (2002)
   PUBMED   11739732
REFERENCE   9  (bases 1 to 1443)
  AUTHORS   Kim,E., Ambroziak,P., Otto,J.C., Taylor,B., Ashby,M., Shannon,K.,
            Casey,P.J. and Young,S.G.
  TITLE     Disruption of the mouse Rce1 gene results in defective Ras
            processing and mislocalization of Ras within cells
  JOURNAL   J Biol Chem 274 (13), 8383-8390 (1999)
   PUBMED   10085069
REFERENCE   10 (bases 1 to 1443)
  AUTHORS   Dode,L., De Greef,C., Mountian,I., Attard,M., Town,M.M.,
            Casteels,R. and Wuytack,F.
  TITLE     Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3
            gene. Promoter analysis and alternative splicing of the SERCA3
            pre-mRNA
  JOURNAL   J Biol Chem 273 (22), 13982-13994 (1998)
   PUBMED   9593748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC128739.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.272168.1,
                                           SRR13422589.325846.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AC128739.4         69532-69744
            214-316             AC128739.4         69882-69984
            317-400             AC128739.4         70081-70164
            401-479             AC128739.4         70414-70492
            480-647             AC128739.4         70996-71163
            648-719             AC128739.4         71280-71351
            720-795             AC128739.4         71601-71676
            796-1443            AC128739.4         71935-72582
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.07 cM"
     gene            1..1443
                     /gene="Rce1"
                     /gene_synonym="D19Ertd283e; D19Ertd98e"
                     /note="Ras converting CAAX endopeptidase 1"
                     /db_xref="GeneID:19671"
                     /db_xref="MGI:MGI:1336895"
     exon            1..213
                     /gene="Rce1"
                     /gene_synonym="D19Ertd283e; D19Ertd98e"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1156
                     /gene="Rce1"
                     /gene_synonym="D19Ertd283e; D19Ertd98e"
                     /EC_number="3.4.26.1"
                     /note="isoform a is encoded by transcript variant 1; CAAX
                     prenyl protease 2; FACE-2; prenyl protein-specific
                     endoprotease 2; farnesylated proteins-converting enzyme 2;
                     RCE1 homolog, prenyl protein peptidase; Ras and
                     a-factor-converting enzyme 1 homolog"
                     /codon_start=1
                     /product="CAAX prenyl protease 2 isoform a"
                     /protein_id="NP_001355641.1"
                     /db_xref="GeneID:19671"
                     /db_xref="MGI:MGI:1336895"
                     /translation="MAALGGDGLRLLSVSRPERQPESAALSGPGSGLCCWVSVFSCFS
                     LACSYVGSLYVWKSELPRDHPAVIKRRSTSVLVVSSLSPLCVLLWRELTGIQPGTSLL
                     TLMGFRLEGIFPAALLPLLLTMILFLGPLMQLSMDCPCDLTDGLKVVLAPRSWARCLT
                     DMRWLRNQVIAPLTEELVFRACMLPMLAPCTGLGPAVFTCPLFFGVAHFHHIIEQLRF
                     RQSSVGSIFVSAASISSVPVLLHRCLRCLYSFPLHPHRTPDRAGSLPLFLQLHGLPCS
                     VCSPGASTEVATAGRLCPRCGTFPASASTPDRPQALWQPSSLYAFGKNRGLRDPTVLL
                     TITLLCTPVNSDGLSSSSLPRNTAREGLAGVPEISGIFVGD"
     exon            214..316
                     /gene="Rce1"
                     /gene_synonym="D19Ertd283e; D19Ertd98e"
                     /inference="alignment:Splign:2.1.0"
     exon            317..400
                     /gene="Rce1"
                     /gene_synonym="D19Ertd283e; D19Ertd98e"
                     /inference="alignment:Splign:2.1.0"
     exon            401..479
                     /gene="Rce1"
                     /gene_synonym="D19Ertd283e; D19Ertd98e"
                     /inference="alignment:Splign:2.1.0"
     exon            480..647
                     /gene="Rce1"
                     /gene_synonym="D19Ertd283e; D19Ertd98e"
                     /inference="alignment:Splign:2.1.0"
     exon            648..719
                     /gene="Rce1"
                     /gene_synonym="D19Ertd283e; D19Ertd98e"
                     /inference="alignment:Splign:2.1.0"
     exon            720..795
                     /gene="Rce1"
                     /gene_synonym="D19Ertd283e; D19Ertd98e"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1443
                     /gene="Rce1"
                     /gene_synonym="D19Ertd283e; D19Ertd98e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgccgcgc gccacgggtc cgggcgtgat ggcggcgctg ggcggggacg ggctgcgttt
       61 actgtcggta tcgcggccag agcggcagcc cgagtcagcc gcgctgagcg gcccgggctc
      121 ggggctgtgc tgctgggtgt ctgtgttctc ctgcttcagc ctcgcctgct cctacgtggg
      181 cagcctctac gtgtggaaga gcgagctgcc cagggaccac cccgctgtta tcaagcggcg
      241 ttccaccagt gtcctggtag tgtccagctt gtcccctctt tgcgtgctgc tctggaggga
      301 actcactggc atccagccag gcacatcact gcttaccttg atgggcttca ggctggaggg
      361 cattttccca gcagcgctgc tgcccctgct gctaactatg atccttttcc tgggtccact
      421 gatgcagctc tctatggatt gcccttgtga cctgacagat gggctgaagg ttgtcctggc
      481 ccctcgttct tgggcccgct gcctcacaga catgcgctgg ctacgaaacc aagttattgc
      541 accgctgaca gaggagctgg tgttccgggc ttgcatgctg cccatgctag cgccgtgcac
      601 gggtctgggc cctgctgtgt tcacctgccc actctttttt ggagtcgccc attttcacca
      661 cattattgag cagctgcgct tccgccagag cagtgtggga agtatcttcg tgtctgcagc
      721 ctccatctcc agcgttccag ttctcctaca ccgctgtctt cggtgcttat acagctttcc
      781 tcttcatccg cacaggacac ctgatagggc cggttctctg ccactctttc tgcaactaca
      841 tgggcttccc tgcagtgtgt gcagccctgg agcatccaca gaagtggcca ctgctggcag
      901 gctatgccct cggtgtggga cttttcctgc ttctgcttca acccctgaca gaccccaagc
      961 tctatggcag ccttcctctt tgtatgcttt tggaaagaac aggggcctca gagaccctac
     1021 tgtgctcctg acgatcactc ttttgtgcac tccagtgaac tctgacgggc tctccagctc
     1081 ctccttacca aggaatactg caagggaggg actggctggg gtccccgaga tctcaggaat
     1141 ttttgtaggg gattgaagcc agagctagtt gaatcccagg gaccaagaga aaggagcaga
     1201 tatccaaagg gtgcagcccc tctcgaaggg gggatgagca gcaactggag gtgaggggac
     1261 aagggcaaat cctaggagct gtggactgac gcttccttgg ctcctttgcg tccccccttt
     1321 ccccttgaaa agctgctcgg tgggtttatt tataaaaccc ctcctctcaa cttcccaggg
     1381 ttttctcatt gtctttttgc atcaagactt tgtattggga tattaaagag atttaacttg
     1441 ggt
//
