LOCUS       NM_173867               3790 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus regulator of chromosome condensation 2 (Rcc2), mRNA.
ACCESSION   NM_173867 XM_917033 XM_924624
VERSION     NM_173867.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3790)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3790)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3790)
  AUTHORS   Calderon-Aparicio,A., Yamamoto,H., De Vitto,H., Zhang,T., Wang,Q.,
            Bode,A.M. and Dong,Z.
  TITLE     RCC2 Promotes Esophageal Cancer Growth by Regulating Activity and
            Expression of the Sox2 Transcription Factor
  JOURNAL   Mol Cancer Res 18 (11), 1660-1674 (2020)
   PUBMED   32801160
  REMARK    GeneRIF: RCC2 Promotes Esophageal Cancer Growth by Regulating
            Activity and Expression of the Sox2 Transcription Factor.
REFERENCE   4  (bases 1 to 3790)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3790)
  AUTHORS   Bichsel,K.J., Hammiller,B., Trempus,C.S., Li,Y. and Hansen,L.A.
  TITLE     The epidermal growth factor receptor decreases Stathmin 1 and
            triggers catagen entry in the mouse
  JOURNAL   Exp Dermatol 25 (4), 275-281 (2016)
   PUBMED   26661905
  REMARK    GeneRIF: EGFR suppression of mitotic regulators including Rcc2 and
            Stathmin 1 are a mechanism for catagen induction in mouse skin
REFERENCE   6  (bases 1 to 3790)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   7  (bases 1 to 3790)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   8  (bases 1 to 3790)
  AUTHORS   Kerns,R.T., Ravindranathan,A., Hassan,S., Cage,M.P., York,T.,
            Sikela,J.M., Williams,R.W. and Miles,M.F.
  TITLE     Ethanol-responsive brain region expression networks: implications
            for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J
            mice
  JOURNAL   J Neurosci 25 (9), 2255-2266 (2005)
   PUBMED   15745951
REFERENCE   9  (bases 1 to 3790)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 3790)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA751510.1, AK076040.1, AL954710.27 and BC060624.1.
            
            On May 1, 2010 this sequence version replaced NM_173867.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060624.1, AK076040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               CA751510.1         1-467
            468-1646            AK076040.1         399-1577
            1647-3720           AL954710.27        185910-187983
            3721-3790           BC060624.1         3673-3742
FEATURES             Location/Qualifiers
     source          1..3790
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 72.15 cM"
     gene            1..3790
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /note="regulator of chromosome condensation 2"
                     /db_xref="GeneID:108911"
                     /db_xref="MGI:MGI:1919784"
     exon            1..178
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     exon            179..467
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1751
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /codon_start=1
                     /product="protein RCC2"
                     /protein_id="NP_776292.1"
                     /db_xref="CCDS:CCDS18852.1"
                     /db_xref="GeneID:108911"
                     /db_xref="MGI:MGI:1919784"
                     /translation="MPRKKGAAWEEPSSGNGTARAGPRRRGGPAGRKRERPERCSSSS
                     GGGSSGDEDGPELDGAPGGGKRTARPATAGKAAGAAAIITEPEHTKERVKLEGSKCKG
                     QLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLSGVRVRTVVSGSCAAHS
                     LLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTDT
                     GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMLMDCKGNLYSF
                     GCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVA
                     CGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYAGYT
                     CSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTIS
                     WGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESEAEKEK
                     LQRLPEYTPRTL"
     exon            468..561
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     exon            562..705
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     exon            706..837
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     exon            838..926
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1041
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1208
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1389
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1495
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1568
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1646
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..3767
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1943..1948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /note="hexamer: ATTAAA"
     polyA_site      1961
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /note="major polyA site"
     polyA_site      2017
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /note="major polyA site"
     regulatory      3742..3747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /note="hexamer: AATAAA"
     polyA_site      3762
                     /gene="Rcc2"
                     /gene_synonym="2610510H01Rik; 2610529N02Rik; mKIAA1470;
                     Td60"
                     /note="major polyA site"
ORIGIN      
        1 ccgcccggcc gcacatgtgt ttctgttttg tgttgtagca tttgttctgg aagctcgtat
       61 ttacatttta agtgtatctg gtgagtgggc tggagccctc gtcccggccg gggagagaag
      121 aagccttcga ccccgtcttt cagtcgcttc cctcctcgtt tctcatcact ccaaccagcc
      181 cggcgaccat gcccaggaag aagggggcgg cctgggagga gccgagttcg ggcaacggca
      241 cggcgcgcgc ggggccccgg cgacgcggcg gccccgcggg caggaagcgc gagcggcccg
      301 agcgctgcag cagcagcagc ggcggcggca gcagcggcga cgaggacggc ccggagctgg
      361 acggggcccc cggcggcggc aagcgcacag ccaggccggc gacggcgggc aaggcggccg
      421 gcgcggccgc gatcatcacg gagcccgagc acacgaagga gcgcgtcaaa cttgaagggt
      481 ctaagtgcaa agggcagctt ttgatttttg gggcaaccaa ctgggacttg attggacgga
      541 aggaagtgcc taaacagcaa gctgcgtacc gcaaccttgg tcagaatttg tgggggcccc
      601 ataggtatgg gtgcctgtca ggagtccggg tgcgaaccgt ggtttcaggc tcatgtgctg
      661 cccacagcct cctcatcacc acagaaggga agctgtggag ctggggtcgg aatgagaagg
      721 ggcagctggg ccatggtgat accaagaggg tggaagcccc cagactcatc gaggccctca
      781 gccatgaggc aatcgtgctg gcagcctgtg ggcgcaacca caccctggcc ttgacagata
      841 ctggatcagt gtttgccttc ggagagaata aaatggggca gctgggtctc gggaaccaga
      901 cagatgccgt cccaagtcct gctcagataa tgtacaacgg gcagccaatc accaagatgg
      961 cctgcggggc cgagttcagc atgctgatgg actgtaaagg aaacctctac tcctttgggt
     1021 gccctgagta tggccagctg gggcacaact cagatggcaa gttcatcgcc cgggcgcaga
     1081 ggatagaata tgattgtgag ctggtgcccc gcagagtggc catcttcatc gagaagacca
     1141 aggacgggca gatcttacct gtccccaacg tggtggttcg agatgtagcc tgtggcgcta
     1201 accacacact ggtcctggac tctcagaagc gagtgttctc ctggggcttt ggtggctatg
     1261 gccggctggg ccatgccgag cagaaggatg agatggtgcc tcgcctggtg aagctgttcg
     1321 acttcccggg gcgtggtgca acccagatct atgccggcta cacctgctcc ttcgctgtca
     1381 gtgaagtggg tggcctgttt ttctgggggg ccaccaatac ctcccgagag tctaccatgt
     1441 acccgaaggc agtgcaggac ctctgcggct ggcggatccg gagccttgcc tgcgggaaga
     1501 gcagcatcat cgtagctgcg gacgagagta ctatcagttg gggtccatcg ccaaccttcg
     1561 gggaattggg gtatggggac cacaagccca agtcttctac tgcggcccag gaggtgaaga
     1621 ctctggatgg catcttctcc gaacaggtgg ccatgggcta ttcacactcc ttggtgatag
     1681 cgcgagacga gagcgaggct gagaaggaga agctgcagag gctacctgag tacaccccgc
     1741 gcaccctctg agcaggccgg ccctcccctc gtggcagctg tcctttccac gtgcactggg
     1801 accagaagtc agacaaggaa tttaggaagc aaaagttgac caagggtgca ttgggttcgc
     1861 ctccccgagg ctccgtttcc aagcgattca acgttaacta cctttttctg tatgctttcc
     1921 aaagtgtttc cctcaatgtt tgattaaaac atttgctcat agccagcctg cctttctacg
     1981 agataggcag gacctctgag cgatgtaggt ttttttattt ttaagttgta tttcttttct
     2041 ccctgctctt gagtgtcctt gtcctgccct cccattccag ccgtgatgag cattgtgatc
     2101 cgagtgggtg ccacgtgaga gagggactgt cactttccca gacagaaacg gccttttcag
     2161 gaaccagcag ccgctaggcc aatccctggt ggtcggtctc catcccgatt cctgcctgcc
     2221 cgctttgaga gacccggtca cttgcttgtg ggccctccca cttgcctctg ccacctcccc
     2281 tcatagctat tcctggcttg ctgtctgcaa ggcccatgtg ggccttttgg ctgaagcatt
     2341 tgtagaagca gccatcttcc ccctggtggg gctttggggt ctatgttagc catttgtatc
     2401 tactttagct ctcaagtcca gatgagaata gggaccgtgg ggtatggggt gggcagttag
     2461 aggttggtca tccagcagtc agatgtgtcc tcggtcctct gtggccctcc gttgccgcct
     2521 gtgtgctttg cccgtgtgct cctgctgtcc ctctgcctgg gatggccgcc ctgctctgag
     2581 acttggccac tcttgtcctg gccaagtgtt ctgcttgcat ttgcttggct ctggtaccaa
     2641 atagttggga ttcttgatga aatcccctgc cccgcgtgcg tgtcagtgca gatcctgcgc
     2701 accacgcccc ctcccccaag tgccctctgc cgagcccgtc ctggtattga ctttgtggct
     2761 gagttccgag gtgcctttcc cggatcctcc tcgctgggcc cgagtgtggc agcagctcgg
     2821 gtcggggcct tggtttccag agggtccggg ctggtttgac tgctttaact aggattagtt
     2881 cagtggtgct tgggggaggg gctgaggatg gaagtgtgag gggggtggat gggaaagtca
     2941 aagtctggtc ttgagggtca tgggtttgct tttgctgttg tgacgcctgt tcccgtctct
     3001 atgttaaaat gccaaaaatg acccagtctg tcgctttcct ccgccccagc gcttcacagc
     3061 cgcttctggc tttgcaaggt gtctgtctcg gccagtgccg tggcctgctg ggaagggtca
     3121 gagtcctcac tgtcccccgt ctgtccagca atagtctgtc cagagacaag cttctgtagc
     3181 ggcagggctt ccgcaaaact aacctgcttt gtccaggtca ccccagacac cgcccctcac
     3241 ttcatgtact ggacgggagc cgtccgtcca tctgtccctg ctggtctctg tctagagagt
     3301 gctgttcggg atctgctcct tctgtcccag gaggtctact ggagttagtt gtgtggtcac
     3361 caagaggact gaggacacag tagccctgag ccaagttggg ctcatcttcc agggagcaaa
     3421 cctaaagctg gcagtcagcc gccctggcta gaggcctgca gtggatgagc gcaaagtgcc
     3481 cggccacagc cccctccctt taggctaaaa ttctcaccca agctttccca cgggaagctc
     3541 taggacagga ggaaggcggg aagccctggg caggaaccac tctggctgtc caggggctcc
     3601 tgaaatcttc tggtcatcta caaagggtaa caggaaggga gttaacgagg atggtgggat
     3661 tcggttgaag gtgcctggtt tagtgctgtt aattgtctta tttttttttt tatatctata
     3721 tttctgggag taaacatttt aaataaacgg cgtcattgtt tactctgaaa aaaaaaaaaa
     3781 aaaaaaaaaa
//
