LOCUS       NM_133878               2293 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus regulator of chromosome condensation 1 (Rcc1),
            transcript variant 2, mRNA.
ACCESSION   NM_133878
VERSION     NM_133878.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Lu,L.Y., Kuang,H., Korakavi,G. and Yu,X.
  TITLE     Topoisomerase II regulates the maintenance of DNA methylation
  JOURNAL   J Biol Chem 290 (2), 851-860 (2015)
   PUBMED   25451918
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Schulze,H., Dose,M., Korpal,M., Meyer,I., Italiano,J.E. Jr. and
            Shivdasani,R.A.
  TITLE     RanBP10 is a cytoplasmic guanine nucleotide exchange factor that
            modulates noncentrosomal microtubules
  JOURNAL   J Biol Chem 283 (20), 14109-14119 (2008)
   PUBMED   18347012
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Mencinger,M. and Aman,P.
  TITLE     Characterization of TFG in mus musculus and Caenorhabditis elegans
  JOURNAL   Biochem Biophys Res Commun 257 (1), 67-73 (1999)
   PUBMED   10092511
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Kerr,S.M., Taggart,M.H., Lee,M. and Cooke,H.J.
  TITLE     Ott, a mouse X-linked multigene family expressed specifically
            during meiosis
  JOURNAL   Hum Mol Genet 5 (8), 1139-1148 (1996)
   PUBMED   8842733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076089.1, AK150610.1 and CR516684.1.
            
            On Oct 5, 2010 this sequence version replaced NM_133878.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1, resulting in
            an isoform (2) that is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076089.1, AK150153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AK076089.1         2-52
            52-868              AK150610.1         2-818
            869-965             AK076089.1         870-966
            966-1844            AK150610.1         916-1794
            1845-2281           AK076089.1         1845-2281
            2282-2293           CR516684.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 65.2 cM"
     gene            1..2293
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /note="regulator of chromosome condensation 1"
                     /db_xref="GeneID:100088"
                     /db_xref="MGI:MGI:1913989"
     exon            1..105
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /inference="alignment:Splign:2.1.0"
     exon            106..187
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1380
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     chromosome condensation protein 1"
                     /codon_start=1
                     /product="regulator of chromosome condensation isoform 2"
                     /protein_id="NP_598639.1"
                     /db_xref="CCDS:CCDS18723.1"
                     /db_xref="GeneID:100088"
                     /db_xref="MGI:MGI:1913989"
                     /translation="MPPKRIAKRRSPPEDAIPKSKKVKVSHRSHNTEPGLVLTLGQGD
                     VGQLGLGESVLERKKPALVPLLQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRD
                     TSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMK
                     KSMVPVQVQLDAPVVKVASGNDHLVMLTNDGDLYTLGCGEQGQLGRVPELFANRGGRQ
                     GLGRLLVPRCVLLKSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPG
                     TGSCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEE
                     KSIPTLISRLPVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMT
                     GKQLENRVVLTVSSGGQHTVLLVKDQAQS"
     exon            188..375
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..555
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..652
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..775
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..931
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1051
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1204
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..2288
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2263..2268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /note="hexamer: AATAAA"
     polyA_site      2284
                     /gene="Rcc1"
                     /gene_synonym="4931417M11Rik; Chc1"
                     /note="major polyA site"
ORIGIN      
        1 cccttctggc cagggtcgcg gccggaggcc cgcagagcgc atgctcgggg cagttcaccg
       61 ccggccgccg agcgccggag ttgcttgtgg ccgccctgtc ccgaggacaa gaagatgcca
      121 cccaagcgca tagctaagag aaggtcaccc ccagaagatg ccatccccaa aagcaagaag
      181 gtgaaagtct cacacaggtc ccacaacaca gaaccaggct tggtgctgac actgggccag
      241 ggcgacgtgg gccagctggg gctgggtgaa agtgtgctgg agaggaagaa gccggccttg
      301 gtgccccttc tgcaggatgt tgtgcaggct gaggccgggg gcatgcatac tgtgtgtctg
      361 agccaaagtg gccaggtcta ctcctttggc tgcaatgacg agggtgccct gggaagggac
      421 acttcagtcg aaggctcaga aatggtccct gggaaagtgg aactgcaaga gaaagtggtg
      481 caagtgtcag cgggggacag tcacacagca gccctcaccg aagacggccg tgtcttcctt
      541 tggggctctt tccgggacaa taatggtgtg atcgggttgt tggagcccat gaagaagagc
      601 atggtacctg ttcaagtgca gctggatgcg cccgtggtaa aggtggcctc ggggaacgac
      661 cacttggtga tgctcacgaa cgatggcgac ctctacacct tgggttgtgg ggagcaaggt
      721 cagctgggcc gtgtacctga attatttgcc aaccgaggtg gccgtcaggg ccttgggcga
      781 ctcctggtcc ccagatgtgt gctgctgaaa tccaggggga cccggggccg tgtgcggttc
      841 caggatgcct tctgtggcgc ctatttcact tttgccatct cccgagaggg ccacgtgtat
      901 ggctttggcc tctccaacta tcaccagctc gggactccag gcactggatc ttgcttcatt
      961 cctcaaaact tgacatcctt caagaattcc accaagtcct gggtaggctt ctccggtggc
     1021 cagcatcaca cagtctgcat ggattcggaa gggaaggcgt acagcctggg ccgggctgag
     1081 tacgggcgcc tgggccttgg ggagggtgct gaggagaaga gcatacccac cctcatttcc
     1141 cggctgcccg tggtctcctc agtggcctgt ggggcttctg tgggttatgc tgtgtccaag
     1201 gatggtcgtg tttttgcctg gggcatgggc accaactacc agctgggcac cgggcaggat
     1261 gaagatgcct ggagtcctgt ggaaatgact ggcaaacagc tggagaaccg tgtggtgtta
     1321 actgtgtcca gtgggggcca gcacacggtc ttactagtta aggaccaggc acagagctga
     1381 tgaagtcttt gtgggcctgg cttctggccc cagctcagct tctcaggaca ggaaaagagc
     1441 cagctacaga ttccaaccct gaacagatag catctcctgt cttttcccat caccacagca
     1501 gaatcctttt tcttctgttt cgtccgtcct ctttctagaa catactggta cttgtaggat
     1561 gtgtggggat gggaggagga cctcagaagg atctttgctt actttattag acctcccccc
     1621 ctcccctttg ataccctcct tcctgtggtc ctagctggca ctggctcatt acctacaaaa
     1681 cccaaaacgg tagcttaaga ctacgtgcaa catcctgccc cggggttttg ctgcccagac
     1741 tctgaaaagt tgggactctg tgaagccctg cttaccacga gcctctttct gttcctaaca
     1801 gtagtttaca aggacacaga tggtttgtat tgtcatcgga tccagttgtc atggacccat
     1861 gcctggggag atctggacaa aggcttttca aggctctgag tgatctaagc caaatatttg
     1921 actctaaaca ggtgtccatg ggcaaaaaca ctgacccact tgaaaaaaac caactgtcct
     1981 cccaaagcac aaggcatccc agtatccctt gggtgtcacc tgtcccttcc ccatcagcct
     2041 ttctgccata gaggactgga tagccatgct gggctcggct gggcagtcaa ggcaaggcag
     2101 ggtattggga aaggggtggg agttgtttta taacggtgct gagggaggag tggaggggcg
     2161 gaggctggtc ctaaggaaag taacagtggc tgagaaaata gttttgaatt ttttttaatt
     2221 gtataatatt ttggagggga gattaaaatc ttgtaacact ttaataaact tagagttttg
     2281 taaatgggaa aaa
//
