LOCUS       NM_001170694            3411 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus regulator of chromosome condensation (RCC1) and BTB
            (POZ) domain containing protein 2 (Rcbtb2), transcript variant 1,
            mRNA.
ACCESSION   NM_001170694
VERSION     NM_001170694.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3411)
  AUTHORS   Spillane,D.R., Wang,D.Y., Newbigging,S., Wang,Y., Shi,C.X.,
            Cho,H.R., Shimizu,H., Gramolini,A., Liu,M. and Wen,X.Y.
  TITLE     Chromosome Condensation 1-Like (Chc1L) Is a Novel Tumor Suppressor
            Involved in Development of Histiocyte-Rich Neoplasms
  JOURNAL   PLoS One 10 (8), e0135755 (2015)
   PUBMED   26291700
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3411)
  AUTHORS   Zhang,L., Li,W., Ni,J., Wu,J., Liu,J., Zhang,Z., Zhang,Y., Li,H.,
            Shi,Y., Teves,M.E., Song,S., Strauss,J.F. 3rd and Zhang,Z.
  TITLE     RC/BTB2 is essential for formation of primary cilia in mammalian
            cells
  JOURNAL   Cytoskeleton (Hoboken) 72 (4), 171-181 (2015)
   PUBMED   25762510
  REMARK    GeneRIF: findings suggest that RC/BTB2 is a necessary component of
            the process of formation of primary cilia in somatic cells, perhaps
            through the transportation of cargos from Golgi bodies to
            centrosomes for cilia assembling.
REFERENCE   3  (bases 1 to 3411)
  AUTHORS   Wang,J., Teves,M.E., Shen,X., Nagarkatti-Gude,D.R., Hess,R.A.,
            Henderson,S.C., Strauss,J.F. 3rd and Zhang,Z.
  TITLE     Mouse RC/BTB2, a member of the RCC1 superfamily, localizes to
            spermatid acrosomal vesicles
  JOURNAL   PLoS One 7 (6), e39846 (2012)
   PUBMED   22768142
  REMARK    GeneRIF: The expression and localization of mouse RC/BTB2 in the
            testis and male germ cells, was characterized.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA119207.1, AK031248.1, AK160881.1 and CX209814.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031248.1, SRR5189673.164515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AA119207.1         1-35
            36-2600             AK031248.1         2-2566
            2601-3348           AK160881.1         2788-3535
            3349-3411           CX209814.1         337-399
FEATURES             Location/Qualifiers
     source          1..3411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 38.66 cM"
     gene            1..3411
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /note="regulator of chromosome condensation (RCC1) and BTB
                     (POZ) domain containing protein 2"
                     /db_xref="GeneID:105670"
                     /db_xref="MGI:MGI:1917200"
     exon            1..84
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            85..167
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            168..261
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            262..325
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1939
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /note="regulator of chromosome condensation and BTB
                     domain-containing protein 2"
                     /codon_start=1
                     /product="RCC1 and BTB domain-containing protein 2"
                     /protein_id="NP_001164165.1"
                     /db_xref="CCDS:CCDS27266.1"
                     /db_xref="GeneID:105670"
                     /db_xref="MGI:MGI:1917200"
                     /translation="MEEEVPGFYGESGKSVQATLSSLKMLDVGKWPIFSLCSEEELQL
                     IRQACVFGSAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIAS
                     LSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACG
                     SYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSM
                     AVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEG
                     QIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMW
                     GQCRGQSVILPHHTHFCCTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPD
                     TADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYT
                     DNISLSPEEAVGLLDLATFYSETRLKKLCQQTIKQGICEENAIALLSAAVKYDAQDLE
                     EFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN"
     exon            326..481
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..632
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            633..799
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..958
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1066
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1209
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1400
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1527
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1667
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1798
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..3395
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2006..2011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /note="hexamer: AATAAA"
     polyA_site      2029
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /note="major polyA site"
     regulatory      3373..3378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
                     /note="hexamer: AATAAA"
     polyA_site      3395
                     /gene="Rcbtb2"
                     /gene_synonym="2610028E02Rik; 2810420M18Rik; Chc1l;
                     RC/BTB2"
ORIGIN      
        1 gctcccttct ccctagtccc agtaaccacc tctctacttt ctgttggtgc gacttgactt
       61 tttcagtgct ccttaatgag atcctcacat tagctttttt ctggaagaca gctttacaag
      121 aatctagtcg gaccaaattt cgggctccag aacattccac caaccagctt agcagatcat
      181 acattcttca ggagctgaga gctgataagt ctcttcttca ccgtgatttg aaactttcca
      241 gtctcagaaa agctgaccaa gggactgcac aggactgatc catatggaag aagaagtgcc
      301 tggtttctat ggagaaagtg gcaagtcagt acaggctacc ctgtcatcgt tgaagatgtt
      361 agatgtggga aagtggccaa ttttttccct ttgttctgag gaagagttac agttgattcg
      421 tcaggcttgt gtcttcggca gtgctggcaa tgaagtttta tacactacag tcaacgatga
      481 gatttttgtg cttggcacaa actgcagtgg ctgtctgggg gtaggcgaca ttcagagcac
      541 tattgagcct cggagactgg attctctaac tggcaaaaaa atagccagcc tcagctatgg
      601 gagtggccct catatcgtcc ttgcgacaac agatggagaa gtctttacct ggggtcacaa
      661 tgcttatagc cagctgggca atgggacaac gaatcatggt ttagtgccct gccatatctc
      721 tacgaatttg tcaaacaaac aagtcattga ggtcgcctgt gggtcttacc actctttggt
      781 tctaacatct gatggggagg tgtttgcctg gggttataat aactcagggc aagtaggatc
      841 tggatcaaca gctaaccagc ccattccccg aagagtcact ggatgcttgc agaataaagt
      901 agttatgaac atagcatgtg ggcagatgtg ctccatggct gttgtggaca ctggagaggt
      961 ctacgtctgg ggttacaatg gcaatgggca gctgggcctg ggcagcagtg gcaaccagcc
     1021 caccccatgc agagtggccg ccctgcaagg catccgtgtc cagcgggttg cctgtggcta
     1081 cgcacacaca ttagtattaa cagatgaagg tcaaatatat gcttggggtg caaattctta
     1141 tggccagttg ggcactggca ataaaagtaa ccagtcctat cctacccctg ttgttgtgga
     1201 aaaggacaga atcatagaga ttgcagcctg tcactctgcc cacacatctg ctgccaagac
     1261 acaaggtggg cacgtgtaca tgtggggcca gtgccggggc cagtcggtga tccttccaca
     1321 ccacactcac ttctgctgca ccgatgacgt gtttgcctgc ttcgccaccc cggctgtcac
     1381 ctggcgcctt ctctccgtgg aacctgacga ccacctcact gtggccgagt ctctgaagag
     1441 ggagtttgac aaccctgaca ctgcagacct caagtttctg gttgatggaa aatacattta
     1501 tgctcacaaa gtccttctca aaattaggtg tgaacatttt cgttcttcat tagaagacag
     1561 tgaagacgat attgtagaaa tgagcgagtt ttcgtatcct gtgttccgag ctttcctgga
     1621 gtatctatac acagataaca tcagcctatc tcctgaggag gcagtagggt tgctagatct
     1681 ggctacattt tacagtgaga ctcggttgaa aaagctctgt caacaaacta tcaagcaagg
     1741 aatctgtgag gagaatgcta ttgctctgct ctctgctgct gtcaagtatg atgcccagga
     1801 cttagaagag ttctgcttca ggttctgcat caaccatctg actgtagtaa cacaaacgtc
     1861 aggctttgca gaaatggacc acgatcttct aaagaacttt atcagcaaag ccagcagagt
     1921 tggagccttt aagaactgat cctgaatgtg gaaaagaatg cttaagcctt cccatttcac
     1981 cccagcaaag ataaataaat aaatgaataa atagtaatta ccaaaaaaag ccattgacga
     2041 acaacttctc tgtaactaac agtgttgatg agaactacat ctggccagat tcttgtcttc
     2101 tgtcaaaagg ctgtagtcag ttctctctat ctgcctaccc cgagatttac agtagcaggc
     2161 actgagggct ccaactgggt atgatatacc acatagaagc tgaaagtgta ccagtgccac
     2221 tcttgtgggg agtctccctc tcccagcacg tgccaactgt aaatagcttt gtgggtaggt
     2281 tggtggggac tgtgttcacc tcctttctct gaccagggat ctgtctggta tgagcttgta
     2341 caggtctctt acatgctgtc agtctctgat ttcatacctg tgtgtcctgt tctttcaggg
     2401 taggcccaat gcttatgagt aactcgctaa cagctttctt ggctctgttt tgtgtgtgtg
     2461 tgtgtgtgtg tgtgcttttt gttttgttgt cacttttgtt ggctagttgt cttttttgga
     2521 aagttgggag gttttggaag aggttgaagt tgagaaagaa gaagtatcat ctaaaaaata
     2581 aacattatag ttaccatttc ttcctttgag tcacctatgg tagatatctg tggggaattg
     2641 atagtttgct aatctggaga aatggttcag tattcagctg gctgatacat agttatacaa
     2701 ggaatgctgt catgcccaca tttttagcct ctaacatagt accttatata taaaaggcac
     2761 tcagttaatt cactgtccat cataagggtg ccccaagaac agctagaagg ttggaaaagg
     2821 aataaacaaa attagaagtc tgtaattact gatattcata ttcttttagt ttgtaattct
     2881 gagaaacagt agctaattta gagcatatta gcattcataa aatgccttag caactacgtt
     2941 gtcaaaggcc caagggctac ttttgatttt ctactttctg cattaacttc tcataatggc
     3001 attgttgaaa ataaaacatt aactttgaat gttacttctg gaatcctatg ccttatgtaa
     3061 ttgcataaag ccctttgctt ttctttatat tgagggtctc tctatataag attgattata
     3121 ggtttttctt gtagctagct ttggtttctt aaccaggcac tagtaaatac tagatagaaa
     3181 ggaacacatt tcatgggtag cattgtgatg gagaaatgag tttctagacc aaaacaagcc
     3241 attgtgtagc aaaagagaaa caaactgaac aaaatgtagc actggattcc accaagtgtc
     3301 tcacaatatg atactatgtt aaggaaatct ttttgaaaat agaaatctta ttctcatgta
     3361 taattatttg ataataaaga acttgataga acaaaaaaaa aaaaaaaaaa a
//
