LOCUS       NM_022980               5101 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus regulator of calcineurin 3 (Rcan3), transcript variant
            1, mRNA.
ACCESSION   NM_022980
VERSION     NM_022980.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5101)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5101)
  AUTHORS   Bicer,A., Lopez-Henares,P., Molero-Magarino,M., Feu-Llaurado,A.,
            Sabariego-Navarro,M., Bayod,S., Padilla,L., Taco,M.R., Larriba,S.,
            Perez-Riba,M. and Serrano-Candelas,E.
  TITLE     The PxIxIT motif of the RCAN3 inhibits angiogenesis and tumor
            progression in Triple Negative breast cancer in immunocompetent
            mice
  JOURNAL   Carcinogenesis 43 (8), 808-812 (2022)
   PUBMED   35640493
  REMARK    GeneRIF: The PxIxIT motif of the RCAN3 inhibits angiogenesis and
            tumor progression in Triple Negative breast cancer in
            immunocompetent mice.
REFERENCE   3  (bases 1 to 5101)
  AUTHORS   Liu,T.Y., Chen,Y.C., Jong,Y.J., Tsai,H.J., Lee,C.C., Chang,Y.S.,
            Chang,J.G. and Chang,Y.F.
  TITLE     Muscle developmental defects in heterogeneous nuclear
            Ribonucleoprotein A1 knockout mice
  JOURNAL   Open Biol 7 (1) (2017)
   PUBMED   28077597
REFERENCE   4  (bases 1 to 5101)
  AUTHORS   Serrano-Candelas,E., Aleman-Muench,G., Sole-Sanchez,S.,
            Aubareda,A., Martinez-Hoyer,S., Adan,J., Aranguren-Ibanez,A.,
            Pritchard,M.A., Soldevila,G. and Perez-Riba,M.
  TITLE     RCAN 1 and 3 proteins regulate thymic positive selection
  JOURNAL   Biochem Biophys Res Commun 460 (2), 295-301 (2015)
   PUBMED   25783055
  REMARK    GeneRIF: found that RCAN1/3 interact with RAF kinases and CN in a
            non-exclusive manner. Our data suggests that the balance of RCAN
            interactions with CN and/or RAF kinases may influence T cell
            positive selection
REFERENCE   5  (bases 1 to 5101)
  AUTHORS   Davies,K.J., Ermak,G., Rothermel,B.A., Pritchard,M., Heitman,J.,
            Ahnn,J., Henrique-Silva,F., Crawford,D., Canaider,S., Strippoli,P.,
            Carinci,P., Min,K.T., Fox,D.S., Cunningham,K.W., Bassel-Duby,R.,
            Olson,E.N., Zhang,Z., Williams,R.S., Gerber,H.P., Perez-Riba,M.,
            Seo,H., Cao,X., Klee,C.B., Redondo,J.M., Maltais,L.J.,
            Bruford,E.A., Povey,S., Molkentin,J.D., McKeon,F.D., Duh,E.J.,
            Crabtree,G.R., Cyert,M.S., de la Luna,S. and Estivill,X.
  TITLE     Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of
            calcineurin
  JOURNAL   FASEB J 21 (12), 3023-3028 (2007)
   PUBMED   17595344
REFERENCE   6  (bases 1 to 5101)
  AUTHORS   Porta,S., Marti,E., de la Luna,S. and Arbones,M.L.
  TITLE     Differential expression of members of the RCAN family of
            calcineurin regulators suggests selective functions for these
            proteins in the brain
  JOURNAL   Eur J Neurosci 26 (5), 1213-1226 (2007)
   PUBMED   17767500
  REMARK    GeneRIF: the adult mice, RCAN3 was mainly expressed in the neuropil
            throughout the brain.
REFERENCE   7  (bases 1 to 5101)
  AUTHORS   Yang,X.Y., Yang,T.T., Schubert,W., Factor,S.M. and Chow,C.W.
  TITLE     Dosage-dependent transcriptional regulation by the calcineurin/NFAT
            signaling in developing myocardium transition
  JOURNAL   Dev Biol 303 (2), 825-837 (2007)
   PUBMED   17198697
REFERENCE   8  (bases 1 to 5101)
  AUTHORS   Bischof,J.M. and Wevrick,R.
  TITLE     Genome-wide analysis of gene transcription in the hypothalamus
  JOURNAL   Physiol Genomics 22 (2), 191-196 (2005)
   PUBMED   15870395
REFERENCE   9  (bases 1 to 5101)
  AUTHORS   Strippoli,P., Petrini,M., Lenzi,L., Carinci,P. and Zannotti,M.
  TITLE     The murine DSCR1-like (Down syndrome candidate region 1) gene
            family: conserved synteny with the human orthologous genes
  JOURNAL   Gene 257 (2), 223-232 (2000)
   PUBMED   11080588
REFERENCE   10 (bases 1 to 5101)
  AUTHORS   Strippoli,P., Lenzi,L., Petrini,M., Carinci,P. and Zannotti,M.
  TITLE     A new gene family including DSCR1 (Down Syndrome Candidate Region
            1) and ZAKI-4: characterization from yeast to human and
            identification of DSCR1-like 2, a novel human member (DSCR1L2)
  JOURNAL   Genomics 64 (3), 252-263 (2000)
   PUBMED   10756093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627185.10.
            
            On Mar 27, 2023 this sequence version replaced NM_022980.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155270.1, SRR9219382.100082.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AL627185.10        95040-95271         c
            233-464             AL627185.10        86642-86873         c
            465-638             AL627185.10        81674-81847         c
            639-810             AL627185.10        79808-79979         c
            811-5101            AL627185.10        73736-78026         c
FEATURES             Location/Qualifiers
     source          1..5101
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 67.59 cM"
     gene            1..5101
                     /gene="Rcan3"
                     /gene_synonym="Csp3; Dscr1l2"
                     /note="regulator of calcineurin 3"
                     /db_xref="GeneID:53902"
                     /db_xref="MGI:MGI:1858220"
     exon            1..232
                     /gene="Rcan3"
                     /gene_synonym="Csp3; Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            233..464
                     /gene="Rcan3"
                     /gene_synonym="Csp3; Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..989
                     /gene="Rcan3"
                     /gene_synonym="Csp3; Dscr1l2"
                     /note="isoform a is encoded by transcript variant 1;
                     calcipressin-3; MCIP3; down syndrome candidate region
                     1-like protein 2; myocyte-enriched calcineurin-interacting
                     protein 3; Down syndrome critical region gene 1-like 2"
                     /codon_start=1
                     /product="calcipressin-3 isoform a"
                     /protein_id="NP_075356.1"
                     /db_xref="CCDS:CCDS18785.1"
                     /db_xref="GeneID:53902"
                     /db_xref="MGI:MGI:1858220"
                     /translation="MLRDSLKSWNDSQSDLCSSDQEEEEEMVFGENEDGLEEMMDLSD
                     LPTSLFACSVHEAVFEVQEQKERFEALFTLYDDQVTFQLFKSFRRVRINFSKPEAAAR
                     ARIELHESEFHGRKLKLYFAQVQVSGEARDKSYLLPPQPTKQFLISPPASPPVGWKQS
                     EDAMPVINYDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEDTKNPKQKI
                     TQTRRPEAPTAALSERLDCAL"
     exon            465..638
                     /gene="Rcan3"
                     /gene_synonym="Csp3; Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            639..810
                     /gene="Rcan3"
                     /gene_synonym="Csp3; Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..5101
                     /gene="Rcan3"
                     /gene_synonym="Csp3; Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1380..1385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcan3"
                     /gene_synonym="Csp3; Dscr1l2"
                     /note="hexamer: AATATA"
     polyA_site      1413
                     /gene="Rcan3"
                     /gene_synonym="Csp3; Dscr1l2"
     regulatory      5075..5080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcan3"
                     /gene_synonym="Csp3; Dscr1l2"
                     /note="hexamer: AATAAA"
     polyA_site      5101
                     /gene="Rcan3"
                     /gene_synonym="Csp3; Dscr1l2"
                     /note="major polyA site"
ORIGIN      
        1 gcagcgcgcc ccctgggcgc gaggaaccca gggagggcgc gaggcgcgcg ggcccgggag
       61 cgcgcgcgac gctggcaacc tcgctcagcc ctaggtcacc gcccgtgtcg ccggctgagg
      121 cggccgctgc ggcccgcgtt gagggcgtgg tggctccggg tggtgagggt ctgtccgccc
      181 caggccgcgc tcgtgggcat cccccctcgg gcctctcccc tcgagcgcac agaagtatct
      241 ggcaggcatc ctagaacttt acagagaaga tgctccgaga cagcctgaaa tcttggaatg
      301 acagccagtc agacctctgt agcagcgacc aggaggagga agaggagatg gtcttcggtg
      361 aaaatgagga cggactggaa gagatgatgg acctaagtga cctgcccacc tcactctttg
      421 cttgcagtgt ccatgaagca gtgtttgagg tccaagagca aaaggagagg tttgaggccc
      481 tgttcaccct ctacgatgac caggtcacat tccagttgtt caagagcttt cgcagagtga
      541 ggatcaactt cagcaagccc gaggctgcgg caagagcgcg gatagagctc cacgagagtg
      601 agttccacgg acggaagctg aagctttact tcgcacaggt gcaggtgtcc ggggaggccc
      661 gggacaagtc ctacttactg ccaccacaac ccaccaagca gttcctcatc tcccctcccg
      721 cctcaccccc cgtggggtgg aagcagagtg aagatgcgat gccagtgatc aactatgacc
      781 tgctctgcgc tgtctccaag ctgggcccag gggagaaata cgaactgcac gcgggaaccg
      841 agtccacccc cagtgtggtg gtgcacgtct gtgagagcga aactgaagag gaagaagaca
      901 caaaaaatcc aaaacagaaa atcacgcaga cgcggcgccc ggaggctccc acggcggcac
      961 tgagtgagcg gctggactgt gcactctgag cggctgcggt gcctgccgcg cctgcctgtc
     1021 ccaccactac agctgcgcct gtctaggagc acagcccagg gatgctgttg catccgtcag
     1081 gcagttgggc cagcctcccc aggccagaac gtggggtgaa gtagcagatt cggccagctg
     1141 tttgaaattc tgaacagtat tctcaatggc actttaagtg acaaggttag ccctgaccat
     1201 gtggcacctg tctcctcccc cagaaatatt agttcccttg aacctgtaga gcattgggta
     1261 ccacaggcca gaactagagt cacccagtgc actgccattt ttacagattt aaaaattagt
     1321 cttacggttt cagtactttg gtgtgggtat ttttgtacag gtgtggcagt gtcttaacaa
     1381 atatattgag caaaggctga gtgttgttca gtagacatga cctttttttt gttgttgcat
     1441 gagaagaaac ccgagataca aaatcatttg tagaagtcat ttctcacaag tattttttca
     1501 ctagctttga ggatgaaagg ccaaatgact gagattgtca gatccagata tcgtgggcag
     1561 atgtgctctt agctctcctg gctgtccgtc tgtcctgcct ctcttggcag tcagtgacag
     1621 tggtgtacag gactctgctc ccagctcagc ccttcccagc ctcggctctg ctggaggaat
     1681 ctccctttgc cagtgggatg tgtcaccggg aagcttggct gaggactaca gagttggagt
     1741 ctgtggggca gctcttcagt tactctcttg accctcctaa tgccggcctg ctactgcttg
     1801 aggtttcctg tgctgtgcgt gtaatcaagg acgttagtcg tcttaacttt agaagataat
     1861 gataagactt tgtgaagacc gctttaaata gggagagcca gtttgctttt gttttcttca
     1921 aagacagggt ttcactttgt agctcctggg cctcaagtcc tctgtgatcc tcctgcctca
     1981 gcttcccaag tgctggaatt agaggggtga gcaccacaca tttcaaagtt ttccattcaa
     2041 gtatttcagc tgttcagaaa gaaaaatcac ctgtcctttc ccccatggat tagggaaagt
     2101 aatcattctt ttgggggtgg ttgggtttgt ttgtttggtt ggttggttgg ttggttggtt
     2161 gattttgaga taaggtttca cgctgtagct catgctagcc tgtcactcat tatgtagccc
     2221 aagctggcct tgaggcccag accactctct ttcctcaggc tctgtttgtt tggattgtag
     2281 gcatgggctt gttgtagtct atgcttcctc ctttaacaat catttccacc tttgcttgca
     2341 gttggccctc aggtagaatt gcttcttaca cttgaagatg tgttgttggg gcctccatag
     2401 gtcactcagc atcactggtc ccttgcagac tttcctgcct ttgagtgctg ggctacaggt
     2461 acatcagctg ctccactcat caagtattca gagctggctg gcctaggtga aggggctggg
     2521 catagaacag agaggaacat agctgcaact gcaaagaaaa gaacgtagag aaatgaagcc
     2581 atgagagccg tgtactttgc gtgacatgtt agggctgagt ccttttgtgg taggattgat
     2641 ttcatgagcg tgcatgcatg agctcacaca caaacacacg cacacaggtg cattgtctgt
     2701 cattaaaacc gggtcccatg tagtccaggt tgacctcaaa cttgctgtgt cccaaggatg
     2761 accctgaact gctcctcctg cctctgtctc ataagtgcta ggactgaggg tgtgtgccac
     2821 catacctgac aagaacagga gagtgtccct tgccttcagg tcctgtggaa tgctgaattc
     2881 tgcgtttgcc attgggagcc ctccgtgcag attcagttgc agattacgat tccacccgca
     2941 ttggttttta gatccaagtc atctgtcaga taaagtgagt ttggttttga ggtgacagct
     3001 cagtgtggcc caggttggtc tcaaacgcca ggcctcagtg ggtcttccca gttgactgga
     3061 tgcaggcaca cagctgctgt aatcctgaga ctttggaggc gaatgcagta gatcaagagt
     3121 tcatccttgg cttacagtgc tttgcagtgc tgagctcggc agtgtacttc atttgattgt
     3181 aaggtagacc ctagctgcca gcaagtgtgt tctcacagtt ggggagtttg tgtgttcccc
     3241 gttatacagt acacgttctc tctaattttc tatgtgatca taaccctgtt ttaaaatttg
     3301 tcttggcttt cattttctac ccctcaatga aagaacattc tttttttttt taagtcaaga
     3361 agttcaaatc tgcatacttg atgctacctt ggccactggc agttgtgttg ccaccttatc
     3421 tgggttccct ggatagtcac attcatgcca tgtgttagaa tttacatgtt aaaatgtaaa
     3481 cagtagtgag agcggagcca ggcacaaagg atgcatggag ttaaaggttc tacggaatgt
     3541 ccctctccct cggtttagag aatcaagttc tattccagac taacggtggg cctgggcttt
     3601 atatttttat gtaaactatt tttagactgg aggatttggt tttcagagga aagctttacg
     3661 cataattaaa ccatgggagt gtactggatt ctttgatgcc ttgggttcac acctacctgc
     3721 ttgccttctt ctctatagag cctgagacct caccccgggt cacctccagc ctccctctgt
     3781 gctccataat acatctatct taaaggaaac cgttgtctgg gtgtggtggc cctggcctgt
     3841 aatctcagcc tgcaggagac tgaggcagga ggattgagag aacggggcta gcttgggcta
     3901 catgagttaa accgtctcag aataaggttt ttcctttttc ttggtgtgac agtacagagc
     3961 aactgggaaa atatttactt ctagccaaga agtctgttct ggactcattc tacacaaact
     4021 taagtacaca cacagagaga gtacgatgta tgaaccttga gcaaccacat gacaaatgac
     4081 tgttggtgtt tcaaactccc ttcaagagtg tgttctccag aaaagccatc cctctcagag
     4141 tgccactgtt tccctcagtc ttgagtggag cgcagttcat agtcaggatt accgtgtatt
     4201 cagcacagtg acataggctg tcctctcagc gcttgggagg cagaggtacc agggcttggc
     4261 aagcttaagg ccagcctggg ccatgtaccg agaccctgtc taaaaacaag gggattcctg
     4321 ggtgtccagg tatcccaggg acagataaca gcaactgtgc atcttgtcca cggctgggaa
     4381 cgtgccgtat tccttccctg tggtttctag tcaaggctag aagtgatccc agatacggtc
     4441 agcatgcaga caccacctac tcactcgggt tagtgctttc tcttggaaac ctgcagttct
     4501 tgaagtgggt cccgagaccc ttgcaggtcc cacatggcct gacctgaccg gatgtgcgtt
     4561 tatgacacag gggggtttct tttctatcta tgcagataat ttgtggtttt ctgtaccgtt
     4621 ccctgttggc acccctcttc ctaagtccaa ttgaggacta agggaccaca ggtctcagtc
     4681 ctgtgccgtg ctgtgccctc tgctgtcagc ctctgagtat ctattcacgt catgtgtgtc
     4741 tttgacgtgt gagaacgcat tcacagctgt tgcacattga tccccacaac tgaacctgca
     4801 gctggattaa gtcccgaatc cagcatgtct gtaatcccct ggtctgtgca ctgtagtatg
     4861 ctcgctgcac gtgtggaaac tggtcagtga gcctcatccg tgtgtcctgt gatttcagta
     4921 tcgttgatct gatgggccac agttcattat cagcttcaac tgtcctgtgt cctgaggctt
     4981 tcgaacattc cttgtcctgt aaggaggtga cagaggcaga ctgtgacccg gaagacactt
     5041 gtgattacct gtaacaaacg ttgatgttga aactaataaa gaattgttgt tttttaagtc
     5101 a
//
