LOCUS       NM_207649               3389 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus regulator of calcineurin 2 (Rcan2), transcript variant
            1, mRNA.
ACCESSION   NM_207649
VERSION     NM_207649.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Wang,S., Wang,G., Dong,L., Liu,X., Pan,W., Han,J. and Lu,Y.
  TITLE     The Overexpression of miR-377 Aggravates Sepsis-Induced Myocardial
            Hypertrophy by Binding to Rcan2 and Mediating CaN Activity
  JOURNAL   Oxid Med Cell Longev 2022, 6659183 (2022)
   PUBMED   36267816
  REMARK    GeneRIF: The Overexpression of miR-377 Aggravates Sepsis-Induced
            Myocardial Hypertrophy by Binding to Rcan2 and Mediating CaN
            Activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Hou,S., Niu,G., Liu,X., Bourbon,P.M., Zhang,D., Cui,P., Zhao,K.,
            Zhao,D. and Zeng,H.
  TITLE     A novel transcriptional complex on the VE-cadherin promoter
            regulated the downregulation of VE-cadherin in the Down Syndrome
            Candidate Region 1 isoform 1L-mediated angiogenesis
  JOURNAL   Microvasc Res 138, 104209 (2021)
   PUBMED   34146582
  REMARK    GeneRIF: A novel transcriptional complex on the VE-cadherin
            promoter regulated the downregulation of VE-cadherin in the Down
            Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis.
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Mammarella,E., Zampieri,C., Panatta,E., Melino,G. and Amelio,I.
  TITLE     NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic
            network
  JOURNAL   Biol Direct 16 (1), 11 (2021)
   PUBMED   34348766
  REMARK    GeneRIF: NUAK2 and RCan2 participate in the p53 mutant
            pro-tumorigenic network.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3389)
  AUTHORS   Ding,L.C., Gong,Q.Q., Li,S.W., Fu,X.L., Jin,Y.C., Zhang,J.,
            Gao,J.G. and Sun,X.Y.
  TITLE     Rcan2 and estradiol independently regulate body weight in female
            mice
  JOURNAL   Oncotarget 8 (29), 48098-48109 (2017)
   PUBMED   28624805
  REMARK    GeneRIF: our results indicate that Rcan2 and estradiol might
            regulate body weight through different mechanisms in female mice.
            Rcan2 increases food intake and promotes weight gain, while
            estradiol increases energy expenditure possibly by regulating
            physical activity.
REFERENCE   6  (bases 1 to 3389)
  AUTHORS   Mizuno,Y., Kanou,Y., Rogatcheva,M., Imai,T., Refetoff,S., Seo,H.
            and Murata,Y.
  TITLE     Genomic organization of mouse ZAKI-4 gene that encodes ZAKI-4 alpha
            and beta isoforms, endogenous calcineurin inhibitors, and changes
            in the expression of these isoforms by thyroid hormone in adult
            mouse brain and heart
  JOURNAL   Eur J Endocrinol 150 (3), 371-380 (2004)
   PUBMED   15012624
REFERENCE   7  (bases 1 to 3389)
  AUTHORS   Vega,R.B., Rothermel,B.A., Weinheimer,C.J., Kovacs,A., Naseem,R.H.,
            Bassel-Duby,R., Williams,R.S. and Olson,E.N.
  TITLE     Dual roles of modulatory calcineurin-interacting protein 1 in
            cardiac hypertrophy
  JOURNAL   Proc Natl Acad Sci U S A 100 (2), 669-674 (2003)
   PUBMED   12515860
REFERENCE   8  (bases 1 to 3389)
  AUTHORS   Strippoli,P., Petrini,M., Lenzi,L., Carinci,P. and Zannotti,M.
  TITLE     The murine DSCR1-like (Down syndrome candidate region 1) gene
            family: conserved synteny with the human orthologous genes
  JOURNAL   Gene 257 (2), 223-232 (2000)
   PUBMED   11080588
REFERENCE   9  (bases 1 to 3389)
  AUTHORS   Rothermel,B., Vega,R.B., Yang,J., Wu,H., Bassel-Duby,R. and
            Williams,R.S.
  TITLE     A protein encoded within the Down syndrome critical region is
            enriched in striated muscles and inhibits calcineurin signaling
  JOURNAL   J Biol Chem 275 (12), 8719-8725 (2000)
   PUBMED   10722714
REFERENCE   10 (bases 1 to 3389)
  AUTHORS   Strippoli,P., Lenzi,L., Petrini,M., Carinci,P. and Zannotti,M.
  TITLE     A new gene family including DSCR1 (Down Syndrome Candidate Region
            1) and ZAKI-4: characterization from yeast to human and
            identification of DSCR1-like 2, a novel human member (DSCR1L2)
  JOURNAL   Genomics 64 (3), 252-263 (2000)
   PUBMED   10756093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY740155.1, BB635249.1 and BC049096.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1, 3 and 5 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138768.1, AK136805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                BY740155.1         8-96
            90-473              BB635249.1         2-385
            474-3389            BC049096.1         348-3263
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.77 cM"
     gene            1..3389
                     /gene="Rcan2"
                     /gene_synonym="Csp2; Dscr1l1; MCIP2; ZAKI-4"
                     /note="regulator of calcineurin 2"
                     /db_xref="GeneID:53901"
                     /db_xref="MGI:MGI:1858219"
     exon            1..246
                     /gene="Rcan2"
                     /gene_synonym="Csp2; Dscr1l1; MCIP2; ZAKI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            247..473
                     /gene="Rcan2"
                     /gene_synonym="Csp2; Dscr1l1; MCIP2; ZAKI-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..980
                     /gene="Rcan2"
                     /gene_synonym="Csp2; Dscr1l1; MCIP2; ZAKI-4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myocyte-enriched calcineurin interactin protein 2;
                     calcipressin-2; calcineurin inhibitory protein ZAKI-4;
                     down syndrome candidate region 1-like protein 1;
                     myocyte-enriched calcineurin-interacting protein 2; Down
                     syndrome critical region gene 1-like 1"
                     /codon_start=1
                     /product="calcipressin-2 isoform 1"
                     /protein_id="NP_997532.1"
                     /db_xref="CCDS:CCDS28800.1"
                     /db_xref="GeneID:53901"
                     /db_xref="MGI:MGI:1858219"
                     /translation="MRGDAYFIGMRSLGQQASIPEDGGLFFLCCIDRDWAVTQCFAEE
                     AFQALTDFSDLPNSLFACNVHQSVFEEEESKEKFEGLFRTYDECVTFQLFKSFRRVRI
                     NFSHPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPP
                     SSPPVGWKPISDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDMEEE
                     EDPKTSPKPKIIQTRRPGLPPSVSN"
     exon            474..647
                     /gene="Rcan2"
                     /gene_synonym="Csp2; Dscr1l1; MCIP2; ZAKI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            648..819
                     /gene="Rcan2"
                     /gene_synonym="Csp2; Dscr1l1; MCIP2; ZAKI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            820..3363
                     /gene="Rcan2"
                     /gene_synonym="Csp2; Dscr1l1; MCIP2; ZAKI-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1220..1225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcan2"
                     /gene_synonym="Csp2; Dscr1l1; MCIP2; ZAKI-4"
                     /note="hexamer: ATTAAA"
     polyA_site      1241
                     /gene="Rcan2"
                     /gene_synonym="Csp2; Dscr1l1; MCIP2; ZAKI-4"
     regulatory      3341..3346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcan2"
                     /gene_synonym="Csp2; Dscr1l1; MCIP2; ZAKI-4"
                     /note="hexamer: AATATA"
     polyA_site      3359
                     /gene="Rcan2"
                     /gene_synonym="Csp2; Dscr1l1; MCIP2; ZAKI-4"
                     /note="major polyA site"
ORIGIN      
        1 cccgggtgac ggcggtggag gttgcgggag caccagcagg aggcacagcc cgggtgaccc
       61 cacgacccgg agagcgggag gcggcgctca gtgcgcacgg ctccacgccc aggcccgcgg
      121 gctccgcgct cgccccggcc gtcaggtgaa caggcagagc cgcgcccgca gcctgctgcc
      181 ccgaggaccc ccgagccgct gccactgtca ccgccgccac agcggcgcat cgcagacgtc
      241 ctgcagggat gaggggagac gcctacttca ttggaatgag gagcttgggg cagcaggcat
      301 ctatccctga agatggggga cttttcttcc tctgctgcat agacagagac tgggctgtca
      361 ctcagtgttt tgctgaagag gccttccaag cactcactga cttcagtgat ctccccaact
      421 cattgtttgc ctgcaatgtt caccagtctg tgtttgaaga agaggagagc aaggaaaaat
      481 tcgagggact gttccggacc tatgatgaat gtgtgacgtt ccagctgttt aagagtttcc
      541 gacgggttcg aataaatttc agccatccca aatctgcagc ccgtgcccgg atagagcttc
      601 atgagactca gttcagaggg aagaagctaa aactctactt cgcccaggtc cagaccccag
      661 agacagatgg agacaaactg catttggcac ctccacagcc tgccaaacag ttcctcatct
      721 cacccccttc atctcctcct gttggctgga agcctatcag cgatgccaca ccagtcctca
      781 actatgacct tctttatgct gtggccaaac taggaccagg agagaaatat gagctgcacg
      841 ctggaactga gtctacaccg agcgtcgtgg tgcatgtgtg tgacagcgac atggaggagg
      901 aggaggaccc aaagacttcc ccaaagccaa aaatcatcca gacccggcgt cccggcctgc
      961 caccctccgt gtccaactga gcacgtccat gataacatgc atctcctctt atcatgcttc
     1021 ccgccccccc ccttgttgtt tgtccaaaca attaattgcc tttaagtccc tgggtgtttg
     1081 gttgtttgcg aatccttcct tgtaattaag cctctcggac aaaagggcta ggcaaaggtg
     1141 atatgtctcc caatcaactc ctacccatta actacaatcc atcacttaga aagttctaga
     1201 tagagggtag tattttctta ttaaataatc agtacagccc atatctctgt tctttcatgt
     1261 tgatccaagc cagagacatc ggtaatgaag agcctttatg ttgtttgtga gctgctccag
     1321 ttcagtcctg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgat gtttttttcc
     1381 tggccactta tataggacca taagtaaact tggctttgac tgcatgagat ccccctatct
     1441 ggtctcaccc agtcctctgc atcccgacat tcccaggaca tgcacgatca ccagcattga
     1501 ttttgatgat tttgagggta tgccccaact tgtggtatcc cagccctgtc ctgtatagac
     1561 aaggggcatc cgcagcacca ttcagctcaa taagtctggg aatcattatt agtttgagtc
     1621 aattacatca tataactctg gccaaattcc tggaggtaaa attgagcatg gccccaaaga
     1681 tgttgaacat cactaccaca gaggtctacc cagtgttact ggggaggctt gtccaagtga
     1741 cagagaccga tttcagacaa acctatttat tataaaatct catagtgtct gaatgactgt
     1801 cccctacccc tttgtatatt tgtacagatg tttgagctgt gcttttaaaa tctggatgtt
     1861 ttttatttag tgattgttca accattagct gcttaatgac atcatacctg tgttgcttct
     1921 gaatgcattc tgattctaat gtagataacc tgatactatt acatgctatt gcggttcgtg
     1981 ctaagttgta aaagggaaca gcaatgtctc atgccaatag ataactgact agccaacctt
     2041 tgctgtccaa accacctgtt tccaaacaaa gatccaagta tcagttataa gcaacttggg
     2101 tgacgctaaa tccaagaaat gtatacagct gagcatttca gagcacaaag gatgatgggt
     2161 aaacggatgc ccttcccatt catccaatgc ccatgcgctc aaaagttcct tgtttttgtt
     2221 atgtgtgact tttgtatatc tctagcccaa agtgcattac agaagataca cctgcagaac
     2281 catactttct gctccatgtg tcaagcctca tctattcctg ttcattaact agtaactttg
     2341 gatgcaaata ccatttacca cacaacaggc aaggactttc atggcctaag cctcggagta
     2401 acacacaaga acactaacac agccacctga tggggggata attgtggttt tttgattaag
     2461 gtgtatgtta gtttccgcag aaacttcaaa cctagactga tcattcagaa aattaaaagt
     2521 ccgttctact gtgaaatata gcaatatagt gccggacacg gtacagtacg attgagaccg
     2581 aggacagtat tgcttgtgga atcctaagtt tccatgggga aaacaagtcg tcttttcaaa
     2641 atcagatctg aggagtgtac acagtaagca aaggctttga ctttcctttg ttgtggaagg
     2701 ttttgttttc ttttttttaa attggccatg gaaagactag aaatagtggc gagatgatgc
     2761 cctctcgtgg cagaaacagt gaaatcggtt gtatagatgg attgattaca acagtcaact
     2821 accaggggct gaccttctaa tccacattaa ctttcaggat gcaggagaga gagagagaga
     2881 gagagagaga gagagagaga gagagagaga gagaaacaaa atgaaagtct gggaaataat
     2941 ttgcgcttcc aaacaatgat agcagaaatg tctaatttag taaaagttga gtgtgactac
     3001 cttgcatagt ccttaagaac tcagtgttct agacggccca gatgattagt cttagtaaac
     3061 tgtattgcca tctgttgacg ttaacctgct acagatcaag gggttctcgc gctagattga
     3121 gcatggggac gggggagggg gagctttccc cagaaggaat ggggaagcca cgggacctcc
     3181 cagcatcgag aaagtcacct ggacacttcc atgatgctca ttatgcaaac ctctttagcg
     3241 ctcttttaag tttgaaacgt ttttaaatgg aggggaaggg gaaggtttcc accaactgaa
     3301 tcatttgtgc acgtgtacag ctcaaagagc ttagagttca aatatatctg gtgaatgact
     3361 gtcaaaaaaa aaaaaaaaaa aaaaaaaaa
//
