LOCUS       NM_001081549            2349 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus regulator of calcineurin 1 (Rcan1), transcript variant
            1, mRNA.
ACCESSION   NM_001081549
VERSION     NM_001081549.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Shu,S., Cui,H., Liu,Z., Zhang,H., Yang,Y., Chen,X., Zeng,Z., Du,L.,
            Fu,M., Yang,Z., Wang,P., Wang,C., Gao,H., Yang,Q., Lin,X., Yang,T.,
            Chen,Z., Wu,S., Wang,X., Zhao,R., Hu,S. and Song,J.
  TITLE     Suppression of RCAN1 alleviated lipid accumulation and
            mitochondrial fission in diabetic cardiomyopathy
  JOURNAL   Metabolism 158, 155977 (2024)
   PUBMED   39053690
  REMARK    GeneRIF: Suppression of RCAN1 alleviated lipid accumulation and
            mitochondrial fission in diabetic cardiomyopathy.
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Pang,Z. and Lin,T.J.
  TITLE     Mice with double knockout of Egr-1 and RCAN1 exhibit reduced
            inflammation during Pseudomonas aeruginosa lung infection
  JOURNAL   Immunobiology 228 (3), 152377 (2023)
   PUBMED   36933529
  REMARK    GeneRIF: Mice with double knockout of Egr-1 and RCAN1 exhibit
            reduced inflammation during Pseudomonas aeruginosa lung infection.
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Broadway-Stringer,S., Jiang,H., Wadmore,K., Hooper,C., Douglas,G.,
            Steeples,V., Azad,A.J., Singer,E., Reyat,J.S., Galatik,F.,
            Ehler,E., Bennett,P., Kalisch-Smith,J.I., Sparrow,D.B., Davies,B.,
            Djinovic-Carugo,K., Gautel,M., Watkins,H. and Gehmlich,K.
  TITLE     Insights into the Role of a Cardiomyopathy-Causing Genetic Variant
            in ACTN2
  JOURNAL   Cells 12 (5), 721 (2023)
   PUBMED   36899856
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Choi,C., Kim,H., Oh,J., Park,C., Kim,M., Kim,C.S. and Park,J.
  TITLE     DSCR1 deficiency ameliorates the Abeta pathology of Alzheimer's
            disease by enhancing microglial activity
  JOURNAL   Life Sci Alliance 6 (2), e202201556 (2022)
   PUBMED   36450444
  REMARK    GeneRIF: DSCR1 deficiency ameliorates the Abeta pathology of
            Alzheimer's disease by enhancing microglial activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   Casas,C., Martinez,S., Pritchard,M.A., Fuentes,J.J., Nadal,M.,
            Guimera,J., Arbones,M., Florez,J., Soriano,E., Estivill,X. and
            Alcantara,S.
  TITLE     Dscr1, a novel endogenous inhibitor of calcineurin signaling, is
            expressed in the primitive ventricle of the heart and during
            neurogenesis
  JOURNAL   Mech Dev 101 (1-2), 289-292 (2001)
   PUBMED   11231093
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Strippoli,P., Petrini,M., Lenzi,L., Carinci,P. and Zannotti,M.
  TITLE     The murine DSCR1-like (Down syndrome candidate region 1) gene
            family: conserved synteny with the human orthologous genes
  JOURNAL   Gene 257 (2), 223-232 (2000)
   PUBMED   11080588
REFERENCE   9  (bases 1 to 2349)
  AUTHORS   Rothermel,B., Vega,R.B., Yang,J., Wu,H., Bassel-Duby,R. and
            Williams,R.S.
  TITLE     A protein encoded within the Down syndrome critical region is
            enriched in striated muscles and inhibits calcineurin signaling
  JOURNAL   J Biol Chem 275 (12), 8719-8725 (2000)
   PUBMED   10722714
REFERENCE   10 (bases 1 to 2349)
  AUTHORS   Strippoli,P., Lenzi,L., Petrini,M., Carinci,P. and Zannotti,M.
  TITLE     A new gene family including DSCR1 (Down Syndrome Candidate Region
            1) and ZAKI-4: characterization from yeast to human and
            identification of DSCR1-like 2, a novel human member (DSCR1L2)
  JOURNAL   Genomics 64 (3), 252-263 (2000)
   PUBMED   10756093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY276032.1, AK146764.1 and BY454038.1.
            
            On Jan 18, 2014 this sequence version replaced NM_001081549.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146764.1, SRR1660815.176081.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY276032.1         2-27
            27-2345             AK146764.1         2-2320
            2346-2349           BY454038.1         471-474
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.6 cM"
     gene            1..2349
                     /gene="Rcan1"
                     /gene_synonym="Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1;
                     RCN1"
                     /note="regulator of calcineurin 1"
                     /db_xref="GeneID:54720"
                     /db_xref="MGI:MGI:1890564"
     exon            1..337
                     /gene="Rcan1"
                     /gene_synonym="Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1;
                     RCN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..847
                     /gene="Rcan1"
                     /gene_synonym="Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1;
                     RCN1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcipressin-1; calcineurin inhibitor; down syndrome
                     critical region protein 1 homolog; myocyte-enriched
                     calcineurin-interacting protein 1"
                     /codon_start=1
                     /product="calcipressin-1 isoform 1"
                     /protein_id="NP_001075018.1"
                     /db_xref="CCDS:CCDS37405.1"
                     /db_xref="GeneID:54720"
                     /db_xref="MGI:MGI:1890564"
                     /translation="MEDGVAGPRLGEVAEAVEARAPRRVTLRPFAPFSAAAEGDGGGG
                     GDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDTTFQYFK
                     SFKRVRINFSNPLSAADARLRLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLI
                     SPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQ
                     ENEEEEEEMERMKRPKPKIIQTRRPEYTPIHLS"
     exon            338..511
                     /gene="Rcan1"
                     /gene_synonym="Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1;
                     RCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            512..671
                     /gene="Rcan1"
                     /gene_synonym="Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1;
                     RCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..2349
                     /gene="Rcan1"
                     /gene_synonym="Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1;
                     RCN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2319..2324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rcan1"
                     /gene_synonym="Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1;
                     RCN1"
                     /note="hexamer: AATAAA"
     polyA_site      2347
                     /gene="Rcan1"
                     /gene_synonym="Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1;
                     RCN1"
                     /note="major polyA site"
ORIGIN      
        1 gtcccggcgc cgcggtgacc cccagagggt gaagcgggag ccggcggccg cggcgccgag
       61 tggagcggag ctaagggagc gcgcgccggg catggaggac ggcgtggccg ggccgcggct
      121 cggagaggtg gcggaggcgg tcgaggcacg ggcgccccgt agggtgactc tgcggccctt
      181 cgcgcccttc tctgcggctg ccgaggggga cgggggcggc ggcggcgact ggagcttcat
      241 cgactgcgag atggaggagg tggatctgca ggacctgccg agcgccacca tcgcctgcca
      301 cctggacccg cgcgtgttcg tggacggcct gtgccgggcc aaatttgaat ccctcttcag
      361 aacatatgac aaggacacca ccttccagta ttttaagagc ttcaaacgtg tccggataaa
      421 cttcagcaac cccttatctg cagccgatgc caggctgcgg ctgcacaaga ccgagttcct
      481 ggggaaggaa atgaagttgt attttgctca gactttacac ataggaagtt cacacctggc
      541 tccgcccaat cccgacaaac agttcctcat ctcccctccg gcctctcctc ccgttggctg
      601 gaaacaagta gaagatgcca cccccgtcat aaattacgat cttttatatg ccatctccaa
      661 gctggggcca ggagagaagt atgaactgca tgcagcgaca gacaccactc ccagtgtggt
      721 ggtccacgtg tgtgagagtg accaagagaa tgaggaggaa gaggaagaga tggagagaat
      781 gaagagaccc aagcccaaaa tcatccagac acggagaccg gagtacacac ccatccacct
      841 cagctgaacc ggcgcgcaga ctgagacagc gctctgaatc ccacgtgtgg gaaggaatct
      901 tttactgtgc aggtggctgg ccgtggcttt ggagggagcg gccgtgacca ctgtggcaga
      961 aattccagtt catgatgctc agaagagagt caaggcctcc tccccttgtt ctgatgctgc
     1021 ccctcagtcc atgtccacgg cacctgggac tgtcttgggc cattcactga atgtgtggca
     1081 gtcacacaag gacactgggg acatcctgag aaaactgata gttcttgtaa ttgctcattt
     1141 ctaggttctg tttttggcaa ggacaggttg actggtggcc cagggagaga tttctgtttc
     1201 caaccagagt tcagggtgca gcccccccac tggtaggcag aggcacaccc cccaaagcca
     1261 ccaagtgtcc agtgcagaaa ggtggtggga caacccccga accgtgtgga attgtccttc
     1321 tcgttccttc cccatggtct gacgttcatg catgtgtatt actgggtccc aggaccagcc
     1381 tttgttcacg taggaagtta cgctgttttc catcttggga agccaggaaa gttctggaac
     1441 actcttacca cgtgtcctcg ttttctctgc acatggggtc gaggctggag acatccacac
     1501 gtcaccctgc ctggtgcatt gtgtcacttg tgcttccctg caaaagaagt tgatcttgag
     1561 tccccaagta gaacttagcc taacctgtgg gagagcagca gggttgctgc cagccgtctg
     1621 tctgggctgg gaaggtttgg tgtgggtgct tgcgttcagc accggtctcc gttgtttcct
     1681 tcatgtagtg gtttgtgtgt gaatttcatc ccagacagtc tttgggaact gttggttgag
     1741 acagtttttc acccccattg aaacgtgaag ataaacttgt aaatacagcc aagagcatat
     1801 cttagtacct gtctgtacct gggtggaagt agagggcaga gggagtttca agctacctgt
     1861 gacttgtgtg tggtagaggt tactgtcatg tgtttaatgg ggtgaatcag agcatgtgga
     1921 gtccgtcgta gccatgtgtt cctagaggga cacagtgcct ttcccctttc atccagatga
     1981 ccacgacact cggtgaacat ttgagaattt ctgctttccc agtcatcgtg tgtgtgtctg
     2041 gtaaataggt attctatttt ggtcttacca ttgccattac aaagtttgtc actctgaata
     2101 acctgatgcc agttaacagt gcatgctttg gggactccgg aggtggcttc ccctggggag
     2161 caaatgggtt gatgttctcc aaaccctgtt tccagcgctc ggtgggaggg agcccacagg
     2221 tgggaggcca tcccgttgcc gccggcccag tgtttctagt tctgcacttt gaaccggaga
     2281 ggctaacctc aaagatattt tttttaactg cattctataa taaatcagca caatatgctc
     2341 ttctggaga
//
