LOCUS       NM_001080927            5508 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus recombination signal binding protein for
            immunoglobulin kappa J region (Rbpj), transcript variant 2, mRNA.
ACCESSION   NM_001080927
VERSION     NM_001080927.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5508)
  AUTHORS   Sisl,D., Planinic,P., Novak,S., Filipovic,M., Flegar,D., Sucur,A.,
            Turcic,P., Kovacic,N., Kalajzic,I., Grcevic,D. and Kelava,T.
  TITLE     Modulation of Notch signaling pathway in activated hepatic stellate
            cells does not ameliorate the outcome of liver fibrosis in carbon
            tetrachloride and DDC-feeding models
  JOURNAL   Front Pharmacol 15, 1440236 (2024)
   PUBMED   39529885
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5508)
  AUTHORS   Guo,W., Li,Z., Anagnostopoulos,G., Kong,W.T., Zhang,S.,
            Chakarov,S., Shin,A., Qian,J., Zhu,Y., Bai,W., Cexus,O., Nie,B.,
            Wang,J., Hu,X., Bleriot,C., Liu,Z., Shen,B., Venteclef,N., Su,B.
            and Ginhoux,F.
  TITLE     Notch signaling regulates macrophage-mediated inflammation in
            metabolic dysfunction-associated steatotic liver disease
  JOURNAL   Immunity 57 (10), 2310-2327 (2024)
   PUBMED   39317200
REFERENCE   3  (bases 1 to 5508)
  AUTHORS   Lingamallu,S.M., Deshpande,A., Joy,N., Ganeshan,K., Ray,N.,
            Ladher,R.K., Taketo,M.M., Lafkas,D. and Guha,A.
  TITLE     Neuroepithelial bodies and terminal bronchioles are niches for
            distinctive club cells that repair the airways following acute
            notch inhibition
  JOURNAL   Cell Rep 43 (9), 114654 (2024)
   PUBMED   39182223
REFERENCE   4  (bases 1 to 5508)
  AUTHORS   Xia,Y., Inoue,K., Zheng,T., Qin,Y. and Zhao,B.
  TITLE     Reciprocal suppression between TGFbeta signaling and TNF
            stimulation finetunes the macrophage inflammatory response
  JOURNAL   FASEB J 38 (13), e23704 (2024)
   PUBMED   38884155
REFERENCE   5  (bases 1 to 5508)
  AUTHORS   Le,N., Vu,T.D., Palazzo,I., Pulya,R., Kim,Y., Blackshaw,S. and
            Hoang,T.
  TITLE     Robust reprogramming of glia into neurons by inhibition of Notch
            signaling and nuclear factor I (NFI) factors in adult mammalian
            retina
  JOURNAL   Sci Adv 10 (28), eadn2091 (2024)
   PUBMED   38996013
REFERENCE   6  (bases 1 to 5508)
  AUTHORS   Jarriault,S., Brou,C., Logeat,F., Schroeter,E.H., Kopan,R. and
            Israel,A.
  TITLE     Signalling downstream of activated mammalian Notch
  JOURNAL   Nature 377 (6547), 355-358 (1995)
   PUBMED   7566092
REFERENCE   7  (bases 1 to 5508)
  AUTHORS   Kawaichi,M., Oka,C., Shibayama,S., Koromilas,A.E., Matsunami,N.,
            Hamaguchi,Y. and Honjo,T.
  TITLE     Genomic organization of mouse J kappa recombination signal binding
            protein (RBP-J kappa) gene
  JOURNAL   J Biol Chem 267 (6), 4016-4022 (1992)
   PUBMED   1740450
REFERENCE   8  (bases 1 to 5508)
  AUTHORS   Hamaguchi,Y., Mastunami,N., Yamamoto,Y., Kuze,K., Kangawa,K.,
            Matsuo,H., Kawaichi,M. and Honjo,T.
  TITLE     Cloning and characterization of a protein binding to the J kappa
            recombination signal sequence of immunoglobulin genes
  JOURNAL   Adv Exp Med Biol 292, 177-186 (1991)
   PUBMED   1950768
REFERENCE   9  (bases 1 to 5508)
  AUTHORS   Matsunami,N., Hamaguchi,Y., Yamamoto,Y., Kuze,K., Kangawa,K.,
            Matsuo,H., Kawaichi,M. and Honjo,T.
  TITLE     A protein binding to the J kappa recombination sequence of
            immunoglobulin genes contains a sequence related to the integrase
            motif
  JOURNAL   Nature 342 (6252), 934-937 (1989)
   PUBMED   2556644
REFERENCE   10 (bases 1 to 5508)
  AUTHORS   Siminovitch,K.A., Moore,M.W., Durdik,J. and Selsing,E.
  TITLE     The human kappa deleting element and the mouse recombining segment
            share DNA sequence homology
  JOURNAL   Nucleic Acids Res 15 (6), 2699-2705 (1987)
   PUBMED   3104881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084054.12, BY716845.1, AK080359.1, AK028363.1 and AK132145.1.
            
            On Mar 9, 2013 this sequence version replaced NM_001080927.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) is shorter and has a distinct N-terminus, compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145187.1, BC051387.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC084054.12        122708-122735
            29-206              BY716845.1         2-179
            207-1126            AK080359.1         2-921
            1127-3120           AK028363.1         1187-3180
            3121-3778           AK132145.1         2964-3621
            3779-4320           AK028363.1         3839-4380
            4321-5508           AK132145.1         4165-5352
FEATURES             Location/Qualifiers
     source          1..5508
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 29.37 cM"
     gene            1..5508
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /note="recombination signal binding protein for
                     immunoglobulin kappa J region"
                     /db_xref="GeneID:19664"
                     /db_xref="MGI:MGI:96522"
     exon            1..239
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1683
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /note="isoform 2 is encoded by transcript variant 2;
                     recombining binding protein suppressor of hairless;
                     J-kappa recombination signal binding protein; Jkappa
                     recombination signal binding protein"
                     /codon_start=1
                     /product="recombining binding protein suppressor of
                     hairless isoform 2"
                     /protein_id="NP_001074396.1"
                     /db_xref="CCDS:CCDS51504.1"
                     /db_xref="GeneID:19664"
                     /db_xref="MGI:MGI:96522"
                     /translation="MAPVVTGKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQ
                     KSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQL
                     NLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQS
                     LKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLLDDDESE
                     GEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFY
                     LKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGASWTIISTDKAEYTFYEGMGPV
                     LAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVV
                     PDISAFREGWRWVRQPVQVPVTLVRNDGVIYSTSLTFTYTPEPGPRPHCSAAGAILRA
                     NSSQVPSNESNTNSEGNYTNASTNSTSVTSSTATVVS"
     exon            240..278
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /inference="alignment:Splign:2.1.0"
     exon            279..374
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /inference="alignment:Splign:2.1.0"
     exon            375..540
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /inference="alignment:Splign:2.1.0"
     exon            541..715
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /inference="alignment:Splign:2.1.0"
     exon            716..853
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /inference="alignment:Splign:2.1.0"
     exon            854..966
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1107
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1263
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1367
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..5508
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4067..4072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /note="hexamer: AATAAA"
     polyA_site      4110
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /note="major polyA site"
     regulatory      4179..4184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /note="hexamer: ATTAAA"
     polyA_site      4208
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /note="major polyA site"
     regulatory      5403..5408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /note="hexamer: AATAAA"
     polyA_site      5424
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
ORIGIN      
        1 ggtaggtttc tagggaaagg cagtgagcag atcccttagt ccgcgggcgg cgcgaggcgg
       61 ctggctcccg gcggcggcgg cggcgaagcg gggaaagacg gcgcgggggc cgggtggcag
      121 cgatcggcga ggccgaggga aggggcgggg gagaggagca gggaaaggcg gcggggggaa
      181 tctcgcgagg gttggagttt tggcgagagt ttgtggaaga tggcgcctgt tgtgacaggg
      241 aagtttggtg agcggcctcc acccaaacga ctcactaggg aagctatgcg aaattattta
      301 aaagaacgag gggatcaaac agtgctcatt cttcatgcaa aagttgcaca gaagtcttac
      361 ggaaatgaaa aacgattttt ttgccctcct ccttgtgtgt atcttatggg cagtggttgg
      421 aagaaaaaaa aagagcaaat ggaacgagat ggatgttctg aacaagagtc tcaaccctgt
      481 gcgtttattg gaataggaaa cagtgaccaa gaaatgcagc agctgaactt ggaagggaag
      541 aactactgta cagccaaaac attgtacata tctgattcag acaagagaaa acatttcatg
      601 ttgtctgtaa agatgttcta tggcaacagc gatgacattg gtgtgttcct cagcaagcgg
      661 ataaaggtca tctccaaacc ctccaaaaag aagcagtcac tgaagaatgc tgacttgtgc
      721 attgcttcag gaacgaaggt ggcactgttc aatcgccttc ggtcccagac agttagtacc
      781 aggtacctgc atgtagaagg agggaatttc cacgccagtt cacaacagtg gggagcattt
      841 tacatccatc tcttggacga cgacgagtcg gaaggagagg agttcacagt tagagatggc
      901 tacatccatt acgggcagac tgtcaagctt gtgtgctcag tgactggcat ggcactccca
      961 agattgataa ttaggaaagt tgataagcag acggcattac tggatgcaga cgaccctgta
     1021 tcacaactcc acaaatgtgc attttacctt aaggatacag aaagaatgta cttgtgcctt
     1081 tctcaagaaa gaataatcca atttcaggcc actccatgtc caaaagaaca aaataaggaa
     1141 atgataaacg atggagcttc ctggacaatc attagcacag acaaggccga gtacacgttc
     1201 tatgagggaa tgggccccgt ccttgcccca gtcacccctg tgcctgtcgt agaaagtctt
     1261 cagttgaatg gcggcgggga cgtagcaatg cttgaactta caggacaaaa ctttactcca
     1321 aatttaagag tgtggtttgg ggatgtagaa gccgaaacaa tgtacagatg tggagagagc
     1381 atgctctgtg tggtcccaga catttctgca ttccgggaag gttggagatg ggtccgccag
     1441 ccagtccagg ttccagtgac tttggtccga aatgacgggg tcatttactc caccagcctt
     1501 accttcacct acacaccaga gccagggccg aggccacact gcagcgctgc aggagcgatt
     1561 ctcagagcca actccagcca agtgccctcc aatgagtcaa acacaaacag cgaggggaat
     1621 tacacaaatg ccagcacaaa ttctaccagt gtcacatcgt ccacagcaac cgtggtgtcc
     1681 taactaccgt ctttttgctg ggactgaaac tgacttgaat gcagcaaaaa gttgacagag
     1741 aaaggcaagg ataaagtgaa caatcttttg tggtttcttg gggaaacgtt tcgtaccagg
     1801 tgatctattc aaaactgcca gtgcaggtgt gacatgcaga ggccacagta caatgaacaa
     1861 catcagaatg cacaggctga tggaaatcca ggttttcagc tgtccctctc acacgcaccc
     1921 ctttttggtt gttttggttt ggttttgatt taatggccag gaaacagata tgtggctgga
     1981 gcacaggcta agctagaaga cacaaaccta acatagactt atggaccaag ggactcgcat
     2041 aagctttagt gaaaggtaca ttttcaccat gcctttttta tatcacagtg tgtactacac
     2101 cttgttacca aacaggttgc gctccccacc ctttgagggt tggctctaaa gtacattcat
     2161 tcaggttcga gcctcaccat gtttgttcag tctgaacact gaacacttcc aggttcttgt
     2221 ggtctaaggc tggaactttt ttaagctgaa gtcttatgac tttttcataa gttggaatta
     2281 ttttgatttc agcaagtcaa attttgtaaa ggcctgcata ttttttttaa gattatatga
     2341 agtctgcaaa agctttaaaa atgcctctgc cttgcctgca atacatgcaa tgtgtgttaa
     2401 ctgagtctgt tctcagaatc tgttggtagt tatttctgtg ttttcccttt ttttaaagaa
     2461 atgtatttat agtggtaatc taagagatgc taacagctcc gtgtggccat ttagcccttt
     2521 ctgagttcat ggcagtgagc actgccgttc gaaggctgtg cgcctctgcc tgttcatcag
     2581 ttcatctgtg ttccaggatt tgttcaggtt tccccttccc ccaaatcttg tacataactt
     2641 gtattatgtg taagttaaac attttatctt tacttggaat gttcccagtg attacatttc
     2701 acagggtgtt tcccaccttg ttggcaaatg acaaaaaata tcatgcgaat tatttgctac
     2761 caagatggtg cccgtagggt aaaatgagga acatctctgc aggatgattt attgtatgtt
     2821 ttcctttttt tttagcctag ccagaacatc attataattt taaagaccat aagatggctt
     2881 ttattagatg ataactaaat aaactgaact aagtagccag aagacagtac cttagagact
     2941 gatagttgta agtttataaa aatacaaatg taacttatat ttccattttc ctctttgccc
     3001 ctttgtttat tttccccagt agaaatgttc tgtccagatt tttttccccc tttttagtta
     3061 agccttgctt gcattcaggc ttgtgtgtca gccctgtgtg ccaatatgcc agattcattt
     3121 tgtttccatc cctgcacttt ggttattcct tgttcagttt cttgggaatt gaagcagact
     3181 cattgggcta catttagtac aagaaccaca tgtgtgatgt taaaggacac agtctagtga
     3241 tgccatcatc cttgagtaaa aactacctct agattgtggt aagcttttac tgtcccttaa
     3301 aacaggagcc actagtacct tatgaatgca gactgtaact tctatggcat tttctggtgt
     3361 ctttctggct ctctgggctt ctgaaagttt tcacgtagac ccttagactc ctctgtcagg
     3421 accattgctt tccagcgttg ctgctttcac tcgctgtctc gaagactgta ccactgtaag
     3481 tgccactgcg aacatcttta aacggctcct ccttggcttg tcaaggggaa ggccacctgt
     3541 aagatgtggt ggtgacagcc ttcctgtcca ccccaggctg ctccttacca gctgttctag
     3601 ccgattctct tcagatcagc tacagcccac ctcctccccg ccccgcctca cccctccagg
     3661 ctgtctcagt ggtccagggc agagctcact gtggccttac tgatctatct ctgcagtaac
     3721 tgttctccct cagttgcgat ggaagcaggc ccctgcgatc tgttcagagc ctgagcagtt
     3781 tgcagttccg ttgtgctttc tgaggtccta gattcaggat gtagttaagt cgataactga
     3841 gaacagatga gatgctttta aagaacaaac tcttccttac ccagctttgt agcttaaagt
     3901 aagttttcaa gttcatggct ttattaaaat gaactttgac tttttaaaat gcttatatct
     3961 catttcggtt cttttgttta ttttagtaag aattgaaaca gactataagt agttttcctg
     4021 tttgtttgtt tgtttgtttg ttttttacaa agttcaagaa tgtaacaata aaggcatttt
     4081 gctatggttc tatgtcagac tcctaccaca gaatagtgtg aacagatatg tctgtctgct
     4141 ttaccatgtt attgatagtt cttttgtcag ctgcttttat taaaagtcct cttttgtgaa
     4201 tttgtaaatc aatttcaata tatgatgtac aggagtcttg tcccccgtta ctgtggaatg
     4261 ttcccccctg ttgatgctgg tccctttatc ctcttatctt cttagaaccg ggaattcttc
     4321 agttgtggtg tgtggctgta tttttctatt ctgtttacag tgcgtctaca cagcttctta
     4381 aaacatgtcg aaatgcagaa tccaagatcc accatgaatt tgtcaagaga ttggaaggca
     4441 ggccaaaacc tgaaaatgtg gggtgccctt tgtacaattg cagagtcaag cactagtggg
     4501 agtttgaact ggctactgac cgctcttaaa ctgtggcagt gtccttgggt acagttaact
     4561 agcagaacct gctgtcactc ttcctgccac catcttaacc ttgacagttt tgtttctttt
     4621 ctgtgtggtg ctggggtcaa atccagagcc ttaggcttgc taaggctttt tgtttgtttg
     4681 atttttcctt gagacaagtg tctcacccat ggagcccctc agcattcttg aaagtctctg
     4741 ccttagcctc caggtcctgt ggtaccaggt gtggcaggat gcttttgtca ttagagaaac
     4801 tggtctgtgt ccaaccacag aaaaattcca atgcagtttt taataattaa tccactagtt
     4861 atttaatcaa aatctttttg tagggagaga ttcctgtttg aaagaaaatg ctatttgatt
     4921 attaaccaag gtaacagaca ctgctttcca aagcagctgt gtttctggtg agtactgaac
     4981 aaatgtgtgg ttttctgtgc cacctttgat tcatttttca agcactgtta ctcgggatgg
     5041 atggttagaa acatgatatt ttagtgtttc tacttaaccc tttcaggacc gagctgtatt
     5101 gcctttctat taatttcccc ctgtgttgtg ataaatgttt gctcgtgttc agtcctgtgt
     5161 cagtccagac gtaggtttgt gtaaaagctc agttgtagct tatttcttgt accttgcagc
     5221 atgttctacg catccagtcc ttaaggggtt tactctacaa actgtgcacc tgcgtgtaag
     5281 ggtcattagc aataagatag aaaattgagc aagtttatac cataattttg tagaaaaagg
     5341 aatctgctca attccatatt tcatccatga aaactctgca atacgggcag tttctaggaa
     5401 taaataaaaa ggagatgcaa accattgtag atgtcttctg tgggatgtgc ccgatgcgtg
     5461 catcatcgtc tttgattcca ggtacttcat aaagataaaa ttaaattc
//
