LOCUS       NM_011255                930 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus retinol binding protein 4, plasma (Rbp4), transcript
            variant 2, mRNA.
ACCESSION   NM_011255 XM_915053
VERSION     NM_011255.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 930)
  AUTHORS   Zhang,K.Z., Li,J.W., Xu,J.S., Shen,Z.K., Lin,Y.S., Zhao,C., Lu,X.,
            Rui,Y.F. and Gao,W.
  TITLE     RBP4 promotes denervation-induced muscle atrophy through
            STRA6-dependent pathway
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (4), 1601-1615 (2024)
   PUBMED   39031684
  REMARK    GeneRIF: RBP4 promotes denervation-induced muscle atrophy through
            STRA6-dependent pathway.
REFERENCE   3  (bases 1 to 930)
  AUTHORS   Zhang,X., He,H., Yu,H., Teng,X., Wang,Z., Li,C., Li,J., Yang,H.,
            Shen,J., Wu,T., Zhang,F., Zhang,Y. and Wu,Q.
  TITLE     Maternal RNA transcription in Dlk1-Dio3 domain is critical for
            proper development of the mouse placental vasculature
  JOURNAL   Commun Biol 7 (1), 363 (2024)
   PUBMED   38521877
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 930)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 930)
  AUTHORS   Lowenstein,E.D., Ruffault,P.L., Misios,A., Osman,K.L., Li,H.,
            Greenberg,R.S., Thompson,R., Song,K., Dietrich,S., Li,X.,
            Vladimirov,N., Woehler,A., Brunet,J.F., Zampieri,N., Kuhn,R.,
            Liberles,S.D., Jia,S., Lewin,G.R., Rajewsky,N., Lever,T.E. and
            Birchmeier,C.
  TITLE     Prox2 and Runx3 vagal sensory neurons regulate esophageal motility
  JOURNAL   Neuron 111 (14), 2184-2200 (2023)
   PUBMED   37192624
REFERENCE   6  (bases 1 to 930)
  AUTHORS   Mock,B.A., Connelly,M.A., McBride,O.W., Kozak,C.A. and Marcu,K.B.
  TITLE     CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human
            chromosome 10 and mouse chromosome 19
  JOURNAL   Genomics 27 (2), 348-351 (1995)
   PUBMED   7558004
REFERENCE   7  (bases 1 to 930)
  AUTHORS   Gough,N.M., Rakar,S., Harpur,A. and Wilks,A.F.
  TITLE     Localization of genes for two members of the JAK family of protein
            tyrosine kinases to murine chromosomes 4 and 19
  JOURNAL   Mamm Genome 6 (4), 247-248 (1995)
   PUBMED   7613027
REFERENCE   8  (bases 1 to 930)
  AUTHORS   Dale,B.A., Jones,A.H., Presland,R., Adler,D.A. and Disteche,C.M.
  TITLE     Chromosomal localization of the retinol binding protein gene and
            its elimination as a candidate gene for the repeated epilation (Er)
            mutation in mice
  JOURNAL   J Craniofac Genet Dev Biol 12 (2), 76-81 (1992)
   PUBMED   1613076
REFERENCE   9  (bases 1 to 930)
  AUTHORS   Tan,S.S.
  TITLE     Liver-specific and position-effect expression of a retinol-binding
            protein-lacZ fusion gene (RBP-lacZ) in transgenic mice
  JOURNAL   Dev Biol 146 (1), 24-37 (1991)
   PUBMED   2060705
REFERENCE   10 (bases 1 to 930)
  AUTHORS   Chainani,M., Sampsell,B. and Elliott,R.W.
  TITLE     Localization of the gene for plasma retinol binding protein to the
            distal half of mouse chromosome 19
  JOURNAL   Genomics 9 (2), 376-379 (1991)
   PUBMED   2004789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY112174.1, AK008765.1 and AW113115.1.
            
            On Apr 18, 2009 this sequence version replaced NM_011255.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and uses a downstream
            translational start codon, compared to variant 1. The resulting
            isoform (2) is shorter at the N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008765.1, AK004839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BY112174.1         2-4
            4-920               AK008765.1         2-918
            921-930             AW113115.1         12-21               c
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.75 cM"
     gene            1..930
                     /gene="Rbp4"
                     /gene_synonym="Rbp-4"
                     /note="retinol binding protein 4, plasma"
                     /db_xref="GeneID:19662"
                     /db_xref="MGI:MGI:97879"
     exon            1..54
                     /gene="Rbp4"
                     /gene_synonym="Rbp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            55..183
                     /gene="Rbp4"
                     /gene_synonym="Rbp-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..678
                     /gene="Rbp4"
                     /gene_synonym="Rbp-4"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; retinol-binding protein 4; RBP; PRBP; plasma
                     retinol-binding protein; retinol binding protein 4,
                     cellular"
                     /codon_start=1
                     /product="retinol-binding protein 4 isoform 2 precursor"
                     /protein_id="NP_035385.1"
                     /db_xref="CCDS:CCDS29784.1"
                     /db_xref="GeneID:19662"
                     /db_xref="MGI:MGI:97879"
                     /translation="MEWVWALVLLAALGGGSAERDCRVSSFRVKENFDKARFSGLWYA
                     IAKKDPEGLFLQDNIIAEFSVDEKGHMSATAKGRVRLLSNWEVCADMVGTFTDTEDPA
                     KFKMKYWGVASFLQRGNDDHWIIDTDYDTFALQYSCRLQNLDGTCADSYSFVFSRDPN
                     GLSPETRRLVRQRQEELCLERQYRWIEHNGYCQSRPSRNSL"
     exon            184..320
                     /gene="Rbp4"
                     /gene_synonym="Rbp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            321..427
                     /gene="Rbp4"
                     /gene_synonym="Rbp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            428..640
                     /gene="Rbp4"
                     /gene_synonym="Rbp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            641..930
                     /gene="Rbp4"
                     /gene_synonym="Rbp-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      903..908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbp4"
                     /gene_synonym="Rbp-4"
                     /note="hexamer: ATTAAA"
     polyA_site      923
                     /gene="Rbp4"
                     /gene_synonym="Rbp-4"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctccac gcgcgcgcga acgcggcggc caggcttgca cgcggctcct gctgggcaga
       61 ctccggggtg agatggagtg ggtgtgggcg ctcgtgctgc tggcggctct gggaggcggc
      121 agcgccgagc gcgactgcag ggtgagcagc ttccgagtca aggagaactt cgacaaggct
      181 cgtttctctg ggctctggta tgccatcgcc aaaaaggacc ccgagggtct ctttttgcaa
      241 gacaacatca tcgctgagtt ttctgtggac gagaagggtc atatgagcgc cacagccaag
      301 ggacgagtcc gtcttctgag caactgggaa gtgtgtgcag acatggtggg cactttcaca
      361 gacactgaag atcctgccaa gttcaagatg aagtactggg gtgtagcctc ctttctccag
      421 cgaggaaacg atgaccactg gatcatcgac acggactacg acaccttcgc tctgcagtac
      481 tcctgccgcc tgcagaatct ggatggcacc tgtgcagaca gctactcctt tgtgttttct
      541 cgtgacccca atggcctgag cccagagaca cggaggctgg tgaggcagcg gcaggaggag
      601 ctgtgcctag agaggcagta cagatggatt gaacacaatg gttactgtca aagcaggccc
      661 tccagaaaca gtttgtagca acgtctagga tgtgaagttt gaagatttct gattagcttt
      721 catccggtct tcatctctat ttatcttaga agtttagttt cccccacctc ccctaccttc
      781 tctaggtgga cattaaacca tcgtccaaag tacatgagag tcactgactc tgttcacaca
      841 actgtatgtc ttactgaagg tccctgaaag atgtttgagg cttgggattc caaacttggt
      901 ttattaaaca tatagtcacc atcttcctat
//
