LOCUS       NP_056560               1234 aa            linear   ROD 14-JAN-2025
DEFINITION  retinol-binding protein 3 precursor [Mus musculus].
ACCESSION   NP_056560
VERSION     NP_056560.1
DBSOURCE    REFSEQ: accession NM_015745.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1234)
  AUTHORS   Getz,T.E., Chrenek,M.A., Papania,J.T., Shelton,D.A., Markand,S.,
            Iuvone,P.M., Kozmik,Z., Boatright,J.H. and Nickerson,J.M.
  TITLE     Conditional Knockouts of Interphotoreceptor Retinoid Binding
            Protein Suggest Two Independent Mechanisms for Retinal Degeneration
            and Myopia
  JOURNAL   Invest Ophthalmol Vis Sci 65 (6), 32 (2024)
   PUBMED   38904640
  REMARK    GeneRIF: Conditional Knockouts of Interphotoreceptor Retinoid
            Binding Protein Suggest Two Independent Mechanisms for Retinal
            Degeneration and Myopia.
REFERENCE   2  (residues 1 to 1234)
  AUTHORS   Yin,M., Smith,J.A., Chou,M., Chan,J., Jittayasothorn,Y.,
            Gould,D.B., Caspi,R.R., Anderson,M.S. and DeFranco,A.L.
  TITLE     Tracking the role of Aire in immune tolerance to the eye with a TCR
            transgenic mouse model
  JOURNAL   Proc Natl Acad Sci U S A 121 (5), e2311487121 (2024)
   PUBMED   38261611
REFERENCE   3  (residues 1 to 1234)
  AUTHORS   DeRamus,M.L., Jasien,J.V., Eppstein,J.M., Koala,P. and Kraft,T.W.
  TITLE     Retinal Responses to Visual Stimuli in Interphotoreceptor Retinoid
            Binding-Protein Knock-Out Mice
  JOURNAL   Int J Mol Sci 24 (13), 10655 (2023)
   PUBMED   37445836
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1234)
  AUTHORS   Koli,S., Labelle-Dumais,C., Zhao,Y., Paylakhi,S. and Nair,K.S.
  TITLE     Identification of MFRP and the secreted serine proteases PRSS56 and
            ADAMTS19 as part of a molecular network involved in ocular growth
            regulation
  JOURNAL   PLoS Genet 17 (3), e1009458 (2021)
   PUBMED   33755662
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1234)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1234)
  AUTHORS   Barber,S.A., Fultz,M.J., Salkowski,C.A. and Vogel,S.N.
  TITLE     Differential expression of interferon regulatory factor 1 (IRF-1),
            IRF-2, and interferon consensus sequence binding protein genes in
            lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive
            macrophages
  JOURNAL   Infect Immun 63 (2), 601-608 (1995)
   PUBMED   7822029
REFERENCE   7  (residues 1 to 1234)
  AUTHORS   Mishina,Y., Suzuki,A., Gilbert,D.J., Copeland,N.G., Jenkins,N.A.,
            Ueno,N. and Behringer,R.R.
  TITLE     Genomic organization and chromosomal location of the mouse type I
            BMP-2/4 receptor
  JOURNAL   Biochem Biophys Res Commun 206 (1), 310-317 (1995)
   PUBMED   7818535
REFERENCE   8  (residues 1 to 1234)
  AUTHORS   Stanhope,M.J., Czelusniak,J., Si,J.S., Nickerson,J. and Goodman,M.
  TITLE     A molecular perspective on mammalian evolution from the gene
            encoding interphotoreceptor retinoid binding protein, with
            convincing evidence for bat monophyly
  JOURNAL   Mol Phylogenet Evol 1 (2), 148-160 (1992)
   PUBMED   1342928
REFERENCE   9  (residues 1 to 1234)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA10 homologous loci in cattle
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 123-126 (1991)
   PUBMED   1655359
REFERENCE   10 (residues 1 to 1234)
  AUTHORS   Danciger,M., Kozak,C.A., Nickerson,J., Redmond,T.M. and Farber,D.B.
  TITLE     Localization of the gene for interphotoreceptor retinoid-binding
            protein to mouse chromosome 14 near Np-1
  JOURNAL   Genomics 8 (4), 727-731 (1990)
   PUBMED   2276745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166828.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083133.1, SRR9219382.7330.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1234
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.8 cM"
     Protein         1..1234
                     /product="retinol-binding protein 3 precursor"
                     /note="retinol-binding protein 3; interphotoreceptor
                     retinoid-binding protein"
                     /calculated_mol_wt=132455
     sig_peptide     1..17
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49194.3)"
                     /calculated_mol_wt=2045
     mat_peptide     18..1234
                     /product="Retinol-binding protein 3. /id=PRO_0000021524"
                     /note="propagated from UniProtKB/Swiss-Prot (P49194.3)"
                     /calculated_mol_wt=132455
     Region          18..1228
                     /region_name="4 X approximate tandem repeats"
                     /note="propagated from UniProtKB/Swiss-Prot (P49194.3)"
     Region          27..318
                     /region_name="Peptidase_S41_IRBP"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; cd07563"
                     /db_xref="CDD:143479"
     Site            order(86,237,297)
                     /site_type="active"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     Site            107
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49194.3)"
     Site            205
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49194.3)"
     Region          329..624
                     /region_name="Peptidase_S41_IRBP"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; cd07563"
                     /db_xref="CDD:143479"
     Region          383..417
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P49194.3)"
     Site            order(384,545,605)
                     /site_type="active"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     Site            513
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49194.3)"
     Region          637..929
                     /region_name="Peptidase_S41_IRBP"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; cd07563"
                     /db_xref="CDD:143479"
     Site            order(696,848,906)
                     /site_type="active"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     Region          938..1224
                     /region_name="Peptidase_S41_IRBP"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; cd07563"
                     /db_xref="CDD:143479"
     Site            order(995,1147,1205)
                     /site_type="active"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     CDS             1..1234
                     /gene="Rbp3"
                     /gene_synonym="Irbp; Rbp-3"
                     /coded_by="NM_015745.3:95..3799"
                     /db_xref="CCDS:CCDS26929.1"
                     /db_xref="GeneID:19661"
                     /db_xref="MGI:MGI:97878"
ORIGIN      
        1 mmrewvlvls tllwvpagpt hlfqpslvld makilldnyc fpenlmgmqa aieqamkshe
       61 ilgisdpqtl aqvltagvqs slsdprlfis yepstleapq qapvltnltr eellaqiqrn
      121 irhevlegnv gylrvddlpg qevlselgef lvshvwrqlm stsslvldlr hcsgghfsgi
      181 pyvisylhpg ntvmhvdtvy drpsntttei wtlpevlger ysadkdvvvl tsghtggvae
      241 diayilkqmr raivvgerte ggaldlqklr igqsnffltv pvsrslgplg gggqtwegsg
      301 vlpcvgtpae qalekalail tlrralpgvv lrlqealqdy ytlvdrvpgl lhhlasmdys
      361 avvseedlvt klnaglqavs edprllvrat gprdsssrpe tgpnespaat pevpteedar
      421 ralvdsvfqv svlpgnvgyl rfdrfadaav letlgpyvlk qvweplqdte hlimdlrhnp
      481 ggpssamplv lsyfqgpeag pvrlfttydr rtnitqehfs hrellgqryg nqrgvyllts
      541 hrtataaeef aflmqslgwa tlvgeitags llhtctvpll dspqgglalt vpvltfidnh
      601 geawlgggvv pdaivlaeea leraqevldf hrslgalveg tgrlleahya rpeiaqrara
      661 llqsklaqga yrtavdlesl asqltadlqe vsedhrllvf hspgelvaee vplpppavps
      721 peelsyliea lfktdvlpgq lgylrfdama eletvkaigp qlvqlvwqrl vdtaalivdl
      781 rynpgsyssa vpllcsyffe aeprqhlysv fdratsrvte iwtlplvagq rygshkdlyi
      841 lmshtsgsaa eafahtmqdl qratvigept aggalsvgiy qvgnsplyas mptqmalsas
      901 tgeawdlagv epditvpmse alstaqdivv lrakvptvlq tagklvadny aspelgakma
      961 aklsglqsry arvtsegala emlgadlqil sgdphlktah ipedakdrip givpmqipsp
     1021 evfedlikfs fhtnvledni gylrfdmfgd celltqvsel lvehiwkkiv htdaliidmr
     1081 fnlggptssi salcsyffde appilldkiy nrpndsvsel wthtqltger ygskksvail
     1141 tsgvtagaae eftyimkrlg ralvigevts ggcqppqtyh vddthlyiti ptarsvgaed
     1201 gsswegvgvt pnvvvssela ltrakeilqq alrg
//
