LOCUS       NM_009034                672 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus retinol binding protein 2, cellular (Rbp2), mRNA.
ACCESSION   NM_009034
VERSION     NM_009034.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 672)
  AUTHORS   Calderon,R.M., Smith,C.A., Miedzybrodzka,E.L., Silvaroli,J.A.,
            Golczak,M., Gribble,F.M., Reimann,F. and Blaner,W.S.
  TITLE     Intestinal Enteroendocrine Cell Signaling: Retinol-binding Protein
            2 and Retinoid Actions
  JOURNAL   Endocrinology 163 (7) (2022)
   PUBMED   35552670
REFERENCE   2  (bases 1 to 672)
  AUTHORS   Lee,S.A., Yang,K.J.Z., Brun,P.J., Silvaroli,J.A., Yuen,J.J.,
            Shmarakov,I., Jiang,H., Feranil,J.B., Li,X., Lackey,A.I.,
            Krezel,W., Leibel,R.L., Libien,J., Storch,J., Golczak,M. and
            Blaner,W.S.
  TITLE     Retinol-binding protein 2 (RBP2) binds monoacylglycerols and
            modulates gut endocrine signaling and body weight
  JOURNAL   Sci Adv 6 (11), eaay8937 (2020)
   PUBMED   32195347
  REMARK    GeneRIF: Retinol-binding protein 2 (RBP2) binds monoacylglycerols
            and modulates gut endocrine signaling and body weight.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 672)
  AUTHORS   Ortner,N.J., Pinggera,A., Hofer,N.T., Siller,A., Brandt,N.,
            Raffeiner,A., Vilusic,K., Lang,I., Blum,K., Obermair,G.J.,
            Stefan,E., Engel,J. and Striessnig,J.
  TITLE     RBP2 stabilizes slow Cav1.3 Ca2+ channel inactivation properties of
            cochlear inner hair cells
  JOURNAL   Pflugers Arch 472 (1), 3-25 (2020)
   PUBMED   31848688
REFERENCE   4  (bases 1 to 672)
  AUTHORS   Yu,X., Chen,H., Zuo,C., Jin,X., Yin,Y., Wang,H., Jin,M., Ozato,K.
            and Xu,S.
  TITLE     Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by
            Rbp2 through interacting with Piasy for transcriptional attenuation
  JOURNAL   FASEB J 32 (2), 552-567 (2018)
   PUBMED   28970247
  REMARK    GeneRIF: study demonstrates that Piasy may prevent exaggerated
            transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of
            IFNI, avoiding excessive immune responses
REFERENCE   5  (bases 1 to 672)
  AUTHORS   Luo,F., Liu,X., Sudhof,T.C. and Acuna,C.
  TITLE     Efficient stimulus-secretion coupling at ribbon synapses requires
            RIM-binding protein tethering of L-type Ca2+ channels
  JOURNAL   Proc Natl Acad Sci U S A 114 (38), E8081-E8090 (2017)
   PUBMED   28874522
  REMARK    GeneRIF: genetic deletion of RBP1 and RBP2 did not impair synapse
            ultrastructure of ribbon-type synapses formed between rod bipolar
            cells (RBCs) and amacrine type-2 (AII) cells in the mouse retina
            but dramatically reduced the density of presynaptic Ca(2+)
            channels, decreased and desynchronized evoked neurotransmitter
            release
REFERENCE   6  (bases 1 to 672)
  AUTHORS   Ruberte,E., Dolle,P., Chambon,P. and Morriss-Kay,G.
  TITLE     Retinoic acid receptors and cellular retinoid binding proteins. II.
            Their differential pattern of transcription during early
            morphogenesis in mouse embryos
  JOURNAL   Development 111 (1), 45-60 (1991)
   PUBMED   1849812
REFERENCE   7  (bases 1 to 672)
  AUTHORS   Dolle,P., Ruberte,E., Leroy,P., Morriss-Kay,G. and Chambon,P.
  TITLE     Retinoic acid receptors and cellular retinoid binding proteins. I.
            A systematic study of their differential pattern of transcription
            during mouse organogenesis
  JOURNAL   Development 110 (4), 1133-1151 (1990)
   PUBMED   1966045
REFERENCE   8  (bases 1 to 672)
  AUTHORS   Kasahara,M., Matsumura,E., Webb,G., Board,P.G., Figueroa,F. and
            Klein,J.
  TITLE     Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to
            the vicinity of the d locus on mouse chromosome 9
  JOURNAL   Genomics 8 (1), 90-96 (1990)
   PUBMED   1981995
REFERENCE   9  (bases 1 to 672)
  AUTHORS   Maden,M., Ong,D.E. and Chytil,F.
  TITLE     Retinoid-binding protein distribution in the developing mammalian
            nervous system
  JOURNAL   Development 109 (1), 75-80 (1990)
   PUBMED   2170099
REFERENCE   10 (bases 1 to 672)
  AUTHORS   Demmer,L.A., Birkenmeier,E.H., Sweetser,D.A., Levin,M.S.,
            Zollman,S., Sparkes,R.S., Mohandas,T., Lusis,A.J. and Gordon,J.I.
  TITLE     The cellular retinol binding protein II gene. Sequence analysis of
            the rat gene, chromosomal localization in mice and humans, and
            documentation of its close linkage to the cellular retinol binding
            protein gene
  JOURNAL   J Biol Chem 262 (6), 2458-2467 (1987)
   PUBMED   3029082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117214.3 and BC125551.1.
            
            On Aug 12, 2009 this sequence version replaced NM_009034.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI323478.1, AK003312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC117214.3         134476-134506
            32-538              BC125551.1         1-507
            539-672             AC117214.3         153577-153710
FEATURES             Location/Qualifiers
     source          1..672
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.37 cM"
     gene            1..672
                     /gene="Rbp2"
                     /gene_synonym="Crbp-2; CrbpII; Rbp-2"
                     /note="retinol binding protein 2, cellular"
                     /db_xref="GeneID:19660"
                     /db_xref="MGI:MGI:97877"
     exon            1..146
                     /gene="Rbp2"
                     /gene_synonym="Crbp-2; CrbpII; Rbp-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..478
                     /gene="Rbp2"
                     /gene_synonym="Crbp-2; CrbpII; Rbp-2"
                     /note="CRBP-II; cellular retinol-binding protein II"
                     /codon_start=1
                     /product="retinol-binding protein 2"
                     /protein_id="NP_033060.3"
                     /db_xref="CCDS:CCDS23425.1"
                     /db_xref="GeneID:19660"
                     /db_xref="MGI:MGI:97877"
                     /translation="MTKDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKIIT
                     QDGDNFKTKTNSTFRNYDLDFTVGVEFDEHTKGLDGRHVKTLVTWEGNTLVCVQKGEK
                     ENRGWKQWVEGDKLYLELTCGDQVCRQVFKKK"
     exon            147..325
                     /gene="Rbp2"
                     /gene_synonym="Crbp-2; CrbpII; Rbp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..427
                     /gene="Rbp2"
                     /gene_synonym="Crbp-2; CrbpII; Rbp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..672
                     /gene="Rbp2"
                     /gene_synonym="Crbp-2; CrbpII; Rbp-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      652..657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbp2"
                     /gene_synonym="Crbp-2; CrbpII; Rbp-2"
                     /note="hexamer: AAGAAA"
     polyA_site      672
                     /gene="Rbp2"
                     /gene_synonym="Crbp-2; CrbpII; Rbp-2"
                     /note="major polyA site"
ORIGIN      
        1 atttagcata gtctccctgc agcctgttcc ttcacagtca ccgaacgtcc acatcaaacc
       61 agaggccacc atcatgacga aggaccaaaa tggaacctgg gaaatggaga gtaatgagaa
      121 ctttgaaggc tacatgaagg ccctagatat tgattttgcc acccgcaaga tcgcagtgcg
      181 tctgactcag acgaagatca tcactcaaga cggtgataac ttcaagacga aaaccaacag
      241 cacgttccgc aactacgacc tggatttcac cgtcggggtg gagtttgacg aacacacaaa
      301 gggcctggac ggccgacatg tcaagaccct ggtcacctgg gaaggcaaca ccctcgtgtg
      361 tgtgcagaaa ggggagaagg agaaccgtgg ctggaagcag tgggtggagg gagacaagct
      421 gtacctggag ctgacctgcg gcgaccaggt gtgccgacaa gtgttcaaaa agaagtgatg
      481 ggcacgggaa agcctggaac atgtgcagag ttctctgcca gttccccaaa gcagcatggg
      541 gactcctccc attcctgaca gagccccctt acatcatctg cctgggttta aactggagtg
      601 tataaaagga acctaccccc ctcccagccc ccccccccaa gcttgttatt aaagaaacaa
      661 aatgtcctct ca
//
