LOCUS       NM_001166623            2440 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus RNA binding motif protein, X chromosome (Rbmx),
            transcript variant 3, mRNA.
ACCESSION   NM_001166623
VERSION     NM_001166623.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2440)
  AUTHORS   Prieto C, Nguyen DTT, Liu Z, Wheat J, Perez A, Gourkanti S, Chou T,
            Barin E, Velleca A, Rohwetter T, Chow A, Taggart J, Savino AM,
            Hoskova K, Dhodapkar M, Schurer A, Barlowe TS, Vu LP, Leslie C,
            Steidl U, Rabadan R and Kharas MG.
  TITLE     Transcriptional control of CBX5 by the RNA binding proteins RBMX
            and RBMXL1 maintains chromatin state in myeloid leukemia
  JOURNAL   Nat Cancer 2, 741-757 (2021)
   PUBMED   34458856
REFERENCE   2  (bases 1 to 2440)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2440)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 2440)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2440)
  AUTHORS   Omura Y, Nishio Y, Takemoto T, Ikeuchi C, Sekine O, Morino K, Maeno
            Y, Obata T, Ugi S, Maegawa H, Kimura H and Kashiwagi A.
  TITLE     SAFB1, an RBMX-binding protein, is a newly identified regulator of
            hepatic SREBP-1c gene
  JOURNAL   BMB Rep 42 (4), 232-237 (2009)
   PUBMED   19403048
  REMARK    GeneRIF: These results indicate a major role for SAFB1 in the
            activation of Srebp-1c through its interaction with RBMX.
REFERENCE   6  (bases 1 to 2440)
  AUTHORS   Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J,
            Muhr J, Lenhard B, Sandelin A and Ericson J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 2440)
  AUTHORS   McKee AE, Minet E, Stern C, Riahi S, Stiles CD and Silver PA.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2440)
  AUTHORS   Sandstedt SA and Tucker PK.
  TITLE     Evolutionary strata on the mouse X chromosome correspond to strata
            on the human X chromosome
  JOURNAL   Genome Res 14 (2), 267-272 (2004)
   PUBMED   14762062
REFERENCE   9  (bases 1 to 2440)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2440)
  AUTHORS   Mazeyrat,S., Saut,N., Mattei,M.G. and Mitchell,M.J.
  TITLE     RBMY evolved on the Y chromosome from a ubiquitously transcribed
            X-Y identical gene
  JOURNAL   Nat Genet 22 (3), 224-226 (1999)
   PUBMED   10391207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135164.1 and AK083899.1.
            
            [WARNING] On Nov 30, 2023 this sequence was replaced by
            NM_001166623.2.
            
            Transcript Variant: This variant (3) uses a different splice site
            in the 5' UTR versus variant 1. Variants 1 and 3 encode the same
            functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135164.1, SRR7345562.4046584.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1441              AK135164.1         3-1443
            1442-2440           AK083899.1         2107-3105
FEATURES             Location/Qualifiers
     source          1..2440
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 31.64 cM"
     gene            1..2440
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /note="RNA binding motif protein, X chromosome"
                     /db_xref="GeneID:19655"
                     /db_xref="MGI:MGI:1343044"
     exon            1..185
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /inference="alignment:Splign:2.1.0"
     exon            186..320
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1387
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /note="heterogeneous nuclear ribonucleoprotein G"
                     /codon_start=1
                     /product="RNA-binding motif protein, X chromosome"
                     /protein_id="NP_001160095.1"
                     /db_xref="CCDS:CCDS30153.1"
                     /db_xref="GeneID:19655"
                     /db_xref="MGI:MGI:1343044"
                     /translation="MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRE
                     TNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGLPPPPRS
                     RGPPRGLRGGRGGSGGTRGPPSRGGHMDDGGYSMNFTMSSSRGPLPVKRGPPPRSGGP
                     PPKRSAPSGPVRSSSGLGGRAPVSRGRDGYGGPPRREPLPSRRDVYLSPRDDGYSTKD
                     SYSSREYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGYGRDRDYSDHP
                     SGGSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDL
                     YSSGRDRVGRQERGLPPSMERGYPPPRDSYSSSSRGAPRGGGRGGSRSDRGGGRSRY"
     exon            321..427
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /inference="alignment:Splign:2.1.0"
     exon            428..599
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /inference="alignment:Splign:2.1.0"
     exon            600..752
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /inference="alignment:Splign:2.1.0"
     exon            753..867
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /inference="alignment:Splign:2.1.0"
     exon            868..993
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1076
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..2440
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttcttcag cctcgttccc gggtagtata aagattgcag tctcctttgt tcgccctcgt
       61 tgcgcagtcg tcctagcgtc atttctgttc cgttctgaaa atcggtagct gtcactggtg
      121 cggcgctgct cgggaggtcc ggtcggcgag ctcagaggag cttgagaccg tcgcagtccc
      181 ctcggcagac ccccatcggt taagaggaaa aatggttgaa gcagatcgcc caggaaagct
      241 ctttattggt gggcttaata cagagacgaa tgagaaagcc cttgaggcag tgtttggcaa
      301 atatggacga atagtggaag ttcttttgat gaaggaccga gaaacgaata agtcaagagg
      361 attcgctttt gtcacttttg aaagcccagc agatgcaaag gatgctgcca gagacatgaa
      421 tggaaagtcc ttagatggga aagccatcaa ggtggagcaa gccaccaaac catcatttga
      481 aagtggtaga cgtggactac ccccacctcc aagaagcaga ggccctccca gaggtcttcg
      541 aggaggaaga ggaggaagtg gaggaaccag aggacccccc tcccggggag gacacatgga
      601 tgatggtggc tactccatga attttaccat gagttcttcc agaggacctc tgccagtaaa
      661 acgaggacca ccaccacgaa gtggaggtcc tcctcctaaa agatcagcac cttctggacc
      721 agttcgtagc agcagtggac tgggaggaag agcccctgtg tcccgtggaa gagatggtta
      781 cggaggcccg ccacgaaggg agcccctgcc ttctcgaaga gatgtttatt tgtccccgag
      841 agatgatgga tattccacta aagacagcta ttcaagcaga gaatatccaa gttctcgaga
      901 tacacgagat tatgcaccac caccaagaga ttatacttac cgtgattatg gtcattccag
      961 ttcacgagat gactatccat caagaggcta tagtgataga gatggctatg gtcgggatcg
     1021 ggactattca gatcatccaa gtggaggttc ctacagagat tcgtatgaga gttatggtaa
     1081 ctcacgtagt gctccaccta cacgagggcc cccgccatct tatggtggaa gcagtcgcta
     1141 tgatgattac agcagctcac gtgacggata tggtggaagt cgagacagtt actcaagcag
     1201 ccgaagtgat ctctactcaa gtggtcgtga tcgcgtgggc agacaagaaa gagggcttcc
     1261 cccttctatg gaaagggggt accctcctcc acgtgattcc tacagcagtt caagccgcgg
     1321 agcaccaaga ggtggtggcc gtggaggaag ccgatctgat agagggggag gcagaagcag
     1381 atactaggaa caaacaaaac ttttggacca aaaaaatccc cattcaaagc aacaaacaaa
     1441 agtggaaact ttctgtcata aactacccaa ggactactaa aaggaaaaat tgtgttacct
     1501 ttttaaaatt tcctgttccc ttttaataat ttttatgttc ttgtgaggga aaaagtaaga
     1561 cgtgtttaat tttatttgct agtatgagct gctttcaaca agcaaatggt agatgtgtga
     1621 gccttgactt gttcctagtg ttgtaatttt ccaagtgaaa gtgtccctga aggccagcca
     1681 cttcctgatt tttttcccca gtaaatgagg caagcaaccc caagatcatc cacaaacttc
     1741 cagccatcta gatggcctct ggtctccact gagagctgaa tcgccctgcc tgtgcagaca
     1801 agctagccat tagagagggt tggttgggtg tgctactttc agtatttcag ggtgtcttcc
     1861 aactgaaatc tcaatcttcg cagtatatat attaaaacca acgagcaaac ctgagctccg
     1921 atgcctagga tgtactgttt acccagaaac cccccaaaaa agcagatgga tactggccat
     1981 attttgcttt tttgacactt ccttgggaat ctacaagaac ctcccttccc cctccccgag
     2041 taagacctaa gaccatttaa gtgtgtgtta aacaactaca aaatactcaa taaaacgttt
     2101 ggccaaagtc aaccctgaag ctgcaaaccg atgcttgctc ttactgtttc aaatttttgc
     2161 aactctgtag tgtctcactt ttaaaggaac agcttgattg caaaggagaa aatagataag
     2221 caatgaagtt atctccaact tcctaaaggc ttatgacttc taaaaagtga atctatcagc
     2281 attccacatc agatttaaag caccaaatgc ccgtgaaaca gcaaagatgg taagcaaagc
     2341 aaactagttt ttccgtctaa gtcgaaattg agcacttacc ttcctcatag tacagtgatg
     2401 cctactgtac ttcctggcag tggaaatgcc ttctagattt
//
