LOCUS       NP_001160095             391 aa            linear   ROD 05-MAY-2025
DEFINITION  RNA-binding motif protein, X chromosome [Mus musculus].
ACCESSION   NP_001160095
VERSION     NP_001160095.1
DBSOURCE    REFSEQ: accession NM_001166623.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 391)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 391)
  AUTHORS   Prieto,C., Nguyen,D.T.T., Liu,Z., Wheat,J., Perez,A., Gourkanti,S.,
            Chou,T., Barin,E., Velleca,A., Rohwetter,T., Chow,A., Taggart,J.,
            Savino,A.M., Hoskova,K., Dhodapkar,M., Schurer,A., Barlowe,T.S.,
            Vu,L.P., Leslie,C., Steidl,U., Rabadan,R. and Kharas,M.G.
  TITLE     Transcriptional control of CBX5 by the RNA binding proteins RBMX
            and RBMXL1 maintains chromatin state in myeloid leukemia
  JOURNAL   Nat Cancer 2, 741-757 (2021)
   PUBMED   34458856
REFERENCE   3  (residues 1 to 391)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 391)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (residues 1 to 391)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (residues 1 to 391)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (residues 1 to 391)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 391)
  AUTHORS   Sandstedt,S.A. and Tucker,P.K.
  TITLE     Evolutionary strata on the mouse X chromosome correspond to strata
            on the human X chromosome
  JOURNAL   Genome Res 14 (2), 267-272 (2004)
   PUBMED   14762062
REFERENCE   9  (residues 1 to 391)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 391)
  AUTHORS   Mazeyrat,S., Saut,N., Mattei,M.G. and Mitchell,M.J.
  TITLE     RBMY evolved on the Y chromosome from a ubiquitously transcribed
            X-Y identical gene
  JOURNAL   Nat Genet 22 (3), 224-226 (1999)
   PUBMED   10391207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672106.9.
            
            Transcript Variant: This variant (3) uses a different splice site
            in the 5' UTR versus variant 1. Variants 1, 3, 4, and 5 all encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135164.1, SRR13948564.4086463.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 31.64 cM"
     Protein         1..391
                     /product="RNA-binding motif protein, X chromosome"
                     /note="heterogeneous nuclear ribonucleoprotein G"
                     /calculated_mol_wt=42170
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylvaline, in RNA-binding motif protein, X
                     chromosome, N-terminally processed.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Region          7..86
                     /region_name="RRM_RBMX_like"
                     /note="RNA recognition motif (RRM) found in heterogeneous
                     nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA
                     recognition motif 1 (hRBMY), testis-specific heterogeneous
                     nuclear ribonucleoprotein G-T (hnRNP G-T) and similar
                     proteins; cd12382"
                     /db_xref="CDD:409816"
     Site            order(9,11,13..17,38,40..43,45..51,53,78,80,82..86)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:409816"
     Site            30
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Region          62..391
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            88
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            91
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            125
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            144
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            164
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            165
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Region          167..>306
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Site            172
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Region          173..217
                     /region_name="RBM1CTR"
                     /note="RBM1CTR (NUC064) family; pfam08081"
                     /db_xref="CDD:400429"
     Site            174
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            261
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            328
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            329
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            330
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            332
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     Site            352
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P38159; propagated from
                     UniProtKB/Swiss-Prot (Q9WV02.1)"
     CDS             1..391
                     /gene="Rbmx"
                     /gene_synonym="hnRNP G"
                     /coded_by="NM_001166623.2:157..1332"
                     /db_xref="CCDS:CCDS30153.1"
                     /db_xref="GeneID:19655"
                     /db_xref="MGI:MGI:1343044"
ORIGIN      
        1 mveadrpgkl figglntetn ekaleavfgk ygrivevllm kdretnksrg fafvtfespa
       61 dakdaardmn gksldgkaik veqatkpsfe sgrrglpppp rsrgpprglr ggrggsggtr
      121 gppsrgghmd dggysmnftm sssrgplpvk rgppprsggp ppkrsapsgp vrsssglggr
      181 apvsrgrdgy ggpprreplp srrdvylspr ddgystkdsy ssreypssrd trdyappprd
      241 ytyrdyghss srddypsrgy sdrdgygrdr dysdhpsggs yrdsyesygn srsapptrgp
      301 ppsyggssry ddysssrdgy ggsrdsysss rsdlyssgrd rvgrqerglp psmergyppp
      361 rdsyssssrg aprgggrggs rsdrgggrsr y
//
