LOCUS       NM_001141931            2495 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RNA binding motif, single stranded interacting protein
            1 (Rbms1), transcript variant 2, mRNA.
ACCESSION   NM_001141931
VERSION     NM_001141931.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Liu,Q., Lai,G., Hu,Y., Yang,F., Zhang,C., Le,D., Deng,F., Xing,X.,
            Tang,B., Jie,H., Liang,Y. and Lei,E.
  TITLE     CircRbms1 fosters MST1 mRNA and protein levels to motivate
            myocardial ischaemia-reperfusion injury via autophagic status
  JOURNAL   ESC Heart Fail 11 (2), 1205-1217 (2024)
   PUBMED   38288506
  REMARK    GeneRIF: CircRbms1 fosters MST1 mRNA and protein levels to motivate
            myocardial ischaemia-reperfusion injury via autophagic status.
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2495)
  AUTHORS   Dairi,G., Al Mahri,S., Benabdelkamel,H., Alfadda,A.A.,
            Alswaji,A.A., Rashid,M., Malik,S.S., Iqbal,J., Ali,R., Al
            Ibrahim,M., Al-Regaiey,K. and Mohammad,S.
  TITLE     Transcriptomic and Proteomic Analysis Reveals the Potential Role of
            RBMS1 in Adipogenesis and Adipocyte Metabolism
  JOURNAL   Int J Mol Sci 24 (14), 11300 (2023)
   PUBMED   37511060
  REMARK    GeneRIF: Transcriptomic and Proteomic Analysis Reveals the
            Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2495)
  AUTHORS   Habib,K., Bishayee,K., Kang,J., Sadra,A. and Huh,S.O.
  TITLE     RNA Binding Protein Rbms1 Enables Neuronal Differentiation and
            Radial Migration during Neocortical Development by Binding and
            Stabilizing the RNA Message for Efr3a
  JOURNAL   Mol Cells 45 (8), 588-602 (2022)
   PUBMED   35754370
REFERENCE   5  (bases 1 to 2495)
  AUTHORS   Spruce,T., Plass,M., Gohr,A., Ray,D., Martinez de Lagran,M.,
            Rot,G., Novoa,A., Burguera,D., Permanyer,J., Miret,M., Zheng,H.,
            Swanson,M.S., Morris,Q., Mallo,M., Dierssen,M., Hughes,T.R.,
            Pernaute,B. and Irimia,M.
  TITLE     The X-linked splicing regulator MBNL3 has been co-opted to restrict
            placental growth in eutherians
  JOURNAL   PLoS Biol 20 (4), e3001615 (2022)
   PUBMED   35476669
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2495)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2495)
  AUTHORS   Nomura,J., Matsumoto,K., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Positive regulation of Fas gene expression by MSSP and abrogation
            of Fas-mediated apoptosis induction in MSSP-deficient mice
  JOURNAL   Exp Cell Res 305 (2), 324-332 (2005)
   PUBMED   15817157
REFERENCE   8  (bases 1 to 2495)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2495)
  AUTHORS   Fujimoto,M., Matsumoto,K., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Disruption of MSSP, c-myc single-strand binding protein, leads to
            embryonic lethality in some homozygous mice
  JOURNAL   Genes Cells 6 (12), 1067-1075 (2001)
   PUBMED   11737267
REFERENCE   10 (bases 1 to 2495)
  AUTHORS   Fujimoto,M., Matsumoto,K.I., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Structures and comparison of genomic and complementary DNAs of
            mouse MSSP, a c-Myc binding protein
  JOURNAL   Int J Oncol 16 (2), 245-251 (2000)
   PUBMED   10639566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145897.1, AK161102.1, AK147109.1 and AA175245.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            3' coding region, compared to variant 1. The encoded protein
            (isoform 2) has a shorter C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145897.1, SRR13422601.49247.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AK145897.1         2-194
            194-215             AK161102.1         144-165
            216-536             AK145897.1         218-538
            537-1815            AK147109.1         731-2009
            1816-1906           AA175245.1         207-297
            1907-2495           AK161102.1         1906-2494
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 34.95 cM"
     gene            1..2495
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /note="RNA binding motif, single stranded interacting
                     protein 1"
                     /db_xref="GeneID:56878"
                     /db_xref="MGI:MGI:1861774"
     exon            1..321
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1458
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     single-stranded DNA-binding protein MSSP-1"
                     /codon_start=1
                     /product="RNA-binding motif, single-stranded-interacting
                     protein 1 isoform 2"
                     /protein_id="NP_001135403.1"
                     /db_xref="GeneID:56878"
                     /db_xref="MGI:MGI:1861774"
                     /translation="MIFPSGSGHPGAAGGCRTPYRKQQSLVPAHPMAPPSPSTTSSNN
                     NSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKATNKCKG
                     YGFVDFDSPAAAQKAVSALKANGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLK
                     PFGQVISTRVLRDSSGASRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLL
                     CKFADGGQKKRQNPNKYIPNGRPWPRDGEAGMTLTYDPTTAALHNGFYPSPYSIATNR
                     MITQTSLTPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISP
                     LAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHMQTAAVPVEEASGQQQVAVETSNDH
                     SPYTFPPNK"
     exon            322..497
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..556
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..648
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..806
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..886
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..993
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1043
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1137
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1188
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1299
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1380
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1465
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..2495
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2211..2216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /note="hexamer: AATAAA"
     polyA_site      2243
                     /gene="Rbms1"
                     /gene_synonym="2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; YC1"
                     /note="major polyA site"
ORIGIN      
        1 gggaggtggg gacgcggcgg cgctgctcgt ccgctgccgc cggcaccgcg cgcgaactcc
       61 ggtccatggc acgcagggcg gcggcccccg gagctgctcg agagtcgccg gccgcgcgcg
      121 tcgcgccgca cttttagggc gggagccgcg agccagtccc cggccgcatc ctccctccgc
      181 ctgcccggac aggcgagaga gggagttccc ggagcgccgc ggccccggtt gcctcagctc
      241 cccgcgcccg agatgatctt ccccagcggc agcggccacc ccggcgctgc cggcggctgc
      301 aggacgccct accgcaagca gcagtctctg gtcccagcac accccatggc cccacccagt
      361 cccagcacca ccagcagtaa taacaacagt agcagcagta gcaactcagg atgggatcag
      421 ctgagcaaga caaacctcta catccgaggc ctgcccccca ataccactga tcaagacctg
      481 gtgaagctct gccaaccata tgggaagatc gtgtccacaa aggcgatttt ggataaggcc
      541 accaacaagt gcaaaggtta tggttttgtt gactttgaca gtcctgcagc agcccagaaa
      601 gctgtctccg ccctgaaggc gaatggagtc caggctcaga tggcaaagca acaggaacaa
      661 gatcctacca acctgtacat ttctaacctg ccgctgtcca tggatgagca ggaacttgaa
      721 aatatgctca aaccctttgg acaagttatt tctacaaggg tcctacgtga ttccagtggt
      781 gccagccgtg gtgttggctt tgccaggatg gaatcaacgg aaaaatgcga agctgtaatt
      841 ggtcatttta atggaaaatt catcaagacc ccaccaggag tttctgctcc tacagaacct
      901 ttactgtgca agtttgcgga tggaggacag aaaaagagac agaacccaaa caagtacatc
      961 cctaacgggc ggccatggcc cagagatgga gaggctggaa tgacactcac ttatgacccg
     1021 actacagctg ctctacacaa cggattttat ccttcaccat acagtattgc cacaaaccga
     1081 atgatcactc aaacttctct tacaccctat attgcatctc ctgtatctgc ctaccaggtg
     1141 cagagcccct cttggatgca gcctcagccg tacattctgc agcatcctgg tgccgtgtta
     1201 actccctcaa tggaacatac catgtcacta caacctgctt ccatgatcag ccctctggct
     1261 cagcagatga gtcatctgtc actgggcagc accggaacat acatgcctgc aacatcagcc
     1321 atgcaaggag cctacttgcc acagtataca cacatgcaga ccgcggcggt gcccgttgag
     1381 gaagcaagtg gccagcagca ggtggctgtg gagacgtcta atgaccattc tccatatacc
     1441 tttccaccca ataagtaact gtgagatgta ccgaagggag ttcttacctg aagaagggtg
     1501 tgaaggctga acaatcatgg atttttctga tcaattgtgc tttaggaaat tattgacagt
     1561 tttgcacagg ttcttgaaaa cgttatttat aatgaaatca actaaaacta tttttgctat
     1621 aagttctata aggtgcataa aacccttaaa ttcatctagt agctgttccc ctgaacaggt
     1681 ttattttagt aaaaaacaaa aacaaaacga aaaaaaaaaa aaaaaacgga aaaaaaatca
     1741 aagattttta tcaaatataa tgatgcaaaa aaagaaaaag aaaaaaaaag agaaaaagaa
     1801 aacttcaatt ttctgggtat gcacaaagac cacgaagact tatccaagtg catgaccgga
     1861 tttttgtggt tttgttcatt ttgtgtttaa tttgtctttt ttttttcagc tgtatgaaat
     1921 gggctttctg aagtttcaat tgtccgactt cacccatggt gtcccgtgct tgcgagtgtc
     1981 gcagtaactc agtgttggcc tcactgtctt tgcttagctc tccgtttttt tctttcgacg
     2041 tagtgtgaag tgtcttatcc ttttctatga attccaattt gccttaactc ttttgatgct
     2101 gtagctgttt cagtaaagtt agttcaacct aatgatgtag aatgctttga ccaaatgggc
     2161 tggtctagtg caccttgtaa gcagcagcct agggctttta aaaggtagtc aataaaagtt
     2221 gctgaaattt tggctttttt aaatatgtag taggtgtttt taatgatttt tcacatagcg
     2281 tgtaaggtag tgaagtgcaa ggagggaaaa ctgttttgtg tgaaacacat tttctgactg
     2341 gggggacttt taatagggta aattgtttat aaggctgtac actaacagtt tcccctaata
     2401 gtgtgactga tttaggatat ctgctgtatg atgcaatgta aagtcttttt tgcctttttt
     2461 tcaggaagaa aaaaaaataa aacttaacga tgttc
//
