LOCUS       NM_001102407            2631 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus RNA binding motif protein 8a (Rbm8a), transcript
            variant 1, mRNA.
ACCESSION   NM_001102407
VERSION     NM_001102407.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2631)
  AUTHORS   Asthana,S., Mott,J., Tong,M., Pei,Z. and Mao,Y.
  TITLE     The Exon Junction Complex Factor RBM8A in Glial Fibrillary Acid
            Protein-Expressing Astrocytes Modulates Locomotion Behaviors
  JOURNAL   Cells 13 (6), 498 (2024)
   PUBMED   38534343
  REMARK    GeneRIF: The Exon Junction Complex Factor RBM8A in Glial Fibrillary
            Acid Protein-Expressing Astrocytes Modulates Locomotion Behaviors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2631)
  AUTHORS   McSweeney,C., Chen,M., Dong,F., Sebastian,A., Reynolds,D.J.,
            Mott,J., Pei,Z., Zou,J., Shi,Y. and Mao,Y.
  TITLE     Transcriptomic Analyses of Brains of RBM8A Conditional Knockout
            Mice at Different Developmental Stages Reveal Conserved Signaling
            Pathways Contributing to Neurodevelopmental Diseases
  JOURNAL   Int J Mol Sci 24 (5), 4600 (2023)
   PUBMED   36902031
  REMARK    GeneRIF: Transcriptomic Analyses of Brains of RBM8A Conditional
            Knockout Mice at Different Developmental Stages Reveal Conserved
            Signaling Pathways Contributing to Neurodevelopmental Diseases.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2631)
  AUTHORS   Song,T. and Zhang,H.
  TITLE     RBM8A Depletion Decreases the Cisplatin Resistance and Represses
            the Proliferation and Metastasis of Breast Cancer Cells via
            AKT/mTOR Pathway
  JOURNAL   Breast J 2022, 4576789 (2022)
   PUBMED   36105365
  REMARK    GeneRIF: RBM8A Depletion Decreases the Cisplatin Resistance and
            Represses the Proliferation and Metastasis of Breast Cancer Cells
            via AKT/mTOR Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2631)
  AUTHORS   Su,C.H., Liao,W.J., Ke,W.C., Yang,R.B. and Tarn,W.Y.
  TITLE     The Y14-p53 regulatory circuit in megakaryocyte differentiation and
            thrombocytopenia
  JOURNAL   iScience 24 (11), 103368 (2021)
   PUBMED   34816104
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2631)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2631)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2631)
  AUTHORS   Bodnar,J.S., Chatterjee,A., Castellani,L.W., Ross,D.A., Ohmen,J.,
            Cavalcoli,J., Wu,C., Dains,K.M., Catanese,J., Chu,M., Sheth,S.S.,
            Charugundla,K., Demant,P., West,D.B., de Jong,P. and Lusis,A.J.
  TITLE     Positional cloning of the combined hyperlipidemia gene Hyplip1
  JOURNAL   Nat Genet 30 (1), 110-116 (2002)
   PUBMED   11753387
REFERENCE   8  (bases 1 to 2631)
  AUTHORS   Le Hir,H., Gatfield,D., Izaurralde,E. and Moore,M.J.
  TITLE     The exon-exon junction complex provides a binding platform for
            factors involved in mRNA export and nonsense-mediated mRNA decay
  JOURNAL   EMBO J 20 (17), 4987-4997 (2001)
   PUBMED   11532962
REFERENCE   9  (bases 1 to 2631)
  AUTHORS   Kataoka,N., Yong,J., Kim,V.N., Velazquez,F., Perkinson,R.A.,
            Wang,F. and Dreyfuss,G.
  TITLE     Pre-mRNA splicing imprints mRNA in the nucleus with a novel
            RNA-binding protein that persists in the cytoplasm
  JOURNAL   Mol Cell 6 (3), 673-682 (2000)
   PUBMED   11030346
REFERENCE   10 (bases 1 to 2631)
  AUTHORS   Zhao,X.F., Nowak,N.J., Shows,T.B. and Aplan,P.D.
  TITLE     MAGOH interacts with a novel RNA-binding protein
  JOURNAL   Genomics 63 (1), 145-148 (2000)
   PUBMED   10662555
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ072219.1, AK082925.1, AC122037.2 and AI845155.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF235880.1, AK082925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CJ072219.1         2-13
            13-723              AK082925.1         2-712
            724-2614            AC122037.2         16314-18204         c
            2615-2631           AI845155.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2631
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.93 cM"
     gene            1..2631
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /note="RNA binding motif protein 8a"
                     /db_xref="GeneID:60365"
                     /db_xref="MGI:MGI:1913129"
     exon            1..101
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..559
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /note="isoform a is encoded by transcript variant 1;
                     RNA-binding protein 8A; ribonucleoprotein RBM8A;
                     RNA-binding motif protein 8A"
                     /codon_start=1
                     /product="RNA-binding protein 8A isoform a"
                     /protein_id="NP_001095877.1"
                     /db_xref="CCDS:CCDS51005.1"
                     /db_xref="GeneID:60365"
                     /db_xref="MGI:MGI:1913129"
                     /translation="MADVLDLHEAGGEDFAMDEDGDESIHKLKEKAKKRKGRGFGSEE
                     GSRARMREDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEYGEIKNI
                     HLNLDRRTGYLKGYTLVEYETYKEAQAAMEGLNGQDLMGQPISVDWCFVRGPPKGKRR
                     GGRRRSRSPDRRRR"
     exon            102..161
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /inference="alignment:Splign:2.1.0"
     exon            162..239
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /inference="alignment:Splign:2.1.0"
     exon            240..376
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /inference="alignment:Splign:2.1.0"
     exon            377..513
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /inference="alignment:Splign:2.1.0"
     exon            514..2616
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      701..706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /note="hexamer: AATAAA"
     polyA_site      725
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /note="major polyA site"
     regulatory      1710..1715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /note="hexamer: ATTAAA"
     polyA_site      1737
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
                     /note="hexamer: AATAAA"
     polyA_site      2616
                     /gene="Rbm8a"
                     /gene_synonym="2310057C03Rik; Rbm8"
ORIGIN      
        1 ttctagagac tcagaaagcg ccgagagaag caagatggcg gacgtgctgg atcttcacga
       61 ggcggggggc gaagatttcg ccatggatga ggatggggac gaaagcatcc acaaactaaa
      121 agaaaaagca aagaaacgga agggccgcgg ctttggctcc gaagaggggt cccgagcgcg
      181 gatgcgggag gattacgaca gtgtggagca ggacggcgat gaacctggac cacagcgctc
      241 tgttgaaggt tggattctct ttgtcactgg agtccacgaa gaagccactg aagaagatat
      301 ccatgacaaa ttcgctgaat atggggaaat aaaaaatatt caccttaatt tggacaggcg
      361 cacgggatac ttgaaggggt atactctagt tgaatatgaa acatacaaag aggctcaggc
      421 tgccatggaa ggactaaatg gtcaagattt gatggggcag ccaatcagtg tggactggtg
      481 ttttgttcgt ggaccaccaa agggcaagag gagaggaggc cgaagacgaa gcaggagtcc
      541 agaccggaga cgccgttgat aaatcctctg tcgactgggt ggtctctcta caagtccatt
      601 tggttatgct gccttggata aacagggcta gggcggacct tgtgtttata tttaatttct
      661 taccctatct acttggcatt gcttttgagt tttagaaaaa aataaatgtt ccattttgtt
      721 ttctatgttt attactttac tgttctggaa actgaacaac tacagtgggg cattgtgaat
      781 gattgtgaag atccttctgt ctggcgtggc attctaagtt tctagaaagg ctcatggaga
      841 ctgttcagca tttctttgtc ttagaagata agggtaggga taatgagatt tttcttgtgg
      901 aattaaggaa tgtattttgc ataactcttg tgagcagatg ttatattagt gtctcttgct
      961 tctctgtcag agcctgtgca gctggccttg aacttcaggg gctttgtgat gcttagccta
     1021 ctctatgttg aatatggtgc tgaactgtga agtttattag ttcttacaat gtaaaagaaa
     1081 cccagcttga tgggctggag agatggctca gtagttaagg gcactgactg tccttccaga
     1141 ggtcctgagt tcaattccca gcacccacat ggtggctcac catgggatcc catgccctct
     1201 gaagatagct acaacatact catataaata attttttttt ttaagaaaaa aaacccagct
     1261 tgggtactat gtaacaatat gcacaccttt aatcccagca cttgggaagc aggtggatct
     1321 tttggtttaa ggccaacctg gtctacagga gagttttagg atagccaggg ctgcacagag
     1381 agatcctgtc tcaagaaaaa aagacattgc tatcccttta tcatagggtt ttggttgttt
     1441 ttttttttgg gggggggttt tgtttttttt tttaattttt ctgagacagg gtttctctgt
     1501 gtagccctga ctgtctcccc tgtgcctccc aggtgctagg attaaaggcg tgcaccacca
     1561 ctgcccggct tttatcatag tttttagttg aaattatttt ttggtatgtc tgtagcagct
     1621 ggtttgttgt ttgtgtaggt ccctatgtga cccacactgg cctcagactg atgttcctgt
     1681 ctctctctcc ccagtgcata atggcaaata ttaaacttaa cgttttttca gatgctattg
     1741 gcccttctct tccttttgat aaattgcttg gggtttgaat tgaattggtt aagaatatat
     1801 cttagttgag atttgcaggg tttaggatgc cttggtggtt tctgagaagg tagattaaat
     1861 aagtattggt tttgtggaag atacgcctgg ttctcagatt tctagctgtt gtaaggtatt
     1921 tggaagagtg agttgagtaa gcatgaggtc ctgagggctg gtaaacagta tcagccagag
     1981 aaccagtagg tgagctgcct ggataggaag ggtatggtca cgtagttggg aagatgctct
     2041 tctggcttta ctctgagaaa taagaatagc tcatagggat tagagatgtg gctcagttgg
     2101 tagaatgact gcctagtatg cacagcccca ggctttataa caggaccaaa tgggtacgac
     2161 actcctgcct ttgatcctgg cacttactgg ggaggtgaag gctaaagaat cataagttga
     2221 agtcatcccc agctgcatag ccaggtggag gattagccta tgagatcttg tcctgggtga
     2281 aaggggatgg aaagggggga aacctcatca atttactgtg tgaccttcta actccccttc
     2341 tttatacaga acttaaccat gtacagtaga aaccctcttt aacatactat gactttaaaa
     2401 cttgagctta aagaagtaag caatttcttg gggctggtga gatggcttag cgggtgggta
     2461 agaaccacct cttccagagg tcctaagtcc aaatccagca actacatggt agctcacaac
     2521 cacctggaat gagatctgat gccctcttct ggtgtgtcta acgtctgcta cagtgtactt
     2581 acatataata ataaataaat ctttaaaaaa aggcaaaaaa aaaaaaaaaa a
//
