LOCUS       NM_144948               1810 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus RNA binding motif protein 7 (Rbm7), transcript variant
            1, mRNA.
ACCESSION   NM_144948 NM_025906 XM_903211
VERSION     NM_144948.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1810)
  AUTHORS   Fukushima,K., Satoh,T., Sugihara,F., Sato,Y., Okamoto,T.,
            Mitsui,Y., Yoshio,S., Li,S., Nojima,S., Motooka,D., Nakamura,S.,
            Kida,H., Standley,D.M., Morii,E., Kanto,T., Yanagita,M.,
            Matsuura,Y., Nagasawa,T., Kumanogoh,A. and Akira,S.
  TITLE     Dysregulated Expression of the Nuclear Exosome Targeting Complex
            Component Rbm7 in Nonhematopoietic Cells Licenses the Development
            of Fibrosis
  JOURNAL   Immunity 52 (3), 542-556 (2020)
   PUBMED   32187520
REFERENCE   2  (bases 1 to 1810)
  AUTHORS   Tiedje,C., Lubas,M., Tehrani,M., Menon,M.B., Ronkina,N.,
            Rousseau,S., Cohen,P., Kotlyarov,A. and Gaestel,M.
  TITLE     p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human
            nuclear exosome targeting complex
  JOURNAL   RNA 21 (2), 262-278 (2015)
   PUBMED   25525152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY087243.1, AK151056.1 and AA178228.1.
            
            On Nov 23, 2010 this sequence version replaced NM_144948.4.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151056.1, AK005200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY087243.1         2-23
            23-1798             AK151056.1         2-1777
            1799-1810           AA178228.1         456-467
FEATURES             Location/Qualifiers
     source          1..1810
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.43 cM"
     gene            1..1810
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /note="RNA binding motif protein 7"
                     /db_xref="GeneID:67010"
                     /db_xref="MGI:MGI:1914260"
     exon            1..176
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..878
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein 7"
                     /codon_start=1
                     /product="RNA-binding protein 7 isoform 1"
                     /protein_id="NP_659197.2"
                     /db_xref="CCDS:CCDS23155.1"
                     /db_xref="GeneID:67010"
                     /db_xref="MGI:MGI:1914260"
                     /translation="MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKD
                     KDGKLKQFAFVNFKHEVSVPYAMNLLNGIKLFGRPIKIQFRSGSSHASQDASVSYPQH
                     HVGNLSPTSTSPNSYERTVGNVSPTAQMVQRSFSSPEDYQRQAVMNSVFRQMSYAGKF
                     GSPHADQLGFSPSAQPHGHTFNQSSSSQWRQDALSSQRKRQNSHPYLADRHYSREQRY
                     SDHGSDYHYRGSREDFYYDDRNHDGWSHDYDNRRDSSRGGKWPSSRH"
     exon            177..339
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            340..427
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            428..518
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            519..1810
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1790..1795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /note="hexamer: ATTAAA"
     regulatory      1794..1799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /note="hexamer: AATACA"
     polyA_site      1807
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /note="major polyA site"
     polyA_site      1810
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgagtgttt ctgagggtgc gcagtagggt cggtcggccc tgagcaggca gcctaggcct
       61 gggactggaa cagcgcggag atgggggcgg cggccgcaga ggccgaccgc actctgttcg
      121 tgggtaacct ggagacgaag gtgacagagg agctcctctt cgagctgttc caccaggctg
      181 ggccggtaat aaaagtgaaa atcccgaaag ataaagatgg caaactgaag cagtttgcat
      241 tcgtgaactt caaacatgaa gtgtctgttc cctatgccat gaatctgctc aacggaatca
      301 aacttttcgg gaggcctatc aaaattcagt ttagatcagg aagcagtcac gcctctcagg
      361 atgccagtgt gtcatatccc cagcatcatg ttggaaattt aagcccaacc tccacatctc
      421 ctaacagcta tgaaaggaca gtgggtaacg tgtctccgac agctcagatg gtccagaggt
      481 ccttttcttc tccagaagat tatcagcggc aagcagtgat gaacagtgtt ttcagacaga
      541 tgtcatatgc tgggaaattt ggttctccac atgcggatca gttgggattt tcaccatcag
      601 ctcaaccaca tggccatacc tttaaccagt cttccagctc ccagtggcgc caagatgcac
      661 tgtcatcaca gcgtaaaaga cagaattctc acccctacct agcagataga cactatagcc
      721 gtgagcagcg ctactctgac catgggtctg actatcatta cagaggcagc cgagaggatt
      781 tctactatga cgacaggaat catgatggct ggagccatga ctatgataac agaagggaca
      841 gtagtagagg tgggaagtgg ccctcatcca gacactaaca agcattccaa ggacactgtt
      901 tacagggcca ttttaggtcc ttttaattaa gttgttggag aaatatttct aaaagctgta
      961 cagagtaatc ccacaatttt ccacctgtct ttgaaaaaaa ttttttttaa acctagtaac
     1021 agtttgacag aactgagaac tgtggctcct tgtgtgctac tttaattacc taacctcagg
     1081 ggttctgaag aggaaggttc atacaagagt gtgtcaccat cccggccatg tcagacagtc
     1141 tcagaaagat gaaacggata ggttggttgt attctaaagc aaatatttta agtatctcac
     1201 cttttatgtt gcaagaaatt tcatggtaat gaatcaattt ggtatatata ataggaaaca
     1261 tctaagttgg aagtctgaaa tggctgtctg cattttgtta ataaatgaga aaatagaact
     1321 tttcagtcat ctgcttatta atagtttatt taaaacagtt tattggcttt gtttggagat
     1381 aaatcatatt tcctaactca gaatttaagt acaaattctg tggtatgctc ttgaatttta
     1441 ccacaattga acatacatta taaatcttta ctagttcatt ctaagaactt taaaattctt
     1501 tcattatatt tgatgtatga ctagtcgctc aggaagttaa atatctcaat gtatattttt
     1561 acacaaaatg acagtgttgg tgaaaattcg ttttagaatg atgttcatac atagagaaaa
     1621 tgacagtgtt tgactgcaag gattgtaatt ttgaaatttt gtttaacaaa acttccatgt
     1681 ttcaagatcc tgttgctctt tgactgcaaa actgtttcta agaattcatt ccatgaaaaa
     1741 tgtggatcct ctttatacca cagcatttat actatgttcc ttttaatata ttaaatacac
     1801 aaaaagagaa
//
