LOCUS       NP_659197                265 aa            linear   ROD 01-JUN-2024
DEFINITION  RNA-binding protein 7 isoform 1 [Mus musculus].
ACCESSION   NP_659197 NP_080182 XP_908304
VERSION     NP_659197.2
DBSOURCE    REFSEQ: accession NM_144948.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 265)
  AUTHORS   Fukushima,K., Satoh,T., Sugihara,F., Sato,Y., Okamoto,T.,
            Mitsui,Y., Yoshio,S., Li,S., Nojima,S., Motooka,D., Nakamura,S.,
            Kida,H., Standley,D.M., Morii,E., Kanto,T., Yanagita,M.,
            Matsuura,Y., Nagasawa,T., Kumanogoh,A. and Akira,S.
  TITLE     Dysregulated Expression of the Nuclear Exosome Targeting Complex
            Component Rbm7 in Nonhematopoietic Cells Licenses the Development
            of Fibrosis
  JOURNAL   Immunity 52 (3), 542-556 (2020)
   PUBMED   32187520
REFERENCE   2  (residues 1 to 265)
  AUTHORS   Tiedje,C., Lubas,M., Tehrani,M., Menon,M.B., Ronkina,N.,
            Rousseau,S., Cohen,P., Kotlyarov,A. and Gaestel,M.
  TITLE     p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human
            nuclear exosome targeting complex
  JOURNAL   RNA 21 (2), 262-278 (2015)
   PUBMED   25525152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY087243.1, AK151056.1 and AA178228.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_908304.1, NP_080182.1, NP_659197.1.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151056.1, AK005200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.43 cM"
     Protein         1..265
                     /product="RNA-binding protein 7 isoform 1"
                     /note="RNA-binding protein 7"
                     /calculated_mol_wt=30017
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylglycine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y580; propagated from
                     UniProtKB/Swiss-Prot (Q9CQT2.1)"
     Region          9..83
                     /region_name="RRM_RBM7"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     RNA-binding protein 7 (RBM7); cd12592"
                     /db_xref="CDD:410005"
     Region          <12..>175
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          25..35
                     /region_name="ZCCHC8 binding.
                     /evidence=ECO:0000250|UniProtKB:Q9Y580"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQT2.1)"
     Region          59..76
                     /region_name="ZCCHC8 binding.
                     /evidence=ECO:0000250|UniProtKB:Q9Y580"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQT2.1)"
     Region          91..125
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQT2.1)"
     Site            136
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPKAPK2.
                     /evidence=ECO:0000269|PubMed:25525152; propagated from
                     UniProtKB/Swiss-Prot (Q9CQT2.1)"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9CQT2.1)"
     Site            152
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y580; propagated from
                     UniProtKB/Swiss-Prot (Q9CQT2.1)"
     Region          166..224
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQT2.1)"
     Site            203
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y580; propagated from
                     UniProtKB/Swiss-Prot (Q9CQT2.1)"
     Region          237..265
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQT2.1)"
     CDS             1..265
                     /gene="Rbm7"
                     /gene_synonym="1200007M24Rik; 1500011D06Rik"
                     /coded_by="NM_144948.5:81..878"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23155.1"
                     /db_xref="GeneID:67010"
                     /db_xref="MGI:MGI:1914260"
ORIGIN      
        1 mgaaaaeadr tlfvgnletk vteellfelf hqagpvikvk ipkdkdgklk qfafvnfkhe
       61 vsvpyamnll ngiklfgrpi kiqfrsgssh asqdasvsyp qhhvgnlspt stspnsyert
      121 vgnvsptaqm vqrsfssped yqrqavmnsv frqmsyagkf gsphadqlgf spsaqphght
      181 fnqssssqwr qdalssqrkr qnshpyladr hysreqrysd hgsdyhyrgs redfyyddrn
      241 hdgwshdydn rrdssrggkw pssrh
//
