LOCUS       NM_011251               3720 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RNA binding motif protein 6 (Rbm6), transcript variant
            1, mRNA.
ACCESSION   NM_011251
VERSION     NM_011251.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3720)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3720)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3720)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   4  (bases 1 to 3720)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 3720)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   6  (bases 1 to 3720)
  AUTHORS   Heng,Y.M., Fox,M. and Sablitzky,F.
  TITLE     Assignment of the murine def-3 gene (Rbm6) to chromosome 9F1-F2 and
            its pseudogenes Rbm6-ps1 and Rbm6-ps2 to chromosome 1 by in situ
            hybridisation
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 238-239 (2000)
   PUBMED   10965133
  REMARK    GeneRIF: rbm6 (def-3) maps to mouse chromosome 9F1-F2 two
            pseudogenes of def-3 map both to mouse chromosome 1
REFERENCE   7  (bases 1 to 3720)
  AUTHORS   Hotfilder,M., Baxendale,S., Cross,M.A. and Sablitzky,F.
  TITLE     Def-2, -3, -6 and -8, novel mouse genes differentially expressed in
            the haemopoietic system
  JOURNAL   Br J Haematol 106 (2), 335-344 (1999)
   PUBMED   10460589
  REMARK    GeneRIF: rbm6 (def-3) was identified in a retroviral gene-trap
            screen
REFERENCE   8  (bases 1 to 3720)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 3720)
  AUTHORS   Drabkin,H.A., West,J.D., Hotfilder,M., Heng,Y.M., Erickson,P.,
            Calvo,R., Dalmau,J., Gemmill,R.M. and Sablitzky,F.
  TITLE     DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3
            homozygous deletion region in SCLC
  JOURNAL   Oncogene 18 (16), 2589-2597 (1999)
   PUBMED   10353602
  REMARK    GeneRIF: rbm6 (def-3) defines a novel RNA-binding protein family
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ155377.1, AK145612.1 and BY380685.1.
            
            On Nov 15, 2007 this sequence version replaced NM_011251.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript yet it encodes the longer protein (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ006486.2, SRR13861889.656.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               CJ155377.1         3-114
            113-282             AK145612.1         2-171
            283-3712            AK145612.1         443-3872
            3713-3720           BY380685.1         377-384
FEATURES             Location/Qualifiers
     source          1..3720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..3720
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /note="RNA binding motif protein 6"
                     /db_xref="GeneID:19654"
                     /db_xref="MGI:MGI:1338037"
     exon            1..171
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            172..282
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..3595
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="RNA-binding protein 6 isoform a"
                     /protein_id="NP_035381.2"
                     /db_xref="CCDS:CCDS59749.1"
                     /db_xref="GeneID:19654"
                     /db_xref="MGI:MGI:1338037"
                     /translation="MWGDSRSANRTGPFRGSQEERFAPGWNRDYPPPPLKSHAQERHS
                     GNFPGRDSLPFDFQGHSGPPFANVEEHSFSYGGRDGPHGDYQGGEGPGHDFRGGDFSS
                     SDFQSRDSAQLDFRNRDIHSGDFRDREGPPMDYRGGDGTPMDYRGRETPHMNYRDRDS
                     HTVDFRSRDVPPTDFRGRGTYDLDFRGREGSHSDFRGRDLSDLDFRSRDQSRSDFRNR
                     DVSDLDFRDKDGTQVDFRGRGSATTDLDFRNRDTPHSDFRGRHRTRTYQDFRGREVGP
                     CMEFKDREMPPMDPKVLDYIQPSPQEREHSGMNMNKREESIHDHAMERPAFGVQKGEF
                     EHSETREGETQSGTFEHESQSDFQNSQSPVQEQDKPKLSGGEQQSSDAGLFKEEGDLD
                     FLGQQDTDYRSIEYCDVDHRLPGNQIFGYGQSKSFSQGKMSRDAQQDLQDQDYRTGPS
                     EEKPNRLIRLSGVPENATKEEILNAFRTSDGIPVKDLQLKEYNTGYDYGYVCVEFSLL
                     EDAIGCMEANQGTLMIHDKEVTLEYVPSPDFWYCKRCKASTGGHQSSCSFCKGPKEEV
                     KQELVSYPQPQKTSIPVPSEKQPNQPRPADKEHELRKREEGQESRLGHQKRDTERYFP
                     HSRREGLTFRRDREKEPWSGDSRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVHLTTA
                     NVRIIKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGKRR
                     NDSGDHSDHMHYYQGKKYFRDRRGGNRNSDWSSDTNRQGQQSSSDCYIYDSTTGYYYD
                     PLAGTYYDPNTQQEVYVPQDPESPDEEEIKEKKSTSQGKSNSKKETSKRDGKEKKDRG
                     MTKFQESTSEGKPPLEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEE
                     EEEEQAPPVQPRTAQPREEMTKKENEDDKLTDWNKLACLLCRRQFPNKEVLTKHQQLS
                     DLHKQNLEIHRKIKQSEQELAYLERREREGRFKEKGNDRREKLQSFDSPERKRIKYSR
                     ETDSDRNPVDKEDTDTSSKGGCAQQATGWRKGAGLGYSHPGLGSSEEIEGRMRGPGGG
                     PPGRTSKRQSNETYRDAVRRVMFARYKELD"
     exon            283..1561
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1651
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1721
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1795
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1870
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1931
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2198
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2359
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2457
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2500
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2582
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2668
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2815
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2911
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3166
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3241
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3339
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3469
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3718
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3692..3697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /note="hexamer: AATAAA"
     polyA_site      3714
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /note="major polyA site"
ORIGIN      
        1 gggatttgcg gccgtacttc atctcccggc gggcccagcg ctgaaggcgg tggcgcgacg
       61 cctttgtgga agccggagcc caccgggagg aagttccggt ctccgggacg ctgggtccgt
      121 ggcggcctct gaggaggagg agaagcgggc cgcggcggct acgctgcttt ggtaccaccg
      181 tgctagagtt tggtaggaaa aagatctact tattgaagct ttcttgacat agaaagagat
      241 gtggggggat tctcgatctg ctaacagaac aggacctttt cgtgggagcc aagaagaaag
      301 gtttgctccc gggtggaaca gggattatcc tcctcctccc cttaagagtc atgctcaaga
      361 gagacactct ggcaactttc ctggcagaga ttcacttccc tttgatttcc aggggcattc
      421 aggacctccc tttgcaaatg tagaggagca ttctttcagc tatggaggta gagatggacc
      481 acatggtgac tatcaaggag gggagggacc tggacacgat ttcagagggg gagatttttc
      541 atcttcggat ttccagagta gagattcagc acagttggac ttcaggaaca gggacataca
      601 ttctggggat tttcgggata gagaaggacc acctatggac tacaggggtg gagatggtac
      661 tcctatggat tatagaggta gggagacacc tcatatgaat tatagagaca gggattctca
      721 tactgttgac tttagaagta gagatgtccc tccaactgac tttagggggc ggggcacata
      781 tgatttagat tttagaggcc gagagggatc ccattcagat tttaggggaa gagatttatc
      841 agatttggat tttagatcca gagatcagtc tcgttctgat tttaggaaca gagatgtatc
      901 tgatttggac ttcagggata aagatggaac acaggtggac tttagaggcc gaggttcagc
      961 tactactgat ctagacttta ggaacaggga tacaccacat tcggatttca gaggtagaca
     1021 tcgtactagg acttaccaag attttcgggg cagagaggta ggaccttgta tggaatttaa
     1081 agatagggag atgcctccta tggatccaaa agttttggat tacattcagc cttctccaca
     1141 agagagagaa cattctggta tgaatatgaa caagagagaa gaatccatac atgaccatgc
     1201 aatggaaaga cctgcttttg gtgttcagaa gggagaattt gagcattcag aaacaagaga
     1261 aggagaaaca caaagtggaa cttttgaaca tgaatctcaa tcagactttc aaaacagcca
     1321 aagtccagtt caagaacaag ataagccaaa gctttctgga ggtgaacaac agagttcaga
     1381 tgctggtctg tttaaagaag aaggtgattt ggactttctt ggccaacaag acactgatta
     1441 cagaagcatt gaatactgtg atgtggatca caggttgcca ggaaaccaga tttttggcta
     1501 tggccagagc aagtcatttt ctcagggcaa aatgtccaga gatgcccaac aagaccttca
     1561 ggatcaagat tataggactg gcccaagcga ggagaaacct aacaggctta ttcgattaag
     1621 tggggttcca gaaaatgcca caaaagaaga gattcttaat gcctttcgaa cttctgatgg
     1681 catacctgta aaggacttgc agttgaagga gtataacaca ggttacgact atggctatgt
     1741 ctgcgtggaa ttttcactct tggaagatgc catcggatgc atggaggcca accagggaac
     1801 tctaatgatc catgacaaag aggtcactct tgagtatgta ccaagcccag atttttggta
     1861 ctgtaaacga tgtaaggcta gcactggtgg gcatcagtct tcttgttcat tctgcaaggg
     1921 cccaaaggaa gaagtcaagc aggaactagt gtcctatcct caacctcaga aaacatccat
     1981 accagtacct tcagaaaaac agcccaacca gccacgacct gctgataagg agcatgaact
     2041 caggaaacgg gaggaaggcc aagagtcaag attaggacat cagaagagag atacagaaag
     2101 atacttccct cactctcgaa gggaagggct tactttccga agagaccggg aaaaggagcc
     2161 atggtctgga gattcacgcc aggatgggga gagtaaaaca atcatgctaa agcgtatcta
     2221 tcgttccact ccacccgaag tgatagtcga agtgctggag ccctacgtgc atctcactac
     2281 tgccaatgtc cgcatcatca agaacaggac tggccccatg ggtcacactt acggttttat
     2341 agaccttgac tcccatgcag aagctcttcg agtagtgaag attttgcaga accttgatcc
     2401 accatttagc attgatggga agatggtagc tgtaaacctg gccactggaa aacgaagaaa
     2461 tgattctggg gaccattctg accacatgca ttactatcag ggtaaaaaat attttcgaga
     2521 taggagagga ggaaacagaa attcagactg gtcttcagat acaaatcgac aagggcaaca
     2581 gtcatcatct gactgctaca tatatgattc tactactggc tactattatg accccttggc
     2641 aggaacttac tatgatccca acacccagca agaagtctat gtgccccagg accctgagtc
     2701 acctgatgaa gaagaaatca aggaaaagaa atctaccagt caaggaaagt caaatagcaa
     2761 gaaagaaaca tctaaaagag atggcaagga gaaaaaagac agaggaatga caaagtttca
     2821 agaaagtacc agtgagggga agcctcccct agaagatgtt tttaagaagc ctctacctcc
     2881 tactgtgaaa aaggaagaga gtcctcctcc acctaaggtg gtaaatccac tgattggtct
     2941 cctgggtgaa tatggaggag acagtgacta tgaggaagag gaagaagagg aacaggctcc
     3001 tcctgtgcag cctcgcacag cacagcctcg cgaggaaatg accaagaaag agaatgaaga
     3061 cgacaaactc actgactgga ataaactggc ttgtctgctc tgcagaaggc agtttcccaa
     3121 taaagaagtt cttacgaaac accaacaact gtccgacctg cacaagcaaa acctggaaat
     3181 tcaccggaag ataaaacagt cagagcaaga gctcgcctat ctggagagga gagagcggga
     3241 gggaaggttt aaagaaaaag gaaatgaccg aagggaaaaa ctacaatctt ttgattctcc
     3301 agaaaggaaa cggattaaat actccagaga aacagacagt gatcgtaacc ctgttgataa
     3361 agaagacact gacactagta gcaaaggagg ctgtgcccag caggccactg gctggaggaa
     3421 aggggcgggc ctgggatata gccatcctgg attgggttca tcagaggaga ttgaagggcg
     3481 gatgagggga cctgggggtg gtcccccagg aagaaccagc aagagacagt ctaatgagac
     3541 ttaccgagac gctgttcgaa gagtcatgtt tgctcgatat aaagaactcg attaagagtg
     3601 gagacacccc gcaggacaca atttcctctt tgttttgttt gtccttttct ccttttgttt
     3661 tgttactgtt cttgctgcta gaactttttt aaataaactt tttttcaatg tgaataaaaa
//
