LOCUS       NP_035381               1118 aa            linear   ROD 30-APR-2024
DEFINITION  RNA-binding protein 6 isoform a [Mus musculus].
ACCESSION   NP_035381
VERSION     NP_035381.2
DBSOURCE    REFSEQ: accession NM_011251.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1118)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1118)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1118)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   4  (residues 1 to 1118)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (residues 1 to 1118)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   6  (residues 1 to 1118)
  AUTHORS   Heng,Y.M., Fox,M. and Sablitzky,F.
  TITLE     Assignment of the murine def-3 gene (Rbm6) to chromosome 9F1-F2 and
            its pseudogenes Rbm6-ps1 and Rbm6-ps2 to chromosome 1 by in situ
            hybridisation
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 238-239 (2000)
   PUBMED   10965133
  REMARK    GeneRIF: rbm6 (def-3) maps to mouse chromosome 9F1-F2 two
            pseudogenes of def-3 map both to mouse chromosome 1
REFERENCE   7  (residues 1 to 1118)
  AUTHORS   Hotfilder,M., Baxendale,S., Cross,M.A. and Sablitzky,F.
  TITLE     Def-2, -3, -6 and -8, novel mouse genes differentially expressed in
            the haemopoietic system
  JOURNAL   Br J Haematol 106 (2), 335-344 (1999)
   PUBMED   10460589
  REMARK    GeneRIF: rbm6 (def-3) was identified in a retroviral gene-trap
            screen
REFERENCE   8  (residues 1 to 1118)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (residues 1 to 1118)
  AUTHORS   Drabkin,H.A., West,J.D., Hotfilder,M., Heng,Y.M., Erickson,P.,
            Calvo,R., Dalmau,J., Gemmill,R.M. and Sablitzky,F.
  TITLE     DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3
            homozygous deletion region in SCLC
  JOURNAL   Oncogene 18 (16), 2589-2597 (1999)
   PUBMED   10353602
  REMARK    GeneRIF: rbm6 (def-3) defines a novel RNA-binding protein family
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ155377.1, AK145612.1 and BY380685.1.
            
            On Nov 15, 2007 this sequence version replaced NP_035381.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript yet it encodes the longer protein (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ006486.2, SRR13861889.656.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1118
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     Protein         1..1118
                     /product="RNA-binding protein 6 isoform a"
                     /calculated_mol_wt=128245
     Region          94..259
                     /region_name="YjbI"
                     /note="Uncharacterized conserved protein YjbI, contains
                     pentapeptide repeats [Function unknown]; COG1357"
                     /db_xref="CDD:440968"
     Region          456..533
                     /region_name="RRM1_RBM6"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 6 (RBM6); cd12314"
                     /db_xref="CDD:409753"
     Region          651..737
                     /region_name="RRM2_RBM6"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 6 (RBM6); cd12563"
                     /db_xref="CDD:409979"
     Region          763..828
                     /region_name="OCRE_RBM6"
                     /note="OCRE domain found in RNA-binding protein 6 (RBM6)
                     and similar proteins; cd16163"
                     /db_xref="CDD:293882"
     Region          769..776
                     /region_name="OCRE repeat 1"
                     /note="OCRE repeat 1 [structural motif]"
                     /db_xref="CDD:293882"
     Region          785..792
                     /region_name="OCRE repeat 2"
                     /note="OCRE repeat 2 [structural motif]"
                     /db_xref="CDD:293882"
     Region          793..800
                     /region_name="OCRE repeat 3"
                     /note="OCRE repeat 3 [structural motif]"
                     /db_xref="CDD:293882"
     Region          801..808
                     /region_name="OCRE repeat 4"
                     /note="OCRE repeat 4 [structural motif]"
                     /db_xref="CDD:293882"
     Region          811..818
                     /region_name="OCRE repeat 5"
                     /note="OCRE repeat 5 [structural motif]"
                     /db_xref="CDD:293882"
     Region          1046..>1079
                     /region_name="G-patch"
                     /note="G-patch domain; pfam01585"
                     /db_xref="CDD:396249"
     CDS             1..1118
                     /gene="Rbm6"
                     /gene_synonym="4930506F14Rik; Def-3; g16; mKIAA4015;
                     NY-LU-12"
                     /coded_by="NM_011251.3:239..3595"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS59749.1"
                     /db_xref="GeneID:19654"
                     /db_xref="MGI:MGI:1338037"
ORIGIN      
        1 mwgdsrsanr tgpfrgsqee rfapgwnrdy pppplkshaq erhsgnfpgr dslpfdfqgh
       61 sgppfanvee hsfsyggrdg phgdyqggeg pghdfrggdf sssdfqsrds aqldfrnrdi
      121 hsgdfrdreg ppmdyrggdg tpmdyrgret phmnyrdrds htvdfrsrdv pptdfrgrgt
      181 ydldfrgreg shsdfrgrdl sdldfrsrdq srsdfrnrdv sdldfrdkdg tqvdfrgrgs
      241 attdldfrnr dtphsdfrgr hrtrtyqdfr grevgpcmef kdremppmdp kvldyiqpsp
      301 qerehsgmnm nkreesihdh amerpafgvq kgefehsetr egetqsgtfe hesqsdfqns
      361 qspvqeqdkp klsggeqqss daglfkeegd ldflgqqdtd yrsieycdvd hrlpgnqifg
      421 ygqsksfsqg kmsrdaqqdl qdqdyrtgps eekpnrlirl sgvpenatke eilnafrtsd
      481 gipvkdlqlk eyntgydygy vcvefslled aigcmeanqg tlmihdkevt leyvpspdfw
      541 yckrckastg ghqsscsfck gpkeevkqel vsypqpqkts ipvpsekqpn qprpadkehe
      601 lrkreegqes rlghqkrdte ryfphsrreg ltfrrdreke pwsgdsrqdg esktimlkri
      661 yrstppeviv evlepyvhlt tanvriiknr tgpmghtygf idldshaeal rvvkilqnld
      721 ppfsidgkmv avnlatgkrr ndsgdhsdhm hyyqgkkyfr drrggnrnsd wssdtnrqgq
      781 qsssdcyiyd sttgyyydpl agtyydpntq qevyvpqdpe spdeeeikek kstsqgksns
      841 kketskrdgk ekkdrgmtkf qestsegkpp ledvfkkplp ptvkkeespp ppkvvnplig
      901 llgeyggdsd yeeeeeeeqa ppvqprtaqp reemtkkene ddkltdwnkl acllcrrqfp
      961 nkevltkhqq lsdlhkqnle ihrkikqseq elaylerrer egrfkekgnd rreklqsfds
     1021 perkrikysr etdsdrnpvd kedtdtsskg gcaqqatgwr kgaglgyshp glgsseeieg
     1081 rmrgpgggpp grtskrqsne tyrdavrrvm farykeld
//
