LOCUS       NM_148930               3104 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus RNA binding motif protein 5 (Rbm5), transcript variant
            1, mRNA.
ACCESSION   NM_148930
VERSION     NM_148930.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3104)
  AUTHORS   Snyder,K., Dixon,C.E., Henchir,J., Gorse,K., Vagni,V.A.,
            Janesko-Feldman,K., Kochanek,P.M. and Jackson,T.C.
  TITLE     Gene knockout of RNA binding motif 5 in the brain alters RIMS2
            protein homeostasis in the cerebellum and Hippocampus and
            exacerbates behavioral deficits after a TBI in mice
  JOURNAL   Exp Neurol 374, 114690 (2024)
   PUBMED   38218585
  REMARK    GeneRIF: Gene knockout of RNA binding motif 5 in the brain alters
            RIMS2 protein homeostasis in the cerebellum and Hippocampus and
            exacerbates behavioral deficits after a TBI in mice.
REFERENCE   2  (bases 1 to 3104)
  AUTHORS   Mullari,M., Fossat,N., Skotte,N.H., Asenjo-Martinez,A.,
            Humphreys,D.T., Bukh,J., Kirkeby,A., Scheel,T.K.H. and Nielsen,M.L.
  TITLE     Characterising the RNA-binding protein atlas of the mammalian brain
            uncovers RBM5 misregulation in mouse models of Huntington's disease
  JOURNAL   Nat Commun 14 (1), 4348 (2023)
   PUBMED   37468457
  REMARK    GeneRIF: Characterising the RNA-binding protein atlas of the
            mammalian brain uncovers RBM5 misregulation in mouse models of
            Huntington's disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3104)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3104)
  AUTHORS   Jackson,T.C., Janesko-Feldman,K., Gorse,K., Vagni,V.A.,
            Jackson,E.K. and Kochanek,P.M.
  TITLE     Identification of Novel Targets of RBM5 in the Healthy and Injured
            Brain
  JOURNAL   Neuroscience 440, 299-315 (2020)
   PUBMED   32335213
REFERENCE   5  (bases 1 to 3104)
  AUTHORS   Huang,Y.Z., Zhao,L., Wang,C.L., Tian,S.J., Liu,S. and Ge,J.F.
  TITLE     RBM5-AS1 participates in fracture healing and inhibits apoptosis of
            bone cells through the up-regulation of beta-catenin
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (16), 5091-5097 (2018)
   PUBMED   30178827
  REMARK    GeneRIF: RBM5 can inhibit the apoptosis of bone cells by promoting
            the expression of beta-catenin and can be used as a biomarker for
            fracture healing.
REFERENCE   6  (bases 1 to 3104)
  AUTHORS   Auphan-Anezin,N., Mazza,C., Guimezanes,A., Barrett-Wilt,G.A.,
            Montero-Julian,F., Roussel,A., Hunt,D.F., Malissen,B. and
            Schmitt-Verhulst,A.M.
  TITLE     Distinct orientation of the alloreactive monoclonal CD8 T cell
            activation program by three different peptide/MHC complexes
  JOURNAL   Eur J Immunol 36 (7), 1856-1866 (2006)
   PUBMED   16761314
REFERENCE   7  (bases 1 to 3104)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3104)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3104)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3104)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY140862.1, AK146880.1 and AW047301.1.
            
            [WARNING] On Aug 9, 2024 this sequence was replaced by NM_148930.4.
            
            On Aug 26, 2009 this sequence version replaced NM_148930.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031899.1, AK146880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY140862.1         1-6
            7-3085              AK146880.1         2-3080
            3086-3104           AW047301.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3104
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     gene            1..3104
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /note="RNA binding motif protein 5"
                     /db_xref="GeneID:83486"
                     /db_xref="MGI:MGI:1933204"
     exon            1..118
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            119..184
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2615
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein 5; putative tumor suppressor LUCA15"
                     /codon_start=1
                     /product="RNA-binding protein 5 isoform 1"
                     /protein_id="NP_683732.1"
                     /db_xref="CCDS:CCDS23506.1"
                     /db_xref="GeneID:83486"
                     /db_xref="MGI:MGI:1933204"
                     /translation="MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSD
                     DRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHDISDERESKTIML
                     RGLPITITESDIREMMESFEGPQPADVRLMKRKTGVSRGFAFVEFYHLQDATSWMEAN
                     QKKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPG
                     TTESAQSVDYYCDTIILRNIAPHTVVDSIMTALSPYASLAVNNIRLIKDKQTQQNRGF
                     AFVQLSSAMDASQLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLPDGNRVSAFSVA
                     STAIAAAQWSSTQSQSGEGGSVDYSYMQPGQDGYTQYTQYSQDYQQFYQQQAGGLESD
                     TSATSGTTVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVP
                     GTKYAVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPA
                     AEASSNQQTGLPSTKEGKEKKEKPKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPVN
                     SLREEERRESAAADAGFALFEKKGALAERQQLLPELVRNGDEENPLKRGLVAAYSGDS
                     DNEEELVERLESEEEKLADWKKMACLLCRRQFPNRDALVRHQQLSDLHKQNMDIYRRS
                     RLSEQELEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKDG
                     IDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADS
                     YKDAVRKAMFARFTEME"
     exon            185..350
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            351..506
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            507..576
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            577..650
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            651..734
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            735..795
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            796..861
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1022
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1120
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1208
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1286
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1359
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1445
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1530
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1622
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1784
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1934
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2006
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2186
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2261
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2359
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2489
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..3087
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3066..3071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      3087
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggactgtgg gtaggagaag acggtcggtg gagacgccat tttgtggagc ggccgaacct
       61 tgtaggaggt tctggggcgc agagccgcta ctgctcctgc tttgttccct ctgtgggggg
      121 gaaaatttaa gccttttgaa gcagtgtgct agctcttccg tgagacgatg ggttcagaca
      181 aaagagtgag tagaacagaa cgtagtggaa gatatggttc catcatagat agggatgacc
      241 gtgatgagcg tgaatctaga agcaggcggc gggactcaga ttacaaaaga tcaagcgatg
      301 atcggagagg tgatagatat gatgactatc gggactatga tagtccagag agagagcgtg
      361 aaagaaggaa cagtgaccgg tctgaagatg gctatcattc agatggtgac tatggagaac
      421 atgactatag acatgacatc agtgatgaga gagagagcaa gaccatcatg ctccgtggcc
      481 ttcctatcac catcaccgag agcgatattc gagaaatgat ggagtccttt gaaggccctc
      541 agcctgcaga tgtgaggctg atgaagagga aaacaggtgt aagccgtggt ttcgccttcg
      601 tggagtttta tcacttgcaa gatgctacca gctggatgga agccaatcag aaaaaattgg
      661 tgattcaagg aaagcacatt gcaatgcatt atagcaatcc cagacctaaa tttgaagatt
      721 ggctttgtaa caagtgctgc cttaacaatt tcaggaaaag actaaaatgc ttccgatgtg
      781 gagcagacaa gtttgactct gaacaggaag tgccccccgg aaccacagag tctgctcagt
      841 ccgtggatta ctactgtgat actatcattc ttcggaacat agctccgcac actgtggtgg
      901 attccatcat gacagcccta tctccctatg cttccttagc tgtcaataac attcgcctca
      961 taaaagacaa acagacacaa cagaacagag ggtttgcatt tgtgcagcta tcttctgcaa
     1021 tggatgcctc tcagctgctt cagatattac agagtctcca tcctccattg aaaattgatg
     1081 ggaaaactat tggagttgat tttgcaaaaa gtgccagaaa agatttggtc cttccagatg
     1141 gtaaccgagt cagcgccttc tctgtagcta gtacagccat tgctgctgct cagtggtcat
     1201 ccactcagtc tcaaagtggt gaaggaggca gtgttgacta cagttacatg cagccaggcc
     1261 aggatggcta cacacagtac actcaatact cacaggatta ccagcagttt tatcagcagc
     1321 aagctggagg gctggagtct gatacatcag ctacatcagg caccacagtg actaccacct
     1381 cagcagctgt agtatcccaa agtccccaac tctataatca gacctccaac ccacctggct
     1441 ctccgactga ggaagcacag cctagcacta gcacaagtac acaggccccc gctgcttccc
     1501 ctactggtgt agttcctggt accaagtatg cagtacctga cacgtctact tatcaatatg
     1561 atgaatcatc aggatattat tatgatccta caacagggct ctactatgac cctaactcac
     1621 agtactacta taactcctta acacagcagt acttgtactg ggatggcgag aaggagacct
     1681 acgtgccagc tgcagaggct agctcgaacc agcagactgg cctgccttcc acaaaagagg
     1741 gaaaggagaa gaaagaaaag cccaagagca aaactgctca gcagattgcc aaagacatgg
     1801 aacgctgggc caagagttta aataagcaga aagaaaattt taaaaacagc tttcaacctg
     1861 tcaattcatt gagagaagaa gaaaggagag aatctgccgc agcagatgct ggctttgctc
     1921 tttttgagaa gaagggagcc ttagctgaaa ggcagcaact cctccctgaa ttggtgcgca
     1981 atggagatga agaaaacccc cttaaaagag gtctggttgc tgcttacagt ggtgacagtg
     2041 acaatgagga ggagctggta gagagacttg agagtgagga agagaaacta gctgactgga
     2101 agaagatggc ctgcctgctg tgccgacgtc agttcccaaa cagagatgcc ctggtcaggc
     2161 accagcagct ctccgactta cacaagcaaa atatggacat ctaccgaaga tccaggctga
     2221 gcgagcagga gttggaagcc ttggagctga gggagagaga gatgaaatac agagaccgag
     2281 cagcagaaag acgagagaaa tacggaattc cagagccccc agagcccaag cgcaagaagc
     2341 agtttgatgc tggcactgtg aattacgagc agcccaccaa agatggcatt gaccacagta
     2401 acattggcaa caagatgctg caggctatgg gttggcggga aggctcaggc ttaggaagaa
     2461 agtgtcaagg catcacagct cccattgagg ctcaagtccg actaaaagga gctggcttgg
     2521 gagccaaagg cagtgcctat gggttgtcag gtgccgattc ctacaaagat gctgttcgga
     2581 aagccatgtt tgcccggttc actgagatgg agtgaaactg gggaagcaat gctgagcaca
     2641 gggagcaagc catctcctca gttgctctta ctgcctgtct ctaagggcat gccttgtgct
     2701 attaatagtt ttaggatgaa ccacttcatt ctgaggggtt ctcctacctt aaatgagctc
     2761 ccttacgtgg gtaaacaacc ttccttccca cctgagggac tgtgaacaga ggggacaatg
     2821 ggctttttat actaaggtgt atatagtgta aatgtaatga gttttacatg ttgtagcctg
     2881 tgttgtgtcc ctacttcctg ggggcttgag aagctcggag tggttgtcaa caccaaagcc
     2941 accactgtca tttattgttg ttatgtcttt tcttggcaat agccttgtgt atatttgtat
     3001 attatacatt tgtacagaat tttggaagat tttcagtcta gctgccacgt ctggctcctt
     3061 tacaaaagaa ataccttcaa aactgggaaa aaaaaaaaaa aaaa
//
