LOCUS       NP_683732                815 aa            linear   ROD 09-AUG-2024
DEFINITION  RNA-binding protein 5 isoform 1 [Mus musculus].
ACCESSION   NP_683732
VERSION     NP_683732.1
DBSOURCE    REFSEQ: accession NM_148930.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 815)
  AUTHORS   Snyder,K., Dixon,C.E., Henchir,J., Gorse,K., Vagni,V.A.,
            Janesko-Feldman,K., Kochanek,P.M. and Jackson,T.C.
  TITLE     Gene knockout of RNA binding motif 5 in the brain alters RIMS2
            protein homeostasis in the cerebellum and Hippocampus and
            exacerbates behavioral deficits after a TBI in mice
  JOURNAL   Exp Neurol 374, 114690 (2024)
   PUBMED   38218585
  REMARK    GeneRIF: Gene knockout of RNA binding motif 5 in the brain alters
            RIMS2 protein homeostasis in the cerebellum and Hippocampus and
            exacerbates behavioral deficits after a TBI in mice.
REFERENCE   2  (residues 1 to 815)
  AUTHORS   Mullari,M., Fossat,N., Skotte,N.H., Asenjo-Martinez,A.,
            Humphreys,D.T., Bukh,J., Kirkeby,A., Scheel,T.K.H. and Nielsen,M.L.
  TITLE     Characterising the RNA-binding protein atlas of the mammalian brain
            uncovers RBM5 misregulation in mouse models of Huntington's disease
  JOURNAL   Nat Commun 14 (1), 4348 (2023)
   PUBMED   37468457
  REMARK    GeneRIF: Characterising the RNA-binding protein atlas of the
            mammalian brain uncovers RBM5 misregulation in mouse models of
            Huntington's disease.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 815)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 815)
  AUTHORS   Jackson,T.C., Janesko-Feldman,K., Gorse,K., Vagni,V.A.,
            Jackson,E.K. and Kochanek,P.M.
  TITLE     Identification of Novel Targets of RBM5 in the Healthy and Injured
            Brain
  JOURNAL   Neuroscience 440, 299-315 (2020)
   PUBMED   32335213
REFERENCE   5  (residues 1 to 815)
  AUTHORS   Huang,Y.Z., Zhao,L., Wang,C.L., Tian,S.J., Liu,S. and Ge,J.F.
  TITLE     RBM5-AS1 participates in fracture healing and inhibits apoptosis of
            bone cells through the up-regulation of beta-catenin
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (16), 5091-5097 (2018)
   PUBMED   30178827
  REMARK    GeneRIF: RBM5 can inhibit the apoptosis of bone cells by promoting
            the expression of beta-catenin and can be used as a biomarker for
            fracture healing.
REFERENCE   6  (residues 1 to 815)
  AUTHORS   Auphan-Anezin,N., Mazza,C., Guimezanes,A., Barrett-Wilt,G.A.,
            Montero-Julian,F., Roussel,A., Hunt,D.F., Malissen,B. and
            Schmitt-Verhulst,A.M.
  TITLE     Distinct orientation of the alloreactive monoclonal CD8 T cell
            activation program by three different peptide/MHC complexes
  JOURNAL   Eur J Immunol 36 (7), 1856-1866 (2006)
   PUBMED   16761314
REFERENCE   7  (residues 1 to 815)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 815)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 815)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 815)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152718.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031899.1, AK146880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..815
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     Protein         1..815
                     /product="RNA-binding protein 5 isoform 1"
                     /note="RNA-binding protein 5; putative tumor suppressor
                     LUCA15"
                     /calculated_mol_wt=92180
     Region          1..93
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YE7.1)"
     Site            18
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52756; propagated from
                     UniProtKB/Swiss-Prot (Q91YE7.1)"
     Site            59
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52756; propagated from
                     UniProtKB/Swiss-Prot (Q91YE7.1)"
     Site            69
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52756; propagated from
                     UniProtKB/Swiss-Prot (Q91YE7.1)"
     Site            72
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52756; propagated from
                     UniProtKB/Swiss-Prot (Q91YE7.1)"
     Site            78
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91YE7.1)"
     Region          93..179
                     /region_name="RRM1_RBM5"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 5 (RBM5); cd12752"
                     /db_xref="CDD:410146"
     Region          181..210
                     /region_name="zf-RanBP"
                     /note="Zn-finger in Ran binding protein and others;
                     pfam00641"
                     /db_xref="CDD:395516"
     Region          185..204
                     /region_name="RanBP2-type Zn finger"
                     /note="RanBP2-type Zn finger [structural motif]"
                     /db_xref="CDD:275375"
     Region          229..314
                     /region_name="RRM2_RBM5"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 5 (RBM5); cd12755"
                     /db_xref="CDD:410149"
     Region          321..809
                     /region_name="Required for interaction with U2AF2.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YE7.1)"
     Region          385..468
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YE7.1)"
     Site            444
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52756; propagated from
                     UniProtKB/Swiss-Prot (Q91YE7.1)"
     Region          452..535
                     /region_name="Sufficient for interaction with ACIN1,
                     PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YE7.1)"
     Region          455..510
                     /region_name="OCRE_RBM5"
                     /note="OCRE domain found in RNA-binding protein 5 (RBM5)
                     and similar proteins; cd16168"
                     /db_xref="CDD:293887"
     Region          460..467
                     /region_name="OCRE repeat 1"
                     /note="OCRE repeat 1 [structural motif]"
                     /db_xref="CDD:293887"
     Region          468..475
                     /region_name="OCRE repeat 2"
                     /note="OCRE repeat 2 [structural motif]"
                     /db_xref="CDD:293887"
     Region          476..483
                     /region_name="OCRE repeat 3"
                     /note="OCRE repeat 3 [structural motif]"
                     /db_xref="CDD:293887"
     Region          484..491
                     /region_name="OCRE repeat 4"
                     /note="OCRE repeat 4 [structural motif]"
                     /db_xref="CDD:293887"
     Region          493..500
                     /region_name="OCRE repeat 5"
                     /note="OCRE repeat 5 [structural motif]"
                     /db_xref="CDD:293887"
     Region          508..539
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YE7.1)"
     Site            621
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91YE7.1)"
     Site            624
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91YE7.1)"
     Region          743..787
                     /region_name="G-patch"
                     /note="G-patch domain; pfam01585"
                     /db_xref="CDD:396249"
     CDS             1..815
                     /gene="Rbm5"
                     /gene_synonym="D030069N10Rik"
                     /coded_by="NM_148930.4:165..2612"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23506.1"
                     /db_xref="GeneID:83486"
                     /db_xref="MGI:MGI:1933204"
ORIGIN      
        1 mgsdkrvsrt ersgrygsii drddrderes rsrrrdsdyk rssddrrgdr yddyrdydsp
       61 erererrnsd rsedgyhsdg dygehdyrhd isdereskti mlrglpitit esdiremmes
      121 fegpqpadvr lmkrktgvsr gfafvefyhl qdatswmean qkklviqgkh iamhysnprp
      181 kfedwlcnkc clnnfrkrlk cfrcgadkfd seqevppgtt esaqsvdyyc dtiilrniap
      241 htvvdsimta lspyaslavn nirlikdkqt qqnrgfafvq lssamdasql lqilqslhpp
      301 lkidgktigv dfaksarkdl vlpdgnrvsa fsvastaiaa aqwsstqsqs geggsvdysy
      361 mqpgqdgytq ytqysqdyqq fyqqqaggle sdtsatsgtt vtttsaavvs qspqlynqts
      421 nppgspteea qpstststqa paasptgvvp gtkyavpdts tyqydessgy yydpttglyy
      481 dpnsqyyyns ltqqylywdg eketyvpaae assnqqtglp stkegkekke kpksktaqqi
      541 akdmerwaks lnkqkenfkn sfqpvnslre eerresaaad agfalfekkg alaerqqllp
      601 elvrngdeen plkrglvaay sgdsdneeel verleseeek ladwkkmacl lcrrqfpnrd
      661 alvrhqqlsd lhkqnmdiyr rsrlseqele alelreremk yrdraaerre kygipeppep
      721 krkkqfdagt vnyeqptkdg idhsnignkm lqamgwregs glgrkcqgit apieaqvrlk
      781 gaglgakgsa yglsgadsyk davrkamfar fteme
//
