LOCUS       NM_025717               1840 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RNA binding motif protein 4B (Rbm4b), mRNA.
ACCESSION   NM_025717
VERSION     NM_025717.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1840)
  AUTHORS   Tsai,Y.Y., Shen,C.L., D,D., Tsai,C.Y. and Tarn,W.Y.
  TITLE     Activation of TrkB signaling mitigates cerebellar anomalies caused
            by Rbm4-Bdnf deficiency
  JOURNAL   Commun Biol 6 (1), 910 (2023)
   PUBMED   37670183
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1840)
  AUTHORS   D,D., Hung,K.Y. and Tarn,W.Y.
  TITLE     RBM4 Modulates Radial Migration via Alternative Splicing of Dab1
            during Cortex Development
  JOURNAL   Mol Cell Biol 38 (12), e00007-18 (2018)
   PUBMED   29581187
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1840)
  AUTHORS   Su,C.H., Hung,K.Y., Hung,S.C. and Tarn,W.Y.
  TITLE     RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells
            by Modulating Alternative Splicing of Pyruvate Kinase M
  JOURNAL   Mol Cell Biol 37 (3), e00466-16 (2017)
   PUBMED   27821480
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1840)
  AUTHORS   Tarn,W.Y., Kuo,H.C., Yu,H.I., Liu,S.W., Tseng,C.T., Dhananjaya,D.,
            Hung,K.Y., Tu,C.C., Chang,S.H., Huang,G.J. and Chiu,I.M.
  TITLE     RBM4 promotes neuronal differentiation and neurite outgrowth by
            modulating Numb isoform expression
  JOURNAL   Mol Biol Cell 27 (10), 1676-1683 (2016)
   PUBMED   27009199
REFERENCE   6  (bases 1 to 1840)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1840)
  AUTHORS   Lin,J.C., Yan,Y.T., Hsieh,W.K., Peng,P.J., Su,C.H. and Tarn,W.Y.
  TITLE     RBM4 promotes pancreas cell differentiation and insulin expression
  JOURNAL   Mol Cell Biol 33 (2), 319-327 (2013)
   PUBMED   23129807
REFERENCE   8  (bases 1 to 1840)
  AUTHORS   Lu,C.C., Chen,T.H., Wu,J.R., Chen,H.H., Yu,H.Y. and Tarn,W.Y.
  TITLE     Phylogenetic and molecular characterization of the splicing factor
            RBM4
  JOURNAL   PLoS One 8 (3), e59092 (2013)
   PUBMED   23527094
REFERENCE   9  (bases 1 to 1840)
  AUTHORS   Kojima,S., Matsumoto,K., Hirose,M., Shimada,M., Nagano,M.,
            Shigeyoshi,Y., Hoshino,S., Ui-Tei,K., Saigo,K., Green,C.B.,
            Sakaki,Y. and Tei,H.
  TITLE     LARK activates posttranscriptional expression of an essential
            mammalian clock protein, PERIOD1
  JOURNAL   Proc Natl Acad Sci U S A 104 (6), 1859-1864 (2007)
   PUBMED   17264215
REFERENCE   10 (bases 1 to 1840)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF782018.1, BC019488.1 and AW475895.1.
            
            On Jul 16, 2005 this sequence version replaced NM_025717.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019488.1, AK142116.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                BF782018.1         17-111
            96-1621             BC019488.1         1-1526
            1622-1840           AW475895.1         1-219               c
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.11 cM"
     gene            1..1840
                     /gene="Rbm4b"
                     /gene_synonym="4921506I22Rik; Lark2; Neosin"
                     /note="RNA binding motif protein 4B"
                     /db_xref="GeneID:66704"
                     /db_xref="MGI:MGI:1913954"
     exon            1..137
                     /gene="Rbm4b"
                     /gene_synonym="4921506I22Rik; Lark2; Neosin"
                     /inference="alignment:Splign:2.1.0"
     exon            138..561
                     /gene="Rbm4b"
                     /gene_synonym="4921506I22Rik; Lark2; Neosin"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1223
                     /gene="Rbm4b"
                     /gene_synonym="4921506I22Rik; Lark2; Neosin"
                     /note="RNA-binding protein 30; RNA-binding motif protein
                     30"
                     /codon_start=1
                     /product="RNA-binding protein 4B"
                     /protein_id="NP_079993.2"
                     /db_xref="CCDS:CCDS29435.1"
                     /db_xref="GeneID:66704"
                     /db_xref="MGI:MGI:1913954"
                     /translation="MVKLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIED
                     KTAAEDAIRNLHHYKLHGVNINVEASKNKSKASTKLHVGNISPTCTNQELRAKFEEYG
                     PVIECDIVKDYAFVHMERAEDAVEAIRGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQS
                     GCYRCGKEGHWSKECPVDRTGRVADFTEQYNEQYGAVRTPYTMGYGESMYYNDAYGAL
                     DYYKRYRVRSYEAVAAAAAASAYNYAEQTMSHLPQVQSSAVPSHLNSTSVDPYDRHLL
                     QNSGSAATSAAMAAAASSSYYGRDRSPLRRNAAVLPAVGEGYGYGPESEMSQASAATR
                     NSLYDMARYEREQYVDRTRYSAF"
     exon            562..1232
                     /gene="Rbm4b"
                     /gene_synonym="4921506I22Rik; Lark2; Neosin"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1829
                     /gene="Rbm4b"
                     /gene_synonym="4921506I22Rik; Lark2; Neosin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm4b"
                     /gene_synonym="4921506I22Rik; Lark2; Neosin"
                     /note="hexamer: AACAAA"
     polyA_site      1356
                     /gene="Rbm4b"
                     /gene_synonym="4921506I22Rik; Lark2; Neosin"
                     /note="major polyA site"
     regulatory      1808..1813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm4b"
                     /gene_synonym="4921506I22Rik; Lark2; Neosin"
                     /note="hexamer: AATAAA"
     polyA_site      1829
                     /gene="Rbm4b"
                     /gene_synonym="4921506I22Rik; Lark2; Neosin"
ORIGIN      
        1 caggcagcgc gcactcgcgc gtgcgtgagc tggcgcgcga gaaagcgccc ggtcgcgccg
       61 aggctcgagc ggccgtcgcc attttgtagg gttctctctg acgcgggacc cgccgccacc
      121 gccggcacca cccggaggct cttgtcagga tggtgaagct gttcattgga aatctgcccc
      181 gggaggccac agagcaggag atccgctcac tcttcgagca gtacgggaag gtgctggaat
      241 gtgacatcat taagaattat ggctttgtgc acatagagga caagacggcc gctgaggatg
      301 ccatacgcaa cctgcaccac tacaagctgc acggagtgaa catcaatgtg gaagccagca
      361 agaataagag caaagcttca accaagttac acgtgggcaa catcagcccc acttgtacca
      421 accaagagct tcgggccaag tttgaggagt acggcccagt catcgaatgt gacatcgtga
      481 aagattatgc ctttgtacac atggagcggg cagaggatgc ggtggaggcc atcaggggcc
      541 tcgacaacac agagtttcaa ggcaaacgaa tgcatgtaca gttgtcaact agccggcttc
      601 ggactgcccc tgggatggga gaccagagtg gttgctatcg gtgtggtaaa gaaggacatt
      661 ggtccaaaga gtgcccagta gaccgtacag ggcgtgtggc agactttact gagcagtaca
      721 atgaacaata tggagcagtg cgcacacctt atactatggg ttatggggag tccatgtatt
      781 acaacgatgc ctatggagca cttgactact ataagcgcta ccgcgtccga tcttacgaag
      841 ctgtggcggc ggcggctgca gcttccgcat acaattacgc agagcagacc atgtctcatc
      901 ttcctcaagt tcagagctca gctgtaccca gtcacctcaa ctccacttct gttgatcctt
      961 atgacagaca cctattgcag aactctggct ctgctgccac ctcagctgca atggctgctg
     1021 ccgcttcctc ttcctattat ggaagggaca ggagcccact acgtcggaat gcggctgtgc
     1081 ttcccgcagt tggagagggc tatggttatg ggccagagag cgagatgtct caggcttcag
     1141 cagcaactcg gaattctctg tatgacatgg cccggtatga gcgggagcag tatgtggacc
     1201 gaacacggta ctcagccttt taaaaactgg aggtaggata attgcggact gaaccctcgg
     1261 gctgcggtca tatatgagaa cttggtcctc gcggtcccct ttgccaggat gtttccattg
     1321 cttcatgttt cagtaaacaa aggaatttgt gaccaactat gttttctttc ttaatttaat
     1381 tcttctaagt tgacttttct ttcctcgatg ctagttgtct gtagcttttc actgttcctt
     1441 ataccctcag cctctgaaca gccctaggta agggttatgc tgacatccct tttcctgtac
     1501 agtagaagcc cctcttaatc ttgcttttct taggagttga gcccttctcc ctgccttcct
     1561 gcagcatctc ctttcccttt aaaatgacca tgtagtggca agcaaccttt aactcttctg
     1621 tcagtgctgg actcttagca ttgaagctgg tcttctgaag tcgctaggac cattgggttt
     1681 tgttgttgtc ttggtttgat tttgttttgg ttttcggttt tgtctgacct gtgatcgtgg
     1741 tacagcattt gctgaaattt agccttgttt tattccactc ctcccaattt ttttttgaaa
     1801 aaaaaaaaat aaatgtttct aatacttaaa aaaaaaaaaa
//
