LOCUS       NM_172991               1872 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus RNA binding motif protein 48 (Rbm48), transcript
            variant 1, mRNA.
ACCESSION   NM_172991
VERSION     NM_172991.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090443.4.
            
            On Apr 21, 2022 this sequence version replaced NM_172991.4.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that has some support in the available
            conservation data. The use of an alternative upstream start codon
            would result in a protein that is 42 aa longer.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029549.1, AK047811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC090443.4         63826-63951
            127-317             AC090443.4         64472-64662
            318-463             AC090443.4         68102-68247
            464-1044            AC090443.4         69114-69694
            1045-1872           AC090443.4         75110-75937
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 2.25 cM"
     gene            1..1872
                     /gene="Rbm48"
                     /gene_synonym="C030048B08Rik"
                     /note="RNA binding motif protein 48"
                     /db_xref="GeneID:269623"
                     /db_xref="MGI:MGI:2442653"
     exon            1..126
                     /gene="Rbm48"
                     /gene_synonym="C030048B08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1131
                     /gene="Rbm48"
                     /gene_synonym="C030048B08Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0712 protein C7orf64 homolog; RNA-binding protein 48"
                     /codon_start=1
                     /product="RNA-binding protein 48 isoform 1"
                     /protein_id="NP_766579.4"
                     /db_xref="CCDS:CCDS19064.2"
                     /db_xref="GeneID:269623"
                     /db_xref="MGI:MGI:2442653"
                     /translation="MASSDGKPGGVFDHHVQTAVCDSRAKYREGRRPRAVKVYTINLE
                     SQYLLIQGVPAVGAMKELVERFALYGAIEQYNALDEYPAEDFTEVYLIKFVKLQSARV
                     AKKKMDEQSFFGGLLHVCYAPEFETVEETRKKLQERKAYITRVTKNQDCYMAKKKPVP
                     EQKGTKDSRQGFHPPMPGFGTAALNTSPESPPENSSSCLPYSCEFPLSCFASKSTCSR
                     GEHVDRVSDSCNSARNHGELSRHRDHSAFSPKLQMNTYKNSVPCSSVQEAIATSQAVG
                     RFMPRTTQLQERKRRRDCDRELGTLLETHTSSNEVLIGPKLPGIPTVDLQDDSLNTTA
                     TLIRRKLKEVISSVPKPPEDNIKDVCTSHPGKQRRRI"
     exon            127..317
                     /gene="Rbm48"
                     /gene_synonym="C030048B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            318..463
                     /gene="Rbm48"
                     /gene_synonym="C030048B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            464..1044
                     /gene="Rbm48"
                     /gene_synonym="C030048B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1872
                     /gene="Rbm48"
                     /gene_synonym="C030048B08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1849..1854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm48"
                     /gene_synonym="C030048B08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1872
                     /gene="Rbm48"
                     /gene_synonym="C030048B08Rik"
                     /note="major polyA site"
ORIGIN      
        1 actagagccg gcaagatggc atccagtgac gggaaacctg gtggcgtatt cgatcaccac
       61 gtccagacgg ctgtgtgtga ctcgcgggcc aaataccggg agggccgacg ccctcgcgcg
      121 gtcaaggtat atacaatcaa tttggagtct cagtacttac taatacaagg agttcctgca
      181 gtgggagcca tgaaggaatt agttgagcgt tttgctctgt atggtgcgat tgaacagtat
      241 aacgctctag atgaataccc agcggaagat tttacagaag tttatctcat taaatttgtg
      301 aaattacaga gtgcaagggt agctaagaaa aagatggatg aacagagctt ctttggaggg
      361 ttacttcatg tgtgctacgc tccagaattt gagacagttg aagaaactag aaaaaaatta
      421 caagaaagaa aggcttatat tacaagagtt actaaaaacc aagattgtta catggcgaag
      481 aagaaaccag ttccagagca gaaaggaaca aaagattcta gacaaggttt ccatccacct
      541 atgcctggat ttggtacagc tgctttaaac acatctcctg agagtcctcc agagaactcg
      601 agttcttgtc ttccttattc ttgtgaattc cctttaagct gttttgcttc caagagcaca
      661 tgttcacgtg gggaacatgt ggacagagta tcagactcct gtaatagtgc taggaaccat
      721 ggtgaactgt ctaggcatcg tgaccacagt gccttttcac caaagctgca gatgaacact
      781 tacaaaaact ccgtcccttg ctctagtgtg caagaggcca ttgctacctc acaggcagtt
      841 ggcaggttca tgcctaggac aacacagctg caggagagga aacggcggcg agactgtgat
      901 cgagaactgg gaactctgct tgagacacac acaagcagta acgaggtttt gattggacct
      961 aagttaccag gtatccccac agtagatctg caggacgact ccttgaatac aacggcaacc
     1021 ttaattcgga ggaaacttaa agaggtgatt tcatctgtgc caaagcctcc agaggacaat
     1081 ataaaagacg tgtgtacaag tcacccagga aaacaaagaa gaagaatata gcttgccagt
     1141 ggggagttag tcttgccttt tcttttttcc tttgaatcag agtctcactg gatagctctg
     1201 gctactctgg gactctctat gtagaccagg ctggcctgag tgctgggact aaagggtgtg
     1261 tgccactacc cccagctaaa ttggtgtgtt ctggagagat tcttttttat gtttggccca
     1321 ttttaattct ttcaggcatc ttactactgc tgttttaaag tttttttctt ttaaaccagt
     1381 tgcaaatgtt tccatctttc ttggatctac acgcaatgtg gcagagactg ttctctttat
     1441 actgtattag ttcttatatt agaatacgta aattgattga aacaaatgta gaaatatgtc
     1501 atacaaataa ggcaatcagg gtctcatttt aattcaggta ttgagcaatc tgtgttcaga
     1561 gactggcagg ggggttgttt ttgaacacca gggcttcaaa gtgaaagcag aactgtagag
     1621 aaaaaaatgc caacaaatgt tacagcaaca ctgatattag aaacacattt ttaaaaaagc
     1681 agcatacata atgtaacttc taagactaat ttaaattgac tatggtgatg gaaaaaacta
     1741 attttggaaa ttctagattt ctacactgtc agcatatctg tactttttct tctgtcagcg
     1801 ggccacagta taatttttca ggctatttat atttcttttc ttggaaaaaa taaagtgaga
     1861 aggcacatgc ta
//
