LOCUS       NM_001127382            4947 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RNA binding motif protein 47 (Rbm47), transcript
            variant 2, mRNA.
ACCESSION   NM_001127382
VERSION     NM_001127382.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4947)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4947)
  AUTHORS   Soleymanjahi,S., Blanc,V., Molitor,E.A., Alvarado,D.M., Xie,Y.,
            Gazit,V., Brown,J.W., Byrnes,K., Liu,T.C., Mills,J.C., Ciorba,M.A.,
            Rubin,D.C. and Davidson,N.O.
  TITLE     RBM47 regulates intestinal injury and tumorigenesis by modifying
            proliferation, oxidative response, and inflammatory pathways
  JOURNAL   JCI Insight 8 (9), e161118 (2023)
   PUBMED   37014710
  REMARK    GeneRIF: RBM47 regulates intestinal injury and tumorigenesis by
            modifying proliferation, oxidative response, and inflammatory
            pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4947)
  AUTHORS   Shivalingappa,P.K.M., Singh,D.K., Sharma,V., Arora,V., Shiras,A.
            and Bapat,S.A.
  TITLE     RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell
            Differentiation
  JOURNAL   Stem Cell Rev Rep 19 (2), 475-490 (2023)
   PUBMED   35986129
  REMARK    GeneRIF: RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell
            Differentiation.
REFERENCE   4  (bases 1 to 4947)
  AUTHORS   Shivalingappa,P.K.M., Sharma,V., Shiras,A. and Bapat,S.A.
  TITLE     RNA binding motif 47 (RBM47): emerging roles in vertebrate
            development, RNA editing and cancer
  JOURNAL   Mol Cell Biochem 476 (12), 4493-4505 (2021)
   PUBMED   34499322
  REMARK    GeneRIF: RNA binding motif 47 (RBM47): emerging roles in vertebrate
            development, RNA editing and cancer.
            Review article
REFERENCE   5  (bases 1 to 4947)
  AUTHORS   Wei,Y., Zhang,F., Zhang,Y., Wang,X., Xing,C., Guo,J., Zhang,H.,
            Suo,Z., Li,Y., Wang,J., Wang,R. and Cai,Z.
  TITLE     Post-transcriptional regulator Rbm47 elevates IL-10 production and
            promotes the immunosuppression of B cells
  JOURNAL   Cell Mol Immunol 16 (6), 580-589 (2019)
   PUBMED   29844590
  REMARK    GeneRIF: Post-transcriptional regulator Rbm47 elevates IL-10
            production and promotes the immunosuppression of B cells.
REFERENCE   6  (bases 1 to 4947)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4947)
  AUTHORS   Fossat,N., Radziewic,T., Jones,V., Tourle,K. and Tam,P.P.
  TITLE     Conditional restoration and inactivation of Rbm47 reveal its
            tissue-context requirement for viability and growth
  JOURNAL   Genesis 54 (3), 115-122 (2016)
   PUBMED   26789794
  REMARK    GeneRIF: Study demonstrated that Rbm47 function is required in the
            embryo proper, and not the visceral endoderm, for viability and
            growth.
REFERENCE   8  (bases 1 to 4947)
  AUTHORS   Fossat,N., Tourle,K., Radziewic,T., Barratt,K., Liebhold,D.,
            Studdert,J.B., Power,M., Jones,V., Loebel,D.A. and Tam,P.P.
  TITLE     C to U RNA editing mediated by APOBEC1 requires RNA-binding protein
            RBM47
  JOURNAL   EMBO Rep 15 (8), 903-910 (2014)
   PUBMED   24916387
  REMARK    GeneRIF: RBM47 and APOBEC1 constitute the basic machinery for C to
            U RNA editing.
REFERENCE   9  (bases 1 to 4947)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   10 (bases 1 to 4947)
  AUTHORS   Yeganeh,M., Seyedjafari,E., Kamrani,F.A. and Ghaemi,N.
  TITLE     RNA-binding protein Rbm47 binds to Nanog in mouse embryonic stem
            cells
  JOURNAL   Mol Biol Rep 40 (7), 4391-4396 (2013)
   PUBMED   23649762
  REMARK    GeneRIF: RNA-binding protein Rbm47 binds to Nanog in mouse
            embryonic stem cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY315501.1, AK085733.1, CJ229698.1, AK152971.1, AK049280.1,
            CJ210661.1 and BY380934.1.
            
            On Mar 30, 2014 this sequence version replaced NM_001127382.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2 and 3 all encode the same
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               BY315501.1         4-347
            345-2448            AK085733.1         537-2640
            2449-2710           CJ229698.1         445-706
            2711-3852           AK152971.1         122-1263
            3853-4566           AK049280.1         1357-2070
            4567-4754           CJ210661.1         52-239
            4755-4925           CJ210661.1         241-411
            4926-4947           BY380934.1         438-459
FEATURES             Location/Qualifiers
     source          1..4947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 33.93 cM"
     gene            1..4947
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /note="RNA binding motif protein 47"
                     /db_xref="GeneID:245945"
                     /db_xref="MGI:MGI:2384294"
     exon            1..100
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            101..263
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            264..345
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            346..472
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            473..1632
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..2276
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /note="isoform a is encoded by transcript variant 2;
                     RNA-binding protein 47"
                     /codon_start=1
                     /product="RNA-binding protein 47 isoform a"
                     /protein_id="NP_001120854.1"
                     /db_xref="CCDS:CCDS19313.1"
                     /db_xref="GeneID:245945"
                     /db_xref="MGI:MGI:2384294"
                     /translation="MTAEDSATAMNSDPTVGSSTKVPEGVAGAPNEAALLALIERTGY
                     TMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFETVGRIYELRL
                     MMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPK
                     MKKRGEILEEIAKVTEGVLNVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGR
                     IQLWGHQIAVDWAEPEIDVDEDVMQTVKILYVRNLMIETTEETIKKSFGQFNPGCVER
                     VKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAAKGG
                     GGSAEAVAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKTGSIRGRGRGAAGNRT
                     PGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEISPVNPVAIKPGTVAIPA
                     IGAQYSMFQAAPAPKIIEDGKIHTMEHMISPIAVQPDPATAAAAAAAAAAAAVIPAVS
                     TPPPFQGRPITPVYTVAPNVQRIPTAGIYGASYVPFAAPATATIATLQKNAAAAVYGG
                     YAGYIPQAFPAALQVPIHDVYQTY"
     exon            1633..1839
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2045
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..4933
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4906..4911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4926
                     /gene="Rbm47"
                     /gene_synonym="9530077J19Rik"
                     /note="major polyA site"
ORIGIN      
        1 tttagtcaca gaattcgatt cctgttggct gtttccgcgc tgcaaacagg cttagcgctc
       61 cattgaaatg cgggaggctc cttaattctt gtataaacag aaaccagctg taacactagg
      121 tcagagcgca ttcagaatga gccactttga acgagcagcg gcgcccaggc cccaggccct
      181 gctgtgaagg ctccggcaaa ggtcagagct ccggcccccc gtgacgtgcc tgcctgtgct
      241 ctccgagcta tgctcagcct cagctcaggt aacacacaag ttagaagaac agcttgtttc
      301 ctgctacgca gccaccctca gcagttccca gctcactgaa gttcgggttt gcctcagagg
      361 acacgtcaag aactgatcag agaaatccca agcgagctgc ctgaaccttc gagaattctc
      421 ttgttctacc ttccatataa agaaccagga ccaatcgcat tggtgacctt tggtttccac
      481 cagctgtgga tgcctttgac attatgactg ctgaagattc cgccacagcc atgaacagcg
      541 atccaacagt ggggtcctcc accaaggtac cggagggtgt ggcgggcgcg cccaatgagg
      601 ctgcactgtt ggcactgata gagcgcaccg gctacaccat ggtacaagag aacgggcagc
      661 gcaagtacgg tggacccccg cccggctggg agggcccgca tccccagcgt ggctgtgagg
      721 tcttcgtggg caagatccca cgtgacgtgt atgaagatga gctggtgcct gtgtttgaga
      781 ccgtaggtcg catctatgag ctgcgactca tgatggattt cgatggcaag aaccgcggct
      841 atgccttcgt gatgtactgc cacaagcatg aggccaagcg agccgttcgg gaactcaaca
      901 actacgagat ccgccccggc cgtctgctgg gtgtgtgctg tagtgtggac aactgccgcc
      961 tcttcattgg tggcatcccc aagatgaaga agcgcgggga gatcctggag gagatcgcca
     1021 aggtcaccga gggcgtactc aacgtgattg tgtatgccag tgcggcagac aagatgaaaa
     1081 accgaggctt cgcctttgtg gagtatgaga gccatcgtgc tgcagccatg gcacgccgca
     1141 agctcatgcc gggtcggatc caactgtggg gccaccagat tgctgtggac tgggccgagc
     1201 cagagattga cgtggacgaa gatgtgatgc agacagtgaa gatcctctac gtgcgcaacc
     1261 tcatgatcga gaccaccgag gagaccatca agaagagctt tggccagttc aacccaggct
     1321 gcgtggaaag ggtcaagaag atccgtgact acgccttcgt gcacttcact agccgtgagg
     1381 atgctgtgca tgctatgaac aacctcaacg gcacagagct ggagggatcc tgcttagaag
     1441 tcacgctggc caagcccgtg gacaaggaac agtactcccg ctaccagaag gcagccaagg
     1501 gtggtggtgg ctcggctgag gccgtagcgc agcaacccag ctacgtgtac tcctgtgacc
     1561 cctacacgtt ggcctactac ggctacccct acaacgctct catcgggccc aaccgggact
     1621 acttcgtgaa aacaggcagc ataagaggcc gagggagagg cgcagctgga aacaggaccc
     1681 cagggcccag gggttcctac ctcggaggat attccgctgg ccgtggtata tatagccgat
     1741 atcacgaagg caaaggcaaa cagcaggaga aaggatatga acttgtgccg aatttggaga
     1801 tctctcctgt caatccagtt gccattaaac ctggcacagt ggccatccct gccatcggtg
     1861 ctcagtactc catgttccag gcagccccag ccccgaaaat aatcgaagat ggcaagatcc
     1921 acacaatgga acacatgatc agccccattg cggtgcagcc tgaccccgcc actgctgctg
     1981 ccgctgcagc cgctgcagcc gctgctgccg tcattcctgc ggtatccaca ccgccacctt
     2041 tccagggccg tccaataact cctgtgtaca ccgtggcacc aaatgttcag agaatcccca
     2101 ccgccggcat ctacggggcc agctacgtcc cctttgctgc tcccgccact gccacaatcg
     2161 ccacactaca gaagaacgcc gcggctgccg tgtatggggg ctacgccggc tacatacctc
     2221 aggccttccc cgctgctctc caggtgccca tccacgacgt ctaccagact tactgagaac
     2281 gggggaccgg agccaaggca agccaccaaa ccccgctgaa ggaacacttt attatttatg
     2341 aagaaagaac gtgtcgggtt ggtacacgtg caaaacctgc aggtgaagaa gaatgttatc
     2401 aaatagcaca ctgaaatatt ttattatatc catgaagttt tcactcgctt tttttttttt
     2461 tttttttttt tttgaaaatg acttttcaac ttagcaggcc cgcgttcata catttctaaa
     2521 agacttgcga cgcctcacgc cttaatgcca tctcttaaag tttgtatgct cttctgcttt
     2581 tgtacagagg tttggttttt tgttttttaa ggatatattt tcagtatgaa ggttattttc
     2641 ttaacttctg cactccagag ttttctattt tgtagaacct ttcaaagtat atcagctata
     2701 tgtatgtata tcaaaaaaaa aaaaaaaaaa aagcacaccc gcgcatctag ggaactattt
     2761 tgaaaactat attcaatatt taaagacaca aactgtagtg ctctgaaata ctacataaaa
     2821 cattatttta ttttttaaag tgatgctgga aagtgcaatt ttaaaatgag gaaaaaaaaa
     2881 gtctctactg tatttccact ggcattaagg gttgacgata atgccattta ttcttgtcat
     2941 gttttctggg tttatggggt tttggtttgg tttggggttt ttgttgttgt tgttgttttg
     3001 ttttgttttt aataacactc tgttcttaag ccaacatgga aaagactcct cacatccaga
     3061 gtcccaacac tggaaagctc tgacctgccc tcactacctt gggctctctc tcctgagtcc
     3121 ttagtaactg tgccccgccc ccgccccgcc gtgccccgcc ccgcccttct ccttccctag
     3181 ctccagtgca actttggcat atctaagaaa aatggataat tccaatagag aagacaactg
     3241 atgcctttta tacttcttcc tgggattgtg ttggggtctt tttaattatt tttggtttgt
     3301 ttagggcgtc tttttaatta tctttgttaa ttatatttgg tttgttctat gtgtatcttc
     3361 agtagcagaa tacacattaa ggacaagatt ttaccatctt tgcctaaggc atctctgcat
     3421 agctatttaa ttgttcagta tgaaacctga cctttctaat tctttgactt tttttttttg
     3481 aagtctgggt ttttagagac caagaatgta tgtgattata gacaagactt gtcagtggga
     3541 agttaagctt ctcgctgcct ttctttctcc tgtgtttcct acagaatgcc tggtgccatc
     3601 agggatgtcg gaagccctgt gtttgtttag cagggcttcc cgccgttgct ctgcatttgg
     3661 taggtgaaca cgggcaggtg aacacgggca tacacatcca ggagaagtct ctgtaggagt
     3721 ttaagggtag attgtaaata acttctgacg cttgctcgcc aaagttgcca agttcatggc
     3781 ctgtagtgta atgcgaaatg cagccatttt atttcaatgt tattcaaagt gtttgccttt
     3841 tttttttttt tttctttttt ggaagtaaat gcacagatgc tgggttttgt gcctgtttta
     3901 aggcttttct ttggcagagt gaatgtaaaa tacagtagaa aagataatat cgtcatctct
     3961 tttatgaatt atatcaactt acatcttttt aagaaggctc agtccaggat gtgaggtgtg
     4021 caataagggt agcagatgca cagttgtgtt tcatggcatg acagagtcca tccaatctcc
     4081 cttcccatca gagttttgct aataggctta actcttattt gtggactaat agtaggatct
     4141 tgccctcagc aaacgctttc tgcttttaaa ttaagagagt cccaattgtc tttttttttt
     4201 ctgcctcccc cccactttat cttgacggga tggattttat atatataaga aatatttatt
     4261 taactattct atagaattat cgagtgcctg ctaagacctt taagcatccc tccttcctta
     4321 ttgcgtggta tagagcagct gggagagtga gaggcgtcac tcgggaagct gcagccacac
     4381 gggcctgttg gaatgagtga cctccttaaa ggtatcaggt cctcatccct tgactggtga
     4441 ggaaaaagtg ccttcctgcc ggccacggac tgacatggag gtcttcggat gagcccggat
     4501 gcccatgttc ttactgtatt ttacaagtgc ctggggaaat attttcaaaa ataatattaa
     4561 taatttaaaa aaaaggaaaa actatgcact aacttaacgt ggcgactacc ttaacggcag
     4621 gcgttggtgg cagccagtta agcaccagtg tctctgcagt ctgtggcctt agctgtccct
     4681 cttgtttctc aaccatttca cgtacactac tgaggtaagt ttataacttg aaatgtgaac
     4741 tttttttttt ttttaggatt aagaacaaac taatataaat gtttttaaaa gttttagtgt
     4801 ttgggtttta gtcatgctac tagtttagtt tttagcttcg tatttgaaaa gctttttaga
     4861 tctcgctgca tttacataca gtacattctt aagatgtatg tggtaaataa agctttcttt
     4921 aaagcagttt caaaaaaaaa aaaaaaa
//
