LOCUS       NM_001277170            3586 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus RNA binding motif protein 46 (Rbm46), transcript
            variant 2, mRNA.
ACCESSION   NM_001277170
VERSION     NM_001277170.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3586)
  AUTHORS   Zhong,J., Xu,J., Chen,X., Li,N., Li,S., Deng,Z., Feng,H., Ling,X.,
            Wang,C., Zhou,Z. and Li,L.
  TITLE     Rbm46 inhibits reactive oxygen species in mouse embryonic stem
            cells through modulating BNIP3-mediated mitophagy
  JOURNAL   Biochem Biophys Res Commun 708, 149779 (2024)
   PUBMED   38518724
  REMARK    GeneRIF: Rbm46 inhibits reactive oxygen species in mouse embryonic
            stem cells through modulating BNIP3-mediated mitophagy.
REFERENCE   2  (bases 1 to 3586)
  AUTHORS   Peart,N.J., Johnson,T.A., Lee,S., Sears,M.J., Yang,F.,
            Quesnel-Vallieres,M., Feng,H., Recinos,Y., Barash,Y., Zhang,C.,
            Hermann,B.P., Wang,P.J., Geyer,C.B. and Carstens,R.P.
  TITLE     The germ cell-specific RNA binding protein RBM46 is essential for
            spermatogonial differentiation in mice
  JOURNAL   PLoS Genet 18 (9), e1010416 (2022)
   PUBMED   36129965
  REMARK    GeneRIF: The germ cell-specific RNA binding protein RBM46 is
            essential for spermatogonial differentiation in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3586)
  AUTHORS   Lv,Y., Lu,G., Cai,Y., Su,R., Liang,L., Wang,X., Mu,W., He,X.,
            Huang,T., Ma,J., Zhao,Y., Chen,Z.J., Xue,Y., Liu,H. and Chan,W.Y.
  TITLE     RBM46 is essential for gametogenesis and functions in
            post-transcriptional roles affecting meiotic cohesin subunits
  JOURNAL   Protein Cell 14 (1), 51-63 (2022)
   PUBMED   36726756
  REMARK    GeneRIF: RBM46 is essential for gametogenesis and functions in
            post-transcriptional roles affecting meiotic cohesin subunits.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3586)
  AUTHORS   Qian,B., Li,Y., Yan,R., Han,S., Bu,Z., Gong,J., Zheng,B., Yuan,Z.,
            Ren,S., He,Q., Zhang,J., Xu,C., Wang,R., Sun,Z., Lin,M., Zhou,J.
            and Ye,L.
  TITLE     RNA binding protein RBM46 regulates mitotic-to-meiotic transition
            in spermatogenesis
  JOURNAL   Sci Adv 8 (34), eabq2945 (2022)
   PUBMED   36001654
  REMARK    GeneRIF: RNA binding protein RBM46 regulates mitotic-to-meiotic
            transition in spermatogenesis.
REFERENCE   5  (bases 1 to 3586)
  AUTHORS   Wang,C., Chen,Y., Deng,H., Gao,S. and Li,L.
  TITLE     Rbm46 regulates trophectoderm differentiation by stabilizing Cdx2
            mRNA in early mouse embryos
  JOURNAL   Stem Cells Dev 24 (7), 904-915 (2015)
   PUBMED   25397698
  REMARK    GeneRIF: Rbm46 directly binds to and stabilizes Cdx2 mRNA in early
            mouse embryos.
REFERENCE   6  (bases 1 to 3586)
  AUTHORS   Auclair,G., Guibert,S., Bender,A. and Weber,M.
  TITLE     Ontogeny of CpG island methylation and specificity of DNMT3
            methyltransferases during embryonic development in the mouse
  JOURNAL   Genome Biol 15 (12), 545 (2014)
   PUBMED   25476147
REFERENCE   7  (bases 1 to 3586)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ047211.1, AC158935.4, AC102130.7 and AV254043.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by a combination of partial mouse transcript alignments
            and RNA-Seq data, and by the full-length human transcript
            AK302720.1.
            
            CCDS Note: The exon combination of this CCDS representation is
            inferred due to a lack of full-length transcript support for this
            gene. It is supported by partial mouse transcript alignments,
            RNA-seq data, and full-length orthologous transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.217258.1,
                                           SRR7345562.4573588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-451               CJ047211.1         2-452
            452-806             AC158935.4         36735-37089         c
            807-1589            AC158935.4         35435-36217         c
            1590-1649           AC158935.4         14004-14063         c
            1650-2313           AC158935.4         9326-9989           c
            2314-3312           AC102130.7         1-999
            3313-3586           AV254043.2         346-619
FEATURES             Location/Qualifiers
     source          1..3586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 36.75 cM"
     gene            1..3586
                     /gene="Rbm46"
                     /gene_synonym="EG633285; Gm761"
                     /note="RNA binding motif protein 46"
                     /db_xref="GeneID:633285"
                     /db_xref="MGI:MGI:3645057"
     exon            1..176
                     /gene="Rbm46"
                     /gene_synonym="EG633285; Gm761"
                     /inference="alignment:Splign:2.1.0"
     exon            177..338
                     /gene="Rbm46"
                     /gene_synonym="EG633285; Gm761"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1645
                     /gene="Rbm46"
                     /gene_synonym="EG633285; Gm761"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable RNA-binding protein 46"
                     /codon_start=1
                     /product="probable RNA-binding protein 46 isoform 2"
                     /protein_id="NP_001264099.1"
                     /db_xref="CCDS:CCDS71255.1"
                     /db_xref="GeneID:633285"
                     /db_xref="MGI:MGI:3645057"
                     /translation="MNEENTDGTNGCSKVRTGTQNEAALLALMEKTGYNMVQENGQRK
                     FGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRG
                     YAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDE
                     MKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQV
                     DWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFSKFKPGAVERVKKLRDYAFV
                     HFFHREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLLVYA
                     NKEESHSKSLGKPPTLPTRLNGQHSPSPPEIERCTYPFFPGTKLTPISMYSLKSNHFN
                     SAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIVIPAIANGSQSYFMPDKLCT
                     TLEDAKELAAQFTLLHLDREHSLFSLDLCRRIWRK"
     exon            339..806
                     /gene="Rbm46"
                     /gene_synonym="EG633285; Gm761"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1589
                     /gene="Rbm46"
                     /gene_synonym="EG633285; Gm761"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1649
                     /gene="Rbm46"
                     /gene_synonym="EG633285; Gm761"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..3586
                     /gene="Rbm46"
                     /gene_synonym="EG633285; Gm761"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3567..3572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm46"
                     /gene_synonym="EG633285; Gm761"
                     /note="hexamer: ATTAAA"
     polyA_site      3584
                     /gene="Rbm46"
                     /gene_synonym="EG633285; Gm761"
                     /note="major polyA site"
ORIGIN      
        1 gtggccccga ggcgcgagga cagcacgagc gccactggcc acgccctgcc ccgtccggcc
       61 ccgcggcgac tcctctgacc accgcttccg cccgcagcgc cgatccgaag ctctggcggc
      121 ggtttgtgct cgttggtcca gggattttta ggtctggcct ctgaagaccc gacggggaat
      181 tgcaaccatg aatgaagaaa acactgatgg tacaaatgga tgcagtaaag tgcgcactgg
      241 cactcagaat gaagccgcat tgctggctct catggaaaag actggctaca acatggtcca
      301 agaaaatggg caaaggaaat ttggtggtcc tcctccaggt tgggaaggtc cacctccccc
      361 tagaggttgt gaagtttttg ttggaaaaat acctcgtgat atgtatgaag atgaactggt
      421 tcctgtattt gaaagagctg ggaagatata tgaatttaga ctgatgatgg aatttagtgg
      481 tgaaaataga ggttatgctt ttgtgatgta tactactaaa gaagaagccc aattagccat
      541 ccggattctt aacaattatg aaattcgacc agggaagttt attggtgtgt gtgtaagctt
      601 ggataattgc agattattta ttggagcaat tcccaaagaa aagaaaaagg aagaaatttt
      661 ggatgaaatg aagaaagtta ccgaaggtgt tgtggatgtg attgtttatc caagtgcaac
      721 tgacaaaacc aagaaccgtg ggtttgcctt tgttgagtat gagtcccaca gagctgctgc
      781 tatggccagg agaaagctga ttccaggaac atttcaactc tggggccaca ccattcaggt
      841 agattgggct gatccagaga aagaagttga tgaggaaacc atgcaaagag ttaaagttct
      901 gtatgtaaga aatctaatga tctcaactac agaggagaca attaaagcag agttcagtaa
      961 attcaagcct ggcgcagtgg agcgagtgaa gaaactgaga gattatgcct ttgttcactt
     1021 tttccaccga gaagatgcag tggctgccat gtctgtgatg aatggaaagt gcattgatgg
     1081 agccagtatt gaggtaaccc tggcaaagcc agtaaataag gaaaatactt ggcgacagca
     1141 tcttaatggc cagatcagcc ccaattctga aaacctactt gtatatgcta acaaggaaga
     1201 gagtcactcc aaaagtctag gcaagccacc aactctcccc actcgtctca atggtcagca
     1261 tagtccaagc ccccctgaga ttgaaagatg tacttaccct ttttttcctg gaacaaagct
     1321 gaccccaatt agtatgtatt ctttaaaatc caatcatttt aattctgcag tgatgcattt
     1381 ggattattac tgcaacaaaa ataattgggc accaccagaa tattatttat attcaacaac
     1441 cagtcaggat gggaaagtac tcttggtgta caagatagtt atccctgcaa tcgcaaatgg
     1501 atctcagagt tacttcatgc cagataaact ctgcacaacg ctggaggatg caaaggagct
     1561 ggcagctcag tttacactgc ttcatttgga cagggaacac agtctcttca gcctggacct
     1621 gtgtagaaga atttggagga aataagcagg tcctttctga tgttgcttga gcttattctc
     1681 ctgcagttgg tctcactcct gttcgttaaa cattaagtta atcctcatgt gttgtagacc
     1741 tcatagtgaa tgttattgga ggctgaaagc ttgacctgta tagtaaatga tcttattcaa
     1801 ttttttccat ttcaacaata gcacaacttt taaaaatgat cattttatag acacagtcaa
     1861 ccactttgac ttatgctata gtaaagagca tagttgagtt tttggaaagt ccaggatcta
     1921 caaatttggt caataaaaca cacacctaca gaattactac aattaaggaa acaggaaatt
     1981 attggtgcat aagatgaacg tttgtttgaa attaatattt caaatataat tgttttaata
     2041 atttggttaa ttttggataa ttttctatac tattaagttg ataatggttt ttgacgttct
     2101 tttggtagag atgattcatt ttactgtttt gtggtaactg tgagactcta atgttaaatt
     2161 gatgtttggt tgtatgaatg tttgtgccag catttaaata atgaaatttt ggacagttag
     2221 tttatatcag aagtccaagg gcaaatgctt atgctggttt gatatctaat atgtttttaa
     2281 aaaaaaaaaa aaaaggaaaa aagaaaagaa actgaattca ctgttctttt atctttttct
     2341 tcatgatcta cccttggtgt cagatccaat ttaagagaaa ctttttgttg attaaagaga
     2401 aatcagaggt tctctttttc tgtgttaaaa agaaaaagat acccaaaatg cactgtagtt
     2461 agaccgttca aacagtgttg ggaagaaccc tgacttgatg taactgctgg tgtttgcact
     2521 gcagagatag taatccacca tcattacagt agcatcaggt atttaaatgt tagaacatta
     2581 tgttaaaacg tgattgtctt ttgaatgttt tgtcttttga attaaatttg tgtccacaaa
     2641 gatgtgcagc ataactgttc atatatttat ttacagactt caatttccgt cgcagctcaa
     2701 taaatagtct ttcccctgtt agcactaccc tctcttctgg gactcccagc atgcttcctt
     2761 acacatcaag gccttcttct tatccaagct atcccttgtc accaacaata tcacttgcta
     2821 atggcagcca tgttggacaa cgactgtata tctccaatca ggcctcattc ttctgaagaa
     2881 agtctggata tagtatataa acttcccttt gtataaggcg tggaaattaa catactgttg
     2941 tattttagaa ttgggtttgc acatgtgact ttaaaagcaa atattttaac atattaaaca
     3001 gctataattc agaatgacaa gagtggtagg atttgcagaa atgcaattaa aagttactca
     3061 gtgatagcaa actactactg ttatttttaa gctttggggg tttccaattc ctgagcttga
     3121 aaggattcct gttgtttatg atttttgtat aacaactttg taaaacagca ttttacaaat
     3181 attgaaagta cttaaagaca gtggttgtac tagattagat taccaaggat cgctatctat
     3241 agtggagttt gaaacagtta tgtaaccaga agcatctaac tattatgtaa aaagaaatga
     3301 tgagacaaaa aagattaaga tgcaaatttt tggcagaagt aatgaaaaat cagtctacct
     3361 ttgtggtcct tgaaagtaag caaatatttt agttaatatt tgttacagaa ataaattaaa
     3421 actttgctgt taatatattt aaggttttta tagttataat tcatttatgt tttgatattc
     3481 attacattgt ttacataaga agtgttaatg ttttttaaat gttgaaatca tgtgttgttt
     3541 aatttttata cttcaaattc ttcaacatta aatatatggc actact
//
