LOCUS       NM_001290122            2594 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus RNA binding motif protein 4 (Rbm4), transcript variant
            2, mRNA.
ACCESSION   NM_001290122
VERSION     NM_001290122.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2594)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2594)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2594)
  AUTHORS   Xu,M., Li,B., Huang,J., Jia,R. and Guo,J.
  TITLE     The N6-methyladenosine demethylase FTO is required for odontoblast
            differentiation in vitro and dentine formation in mice by promoting
            RUNX2 exon 5 inclusion through RBM4
  JOURNAL   Int Endod J 56 (12), 1534-1549 (2023)
   PUBMED   37698901
  REMARK    GeneRIF: The N6-methyladenosine demethylase FTO is required for
            odontoblast differentiation in vitro and dentine formation in mice
            by promoting RUNX2 exon 5 inclusion through RBM4.
REFERENCE   4  (bases 1 to 2594)
  AUTHORS   Tsai,Y.Y., Shen,C.L., D,D., Tsai,C.Y. and Tarn,W.Y.
  TITLE     Activation of TrkB signaling mitigates cerebellar anomalies caused
            by Rbm4-Bdnf deficiency
  JOURNAL   Commun Biol 6 (1), 910 (2023)
   PUBMED   37670183
  REMARK    GeneRIF: Activation of TrkB signaling mitigates cerebellar
            anomalies caused by Rbm4-Bdnf deficiency.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2594)
  AUTHORS   Zhang,L., Zhang,L., Li,S., Zhang,Q., Luo,Y., Zhang,C., Huan,Q. and
            Zhang,C.
  TITLE     Overexpression of mm9_circ_013935 alleviates renal inflammation and
            fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis
  JOURNAL   Can J Physiol Pharmacol 99 (11), 1199-1206 (2021)
   PUBMED   34197715
  REMARK    GeneRIF: Overexpression of mm9_circ_013935 alleviates renal
            inflammation and fibrosis in diabetic nephropathy via the
            miR-153-3p/NFIC axis.
REFERENCE   6  (bases 1 to 2594)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (bases 1 to 2594)
  AUTHORS   Lin,J.C. and Tarn,W.Y.
  TITLE     Exon selection in alpha-tropomyosin mRNA is regulated by the
            antagonistic action of RBM4 and PTB
  JOURNAL   Mol Cell Biol 25 (22), 10111-10121 (2005)
   PUBMED   16260624
REFERENCE   8  (bases 1 to 2594)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 2594)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (bases 1 to 2594)
  AUTHORS   Jackson,F.R., Banfi,S., Guffanti,A. and Rossi,E.
  TITLE     A novel zinc finger-containing RNA-binding protein conserved from
            fruitflies to humans
  JOURNAL   Genomics 41 (3), 444-452 (1997)
   PUBMED   9169144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN670081.1, DV660645.1, AK049659.1 and BM932360.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 all encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.58148.1,
                                           SRR1660815.30659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               CN670081.1         97-207
            112-669             DV660645.1         1-558
            670-2570            AK049659.1         667-2567
            2571-2594           BM932360.1         489-512
FEATURES             Location/Qualifiers
     source          1..2594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.11 cM"
     gene            1..2594
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
                     /note="RNA binding motif protein 4"
                     /db_xref="GeneID:19653"
                     /db_xref="MGI:MGI:1100865"
     exon            1..194
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
                     /inference="alignment:Splign:2.1.0"
     exon            195..617
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1291
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
                     /note="isoform a is encoded by transcript variant 2;
                     RNA-binding protein 4; lark homolog; RNA-binding motif
                     protein 4a"
                     /codon_start=1
                     /product="RNA-binding protein 4 isoform a"
                     /protein_id="NP_001277051.1"
                     /db_xref="CCDS:CCDS29436.1"
                     /db_xref="GeneID:19653"
                     /db_xref="MGI:MGI:1100865"
                     /translation="MVKLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIED
                     KTAAEDAIRNLHHYKLHGVNINVEASKNKSKASTKLHVGNISPTCTNQELRAKFEEYG
                     PVIECDIVKDYAFVHMERAEDAVEAIRGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQS
                     GCYRCGKEGHWSKECPIDRSGRVADLTEQYNEQYGAVRTPYTMSYGDSLYYNNTYGAL
                     DAYYKRCRAARSYEAVAAAAASAYSNYAEQTLSQLPQVQNTAMASHLTSTSLDPYNRH
                     LLPPSGAAAAAAAAAACTAASTSYYGRDRSPLRRATGPVLTVGEGYGYGHDSELSQAS
                     AAARNSLYDMARYEREQYADRARYSAF"
     exon            618..1299
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..2574
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1694..1699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
                     /note="hexamer: AATAAA"
     polyA_site      1714
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
                     /note="major polyA site"
     regulatory      2506..2511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
                     /note="hexamer: AGTAAA"
     regulatory      2524..2529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
                     /note="hexamer: GATAAA"
     polyA_site      2535
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
     polyA_site      2551
                     /gene="Rbm4"
                     /gene_synonym="4921506I22Rik; lark; Lark1; Mlark; Rbm4a"
ORIGIN      
        1 gtaattggcg ttccgggtaa ccaatcagga agaggatctc cgggaacgcc agccttttac
       61 tttaccgaac ggccaatccg gtgggtaggt tcacccctct ttctacccag agtcactgct
      121 gtggccgccg ccattttagc gttttgtcag aaccgtccgc gctgcaagga ggaggacctg
      181 caggtatcca tgcggctgtg tggagatggt gaagctgttc attggaaatc tgccccggga
      241 ggccacagag caggagatcc gctcactctt cgagcagtac gggaaggtgc tggaatgtga
      301 catcattaag aattatggct ttgtgcacat agaggacaag acggccgctg aggatgccat
      361 acgcaacctg caccactaca agctgcacgg agtgaacatc aatgtggaag ccagcaagaa
      421 taagagcaaa gcttcaacca agttacacgt gggcaacatc agccccactt gtaccaacca
      481 agagcttcgg gccaagtttg aggagtacgg cccagtcatc gaatgtgaca tcgtgaaaga
      541 ttatgccttt gtacacatgg agcgggcaga ggatgcggtg gaggccatca ggggcctcga
      601 caacacagag tttcaaggca aacgaatgca cgtgcagttg tccaccagcc ggcttaggac
      661 cgcgcccggg atgggagacc agagcggctg ctatcggtgc gggaaagagg ggcactggtc
      721 caaagagtgt ccaatagatc gttcgggccg cgtggcagac ttgaccgagc aatataatga
      781 gcaatatgga gcagtgcgta cgccttacac catgagttat ggggattcat tgtattacaa
      841 caacacgtac ggagcgctcg atgcctacta caagcgctgc cgtgctgccc ggtcctatga
      901 ggcagtggca gctgcagctg cctctgcgta tagtaactat gcagagcaga ctttgtctca
      961 gctgccacaa gtccagaaca cagccatggc cagtcacctc acctccacct ctctcgatcc
     1021 ctacaataga catctgttgc cgccttcagg agctgcagca gcagcagcag ctgctgctgc
     1081 ttgtactgca gcttctactt catattacgg gcgggatcgg agccccctgc gtcgcgctac
     1141 aggcccagtc ctcactgttg gagagggcta cggttacggg catgacagtg agttgtccca
     1201 agcttcagca gctgctcgga attccctgta cgacatggcc cggtatgagc gggagcagta
     1261 tgcggatcgg gcgcggtact cagcctttta aagtttgagg tgggatgtgt gtgggctgaa
     1321 atcccaagct gcggttgtgc atgagaatac acccttcgtg gtgccccatc tccgggacgt
     1381 tctcggctct gtgcattcag tccccaggaa ccgtggacct taatttacct tgttaagttc
     1441 tttctctttc ctattctctc tcctgctcaa tttcctgttc tcctgtttgc tcttctgtag
     1501 cttccccttt gagttctgct ctcccagcat gcctcctatg cagaaaccgg tggggctgtg
     1561 ctgtctcctc ccttcctcct gactgcagtc agtgggtatt ggatttggga gtgaccttgt
     1621 tgagaatcac tgctcctagt tttctatttt ggcccaaaga ctagacttag aaatttggag
     1681 caccttccag tgaaataaat ggtttttcaa attagggtat gtgtgctttg agaaagttct
     1741 tgtttgggct tgtttctggg ttctttattt atttgtaccc tgaacagaag atgggggagt
     1801 gtttaaagtt taagctactt agcttttggc taacactgag gtttttaaat tttgcttttt
     1861 aaaatagtag atgactttag gtactaaatt aaaaaaagag gttctacaga actcaagtag
     1921 gcatctctgt ttcaatgaag acatctccta ctggtctact tctgttgaag ccagttagct
     1981 agtggtttag agctgtagat ctttacttgc tggagaatta atcattgtgt atacttgcat
     2041 ctgctgttaa cactcagtaa acatatctcc cttgacttat tttcaggaaa aaggtgaagg
     2101 tttgaggaag aagaggtagc tttcatcttt gggaaaaatg aaggtatggc tcccacagag
     2161 ttatttagct actccatagg ccagaactac ctcatgatgc acttcactat ttatagttct
     2221 gccaaaatca agagactgca ttccacaagc atctcatagc ttgtacttaa tgccttcaga
     2281 tgaggtataa agggcccagc gggtcctttg taagtccttg ataaacttac tgagtcttta
     2341 acagtgaaga caagtatttg gattcagtga ggagccactg tttagtgtca tgtttttatt
     2401 gaaacagttt attttctatg ttttatttta acatatatag ggcctcgtct cagaatcatt
     2461 tatttgacca ctactggata cctatgttgt gtcaggcatg cttttagtaa agggctcatt
     2521 aatgataaaa ggaaatatga tagagataaa agatgaaata aagatgagat aagaaaaaaa
     2581 aaaaaaaaaa aaaa
//
