LOCUS       NM_001166410            1341 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus RNA binding motif (RNP1, RRM) protein 3 (Rbm3),
            transcript variant 3, mRNA.
ACCESSION   NM_001166410
VERSION     NM_001166410.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1341)
  AUTHORS   Dey,P., Rajalaxmi,S., Saha,P., Thakur,P.S., Hashmi,M.A., Lal,H.,
            Saini,N., Singh,N. and Ramanathan,A.
  TITLE     Cold-shock proteome of myoblasts reveals role of RBM3 in promotion
            of mitochondrial metabolism and myoblast differentiation
  JOURNAL   Commun Biol 7 (1), 515 (2024)
   PUBMED   38688991
  REMARK    GeneRIF: Cold-shock proteome of myoblasts reveals role of RBM3 in
            promotion of mitochondrial metabolism and myoblast differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1341)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1341)
  AUTHORS   Feng,J., Long,M., Zhao,X., Yan,P., Lin,Y., Wang,M. and Huang,W.
  TITLE     RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2
            Signaling
  JOURNAL   Curr Mol Pharmacol 17 (1), e18761429260980 (2024)
   PUBMED   37982286
  REMARK    GeneRIF: RBM3 Accelerates Wound Healing of Skin in Diabetes through
            ERK1/2 Signaling.
REFERENCE   4  (bases 1 to 1341)
  AUTHORS   Zhang,Z., Liu,X., Yang,Z. and Mo,X.
  TITLE     Study on the protective effect of RNA-binding motif protein 3 in
            mild hypothermia oxygen-glucose deprivation/reoxygenation cell
            model
  JOURNAL   Cryobiology 112, 104544 (2023)
   PUBMED   37211323
  REMARK    GeneRIF: Study on the protective effect of RNA-binding motif
            protein 3 in mild hypothermia oxygen-glucose
            deprivation/reoxygenation cell model.
REFERENCE   5  (bases 1 to 1341)
  AUTHORS   Haniffa,S., Narain,P., Hughes,M.A., Petkovic,A., Susic,M.,
            Mlambo,V. and Chaudhury,D.
  TITLE     Chronic social stress blunts core body temperature and molecular
            rhythms of Rbm3 and Cirbp in mouse lateral habenula
  JOURNAL   Open Biol 13 (7), 220380 (2023)
   PUBMED   37463657
  REMARK    GeneRIF: Chronic social stress blunts core body temperature and
            molecular rhythms of Rbm3 and Cirbp in mouse lateral habenula.
REFERENCE   6  (bases 1 to 1341)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 1341)
  AUTHORS   Means,G.D., Toy,D.Y., Baum,P.R. and Derry,J.M.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
REFERENCE   8  (bases 1 to 1341)
  AUTHORS   Danno,S., Itoh,K., Matsuda,T. and Fujita,J.
  TITLE     Decreased expression of mouse Rbm3, a cold-shock protein, in
            Sertoli cells of cryptorchid testis
  JOURNAL   Am J Pathol 156 (5), 1685-1692 (2000)
   PUBMED   10793079
REFERENCE   9  (bases 1 to 1341)
  AUTHORS   Derry,J.M., Gormally,E., Means,G.D., Zhao,W., Meindl,A.,
            Kelley,R.I., Boyd,Y. and Herman,G.E.
  TITLE     Mutations in a delta 8-delta 7 sterol isomerase in the tattered
            mouse and X-linked dominant chondrodysplasia punctata.
            jderry@immunex.com
  JOURNAL   Nat Genet 22 (3), 286-290 (1999)
   PUBMED   10391218
REFERENCE   10 (bases 1 to 1341)
  AUTHORS   Derry,J.M., Kerns,J.A. and Francke,U.
  TITLE     RBM3, a novel human gene in Xp11.23 with a putative RNA-binding
            domain
  JOURNAL   Hum Mol Genet 4 (12), 2307-2311 (1995)
   PUBMED   8634703
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663032.9, BC106176.1 and BB050916.1.
            
            On Jun 12, 2014 this sequence version replaced NM_001166410.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 3' coding region and alternate 3' terminal exon,
            compared to variant 1. The encoded protein (isoform 2) has a
            shorter protein, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106176.1, AB016424.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AL663032.9         98109-98252         c
            145-1334            BC106176.1         1-1190
            1335-1341           BB050916.1         234-240
FEATURES             Location/Qualifiers
     source          1..1341
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.68 cM"
     gene            1..1341
                     /gene="Rbm3"
                     /gene_synonym="2600016C11Rik"
                     /note="RNA binding motif (RNP1, RRM) protein 3"
                     /db_xref="GeneID:19652"
                     /db_xref="MGI:MGI:1099460"
     exon            1..243
                     /gene="Rbm3"
                     /gene_synonym="2600016C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            244..361
                     /gene="Rbm3"
                     /gene_synonym="2600016C11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..720
                     /gene="Rbm3"
                     /gene_synonym="2600016C11Rik"
                     /note="isoform 2 is encoded by transcript variant 3;
                     putative RNA-binding protein 3; RNA binding motif protein
                     3"
                     /codon_start=1
                     /product="RNA-binding protein 3 isoform 2"
                     /protein_id="NP_001159882.1"
                     /db_xref="CCDS:CCDS52988.1"
                     /db_xref="GeneID:19652"
                     /db_xref="MGI:MGI:1099460"
                     /translation="MSSEEGKLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQ
                     RSRGFGFITFTNPEHASDAMRAMNGESLDGRQIRVDHAGKSARGSRGGAFGGRGRSYS
                     RGGGDQGYGSGRYDSRPGGYGYGYGRSRDYSGSQGGYDRYSGGNYRDNYDN"
     exon            362..468
                     /gene="Rbm3"
                     /gene_synonym="2600016C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            469..568
                     /gene="Rbm3"
                     /gene_synonym="2600016C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            569..662
                     /gene="Rbm3"
                     /gene_synonym="2600016C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            663..741
                     /gene="Rbm3"
                     /gene_synonym="2600016C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1341
                     /gene="Rbm3"
                     /gene_synonym="2600016C11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1309..1314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm3"
                     /gene_synonym="2600016C11Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1338
                     /gene="Rbm3"
                     /gene_synonym="2600016C11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gctcctctcg attcccggaa gcggcgaggc aaattgctgc ctccgccttc ctcgtcctct
       61 tcccaacccc ccccccccgc tggcctcaac caatgagcac gcacgccagg gcgcgctggg
      121 ggacgttgtg tgacgtctcg gctacgcacg ctttatcagg cgtcttcccg cgccgcagtc
      181 tctctgttct cccggttcct tcgagctcgt cgtctctgcc gtcctctgac ttttaatttc
      241 caggacttgc cttctgccat gtcgtctgaa gaagggaaac tcttcgtagg agggctcaac
      301 ttcaacaccg atgaacaggc acttgaagac cacttcagca gctttgggcc tatctctgag
      361 gtggttgttg tcaaggaccg ggagactcaa agatcccggg gttttggctt catcaccttc
      421 acaaacccag agcatgcctc agatgcgatg agagctatga atggagagtc cctggatggg
      481 cgccaaatcc gagttgatca tgcaggaaag tctgccaggg gatccagagg gggtgccttt
      541 ggtgggcgtg gtcgcagtta ctctagaggt ggtggagacc agggatatgg aagtggaaga
      601 tatgacagtc gtcctggagg atatggatat gggtatgggc ggtctagaga ctacagtggc
      661 agccagggtg gctatgaccg ctactcagga ggaaattaca gagacaatta tgacaactga
      721 gatggggcat gcacacaaaa tatacacaag gaataacact tctgatccag gatcgtcctt
      781 gcaaattgct gtatttataa agatttttgg agctgcgctg aaacgtctgt tttagtacat
      841 caagttctat ttttgaattg agctcccaag gtagtttgtt aaagaacttt tagaaagctc
      901 catgtgttct ttaaacattt tttccctttt aaaaacaaat tttaagacat ttgttacagt
      961 cccaatattt ttccttttat cagaattttt gtttaggcac tcaggattat tgtttctggc
     1021 caaaagaaaa aagtggccag gctaaatcag tttttaaagt tgatgtgtat ttagggacat
     1081 tttaaaacct tgtaaacaat gtttatcatg gccagaaagt gatttctgaa tgtacctatg
     1141 aacaatccga gtcaagatca tgattgctta gagatgtttt ttattaaaga tcaccatcct
     1201 gattatatag aagagcttct ttaaaatgtt tgtgaatgtc attttttaat actggaagaa
     1261 aagtattctg ttgtgtctga tgtgtttagg atgtccttta tggagctaat taaaagatga
     1321 aacctgaaca caaatcaata c
//
