LOCUS       NM_027349               4239 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus RNA binding motif protein 25 (Rbm25), transcript
            variant 3, mRNA.
ACCESSION   NM_027349 NM_025930 XM_619008 XM_899912 XM_899918 XM_899944
            XM_899951 XM_899969 XM_899976 XM_899982 XM_899986 XM_899997
            XM_900002 XM_900007 XM_919810 XM_919850 XM_919858 XM_919864
            XM_919876 XM_919885 XM_919900 XM_919911 XM_919919 XM_919927
            XM_919939 XM_919951 XM_992209 XM_992232 XM_992280 XM_992299
            XM_992326 XM_992357 XM_992385 XM_992405 XM_992432 XM_992459
VERSION     NM_027349.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4239)
  AUTHORS   Zhang,Y., Gao,Y., Wang,Y., Jiang,Y., Xiang,Y., Wang,X., Wang,Z.,
            Ding,Y., Chen,H., Rui,B., Huai,W., Cai,B., Ren,X., Ma,F., Xu,S.,
            Zhan,Z. and Liu,X.
  TITLE     RBM25 is required to restrain inflammation via ACLY RNA
            splicing-dependent metabolism rewiring
  JOURNAL   Cell Mol Immunol 21 (11), 1231-1250 (2024)
   PUBMED   39251781
REFERENCE   2  (bases 1 to 4239)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4239)
  AUTHORS   Bramlett,C., Eerdeng,J., Jiang,D., Lee,Y., Garcia,I.,
            Vergel-Rodriguez,M., Condie,P., Nogalska,A. and Lu,R.
  TITLE     RNA splicing factor Rbm25 underlies heterogeneous preleukemic
            clonal expansion in mice
  JOURNAL   Blood 141 (24), 2961-2972 (2023)
   PUBMED   36947858
  REMARK    GeneRIF: RNA splicing factor Rbm25 underlies heterogeneous
            preleukemic clonal expansion in mice.
REFERENCE   4  (bases 1 to 4239)
  AUTHORS   Ge,Y., Schuster,M.B., Pundhir,S., Rapin,N., Bagger,F.O.,
            Sidiropoulos,N., Hashem,N. and Porse,B.T.
  TITLE     The splicing factor RBM25 controls MYC activity in acute myeloid
            leukemia
  JOURNAL   Nat Commun 10 (1), 172 (2019)
   PUBMED   30635567
  REMARK    GeneRIF: tumor suppressive function in acute myeloid leukemia
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4239)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4239)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 4239)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4239)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY169048.1, CJ063347.1, AK011403.1, AK142132.1 and AC055772.16.
            
            On Jun 16, 2018 this sequence version replaced NM_027349.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.121710.1,
                                           SRR1660815.265427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY169048.1         12-29
            19-514              CJ063347.1         21-516
            515-1074            AK011403.1         505-1064
            1075-4235           AK142132.1         360-3520
            4236-4239           AC055772.16        49057-49060         c
FEATURES             Location/Qualifiers
     source          1..4239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 38.81 cM"
     gene            1..4239
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /note="RNA binding motif protein 25"
                     /db_xref="GeneID:67039"
                     /db_xref="MGI:MGI:1914289"
     exon            1..175
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            176..296
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..2707
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /note="isoform 2 is encoded by transcript variant 3;
                     RNA-binding protein 25"
                     /codon_start=1
                     /product="RNA-binding protein 25 isoform 2"
                     /protein_id="NP_081625.3"
                     /db_xref="CCDS:CCDS49107.1"
                     /db_xref="GeneID:67039"
                     /db_xref="MGI:MGI:1914289"
                     /translation="MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPM
                     SIMAPAPTVLVPTVSMVGKHLGARKDHPGLKLKENDENCGPTTTVFVGNISEKASDML
                     IRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVK
                     VDAKTKAQLDEWKAKKKANGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYS
                     SELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLI
                     SREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERER
                     EKEKERERERERDRDRDRTKERDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER
                     EREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEA
                     AYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYY
                     RGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAER
                     RRQPQIKQEPESEEEEEEKQEKEEKREEPVEEEEEPEQKPCLKPTLRPISSAPSVSSA
                     SGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRK
                     KLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKI
                     PTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSS
                     PQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK"
     exon            297..346
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            347..514
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            515..572
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            573..730
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            731..916
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            917..970
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1054
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1335
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1552
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1642
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1716
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1867
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2192
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2467
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2566
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2614
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..4239
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3008..3013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /note="hexamer: ATTAAA"
     polyA_site      3025
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
     regulatory      4168..4173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /note="hexamer: ATTAAA"
     polyA_site      4188
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /note="major polyA site"
     regulatory      4218..4223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
                     /note="hexamer: AATAAA"
     polyA_site      4239
                     /gene="Rbm25"
                     /gene_synonym="2600011C06Rik; 2610015J01Rik;
                     A130095G20Rik; RNPC7"
ORIGIN      
        1 aagccctcca ggagctcccc gcgcagcgcg gctgtgtttt gcggcctagg cgagtaggcg
       61 cttcggaacc agtctctaga gtcgggcggc gcgcagacac ctcgaaccgg tggagcccca
      121 ctccatcacc tgacgcccag aggccgcgaa gacagtaccg ttttcttagc ggcggactgg
      181 tgcagtcaga atgtctttcc cccctcattt gaatcgccct cccatgggaa tcccagctct
      241 ccctccaggg atcccacccc cacagtttcc tggctttcct ccaccagtac ctccagggac
      301 accgatgatt cctgtaccaa tgagtattat ggctcctgct ccaactgtcc tagtacctac
      361 cgtgtccatg gttggaaagc atttgggagc cagaaaggat catccaggct taaaattaaa
      421 agaaaatgat gaaaattgtg gccctactac tacagttttt gttgggaaca tttctgagaa
      481 ggcttcagac atgcttatac gacagctctt agctaaatgt ggtttggtgt tgagctggaa
      541 gagagtgcaa ggtgcttctg ggaaacttca agcttttgga ttttgtgagt ataaagagcc
      601 tgaatctacc ctccgtgctc tcagattatt gcatgacctt cagattggag agaagaagct
      661 acttgttaaa gttgatgcca agacaaaggc acagttggat gaatggaaag caaagaagaa
      721 agctaatggg aacgccagac cagaaactgt cactaatgat gatgaagaag ccttagatga
      781 agaaacaaag cgaagagacc agatgattaa aggggccatt gaagttttaa tccgagaata
      841 ttccagtgaa ctaaatgccc cctcacagga gtctgactct caccccagaa agaagaaaaa
      901 ggaaaagaag gaggacattt tccgtagatt tccagtggcc ccattgatcc cttacccact
      961 catcaccaag gaggatataa atgctattga aatggaagaa gacaaaagag atttgatatc
     1021 ccgagagatc agcaaattca gagatacaca caagaaactg gaagaagaga aaggcaaaaa
     1081 agaaaaagaa agacaggaaa ttgagaaaga acggagagaa agagagaggg aacgtgaaag
     1141 ggaacgagaa aggcgagaac gggaacgaga aagggaaaga gaacgtgaac gagaaaagga
     1201 aaaagaacgg gagcgggaac gagaacggga tagggatcgt gaccgcacaa aagagagaga
     1261 ccgagatcga gagagagatc gggaccgaga tcgagaacgg agctcagatc gaaataagga
     1321 tcggagtcga tcaagagaaa aaagcagaga tcgtgaaagg gaacgggagc gggaaagaga
     1381 gagagaacga gaacgggaac gagaacgaga gcgagagaga gaacgggaga gagaacggga
     1441 acgggaaaga gagaaagaca agaaaagaga cagagaagag gatgaagaag atgcatatga
     1501 acgaagaaaa ctcgaacgaa aactgcgaga gaaagaggct gcttatcaag agcgccttaa
     1561 gaattgggaa atcagagaac gaaagaaaac tagggaatat gagaaggagg cagaaagaga
     1621 agaagaaaga agaagagaaa tggctaagga ggctaaacga ctaaaagaat tcctagaaga
     1681 ttatgatgat gatagagatg acccgaagta ctacaggggt agtgctcttc agaaacggtt
     1741 gcgtgatagg gaaaaagaaa tggaagctga tgaacgagac aggaagagag agaaggaaga
     1801 gcttgaggaa atcaggcagc gcttactggc agaagggcat ccagatccag atgcagagct
     1861 ccagaggatg gaacaagagg ctgagaggcg caggcaacct caaataaagc aagaaccaga
     1921 atccgaggaa gaagaagaag aaaagcaaga aaaagaagaa aaacgagagg agcctgtgga
     1981 agaggaggaa gaaccagagc aaaagccttg tctcaagccg actttgagac ccatcagctc
     2041 tgccccatct gtgtcctctg ccagtggcaa cgcaaccccc aacactcctg gggatgagtc
     2101 tccttgtggt attattattc ctcatgaaaa ctcaccagat caacagcagc ctgaggagca
     2161 taggccaaaa ataggactaa gccttaaatt gggtgcttcc aatagtcctg gccaacctaa
     2221 ttcagtgaag agaaagaaac tacctgtaga tagtgtcttt aacaaattcg aggatgagga
     2281 cagtgatgat gtgccccgaa aaaggaaact cgttcccctg gattatggcg aagatgataa
     2341 aaatgccacc aaaggcactg taaacactga agaaaagcgc aaacacatta agagtctcat
     2401 tgagaaaatt cccacagcca aacctgagct ctttgcttat cctttggatt ggtctattgt
     2461 ggattctata ctgatggaac gaagaatccg gccatggatc aataagaaaa tcatcgaata
     2521 cataggtgaa gaagaagcta cattagttga ttttgtttgc tctaaggtta tggcacatag
     2581 ttcaccacag agcattttag atgatgttgc catggtacta gatgaagaag cagaagtttt
     2641 tatagtcaaa atgtggagat tattgatata tgaaacagaa gccaagaaaa ttggccttgt
     2701 gaagtaaaac tttttacatt cagagttaca tttcagattt cttctttcac acccttcaaa
     2761 ggactttgaa ttttcggtgt cttcaaagac atttgtgaga tctgtaattt tttaatgtag
     2821 aaaatgtgaa ttcttttgtc ctctaatttg ttgatgctct gtgtactcac tcgggtgtaa
     2881 agccatctgt gtccttggtc ctctttatgc tcaccaggca cagactactg gtgtgtttta
     2941 taagctgcag ctactgtaca cagcctatct gatagcatct tgttctgctg atttgttcct
     3001 tgtaaatatt aaaatggctc cccaattctt ttgcagaatt ctacttacta ttaaaactgt
     3061 attgtatagg cgccaacatg aataagttga atactagtca tacccttaca gcctcgttcc
     3121 cactttcctg atcagaaatg gcaagccctt gtaaaggcat ggagtttaaa attagagtgc
     3181 aaaacctagc agacaggtcc ttcctaatgt atctctgtat taatgtgttt atgtgaatgt
     3241 atgtataaaa gtcttttttt taattttttt ggtgggctcc cttaaacatt tcgtaatcat
     3301 caatgcacac ataaaggaaa agtgataatt gtgccaaccc aaatacctag gataattacg
     3361 gtgtattttc cagagactgg tattctgctg tgagcaacac actgctgacc agttttgtgt
     3421 tcttctgtgt ataggatgat acatcataat cttatccctc cctccacctg atggctcaga
     3481 attgaagcag agtctagaat tctggagcat tttgctcaat atattttcaa cttgtcttca
     3541 tttaattttg gcatattcat tttaataaaa caattccaga agtgtaaggt ggggggagga
     3601 gctcactttc ttatgacggg gatgacctca gtgagagagc tatgcttgct tagcatgaac
     3661 gagggcctgg gttctattcc ccgtaccaat aaagaagtga ataaggtaag tttacaaaag
     3721 agatttgaca aaacacaata gtagttaatt caccatggta gttaaaaatg tttacatctt
     3781 tcttccaaag atacatcatc caagacacat tcaagacaat tttctgctca caaaatttta
     3841 ttactggtca tcaagcttta actatattga tgacaagaaa tccttggact ttattagtaa
     3901 ttcagaagat cactaggggc aaaatttatt tgaaaagtac caagttctaa acagctctgt
     3961 caagaaatta ggtgtggctg ctgccatgtt tgcttactaa aaagataaag actgagttgt
     4021 tagaataatg aaactgtgag cttgagttac tagggttttt ggtttttgtt ttgtcttttt
     4081 ttttttttta aacatttgag aggacgtcca aaacactgtt tttaatgttc aaccttgaca
     4141 tggtttcatt atgtaaatat ttcagttatt aaaaatgtat atatttgatc ttggagatgc
     4201 tttctttgag tcttgtaaat aaatgacatt atgttataa
//
