LOCUS       NM_001170847            6607 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RNA binding motif protein 20 (Rbm20), mRNA.
ACCESSION   NM_001170847 XM_001002314 XM_001481268
VERSION     NM_001170847.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6607)
  AUTHORS   Li,Y., Ma,K., Dong,Z., Gao,S., Zhang,J., Huang,S., Yang,J.,
            Fang,G., Li,Y., Li,X., Welch,C., Griffin,E.L., Ramaswamy,P.,
            Valivullah,Z., Liu,X., Dong,J., Wang,D.W., Du,J., Chung,W.K. and
            Li,Y.
  TITLE     Frameshift variants in C10orf71 cause dilated cardiomyopathy in
            human, mouse, and organoid models
  JOURNAL   J Clin Invest 134 (12), e177172 (2024)
   PUBMED   38950288
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6607)
  AUTHORS   Timpani,C.A., Debrincat,D., Kourakis,S., Boyer,R., Formosa,L.E.,
            Steele,J.R., Zhang,H., Schittenhelm,R.B., Russell,A.P., Rybalka,E.
            and Lindsay,A.
  TITLE     Loss of endogenous estrogen alters mitochondrial metabolism and
            muscle clock-related protein Rbm20 in female mdx mice
  JOURNAL   FASEB J 38 (11), e23718 (2024)
   PUBMED   38847487
  REMARK    GeneRIF: Loss of endogenous estrogen alters mitochondrial
            metabolism and muscle clock-related protein Rbm20 in female mdx
            mice.
REFERENCE   3  (bases 1 to 6607)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6607)
  AUTHORS   Gregorich,Z.R., Zhang,Y., Kamp,T.J., Granzier,H.L. and Guo,W.
  TITLE     Mechanisms of RBM20 Cardiomyopathy: Insights From Model Systems
  JOURNAL   Circ Genom Precis Med 17 (1), e004355 (2024)
   PUBMED   38288598
  REMARK    GeneRIF: Mechanisms of RBM20 Cardiomyopathy: Insights From Model
            Systems.
            Review article
REFERENCE   5  (bases 1 to 6607)
  AUTHORS   Grosch,M., Schraft,L., Chan,A., Kuchenhoff,L., Rapti,K.,
            Ferreira,A.M., Kornienko,J., Li,S., Radke,M.H., Kramer,C.,
            Clauder-Munster,S., Perlas,E., Backs,J., Gotthardt,M.,
            Dieterich,C., van den Hoogenhof,M.M.G., Grimm,D. and Steinmetz,L.M.
  TITLE     Striated muscle-specific base editing enables correction of
            mutations causing dilated cardiomyopathy
  JOURNAL   Nat Commun 14 (1), 3714 (2023)
   PUBMED   37349314
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6607)
  AUTHORS   Beraldi,R., Li,X., Martinez Fernandez,A., Reyes,S., Secreto,F.,
            Terzic,A., Olson,T.M. and Nelson,T.J.
  TITLE     Rbm20-deficient cardiogenesis reveals early disruption of RNA
            processing and sarcomere remodeling establishing a developmental
            etiology for dilated cardiomyopathy
  JOURNAL   Hum Mol Genet 23 (14), 3779-3791 (2014)
   PUBMED   24584570
  REMARK    GeneRIF: Study demonstrates that Rbm20 is expressed in early
            cardiogenesis and functions in the patterning of cardiac gene
            expression.
REFERENCE   7  (bases 1 to 6607)
  AUTHORS   Buck,D., Smith,J.E. 3rd, Chung,C.S., Ono,Y., Sorimachi,H.,
            Labeit,S. and Granzier,H.L.
  TITLE     Removal of immunoglobulin-like domains from titin's spring segment
            alters titin splicing in mouse skeletal muscle and causes myopathy
  JOURNAL   J Gen Physiol 143 (2), 215-230 (2014)
   PUBMED   24470489
REFERENCE   8  (bases 1 to 6607)
  AUTHORS   Filippello,A., Lorenzi,P., Bergamo,E. and Romanelli,M.G.
  TITLE     Identification of nuclear retention domains in the RBM20 protein
  JOURNAL   FEBS Lett 587 (18), 2989-2995 (2013)
   PUBMED   23886709
  REMARK    GeneRIF: Nuclear retention domains have been identified in RBM20
            which is a nuclear protein regulating alternative splicing of
            expressed genes.
REFERENCE   9  (bases 1 to 6607)
  AUTHORS   Guo,W., Schafer,S., Greaser,M.L., Radke,M.H., Liss,M.,
            Govindarajan,T., Maatz,H., Schulz,H., Li,S., Parrish,A.M.,
            Dauksaite,V., Vakeel,P., Klaassen,S., Gerull,B., Thierfelder,L.,
            Regitz-Zagrosek,V., Hacker,T.A., Saupe,K.W., Dec,G.W.,
            Ellinor,P.T., MacRae,C.A., Spallek,B., Fischer,R., Perrot,A.,
            Ozcelik,C., Saar,K., Hubner,N. and Gotthardt,M.
  TITLE     RBM20, a gene for hereditary cardiomyopathy, regulates titin
            splicing
  JOURNAL   Nat Med 18 (5), 766-773 (2012)
   PUBMED   22466703
REFERENCE   10 (bases 1 to 6607)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142175.1, CJ099472.1 and BC038663.1.
            
            On or before Jan 6, 2010 this sequence version replaced
            XM_001481268.1, XM_001002314.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849390,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               AK142175.1         2-331
            331-331             CJ099472.1         183-183
            332-2529            AK142175.1         333-2530
            2530-3337           BC038663.1         566-1373
            3338-6607           BC038663.1         1420-4689
FEATURES             Location/Qualifiers
     source          1..6607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 48.28 cM"
     gene            1..6607
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /note="RNA binding motif protein 20"
                     /db_xref="GeneID:73713"
                     /db_xref="MGI:MGI:1920963"
     exon            1..287
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..3702
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /note="probable RNA-binding protein 20"
                     /codon_start=1
                     /product="RNA-binding protein 20"
                     /protein_id="NP_001164318.1"
                     /db_xref="CCDS:CCDS50468.1"
                     /db_xref="GeneID:73713"
                     /db_xref="MGI:MGI:1920963"
                     /translation="MVLAVAMSQDADPSGPEQPDRDACVMPGVQGPSVPQGQQGMQPL
                     PPPPPPQPQASLPQIIQNAAKLLDKSPFSVNNQNPLLTSPASVQLAQIQAQLTLHRLK
                     MAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSVLGTAHGPTGVSQHAASVPSA
                     HFPSTAIAFSPPSQTGGPGPSVSLPSQPPNAMVVHTFSGVVPQTPAQPAVILSLGKAG
                     PTPATTGFYDYGKANSGQAYGSETEGQPGFLPASASATASGSMTYEGHYSHTGQDGQP
                     AFSKDFYGPNAQGPHIAGGFPADQTGSMKGDVGGLLQGTNSQWERPPGFSGQNKPDIT
                     AGPSLWAPPASQPYELYDPEEPTSDRAPPAFGSRLNNSKQGFGCSCRRTKEGQAVLSV
                     RPLQGHQLNDFRGLAPLHLPHICSICDKKVFDLKDWELHVKGKLHAQKCLLFSESAGL
                     RSIRASGEGTLSASANSTAVYNPTGNEDYTSNLGTSYAAIPTRAFAQSNPVFPSASSG
                     TSFAAQRKGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYT
                     EAAQAMVQYYQEKPAIINGEKLLIRMSTRYKELQLKKPGKNVAAIIQDIHSQRERDML
                     READRYGPERPRSRSPMSRSLSPRSHSPPGPSRADWGNGRDSYAWRDEDRETVPRREN
                     GEDKRDRLDVWAHDRKHYPRQLDKAELDERLEGGRGYREKYLKSGSPGPLHSVSGYKG
                     REDGYHRKEPKAKLDKYPKQQPDVPGRSRRKEEARLREPRHPHPEDSGKAEDLEPKIT
                     RAPDGTKSKQSEKSKTKRADRDQEGADDKKESQLAENEAGAEEQEGMVGIQQEGTESC
                     DPENTRTKKGQDCDSGSEPEGDNWYPTNMEELVTVDEVGEEDFIMEPDLPELEEIVPI
                     DQKDKTLPKICTCVTATLGLDLAKDFTKQGETLGNGDAELSLKLPGQVPSTSASCPND
                     TDLEMPGLNLDAERKPAESETGLSLEVSNCYEKEARGEEDSDVSLAPAVQQMSSPQPA
                     DERARQSSPFLDDCKARGSPEDGSHEASPLEGKASPPTESDLQSQACRENPRYMEVKS
                     LNVRSPEFTEAELKEPLSLPSWEPEVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEE
                     AAKVSHCRSTVHYRNLQKYLSQLAEEGLKETEGTDSPSPERGGIGPHLERKKL"
     exon            288..1380
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1442
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1534
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1632
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1776
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1908
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1988
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2610
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2697
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..3337
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3469
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3591
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..6592
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3981..3986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /note="hexamer: CATAAA"
     polyA_site      4003
                     /gene="Rbm20"
                     /gene_synonym="1110018J23Rik; 2010003H22Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaggggactg ggcacaggga ccccggccag tgagcgcttg tgttccggga ccgcccctcc
       61 cgcgcgctct ttcgctgcga gcccgggccg gtgtcgccgc gcatggtgct ggcagtagcc
      121 atgagccagg acgcggatcc cagcggtccg gagcaacccg acagagatgc ctgcgttatg
      181 cccggtgttc aggggccctc cgtgccccag ggccagcaag ggatgcagcc tctgccgcca
      241 ccgccaccgc ctcagcctca agccagcctg ccccagatca tccaaaatgc tgccaagctc
      301 ctggataaga gccccttctc ggtcaataac cagaaccctc tgctcacgtc gccagccagc
      361 gtccagctgg cccagataca ggctcagctc accctccatc ggctgaagat ggcacagacc
      421 gcagtcacca acaacactgc agcggccacg gttctgaacc aagtcctctc caaagtggcc
      481 atgtcccagc ctctcttcaa ccagctccgg catccgtctg tgctcggcac cgcacatggc
      541 cctactgggg tgtcccagca tgctgcctcg gttcccagcg ctcacttccc ctcaaccgca
      601 atcgcctttt cgcccccaag ccagacagga ggcccagggc cttctgtgag cctccccagc
      661 cagcccccca atgctatggt agttcatacc ttcagtggag tggtacctca gacccctgcc
      721 cagccagctg tcatccttag ccttgggaag gctgggccta caccggctac tacagggttc
      781 tatgactatg gcaaagccaa ctccggccaa gcgtatggtt ctgaaacgga gggccagcca
      841 ggcttcttgc cagcctcggc ctcagccaca gcatcaggca gtatgaccta tgaagggcac
      901 tatagccaca cagggcagga tggccaacct gccttttcta aagacttcta tggacccaat
      961 gcccaagggc cacacatagc aggtggattt ccagctgatc agactgggag catgaaggga
     1021 gacgttggtg ggctgttgca aggcaccaac agccagtggg agaggccccc tggattctca
     1081 ggccaaaaca agcccgatat tacagcggga cccagtttgt gggctccacc tgccagccag
     1141 ccttatgagc tctatgaccc tgaagagcct acctcagaca gggcccctcc tgcctttggg
     1201 tctcggctta acaacagcaa gcagggattc ggctgctctt gccgaaggac aaaggaggga
     1261 caggctgtgc tgtccgtgag gcccctgcag ggtcatcaac tgaacgattt ccgaggcttg
     1321 gctccactcc acctaccaca tatctgcagc atctgtgaca agaaggtgtt tgacttgaag
     1381 gactgggagc tacatgtgaa agggaagctg catgcccaga aatgcctgct cttctcagaa
     1441 agtgctggcc tccggagtat acgtgcttca ggagagggga cactgtctgc ctctgctaac
     1501 agcacagctg tttataaccc cactggaaac gaggattata cctcaaatct tggaacatca
     1561 tatgcagcca ttccaacgag ggcctttgct cagtcaaacc ccgtgtttcc ttcagcttcc
     1621 tctgggacaa gttttgcagc acagaggaaa ggcgctggac gggtagtgca catctgcaat
     1681 ctcccggagg gcagctgcac ggagaatgac gtcattaacc tggggctgcc ctttggcaag
     1741 gtcactaatt acatcctcat gaagtcaact aatcaggctt tcttggagat ggcttacaca
     1801 gaagccgccc aggctatggt ccagtactac caagaaaagc ctgcgattat caatggcgag
     1861 aagttactca ttcgcatgtc caccagatac aaggaattgc agctgaagaa acctgggaaa
     1921 aatgtggctg ctatcatcca agacatccat tcccagaggg agagggacat gctccgggaa
     1981 gctgacaggt atggtccaga gcggccacgt tctcgaagtc caatgagccg atcactctcc
     2041 ccaagatccc atagtccccc aggcccctct cgggctgact ggggcaatgg ccgtgactcc
     2101 tacgcgtgga gagacgagga tcgagagact gtccccagga gggagaacgg ggaagacaaa
     2161 agagacaggt tggatgtttg ggcacatgac cggaaacact atcctaggca gctggacaaa
     2221 gctgagttgg atgagcgact cgaaggaggg aggggctacc gggaaaagta cttgaagtca
     2281 gggtctcccg gcccactcca ttctgtgtct ggctacaaag gccgggaaga tggctaccat
     2341 cgaaaagagc ctaaagccaa gttggacaaa tacccaaagc agcagccgga tgtgccagga
     2401 agatccagaa ggaaagaaga ggcgagacta cgggagccca gacaccctca cccagaggat
     2461 tccggcaagg cagaggatct ggagcccaag atcacgcggg cccctgacgg taccaagtcc
     2521 aagcaaagtg agaaaagtaa aaccaagaga gccgacagag accaagaagg agctgacgac
     2581 aaaaaagaaa gccaactggc cgagaatgag gctggagctg aggaacagga aggcatggtg
     2641 ggcatacagc aggaagggac agagtcctgt gatccagaaa acacaaggac aaagaaggga
     2701 caagactgtg acagtgggag tgaacccgag ggggacaact ggtaccccac caacatggag
     2761 gagttggtca cagtggacga agtaggcgag gaagatttca tcatggaacc agacttacca
     2821 gagctggaag aaattgtgcc tattgaccag aaagacaaaa ccctccctaa aatatgtacc
     2881 tgtgtaacgg ccaccttagg tttggacttg gccaaagatt tcaccaagca gggagagacc
     2941 ctagggaacg gagacgcaga actcagcctg aagctgcccg gacaagtgcc gtctacttcc
     3001 gcaagctgtc ccaatgacac ggacctggag atgcctggcc taaatctgga tgctgagcgg
     3061 aagccagctg aaagcgagac aggcctctca ctggaggtct caaattgcta cgagaaggag
     3121 gcaagaggag aggaggactc agatgtgagt ctggcccctg cagtgcagca aatgtcctcc
     3181 ccccagccag cagatgagcg ggcccggcag tccagccctt ttctcgatga ctgcaaggcc
     3241 agggggtccc cagaagatgg gtctcatgaa gccagccccc tggaaggaaa agccagccca
     3301 cctactgaaa gcgacctcca aagccaggct tgccgagaaa accccaggta catggaagtg
     3361 aaatctctga acgtgagatc gccagaattc accgaagcgg agctgaaaga gcccctttct
     3421 ttgccttcct gggaaccgga ggtgttcagt gaacttagca ttcctctagg agtggagttc
     3481 gtggttccca ggactggctt ttattgcaag ctgtgtggcc tgttctacac aagcgaggag
     3541 gcggccaaag tgagccactg ccgcagcact gtccactaca ggaacttaca gaagtacctg
     3601 tctcagctgg cagaggaggg cctgaaggag acggagggga cagacagccc aagccccgag
     3661 cgtggtggga ttggtccaca cttggaaagg aagaagctat gatatcggcg ctgccaccgt
     3721 ctctggaaga tggatgggaa gcctgctgaa ctaaggccag cctggcctca ggcacagaac
     3781 tgagaccaga gaggacggag agccaggcag gacatggtgc ttgggcttgc agaacaggct
     3841 gaagtctctg ggagctgggc tcacccttcc gggcccagcc accgagggtg accagcttcc
     3901 tgtgggttcc tggttctttt agtctgtttt tcctctctcc ctctcaccta tcccttctgt
     3961 gccaaagttc atttcctttt cataaaatcc agcttctcag ggattgtcac tgtgtttcaa
     4021 gatttgattg gatgtggtag gtcggtcgat gaggctgggt cactcaagga gtaagtttaa
     4081 tggaaggcct tgacttagtc acttcagtgc acctgcggtg gccttgcaac ctggtttctg
     4141 tgggtcccaa gggtaggaga gctgagtcag gttctgtgca accaaggaat cgcttggcag
     4201 aggtggaagt ggtttcacta ggatttcctc caggtggatc ccgccatttt gaaaaggcat
     4261 ctttgtcttt tgtttcagtc tcagacgagt gctgggagcc gaacccagaa gcttgtacat
     4321 tctaaacagg cgctctacca ccgagctata gatgccaggc cagaacgtcc cagggttttg
     4381 tttggagaca gggcccatgc agtccagttt gtctttagtt tcctctggag ccaaggttat
     4441 cctgaacacc tcatcttcct gcctctacct cttgagtgtt gtgatcacag gtaccgttct
     4501 ggaggtgaaa cccagggctt ccagcacaag aggcaagcat acccctattt ttaggaagcc
     4561 attcatcctc atccttggct attctagaaa aatcactggg ctaatgcctt aatgtgttat
     4621 tataccatat tgtagtagtc atgtattact acacattatt aataataaat tcatatttat
     4681 tttgtgaagc aaagaagagc ccaacagtaa agaagctctg atagattcaa tccaaacttc
     4741 tcagttggag gatggtttgg gatttgttct atccaggaca gtgaatttgg tatagattca
     4801 ctttaattaa acttgaggcc agccatgcct tctcaaggag gagatagatg gcgggcctac
     4861 agcgcatgct gacctctgac ctctgcactg ctgaccagca tcagcttaac ccaggaacaa
     4921 gggactggca tctgaccttc cttcatcctt ggtgcctcta ctttggggta gttggtatta
     4981 gaatgatttg aaaatgctct cccaatcgaa ggagaaacta ggacacttgg cttgcttggt
     5041 tcttgtaggt aggggtaggg gatggaggga ctgctgatgc caacttggag gttaaaacga
     5101 tagaaagaac tggtccctga ttcccagtgg ggtcagtacc cccgtcccgt gtgggctgta
     5161 gggtcttagt ggaaggtctt aggacagggg tactataaga tatgaactcc actagtgcca
     5221 cagaacagac cccagtgtca aagagagcct ggcactgtct tcacaggtgg acacgcctcc
     5281 ttgaaggggc cctccatgtg gatggtttgc ttatatggtc gcctgtttat gttcccaagc
     5341 aaaggaaggt agtttagata gggagcatgc ctcccccccc tccccttata ttccattcta
     5401 gactctgcac aaacggaagg gcgatagaga aatgatttag ttcagcgctg acattttacc
     5461 agtgaggaag ctggggcaca gaaaggaacg gggcatagaa cctaaaataa ccctgtgtcc
     5521 actttgaggc cagtggttcc tgggcaggag agaactattg gaatctatga aggaggagtt
     5581 aaggcaaaga ggggccagtc tggaaaggag tgacaggaag ctggggcttc aggaagatgt
     5641 aacccgtccc ctggtggatc ccacaggagg tgacccagag ctgtagtcat gagcaaagtc
     5701 tcttctgatt ctcagaaaac ctttgacctc tggaacaact gctggccaca tccctaaatt
     5761 cattagcacc tccatcagaa gctgggcgct tgatcttcca gcagagtgag gcagacctcc
     5821 caaccccact ggctactctg ttaaagcctt tgtacggaaa gccacacggc ccagttctca
     5881 agcagtaaga tggttccctt ggttgtaaat cgaccttcat attagcaaaa ccgaagggtg
     5941 aaagaaatgg cagtctcctt tacatttaaa gtcatggatg gttctatatg tgtgtgcgtg
     6001 tacatatata catatatatt tttatataat tccatggtcc ttgcattttt ttttactcct
     6061 gtgtgtgtgt tccatgcatc atagtattga agacaaccag gaaaatattt atttcttttt
     6121 taaaacatga attcagtgtc tcatcagtca ttacaaagtg tctctccctg aggtggctca
     6181 tgaaaggttg ctaccttata caaagaattc atttgcaccc tggattaatg tgtcagaagg
     6241 cctgtgtcct ttagtgtcac tgtcagcacc tggtggtact ccaggtggca cacccagagg
     6301 cttttgtgag cttttgctat gagcagcagc cattagcggt caggcttccc attcttggac
     6361 agtccgaggc ggtgatcttt aagattatac ttgaactgga ccagagattg tttttgtgag
     6421 attttgaaaa ccagaactat tagttaattt aagtttgaac ttgtaaagta ttagaatatt
     6481 ttgagtctct tatataaatt gtcaccactt tttctgatct ctataactga cctaaagtgt
     6541 ttgtttttac aaaaggataa atggttttta ataaagagaa tttgaaagct tgaaaaaaaa
     6601 aaaaaaa
//
