LOCUS       NM_152824               1569 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus RNA binding motif protein 17 (Rbm17), transcript
            variant 1, mRNA.
ACCESSION   NM_152824
VERSION     NM_152824.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1569)
  AUTHORS   De Maio,A., Yalamanchili,H.K., Adamski,C.J., Gennarino,V.A.,
            Liu,Z., Qin,J., Jung,S.Y., Richman,R., Orr,H. and Zoghbi,H.Y.
  TITLE     RBM17 Interacts with U2SURP and CHERP to Regulate Expression and
            Splicing of RNA-Processing Proteins
  JOURNAL   Cell Rep 25 (3), 726-736 (2018)
   PUBMED   30332651
REFERENCE   2  (bases 1 to 1569)
  AUTHORS   Tan,Q., Yalamanchili,H.K., Park,J., De Maio,A., Lu,H.C., Wan,Y.W.,
            White,J.J., Bondar,V.V., Sayegh,L.S., Liu,X., Gao,Y.,
            Sillitoe,R.V., Orr,H.T., Liu,Z. and Zoghbi,H.Y.
  TITLE     Extensive cryptic splicing upon loss of RBM17 and TDP43 in
            neurodegeneration models
  JOURNAL   Hum Mol Genet 25 (23), 5083-5093 (2016)
   PUBMED   28007900
  REMARK    GeneRIF: we found a significant overlap in genes that undergo both
            RBM17- and TDP-43-dependent cryptic splicing repression, many of
            which are associated with survival. We propose that repression of
            cryptic splicing by RBPs is critical for neuronal health and
            survival
REFERENCE   3  (bases 1 to 1569)
  AUTHORS   Lai,S., O'Callaghan,B., Zoghbi,H.Y. and Orr,H.T.
  TITLE     14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation
            at Ser-776 and transport to the nucleus
  JOURNAL   J Biol Chem 286 (40), 34606-34616 (2011)
   PUBMED   21835928
  REMARK    GeneRIF: dephosphorylation of pS776-ATXN1 by PP2A regulates the
            interaction of ATXN1 with the splicing factors RBM17 and U2AF65
            Erratum:[J Biol Chem. 2013 Mar 1;288(9):6590]
REFERENCE   4  (bases 1 to 1569)
  AUTHORS   Wang,Q., Chow,J., Hong,J., Smith,A.F., Moreno,C., Seaby,P.,
            Vrana,P., Miri,K., Tak,J., Chung,E.D., Mastromonaco,G., Caniggia,I.
            and Varmuza,S.
  TITLE     Recent acquisition of imprinting at the rodent Sfmbt2 locus
            correlates with insertion of a large block of miRNAs
  JOURNAL   BMC Genomics 12, 204 (2011)
   PUBMED   21510876
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1569)
  AUTHORS   Lim,J., Crespo-Barreto,J., Jafar-Nejad,P., Bowman,A.B., Richman,R.,
            Hill,D.E., Orr,H.T. and Zoghbi,H.Y.
  TITLE     Opposing effects of polyglutamine expansion on native protein
            complexes contribute to SCA1
  JOURNAL   Nature 452 (7188), 713-718 (2008)
   PUBMED   18337722
REFERENCE   6  (bases 1 to 1569)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1569)
  AUTHORS   McClive,P.J., Hurley,T.M., Sarraj,M.A., van den Bergen,J.A. and
            Sinclair,A.H.
  TITLE     Subtractive hybridisation screen identifies sexually dimorphic gene
            expression in the embryonic mouse gonad
  JOURNAL   Genesis 37 (2), 84-90 (2003)
   PUBMED   14595844
REFERENCE   8  (bases 1 to 1569)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831794.6.
            
            On Mar 24, 2023 this sequence version replaced NM_152824.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034896.1, AK012296.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AL831794.6         143314-143463
            151-288             AL831794.6         145792-145929
            289-405             AL831794.6         148380-148496
            406-572             AL831794.6         149753-149919
            573-670             AL831794.6         151120-151217
            671-727             AL831794.6         153084-153140
            728-869             AL831794.6         155718-155859
            870-1033            AL831794.6         157457-157620
            1034-1107           AL831794.6         158754-158827
            1108-1206           AL831794.6         159583-159681
            1207-1279           AL831794.6         160642-160714
            1280-1569           AL831794.6         160820-161109
FEATURES             Location/Qualifiers
     source          1..1569
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 8.85 cM"
     gene            1..1569
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /note="RNA binding motif protein 17"
                     /db_xref="GeneID:76938"
                     /db_xref="MGI:MGI:1924188"
     exon            1..150
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            151..288
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1383
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     splicing factor 45; 45 kDa-splicing factor"
                     /codon_start=1
                     /product="splicing factor 45 isoform 1"
                     /protein_id="NP_690037.1"
                     /db_xref="CCDS:CCDS15684.1"
                     /db_xref="GeneID:76938"
                     /db_xref="MGI:MGI:1924188"
                     /translation="MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQR
                     TKQSTVLAPVIDLKRGGSSDDRQIADTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDP
                     MFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFSRRPDPDSDEDED
                     YERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEPD
                     RPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGK
                     IIVGDATEKGEAQDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEEC
                     EKYGKVGKCVIFEIPGAPDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYN
                     LDKFRVLDLAEQV"
     exon            289..405
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            406..572
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            573..670
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            671..727
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            728..869
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1033
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1107
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1206
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1279
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1569
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1549..1554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1569
                     /gene="Rbm17"
                     /gene_synonym="2700027J02Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctcttacccc gcgcggtgca tccctttgcg gactccgtgg aggctcggcg ctgcggcgga
       61 ctccggcggt gggcgggctt ccgcgcaggg cggccgggct ccgcgctgcc gccgccgtgg
      121 cccatgggca caatcgtctc ggaaggccgg cattaaacca aaaagatgtc cctatatgat
      181 gacctgggag tggagaccag tgactcaaaa actgaaggct ggtccaaaaa cttcaagctc
      241 ctgcagtccc agctccaggt gaagaaggcg gcgctcactc aggccaagag ccaaaggacc
      301 aagcaaagta cagtgcttgc tccggtcatc gacctaaagc gaggcggctc ctcagatgac
      361 cggcagattg cagacacacc acctcacgtg gcagctgggc tgaaggaccc tgtgcccagt
      421 gggttttctg caggggaagt tctgatcccc ttagctgatg aatatgaccc tatgttcccc
      481 aatgactatg agaaagtggt gaagcgccag agagaagagc ggcagaggca gcgggagctg
      541 gaaagacaga aggaaataga ggaaagagaa aagaggcgta aagacagaca cgaagccagt
      601 gggttttcaa gacgaccaga ccctgattct gatgaggatg aagattatga gcgagagcgg
      661 aggaaaagaa gtatgggagg agctgccatc gccccaccga cgtctcttgt agagaaagac
      721 aaagagttac cccgcgattt tccttatgaa gaggactcaa gaccgagatc acagtcttcc
      781 aaagctgcta ttcctccccc cgtgtatgag gagccggaca gaccaagatc tccaacaggc
      841 cccagcaact ccttccttgc taacatgggt ggcacagtgg ctcataagat tatgcagaag
      901 tatggcttcc gggaaggtca gggactgggg aaacacgagc aagggctgag tactgcattg
      961 tctgtggaga agaccagcaa gcgtggcggc aagatcattg tgggggatgc gacagagaag
     1021 ggcgaggctc aggatgcatc caagaagtcg gattcaaatc cattaactga aattcttaag
     1081 tgccctacta aagtggtctt gctgaggaac atggttggtg caggagaggt cgatgaagac
     1141 ttggaagttg aaaccaagga agaatgtgaa aaatatggca aagttgggaa atgtgtgata
     1201 tttgagattc ctggtgcccc tgatgatgaa gcagtacgga tatttttaga atttgagaga
     1261 gtcgaatcag caattaaagc tgtggtggat ctgaatggga ggtattttgg tggacgggtg
     1321 gtaaaagcat gtttctacaa tttggataaa ttcagggtct tggatctagc agagcaagtt
     1381 tgattgtaac ttaaagtcac ctccttgatc cttacatgag ctacagactg aacaatgaca
     1441 caggcatggc tgttgtgtcc atggctggtg gacactgaaa ctcttggatg gacttctaaa
     1501 atatatgttg atggatccct tttttatttt gtgttttttt taatatagta taaaaatcct
     1561 ttaaaaatc
//
