LOCUS       NM_001045807            4633 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus RNA binding motif protein 15 (Rbm15), mRNA.
ACCESSION   NM_001045807 XM_131139 XM_900123 XM_913302 XM_987320 XM_987358
VERSION     NM_001045807.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4633)
  AUTHORS   Li,S., Lian,S., Cheng,W., Zhang,T. and Gong,X.
  TITLE     THE ROLE OF N6-METHYLADENOSINE METHYLTRANSFERASE RBM15 IN
            NONALCOHOLIC FATTY LIVER DISEASE
  JOURNAL   Shock 61 (2), 311-321 (2024)
   PUBMED   38150369
  REMARK    GeneRIF: THE ROLE OF N6-METHYLADENOSINE METHYLTRANSFERASE RBM15 IN
            NONALCOHOLIC FATTY LIVER DISEASE.
REFERENCE   2  (bases 1 to 4633)
  AUTHORS   Nie,G., Tang,B., Lv,M., Li,D., Li,T., Ou,R., Xu,Y. and Wen,J.
  TITLE     HPV E6 promotes cell proliferation of cervical cancer cell by
            accelerating accumulation of RBM15 dependently of autophagy
            inhibition
  JOURNAL   Cell Biol Int 47 (8), 1327-1343 (2023)
   PUBMED   37191290
  REMARK    GeneRIF: HPV E6 promotes cell proliferation of cervical cancer cell
            by accelerating accumulation of RBM15 dependently of autophagy
            inhibition.
REFERENCE   3  (bases 1 to 4633)
  AUTHORS   Fang,J., Wu,X., He,J., Zhang,H., Chen,X., Zhang,H., Novakovic,B.,
            Qi,H. and Yu,X.
  TITLE     RBM15 suppresses hepatic insulin sensitivity of offspring of
            gestational diabetes mellitus mice via m6A-mediated regulation of
            CLDN4
  JOURNAL   Mol Med 29 (1), 23 (2023)
   PUBMED   36803098
  REMARK    GeneRIF: RBM15 suppresses hepatic insulin sensitivity of offspring
            of gestational diabetes mellitus mice via m6A-mediated regulation
            of CLDN4.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4633)
  AUTHORS   Xie,Y., Castro-Hernandez,R., Sokpor,G., Pham,L., Narayanan,R.,
            Rosenbusch,J., Staiger,J.F. and Tuoc,T.
  TITLE     RBM15 Modulates the Function of Chromatin Remodeling Factor BAF155
            Through RNA Methylation in Developing Cortex
  JOURNAL   Mol Neurobiol 56 (11), 7305-7320 (2019)
   PUBMED   31020615
  REMARK    GeneRIF: the regulation of BAF155 by RBM15 depends on the activity
            of the mRNA methylation complex core catalytic subunit METTL3.
REFERENCE   5  (bases 1 to 4633)
  AUTHORS   Moindrot,B., Cerase,A., Coker,H., Masui,O., Grijzenhout,A.,
            Pintacuda,G., Schermelleh,L., Nesterova,T.B. and Brockdorff,N.
  TITLE     A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors
            Required for Xist RNA-Mediated Silencing
  JOURNAL   Cell Rep 12 (4), 562-572 (2015)
   PUBMED   26190105
  REMARK    GeneRIF: Rbm15 is required for Xist-mediated silencing.  Rbm15 is
            important for efficient deposition of H3K27me3 on the inactive
            chromosome.
REFERENCE   6  (bases 1 to 4633)
  AUTHORS   Raffel,G.D., Chu,G.C., Jesneck,J.L., Cullen,D.E., Bronson,R.T.,
            Bernard,O.A. and Gilliland,D.G.
  TITLE     Ott1 (Rbm15) is essential for placental vascular branching
            morphogenesis and embryonic development of the heart and spleen
  JOURNAL   Mol Cell Biol 29 (2), 333-341 (2009)
   PUBMED   18981216
  REMARK    GeneRIF: Ott1 (Rbm15) has essential roles in hematopoietic,
            trophoblast, cardiac, and splenic development
REFERENCE   7  (bases 1 to 4633)
  AUTHORS   Raffel,G.D., Mercher,T., Shigematsu,H., Williams,I.R., Cullen,D.E.,
            Akashi,K., Bernard,O.A. and Gilliland,D.G.
  TITLE     Ott1(Rbm15) has pleiotropic roles in hematopoietic development
  JOURNAL   Proc Natl Acad Sci U S A 104 (14), 6001-6006 (2007)
   PUBMED   17376872
  REMARK    GeneRIF: Rbm15 has pleiotropic roles in hematopoietic development.
REFERENCE   8  (bases 1 to 4633)
  AUTHORS   Ma,X., Renda,M.J., Wang,L., Cheng,E.C., Niu,C., Morris,S.W.,
            Chi,A.S. and Krause,D.S.
  TITLE     Rbm15 modulates Notch-induced transcriptional activation and
            affects myeloid differentiation
  JOURNAL   Mol Cell Biol 27 (8), 3056-3064 (2007)
   PUBMED   17283045
  REMARK    GeneRIF: Rbm15 is differentially expressed during hematopoiesis and
            may act to inhibit myeloid differentiation in hematopoietic cells
            via a mechanism that is mediated by stimulation of Notch signaling
            via RBPJkappa.
            GeneRIF: the N terminus of Rbm15 coimmunoprecipitates with
            RBPJkappa, a critical factor in Notch signaling, and the Rbm15 N
            terminus has a dominant negative effect, impairing activation of
            HES1 promoter activity by full-length-Rbm15
REFERENCE   9  (bases 1 to 4633)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4633)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132405.3.
            
            On Jan 12, 2022 this sequence version replaced NM_001045807.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137741.1, AK077048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3747              AC132405.3         47960-51706
            3748-4633           AC132405.3         55617-56502
FEATURES             Location/Qualifiers
     source          1..4633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..4633
                     /gene="Rbm15"
                     /gene_synonym="C230088J01Rik; mKIAA1438"
                     /note="RNA binding motif protein 15"
                     /db_xref="GeneID:229700"
                     /db_xref="MGI:MGI:2443205"
     exon            1..3747
                     /gene="Rbm15"
                     /gene_synonym="C230088J01Rik; mKIAA1438"
                     /inference="alignment:Splign:2.1.0"
     CDS             882..3770
                     /gene="Rbm15"
                     /gene_synonym="C230088J01Rik; mKIAA1438"
                     /note="one-twenty two protein 1; putative RNA-binding
                     protein 15"
                     /codon_start=1
                     /product="RNA-binding protein 15"
                     /protein_id="NP_001039272.1"
                     /db_xref="CCDS:CCDS38590.1"
                     /db_xref="GeneID:229700"
                     /db_xref="MGI:MGI:2443205"
                     /translation="MRSAGREPLPRRSPRWRRASPLCETSAGWRVSQLRRDDLRRPST
                     MKGKERSPVKPKRSRGGEDSSSRGERSKKLGGSGGSNGSSSGKTDSGGSRRSLHLDKS
                     SSRGGSREYETGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAP
                     GGGDGVEYKTLKISELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAF
                     VNFRRPEDARAAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDAYAPSSSVVGTSV
                     GSHRHAPGGGGGQRSLSPGGAALGYRDYRLQQLALGRLPPPPPPPLPRELERERDYPF
                     YDRVRPAYSLEPRVGAGAGAAPFREVDEISPEDDQRANRTLFLGNLDITVTENDLRRA
                     FDRFGVITEVDIKRPSRGQTSTYGFLKFENLDMSHRAKLAMSGKIIIRNPIKIGYGKA
                     TPTTRLWVGGLGPWVPLAALAREFDRFGTIRTIDYRKGDSWAYIQYESLDAAHAAWTH
                     MRGFPLGGPDRRLRVDFADTEHRYQQQYLQPLPLTHYELVTDTFGHRAPDPLRSARDR
                     TPPLLYRDRDRDLYTDSDWVPPPPPVRERSARAATSAVTAYEPLDSLDRRRDGWSLDR
                     DRGDRDLPSSRDQPRKRRLPEESGGRHLDRSPESERPRKQRHCTPSPDRSPELSSNRD
                     RYNSDNDRSSRLLLLERSSPVRDRRGSLEKSQSDKRDRKNSASAERDRKHRTAAPTEG
                     KNPLKKEDRSDGNAPSASTSSSKQKPPSQKQDGGTAPVAASSPKLCLAWQGMLLLKNS
                     NFPSNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQRLRLDQPKLDEVTRRIKVAGPN
                     GYAILLAVPGSSDSRSSSSSATSDTAASTQRPLRNLVSYLKQKQAAGVISLPVGGNKD
                     KENTGVLHAFPPCEFSQQFLDSPAKALAKSEEDYLVMIIVRAKLVNSG"
     exon            3748..4633
                     /gene="Rbm15"
                     /gene_synonym="C230088J01Rik; mKIAA1438"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4087..4092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm15"
                     /gene_synonym="C230088J01Rik; mKIAA1438"
                     /note="hexamer: AATAAA"
     polyA_site      4111
                     /gene="Rbm15"
                     /gene_synonym="C230088J01Rik; mKIAA1438"
                     /note="major polyA site"
     regulatory      4613..4618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm15"
                     /gene_synonym="C230088J01Rik; mKIAA1438"
                     /note="hexamer: AATAAA"
     polyA_site      4633
                     /gene="Rbm15"
                     /gene_synonym="C230088J01Rik; mKIAA1438"
ORIGIN      
        1 aggcagctaa ctaagatggt gtcggctgga ctgtccggga cagctgccta ggcggatcga
       61 gtgagggcca gcagccggaa ggaccaccga gcccattgtc ccgcccagac aggacagtga
      121 ggagcccgca agttccagac tcgaaggacc gaagcacagg caagtacgcc gtaaggacct
      181 aacaaatgtt taagagaacg ccgaaagcgc ggggaggcgg gcctgactca ctgtcaccat
      241 ctcgcgacag caaagtgacg tcgcacagca agcgcgtggt cttagtcttt caccttcaga
      301 cgcctcagtt tatgggccta ctcctttaag tgagtgatgg acagcgcttt tatccaatca
      361 tgttcctcgt caacatccaa tcagatttaa actttcttca gccgccggag aagttggaag
      421 actggggtcg aaagagagcg agcgagtgag cgagtgagcg agcgagctct ttgtctctcg
      481 cgagatcgga gagagccaaa ttctcaggaa aaaacgcctg aactgatgtc cagacttccc
      541 gatagtgatt taaaagacgt ggccacaaac caatgaaagg gaagagaagg tgggatcgct
      601 gcgttcgccg tgctagaagt accgttacag ggcagagttt ttgtccaatc aacgcttcta
      661 ggctttgggt caggtgacca tgaagtgcga ggggcggagc tacagcctgg cgcgaggaac
      721 cgttaagata gacaacgaat ataaccaatg aggtactggg attagggcgt tgggaaccca
      781 ataacagcgt cggggcgggc gccttcccgg agcgcgggga gatgtaaaga cggacaaata
      841 gtttttccaa tgagaaggct gaagagtgaa ttaattgacc aatgaggtct gcggggcggg
      901 agcctttgcc gcggcggagt ccaagatggc ggcgtgcgag tccgctgtgt gaaacgagcg
      961 cggggtggcg ggttagtcag ctccgcagag acgacctccg gcgaccctca acaatgaaag
     1021 gaaaggagcg ctcgccggtc aagcccaagc gctcccgtgg cggtgaggac tccagttctc
     1081 gtggggagcg gagcaagaag ttagggggct ccggcggcag caatgggagc agcagcggga
     1141 agacggacag cggcgggtcg cggcggagcc ttcatctgga caagtccagc agccggggcg
     1201 gcagccgcga gtacgagacc ggcgggggca gctccagtag ccgcttgcac agttacagct
     1261 ccccgagcac caaaaattcc tcaggcgggg gcgagtcgcg cagcagctcc cggggtggag
     1321 gcggggagtc acgttcctcc ggggccgcct cctccgcgcc cggcggcggg gacggcgtgg
     1381 agtacaagac cctgaagatc agcgagctgg ggtcccagct gagcgacgag gcggtggagg
     1441 acgggctgtt tcacgagttc aaacgcttcg gtgatgtaag tgtcaaaatc agtcacctct
     1501 caggttctgg cagcggggat gagcgggtag cctttgtgaa cttccggagg ccagaggacg
     1561 cgagggcggc caagcatgcc agaggccgcc tggtgctcta tgaccggcct ctgaagatag
     1621 aagccgtgta cgtgagccgg cgccgcagcc gctccccgtt agacaaagat gcttacgccc
     1681 cgtcatccag cgtggtcggg acctcagtcg gtagccaccg gcacgcccct ggaggagggg
     1741 gaggtcagag gtcgctttcc cctggaggtg ctgctctggg atacagagac taccggttgc
     1801 agcagttggc cctgggccgc ctgcctcctc cacccccgcc accattgccc cgagagctgg
     1861 aaagagaacg agactatccg ttctatgacc gggtgcgccc ggcctacagc ctggagccga
     1921 gggtgggagc tggagcaggt gcggctcctt tccgagaagt ggatgagata tcacctgagg
     1981 acgatcagcg tgccaaccgg acacttttct tgggcaactt agatatcact gtgacggaaa
     2041 atgatctcag aagggctttt gatcgttttg gagtcatcac agaagtggac attaagaggc
     2101 cttctcgagg ccagaccagt acctatggct ttctcaaatt tgagaatcta gacatgtctc
     2161 acagggccaa acttgcaatg tctggcaaaa ttataattcg gaatccaatc aagattggtt
     2221 atggtaaagc cacacccact acccgacttt gggtgggtgg tctgggaccc tgggtgcctc
     2281 ttgctgccct ggcacgagaa tttgaccgat ttggcaccat tcgaaccata gactaccgta
     2341 aaggtgacag ttgggcatat atacagtatg aaagtttgga tgcagctcat gctgcctgga
     2401 cccatatgcg tggattccca cttggtggcc cagatcgtcg cctcagggta gactttgcag
     2461 acacagaaca tcgttaccag cagcaatatc ttcagcctct gcccttgacc cactatgaac
     2521 tagtgacgga tacttttgga catagagcac ctgacccttt gaggagtgct cgggacagga
     2581 caccaccctt actatacaga gatcgtgata gggaccttta tactgattct gactgggtgc
     2641 cacccccacc accggttcga gaacgcagtg ctcgggctgc aactagtgct gtcactgctt
     2701 atgagccact agatagcttg gatcgaagga gggatggctg gtcactggac agggacagag
     2761 gtgatcggga cttgcccagc agcagggacc agccaaggaa gcgaaggctg cctgaggaaa
     2821 gtggaggacg gcatcttgat agatcacctg agagtgaacg gcctcgaaaa cagcgtcact
     2881 gcactccttc tcctgaccga agtccagaac tgagcagtaa cagagatcgc tacaacagtg
     2941 acaatgatcg atcatctcgt cttctcctct tggaaaggtc ttccccagtc agagatagac
     3001 ggggcagttt ggagaagagc cagagcgaca agcgagaccg taaaaactct gcatcagctg
     3061 aacgggatag gaagcatcgg acagctgctc ccacagaggg aaaaaaccct ctgaaaaagg
     3121 aagaccgatc tgatggcaat gcacccagtg ccagcacttc ttcatcaaag cagaagccac
     3181 cttcccagaa acaggatgga gggacagctc ctgtggcagc atcctctccc aaactctgtt
     3241 tggcttggca gggcatgctt ctactgaaga acagcaactt cccttccaac atgcatctgt
     3301 tgcagggtga cctccaagtt gctagcagtc tacttgtgga gggctcaact ggaggcaaag
     3361 tggcccaact caagatcact cagcggctcc gtttggacca acccaagttg gatgaagtaa
     3421 ctcgacgcat caaagtggca gggcctaatg gttatgccat tctcctggct gtacctggaa
     3481 gttctgacag ccgatcttcc tcttcctcag ccacatcaga cactgccgcc tctactcaga
     3541 ggccacttag gaaccttgtg tcctatttaa agcaaaagca ggcagctggg gtgatcagcc
     3601 tccctgtggg aggcaataaa gacaaggaaa acaccggggt tcttcatgcc ttcccacctt
     3661 gtgagttctc tcagcagttc ctggattccc ctgccaaggc actggccaaa tctgaagaag
     3721 attacctggt catgatcatt gtccgtgcaa aactggtgaa cagcggatga agatacggaa
     3781 ttcaaagctc taatggacct ttttgaagag aagtggctta tgtggagttt acatgggcct
     3841 ctgatggaag aaagctaatc tgtttagtat tttgtgcatt ttactaaaat ggcagcttaa
     3901 cattgtgtat ctgctattgt gatgccaatg ccggtgtttt aagtggaaaa atgacctctt
     3961 tgctttgtgc tgtgtacaca agatttctgg aaaagtaaag aaaaaccctt tttatggctc
     4021 acacagctta aaagtagctg tcactcaaac atgggctcac agttgagctg cttttgtttt
     4081 attctaaata aattgtttct tttgaggaaa atgtttttct gcctggaagt gaattgacgg
     4141 caaaccttga cccctttgtt tgcagcggag ggggtacttg ctgctgctca gattttgtat
     4201 gtcttgagca agaagcaggg agatcatcag tttccttttg actatcacgg tgtgtcaatt
     4261 ctgaaggatc atagtgttac agtgaccccc tttgtttgca gtgaagggga tcctttgctt
     4321 ctcggtcctc aacacgatga gggtgctgtt tgctggcatg caagaagccg gggcaagcac
     4381 tctaagcctc aacacagtgc acgagtcggg ggctttgctg gtttgaagag ccggagttcc
     4441 tgaaatttaa gttttgattt attttgttca cccatcacgt ttggctttag tttcattttt
     4501 taatttgaag aaaagtttga aattgcatta tcttgcactt ttaacatttg caccaaattg
     4561 ccaaaagaag gagaaatgct ccggttgcct tttaaatgtt aatgatgatg ttaataaagc
     4621 ctttcctgac aca
//
