LOCUS       NM_019869               3168 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RNA binding motif protein 14 (Rbm14), mRNA.
ACCESSION   NM_019869
VERSION     NM_019869.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3168)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3168)
  AUTHORS   Xiao,Y., Chen,J., Yang,S., Sun,H., Xie,L., Li,J., Jing,N. and
            Zhu,X.
  TITLE     Maternal mRNA deadenylation and allocation via Rbm14 condensates
            facilitate vertebrate blastula development
  JOURNAL   EMBO J 42 (3), e111364 (2023)
   PUBMED   36477743
  REMARK    GeneRIF: Maternal mRNA deadenylation and allocation via Rbm14
            condensates facilitate vertebrate blastula development.
REFERENCE   3  (bases 1 to 3168)
  AUTHORS   Li,J., Wang,C., Feng,G., Zhang,L., Chen,G., Sun,H., Wang,J.,
            Zhang,Y., Zhou,Q. and Li,W.
  TITLE     Rbm14 maintains the integrity of genomic DNA during early mouse
            embryogenesis via mediating alternative splicing
  JOURNAL   Cell Prolif 53 (1), e12724 (2020)
   PUBMED   31794640
  REMARK    GeneRIF: work reveals that Rbm14 plays an essential role in the
            maintenance of genome integrity during early mouse embryonic
            development by regulating alternative splicing of DDR-related
            genes.
REFERENCE   4  (bases 1 to 3168)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3168)
  AUTHORS   Chen,G., Zhang,D., Zhang,L., Feng,G., Zhang,B., Wu,Y., Li,W.,
            Zhang,Y. and Hu,B.
  TITLE     RBM14 is indispensable for pluripotency maintenance and mesoderm
            development of mouse embryonic stem cells
  JOURNAL   Biochem Biophys Res Commun 501 (1), 259-265 (2018)
   PUBMED   29729270
  REMARK    GeneRIF: RBM14 depletion altered the gene expression profiles of
            mESCs. In particular, pluripotency-associated genes and genes
            involved in the Wnt and TGF-beta signaling pathways were
            downregulated in RBM14 knockout mESCs.
REFERENCE   6  (bases 1 to 3168)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   7  (bases 1 to 3168)
  AUTHORS   Lin,J.C. and Tarn,W.Y.
  TITLE     Exon selection in alpha-tropomyosin mRNA is regulated by the
            antagonistic action of RBM4 and PTB
  JOURNAL   Mol Cell Biol 25 (22), 10111-10121 (2005)
   PUBMED   16260624
REFERENCE   8  (bases 1 to 3168)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3168)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   10 (bases 1 to 3168)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050945.1, BE956494.1 and BM938190.1.
            
            On Feb 26, 2014 this sequence version replaced NM_019869.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088201.1, AK050945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AK050945.1         2-255
            255-2809            AK050945.1         257-2811
            2810-3165           BE956494.1         20-375              c
            3166-3168           BM938190.1         658-660
FEATURES             Location/Qualifiers
     source          1..3168
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.11 cM"
     gene            1..3168
                     /gene="Rbm14"
                     /gene_synonym="1300007E16Rik; p16; p16K; PSP2; Sytip"
                     /note="RNA binding motif protein 14"
                     /db_xref="GeneID:56275"
                     /db_xref="MGI:MGI:1929092"
     exon            1..463
                     /gene="Rbm14"
                     /gene_synonym="1300007E16Rik; p16; p16K; PSP2; Sytip"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2136
                     /gene="Rbm14"
                     /gene_synonym="1300007E16Rik; p16; p16K; PSP2; Sytip"
                     /note="synaptotagmin interacting protein"
                     /codon_start=1
                     /product="RNA-binding protein 14"
                     /protein_id="NP_063922.2"
                     /db_xref="CCDS:CCDS29437.1"
                     /db_xref="GeneID:56275"
                     /db_xref="MGI:MGI:1929092"
                     /translation="MKIFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQFAFVHMRE
                     NAGAVRAIEALHGHELRPGRALVVEMSRPRPLNTWKIFVGNVSAACTSQELRSLFERR
                     GRVIECDVVKDYAFVHMEKEADAKAAIAQLNGKEVKGKRINVELSTKGQKKGPALAIQ
                     SGDKTKKPGAGDTAFPGTGGFSATFDYQQAFGNSTGGFDGQARQPTPPFFGRDRSPLR
                     RSPPRASYVAPLTAQPATYRAQPSVSLGAAYRAQPSASLGVGYRTQPMAAQAASYRAQ
                     PSVSLGAPYRGQLASPSSQSAAASSLGPYGGVQPSASALSTYGGQAAAASSLNSYGAQ
                     GSSLASYGNQPSSYGAQAASSYGVRAAASSYNTQGAASSLGSYGAQAASYGAQSAASS
                     LAYGAQAASYSAQPSASYSAQSAPYAAQQAASYSSQPAAYVAQPATAAAYASQPAAYA
                     AQATTPMAGSYGAQPVVQTQLNSYGAQASIGLSGSYGAQSAAAATGSYGAAAAYGAQP
                     SATLAAPYRTQSSASLAASYAAQQHPQAAASYRGQPGSAYDGTGQPSAAYLSMSQGAV
                     ANANSTPPPYERTRLSPPRASYDDPYKKAVAMSKRYGSDRRLAELSDYRRLSESQLSF
                     RRSPTKSSLDYRRLPDAHSDYARYSGSYNDYLRAAQMHSGYQRRM"
     exon            464..1928
                     /gene="Rbm14"
                     /gene_synonym="1300007E16Rik; p16; p16K; PSP2; Sytip"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..3168
                     /gene="Rbm14"
                     /gene_synonym="1300007E16Rik; p16; p16K; PSP2; Sytip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2781..2786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm14"
                     /gene_synonym="1300007E16Rik; p16; p16K; PSP2; Sytip"
                     /note="hexamer: AATAAA"
     polyA_site      2812
                     /gene="Rbm14"
                     /gene_synonym="1300007E16Rik; p16; p16K; PSP2; Sytip"
                     /note="major polyA site"
     regulatory      3070..3075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm14"
                     /gene_synonym="1300007E16Rik; p16; p16K; PSP2; Sytip"
                     /note="hexamer: AGTAAA"
     polyA_site      3092
                     /gene="Rbm14"
                     /gene_synonym="1300007E16Rik; p16; p16K; PSP2; Sytip"
     regulatory      3144..3149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm14"
                     /gene_synonym="1300007E16Rik; p16; p16K; PSP2; Sytip"
                     /note="hexamer: AATAAA"
     polyA_site      3166
                     /gene="Rbm14"
                     /gene_synonym="1300007E16Rik; p16; p16K; PSP2; Sytip"
ORIGIN      
        1 gagcgcctgc gcggcggggt tctcggtcgc cagccattcc tgtggaggac tgcgggtcgt
       61 tcggacgttt tgcctgtcgc tgtaggagag gtcctgtctc tccgagaagg cggttgcggc
      121 ggcaaaatga agatttttgt gggcaatgtc gatggggcgg atacgacacc ggaggagttg
      181 gcagctctct tcgcgcccta tggcacggtc atgagctgcg ccgtcatgaa acagtttgcc
      241 ttcgtgcaca tgcgcgagaa cgctggcgcg gtgcgcgcca tcgaggccct gcatggccac
      301 gagctgcgtc caggtcgcgc gctcgtggtg gagatgtcgc gcccgaggcc cctgaacact
      361 tggaagattt tcgtgggcaa tgtatcggct gcatgtacaa gtcaggaatt gcgcagcctc
      421 ttcgagcgcc gtggacgcgt catcgagtgt gacgtggtaa aagactacgc gtttgttcac
      481 atggagaagg aagcagatgc caaagccgcc atcgcgcagc tcaacggcaa agaagtgaag
      541 ggcaagcgca tcaacgtgga actctcaacc aaggggcaga agaaggggcc tgccctggct
      601 atccagtctg gggacaagac caagaaacca ggggctgggg acacagcatt ccctggaact
      661 ggtggcttct ctgccacctt cgactaccag caggcttttg gcaacagcac tggtggcttt
      721 gatgggcaag cccgtcagcc cacaccacca ttctttggtc gcgaccgcag ccccctgcgc
      781 cgttcacctc ctcgagcctc ttatgtggcg cctctgacgg cccagccagc cacctaccgg
      841 gcccaaccct cagtgtctct gggagctgca tatagggccc agccttccgc ctctttgggt
      901 gttggctatc ggactcagcc catggcagct caggcagctt cttaccgtgc tcagccctct
      961 gtctcccttg gggccccata caggggtcag ctggctagcc ctagttccca gtctgctgca
     1021 gcttcctcgc ttggcccata tggtggagtc cagccctcag cctcagccct ttccacttat
     1081 gggggtcagg cagctgcagc ttcttcgctt aattcctatg gggctcaggg ctcctccctt
     1141 gcttcctatg gtaaccagcc atcctcttat ggcgcccagg ctgcctcttc gtatggggtt
     1201 cgtgcggctg cttcttccta taacacacaa ggagcagctt cttccctagg ttcctatggg
     1261 gctcaagcag cctcctatgg tgcccagtct gcagcctcct cactagctta tggagcccag
     1321 gcagcgtctt acagtgccca gccctcagcc tcttacagtg cccagtctgc cccatatgct
     1381 gcacaacagg ctgcttctta ttcttcccag cctgctgctt atgtggcaca accagccaca
     1441 gctgctgcct atgctagcca gccagctgcc tatgctgcac aagccactac cccaatggct
     1501 ggttcctatg gggctcaacc agttgttcag acccagctga atagctatgg ggctcaagca
     1561 tctattggcc tgtcaggctc atatggagct cagtctgctg ctgcggccac tggctcctat
     1621 ggggcggcag ctgcttacgg ggctcagcct tctgccaccc tggcagctcc ttaccgcact
     1681 cagtcatcag cctcattggc tgcttcctat gctgcccagc agcatcccca ggctgctgcc
     1741 tcctaccgtg gccagccggg cagtgcctac gatgggacag gccagccatc agcagcctac
     1801 ctgtctatgt cccagggggc cgttgccaac gccaacagca ccccgccgcc ctatgagcgt
     1861 acccgcctct ccccaccccg ggccagctac gacgatccct acaaaaaggc tgtcgccatg
     1921 tcaaaaaggt atggttccga ccggcgttta gccgagctct ctgattaccg ccgtttatca
     1981 gagtcgcagc tttcgttccg ccgctcgccg acaaagtcct cgctggatta ccgtcgcctg
     2041 cccgatgccc attccgatta cgcacgctat tcgggctcct ataatgatta cctgcgggca
     2101 gctcagatgc actctggcta ccagcgccgc atgtagggcc atcctgggga tggggcacca
     2161 caggaaggga gagagaggaa gaggtagggt agggtgcaga cccaggttat caccaccctc
     2221 tctcatacct ctcccaatgg tggcttttca ttccctccct ctatcatgtg ggccttcccc
     2281 aggagaggac ccttttgtgt ttggcagtaa cctgctttgt ttctttgcct cagcagcaca
     2341 tcttgctact ggctttagat ctgtggtttt ccctctaccc agccatctcc ccagaatggg
     2401 aatttctttt atattttaat ttttttcctg gctccctttt atttttgtgc gcgatactta
     2461 aggttgtttg gaggtgatac aaccgacagc tgatgtcagg cggcgcgttt ttctttttag
     2521 atgcgaggga ggccaggaaa gggttacttt agctatttcc tctgtgccca gctatgccag
     2581 cagtccaggg gccctgcctg tccttctgta gaggctgttg agactgagat cctgtgggac
     2641 agtcagttgg tccgtgtcca aatccccgct taccactgat gttttagctg atggtgactg
     2701 gcatagtccc aattccctat ctctccaagt aggtggtgtt agaaatctta attcttttcc
     2761 cttcttttgt atggactaca aataaaactt ggggcgattc gtggtttgga aacctggttg
     2821 tcattgtctt gattgcactg tcaggtgagc cagtttgaca tccaggaaga cgtgacagct
     2881 agaagaaagg cagcctgaag acccagagtg ggtgtggaag ggtgcttgag tgtggggatt
     2941 ggaatggttt cctggcgacc aatggaatta agctcatctt aaatagcatg ccatctttgg
     3001 gactagagag ttcagatcaa gtggttggac tttctcagca atcaatttta gttgatcacg
     3061 tcaaatttca gtaaacatgc ccattacctc tacttatgtt tgaccaatgt ccctgatttt
     3121 tttcccagtt caggaaaaac aaaaataaac caaaagctac acagtaca
//
