LOCUS       NM_145627               3671 bp    mRNA    linear   ROD 13-AUG-2024
DEFINITION  Mus musculus RNA binding motif protein 10 (Rbm10), transcript
            variant 1, mRNA.
ACCESSION   NM_145627
VERSION     NM_145627.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3671)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3671)
  AUTHORS   Bao,Y., Zhang,S., Zhang,X., Pan,Y., Yan,Y., Wang,N., Ren,Y.,
            Zuo,J., Zong,W.X., Wang,Z. and Wang,Y.
  TITLE     RBM10 Loss Promotes EGFR-Driven Lung Cancer and Confers Sensitivity
            to Spliceosome Inhibition
  JOURNAL   Cancer Res 83 (9), 1490-1502 (2023)
   PUBMED   36853175
  REMARK    GeneRIF: RBM10 Loss Promotes EGFR-Driven Lung Cancer and Confers
            Sensitivity to Spliceosome Inhibition.
REFERENCE   3  (bases 1 to 3671)
  AUTHORS   Wang,E., Pineda,J.M.B., Kim,W.J., Chen,S., Bourcier,J., Stahl,M.,
            Hogg,S.J., Bewersdorf,J.P., Han,C., Singer,M.E., Cui,D.,
            Erickson,C.E., Tittley,S.M., Penson,A.V., Knorr,K., Stanley,R.F.,
            Rahman,J., Krishnamoorthy,G., Fagin,J.A., Creger,E., McMillan,E.,
            Mak,C.C., Jarvis,M., Bossard,C., Beaupre,D.M., Bradley,R.K. and
            Abdel-Wahab,O.
  TITLE     Modulation of RNA splicing enhances response to BCL2 inhibition in
            leukemia
  JOURNAL   Cancer Cell 41 (1), 164-180 (2023)
   PUBMED   36563682
REFERENCE   4  (bases 1 to 3671)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3671)
  AUTHORS   Atsumi,T., Suzuki,H., Jiang,J.J., Okuyama,Y., Nakagawa,I., Ota,M.,
            Tanaka,Y., Ohki,T., Katsunuma,K., Nakajima,K., Hasegawa,Y.,
            Ohara,O., Ogura,H., Arima,Y., Kamimura,D. and Murakami,M.
  TITLE     Rbm10 regulates inflammation development via alternative splicing
            of Dnmt3b
  JOURNAL   Int Immunol 29 (12), 581-591 (2017)
   PUBMED   29309623
  REMARK    GeneRIF: this study shows that Rbm10 regulates inflammation
            development via alternative splicing of Dnmt3b
REFERENCE   6  (bases 1 to 3671)
  AUTHORS   Cox,B.J., Vollmer,M., Tamplin,O., Lu,M., Biechele,S.,
            Gertsenstein,M., van Campenhout,C., Floss,T., Kuhn,R., Wurst,W.,
            Lickert,H. and Rossant,J.
  TITLE     Phenotypic annotation of the mouse X chromosome
  JOURNAL   Genome Res 20 (8), 1154-1164 (2010)
   PUBMED   20548051
REFERENCE   7  (bases 1 to 3671)
  AUTHORS   Johnston,J.J., Teer,J.K., Cherukuri,P.F., Hansen,N.F., Loftus,S.K.,
            Chong,K., Mullikin,J.C. and Biesecker,L.G.
  CONSRTM   NIH Intramural Sequencing Center (NISC)
  TITLE     Massively parallel sequencing of exons on the X chromosome
            identifies RBM10 as the gene that causes a syndromic form of cleft
            palate
  JOURNAL   Am J Hum Genet 86 (5), 743-748 (2010)
   PUBMED   20451169
REFERENCE   8  (bases 1 to 3671)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   9  (bases 1 to 3671)
  AUTHORS   Mueller,C.F., Berger,A., Zimmer,S., Tiyerili,V. and Nickenig,G.
  TITLE     The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor
            gene expression via transcriptional and posttranscriptional
            mechanisms
  JOURNAL   Arch Biochem Biophys 488 (1), 76-82 (2009)
   PUBMED   19508861
REFERENCE   10 (bases 1 to 3671)
  AUTHORS   Inoue,A., Tsugawa,K., Tokunaga,K., Takahashi,K.P., Uni,S.,
            Kimura,M., Nishio,K., Yamamoto,N., Honda,K., Watanabe,T., Yamane,H.
            and Tani,T.
  TITLE     S1-1 nuclear domains: characterization and dynamics as a function
            of transcriptional activity
  JOURNAL   Biol Cell 100 (9), 523-535 (2008)
   PUBMED   18315527
  REMARK    GeneRIF: S1-1 constitutes hundreds of nuclear domains, which
            dynamically change their structures in a reversible manner; upon
            globally reducing RNA polymerase II transcription, S1-1 nuclear
            bodies enlarge and decrease in number.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672073.8, AK145991.1 and AL807240.12.
            
            On Dec 13, 2017 this sequence version replaced NM_145627.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145991.1, SRR9219382.80813.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               AL672073.8         186264-186519
            257-609             AK145991.1         1-353
            610-612             AL672073.8         188795-188797
            613-1234            AK145991.1         357-978
            1235-1235           AL672073.8         210003-210003
            1236-3670           AK145991.1         980-3414
            3671-3671           AL807240.12        4838-4838
FEATURES             Location/Qualifiers
     source          1..3671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 16.11 cM"
     gene            1..3671
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /note="RNA binding motif protein 10"
                     /db_xref="GeneID:236732"
                     /db_xref="MGI:MGI:2384310"
     exon            1..549
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            550..690
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     CDS             674..3466
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein 10; Ribosome biogenesis inhibitor
                     MINAS-60"
                     /codon_start=1
                     /product="RNA-binding protein 10 isoform 1"
                     /protein_id="NP_663602.1"
                     /db_xref="CCDS:CCDS40885.1"
                     /db_xref="GeneID:236732"
                     /db_xref="MGI:MGI:2384310"
                     /translation="MEYERRGGRGDRTGRYGATDRSQDDSGENRSRDHDYRDMDYRSY
                     PREYGSQEGKHEYDDSSEEQSAEDSYEASPGSETQRRRRRRHRHSPTGPPGFPRDGDY
                     RDQDYRTEQGEEEEEEDEEEEEEKASNIVMLRMLPQAATEDDIRGQLQSHGVQAREVR
                     LMRNKSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWL
                     CNKCGVQNFKRREKCFKCGVPKSEAEQKLPLGTRLDQQALPLGGRELSQGLLPLPQPY
                     QAQGVLTSQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNVRVI
                     KDKQTQLNRGFAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASN
                     EGSRINAASVASTAIAAAQWAISQASQGGESAWAAPEEPPVDYSYYQQDEGYGSSQGT
                     DSLYAHGYLKNSKGPGMTGTKGDPAGTGPEASLEAGADSVSLQAFSRAQPGAAPGLYQ
                     QSAEGSSGQSTATNSQSYTIISPAVLKAELQSPTQPSSSAFPPATSPTAPEAYSQYPV
                     PDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQSQQYLYWDGERRTYIPALEQSAD
                     GHKDTGASSKEGKEKKEKHKTKTAQQIAKDMERWARSLNKQKENFKNSFQPISALRDD
                     ERRESATADAGYAILEKKGALAERQHTSMDLPKLASDDRPSPPRGLVAAYSGESDSEE
                     EQERGGPEREEKLTDWQKLACLLCRRQFPSKEALIRHQQLSGLHKQNLEIHRRAHLSE
                     NELEALEKNDMEQMKYRDRAAERREKYGIPEPPEPKRRKYGGISTASVDFEQPTRDGL
                     GSDNIGSRMLQAMGWKEGSGLGRKKQGIVTPIEAQTRVRGSGLGARGSSYGVTSTESY
                     KETLHKTMVTRFNEAQ"
     exon            691..874
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1105
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1175
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1249
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1336
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1397
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1574
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1735
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1833
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1921
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2105
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2245
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2366
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2458
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2623
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2773
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2839
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..3028
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3103
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3210
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3340
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3671
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3650..3655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /note="hexamer: AATAAA"
     polyA_site      3671
                     /gene="Rbm10"
                     /gene_synonym="E430039K10Rik; MINAS-60"
                     /note="major polyA site"
ORIGIN      
        1 gaggtctgtt cattttcttc gtaagaagaa agcggtgaca tctagatggc cctgtaggga
       61 aagaggtgga gcttctagtt gtctttcaac ttcaaaggac agcaagcttc taaagagcgg
      121 gcctcttagg ggtagccaat agctactctt ttttctggac tcctgggccg ttctcacagg
      181 gaatggggag gtagcatatg cttgccaatc agagaatgcc agggccagcc aatggtgacc
      241 ggcaaccaat cgtcaaggcc ggccagagcg cgctccctta gtaggtggat ggtggtcgga
      301 tcgccggctc tcttctcgtc gccattttgt gttggtgact gtggccggct aggaggaggt
      361 ggcaccgagt ttccttggga gggcaacgcg tcggtcgcgt ctcccctccc cctttcctcc
      421 tttttgctcc cagtcttgga cttggtagtt gcatgcattg gctcccattt gaactaacag
      481 ttctgaagga ggtggtggcg ggcggaggtg atgcctggga gccctccctt gacagcccgg
      541 gccgagaaga gtctctgcag gaggtatcac ccagacgggc agatcatgct ggcagcaaca
      601 ggggtggctg agaagtgaaa ggagccagct actgaggagg ggccccagca gcccctaaaa
      661 ctcctatcag gacatggagt atgaaagacg aggtggtcgt ggtgacagga ctggccgcta
      721 tggagccact gatcgttcac aggatgatag tggagagaac cgcagccggg accatgatta
      781 tagagacatg gactaccgct catacccacg agagtatggc agtcaggagg gcaagcatga
      841 gtatgacgac tcatctgaag agcaaagtgc agaggattcc tacgaggcct ccccgggctc
      901 cgagactcag cgtaggcggc ggcggcggca caggcacagt cccactggcc cgccaggctt
      961 ccccagagac ggcgactatc gggaccagga ctatcggacc gagcaagggg aggaggagga
     1021 ggaggaggat gaggaggagg aggaggagaa ggccagtaac atcgtcatgc tgaggatgct
     1081 gccacaggca gccactgagg atgacatccg tggacagctg cagtcccatg gtgtccaagc
     1141 acgggaggtc cggctgatgc ggaacaaatc ctcaggtcag agccggggct tcgccttcgt
     1201 cgagtttagt cacttgcagg acgctacacg atggatggaa gccaatcagc actccctcaa
     1261 catcctgggc cagaaggtat ccatgcatta cagcgacccc aagcccaaga tcaatgagga
     1321 ctggctgtgt aataagtgtg gtgtccagaa cttcaagcgc cgagagaagt gcttcaaatg
     1381 tggtgtgccc aaatcagagg cagagcagaa gctgcccctg ggcactcggc tggatcagca
     1441 ggcactgcca ctgggtgggc gggagctaag ccagggctta ctcccactgc cgcagcccta
     1501 ccaggcccag ggagtgctaa cctcacaagc cctgtcacag ggctcagagc caagctccga
     1561 gaacgccaat gacaccatta ttttacgaaa cctgaaccca cacagcacta tggactccat
     1621 cctcggggcc ctagcaccct atgcggtgct gtcctcttcc aatgtgcgtg ttatcaagga
     1681 caaacagact cagctgaacc gaggcttcgc cttcatccag ctctccacca tcgtggaagc
     1741 agcccagctg ctacagatcc tgcaggccct gcaccctccg ctcaccatcg atggcaagac
     1801 catcaacgtg gagtttgcca agggttctaa gagggatatg gcctccaatg aaggcagtcg
     1861 catcaatgct gcctctgtgg ccagtactgc cattgctgct gcccagtggg caatctcaca
     1921 ggcctcccag ggtggagaga gtgcctgggc tgcccccgag gagccaccag ttgactacag
     1981 ctactaccaa caggatgagg gctatggcag cagccaggga acagattccc tctatgccca
     2041 tggctacctg aagaacagca agggccctgg catgactggg accaaagggg acccagctgg
     2101 aacaggtcct gaggcctccc ttgaggctgg agcagactct gtgtcactgc aggctttctc
     2161 tcgagcccag cctggtgctg cccctgggct ctatcagcaa tcagctgagg ggagcagtgg
     2221 ccagagcact gctaccaaca gccagtcata caccatcata tcacctgctg tgctcaaggc
     2281 tgagcttcag agccctactc agcccagcag ctctgccttc ccaccggcta ccagtcccac
     2341 tgcccccgag gcctacagcc agtaccctgt tcctgatgtc tctacttacc aatatgatga
     2401 gacatctggc tactactatg acccccagac tggtctatac tatgatccca attcccagta
     2461 ttactacaat gctcagagtc agcagtacct atactgggat ggggagcggc ggacctacat
     2521 acctgccttg gagcagtctg ctgatggaca taaggacacg ggggcatcat caaaggaggg
     2581 aaaagagaag aaagagaagc ataagacaaa gacagcccaa cagattgcca aggacatgga
     2641 gcggtgggca cgcagtctca ataagcaaaa agaaaacttc aaaaacagct tccagcctat
     2701 tagtgctcta cgagatgatg aaaggcggga atcggccact gcagatgcag gctatgccat
     2761 ccttgagaag aagggagcgc tagctgaaag acagcacacc agcatggatc tcccaaagct
     2821 ggccagtgat gaccgcccaa gcccacctcg agggctggtg gcagcctata gtggggagag
     2881 tgacagtgag gaggaacagg agcgaggagg tcctgaacgg gaagaaaagc tcacagactg
     2941 gcagaagcta gcctgtctgc tctgccgccg ccagtttccc agcaaggagg cactcatccg
     3001 gcaccagcag ctctctgggc tccacaagca aaaccttgag attcatcggc gagcccactt
     3061 gtcagaaaac gaattggaag cactagagaa aaatgacatg gagcaaatga agtatcgaga
     3121 ccgtgcagct gaacgcaggg agaagtatgg tatccctgag ccaccagagc ccaaacggag
     3181 gaagtatggt ggcatatcta cagcctctgt ggactttgaa caacccactc gggatggatt
     3241 aggcagtgac aacattggca gtcgaatgct ccaggccatg ggctggaaag aaggcagtgg
     3301 tctgggccgc aagaaacagg gcattgtgac acccattgag gcccaaacac gagttcgagg
     3361 ttctggcctg ggtgccaggg gcagttccta tggggtcacc tcaacagaat cctataagga
     3421 gacactgcac aagacaatgg tgacccgctt caatgaggcc cagtgaacag ctttgaaagc
     3481 agtttctaca gacatggggt atccatcgag ggacagagaa gatgaactgt ggaatggtct
     3541 aaggaaggct cttctatcta ccagcctcct ccccaaccag agaagccaaa ttagacttgg
     3601 agttggtgac ttttgctggg aaattgggct caaatcatgt tccttttgta ataaaatcta
     3661 aaaagcctgc a
//
