LOCUS       NM_011249               4909 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus RB transcriptional corepressor like 1 (Rbl1),
            transcript variant 1, mRNA.
ACCESSION   NM_011249
VERSION     NM_011249.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4909)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4909)
  AUTHORS   Shimada,R., Kato,Y., Takeda,N., Fujimura,S., Yasunaga,K.I.,
            Usuki,S., Niwa,H., Araki,K. and Ishiguro,K.I.
  TITLE     STRA8-RB interaction is required for timely entry of meiosis in
            mouse female germ cells
  JOURNAL   Nat Commun 14 (1), 6443 (2023)
   PUBMED   37880249
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4909)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4909)
  AUTHORS   Lazaro,S., Lorz,C., Enguita,A.B., Seller,I., Paramio,J.M. and
            Santos,M.
  TITLE     Pten and p53 Loss in the Mouse Lung Causes Adenocarcinoma and
            Sarcomatoid Carcinoma
  JOURNAL   Cancers (Basel) 14 (15), 3671 (2022)
   PUBMED   35954335
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4909)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4909)
  AUTHORS   Huppi,K., Siwarski,D., Mock,B.A., Dosik,J. and Hamel,P.A.
  TITLE     Molecular cloning, chromosomal mapping, and expression of the mouse
            p107 gene
  JOURNAL   Mamm Genome 7 (5), 353-355 (1996)
   PUBMED   8661722
REFERENCE   7  (bases 1 to 4909)
  AUTHORS   Kim,K.K., Soonpaa,M.H., Wang,H. and Field,L.J.
  TITLE     Developmental expression of p107 mRNA and evidence for alternative
            splicing of the p107 (RBL1) gene product
  JOURNAL   Genomics 28 (3), 520-529 (1995)
   PUBMED   7490090
REFERENCE   8  (bases 1 to 4909)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   9  (bases 1 to 4909)
  AUTHORS   Kim,K.K., Soonpaa,M.H., Daud,A.I., Koh,G.Y., Kim,J.S. and
            Field,L.J.
  TITLE     Tumor suppressor gene expression during normal and pathologic
            myocardial growth
  JOURNAL   J Biol Chem 269 (36), 22607-22613 (1994)
   PUBMED   8077211
REFERENCE   10 (bases 1 to 4909)
  AUTHORS   Schneider,J.W., Gu,W., Zhu,L., Mahdavi,V. and Nadal-Ginard,B.
  TITLE     Reversal of terminal differentiation mediated by p107 in Rb-/-
            muscle cells
  JOURNAL   Science 264 (5164), 1467-1471 (1994)
   PUBMED   8197461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147064.1, BC060124.1 and U27177.1.
            
            On Nov 19, 2008 this sequence version replaced NM_011249.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060124.1, U27177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2457              AK147064.1         2-2458
            2458-3451           BC060124.1         2425-3418
            3452-3686           U27177.1           3436-3670
            3687-4909           BC060124.1         3651-4873
FEATURES             Location/Qualifiers
     source          1..4909
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.05 cM"
     gene            1..4909
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /note="RB transcriptional corepressor like 1"
                     /db_xref="GeneID:19650"
                     /db_xref="MGI:MGI:103300"
     exon            1..235
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..3271
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinoblastoma-like protein 1; 107 kDa
                     retinoblastoma-associated protein; retinoblastoma-like 1
                     (p107)"
                     /codon_start=1
                     /product="retinoblastoma-like protein 1 isoform 1"
                     /protein_id="NP_035379.2"
                     /db_xref="CCDS:CCDS16974.1"
                     /db_xref="GeneID:19650"
                     /db_xref="MGI:MGI:103300"
                     /translation="MFEDEPHAEGAAAVAAAREALQALCQELNLDEGSAAEALDDFTA
                     IRGNYSLEGEVIHWLACSLYVACRKSIIPTVGKGVMEGNCVSLTRILRSAKLSLIQFF
                     SKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKFEPIFLDIFQNPYEEPPKLPRS
                     RKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPN
                     RRDLLNPSFKGLPSDFHAPDFKAAEEPPCIIAVLCDLHDGLLVEAKGIKEHYFKPYIS
                     KLFDKKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPR
                     KFTADTPFGKLTSQASVECNLQQHFEKKRSFAPSTPLTGRRYLQEKEAVTTPVASATQ
                     SVSRLQSIVAGLKSAPSEQLLNIFESCMRNPMGNIIKIVKGIGETFCQHYTQSTDKQP
                     GSHIDFAVNRLKLAEILYYKILETIMVQETRRLHGMDMSVLLEQDIFHKSLMACCLEI
                     VLFAYSSPRTFPWIIEVLDLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESL
                     AWTNNSALWEALHASANRVPSCEEVIFPNNFEIGNGGNVQGHLPMMPMSPIIHPRVKE
                     VRTDSGSLRQDMQPLSPISVHERYSSPAAGSAKRRLFGDDPPKDTLMDKIMAEGTKLK
                     IAPSSVTAESLSISPGQALLTMATTTVTGTTGRKVTVPLHGIANDAGEITLVPISMNP
                     TQESTAESPVSLTAQSLIGTSPKQTHLTKAQDAHLTGVSKPKRTGSLALFYRKVYHLA
                     SVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKE
                     ERTFQEIMKSYRNQPQANSHVYRSVLLKSIPGGVVVYNGDCEMTDGDIEDATKTPNCS
                     SEPVKEERGDLIKFYNTVYVGRVKSFALKYDLSNQDHIMDAPPLSPFPHIKQQPGSPR
                     RISQQHSLYVSPHKNGAGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQKTKKRVIAI
                     SGDADSPAKRLCQENDDVLLKRLQDVVSERANH"
     exon            236..369
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..570
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..635
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..764
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..925
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..975
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1162
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1329
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1442
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1546
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1684
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1849
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1982
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2246
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2458
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2635
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2707
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2786
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2935
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3100
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..4884
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4857..4862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /note="hexamer: AATAAA"
     polyA_site      4884
                     /gene="Rbl1"
                     /gene_synonym="p107; PRB1"
                     /note="major polyA site"
ORIGIN      
        1 ggggggttgt gggtagctcg ccgggaggga aaagaaaacc ccgaagccgg tcgcgccgcc
       61 cgtcgggccg gagggggata tgttcgagga cgagccccac gccgaggggg cggcggcggt
      121 cgccgcggcc agggaggcgc tgcaggccct gtgccaggaa ctgaacctgg acgagggaag
      181 cgcggccgaa gccctggatg acttcacggc catccgcggc aactacagcc tagagggaga
      241 agttatacac tggctggcat gctctttata tgttgcttgc cgcaagagca tcattcctac
      301 tgtgggaaag ggcgtcatgg aaggaaactg tgtctcactc accagaatac tgcgctcagc
      361 taagttaagc ttaatacagt tttttagtaa aatgaagaaa tggatggaca tgtcaaacct
      421 accacaagag tttcgtgagc ggatagaaag gctagaaaga aattttgaag tatctactgt
      481 aatttttaaa aaatttgagc ccattttttt agatatcttt caaaatccat atgaagagcc
      541 accaaagttg ccccggagcc gaaaacagag gaggatcccc tgcagtgtta aggacctctt
      601 taacttctgc tggacactct ttgtttacac caaggggaat ttccgtatga ttggtgatga
      661 tttagtaaac tcctatcatt tacttctgtg ctgcttggac ctgatctttg ccaatgctat
      721 aatgtgccca aatagacgag acttgttaaa tccatcattt aaaggcttac catctgattt
      781 ccatgctccg gacttcaaag ccgcagaaga gcctccgtgc atcattgctg tactttgtga
      841 tctgcatgac ggacttctag tagaagcaaa agggataaag gagcattact ttaagccata
      901 tatttcaaag ctctttgata agaagatttt aaaaggtgaa tgcctcttgg atctttccag
      961 ctttactgat aatagcaaag ccgtgaacaa ggaatatgaa gagtatgtcc taactgttgg
     1021 ggacttcgat gagaggatct ttttgggagc agatgcagag gaggagattg gaacacctcg
     1081 aaagttcact gctgacaccc catttgggaa actgacatca caggccagtg tggaatgcaa
     1141 ccttcaacaa cactttgaaa aaaaacggtc atttgcacct tctaccccac ttactggacg
     1201 gcggtattta caagaaaaag aggcagtcac cacgcctgta gcttcagcca ctcaaagtgt
     1261 aagccggtta cagagcatcg tcgctggatt aaaaagcgca ccaagtgagc agcttctgaa
     1321 tatttttgaa tcttgtatgc ggaatcctat gggaaacatt ataaaaattg tgaaaggaat
     1381 aggagagact ttctgccaac actataccca gtccacagat aaacagccag gatctcacat
     1441 agactttgct gtaaacagac taaaactggc agaaattttg tattacaaaa tactggagac
     1501 tataatggtc caggaaacac gacggcttca tggaatggac atgtcggttc ttttagagca
     1561 agatatattt cataaatcct tgatggcttg ttgtttggaa attgtgctct ttgcatatag
     1621 ctcaccccgt actttcccgt ggattattga agttctcgat ttgcagccat tttattttta
     1681 taaggttatt gaggtggtga tccgctcaga ggagggcctt tccagagaca tggtgaaaca
     1741 tctgaacagc attgaagaac agattttgga gagtttggct tggactaata attctgcact
     1801 gtgggaggct ctgcatgctt ctgcaaacag agtcccttcc tgtgaagaag ttatattccc
     1861 taataacttt gaaataggta atggaggaaa tgtgcaaggc catctcccca tgatgccaat
     1921 gtctccaata atacatccaa gagtcaagga agttcgcact gacagtggga gccttcgaca
     1981 ggatatgcaa ccattgtctc cgatttctgt ccatgagcgc tacagctccc ctgctgcagg
     2041 aagtgctaag aggagactgt ttggagatga cccaccaaag gacacactga tggataagat
     2101 tatggcagaa ggaacaaagc tgaaaattgc tccttcgagt gtcactgctg aaagcttatc
     2161 aatttcccct gggcaagctc ttctgacaat ggccacaacc acagtcacag ggacgacggg
     2221 acggaaagtt acagtccctt tgcatggtat cgccaatgat gctggagaaa tcacactggt
     2281 tcctatctcc atgaatccaa ctcaggagtc cacagctgag agccctgtgt cactgactgc
     2341 ccagtcacta attggtactt ctccgaaaca gacccatctg actaaagcac aagatgctca
     2401 tctgaccgga gtaagcaaac ccaagaggac tgggtcctta gcactgttct ataggaaggt
     2461 ctatcatttg gcaagtgtgc gcctacgtga cttatgtcta aaacttgatg tttcaaatga
     2521 attacgaagg aagatctgga catgttttga attcacttta gttcactgcc ctgatttaat
     2581 gaaagatagg catttggatc agctccttct gtgtgcattt tacatcatgg caaaagtaac
     2641 aaaagaagaa agaacttttc aagaaataat gaaaagttat aggaatcagc cccaagctaa
     2701 tagtcacgta tacaggagtg ttctcttgaa gagtattcca ggaggagtcg tggtgtacaa
     2761 tggtgactgt gaaatgaccg atggtgacat agaagatgcc acaaagactc ccaactgttc
     2821 cagtgaacca gtgaaagagg aaagaggtga tcttatcaaa ttttacaata cagtatatgt
     2881 aggaagagtg aagtcatttg cattgaagta tgatttatcc aatcaggacc atataatgga
     2941 tgctcccccg ctctctcctt tcccacacat taagcagcag ccgggttccc cacgccgcat
     3001 ctcccagcag cattccctct atgtgtctcc acacaagaac ggagcgggcc tcacccccag
     3061 gagcgcactg ctgtacaagt tcaacggcag cccttctaag agtttgaaag atatcaacaa
     3121 catgataagg caaggcgagc agaaaaccaa gaagcgcgtg atagccatca gtggagatgc
     3181 agactcacct gccaaacgtc tctgccaaga gaacgatgat gttttactta agcgactaca
     3241 agatgttgtc agtgagagag caaatcatta acgtcaccct ttgcctgatc aaagcacttt
     3301 tggattgttc tggagaaagc tggggctcca tccttcacat ttttatcact gggttataca
     3361 aaaccttgca ccacaagtac gctccttttt aaaagcattt attcaccctt tatagctaac
     3421 agacatatat tttaaggtag attagaaaag aatgttttaa gtgccttcat aaacagtaat
     3481 aagattttct ttttttagtg tttgttccta ggatttcttt ttagggtgaa ttaagaagaa
     3541 actattcttt aaccgtcttt tcaaaatgat caaatgtctc ctgtgctttt taatattcgg
     3601 tcagtgagtc tgtgagatac ttgtctgctt gtgttgaggt tagctcccac agtaggagag
     3661 ctcactgatg gaccagcctg ccttgggcct gctggagcaa ctgcccctca ggtgccacca
     3721 gtgtgtggga ctgtccgtgc cccgtcttct tccgctcgtt gagtacaagc agctctgtac
     3781 ctgggctctg taccttttag cttgatgtta tcaccctata aaagggatac tcatttttaa
     3841 aactacgatt ttcatgatat tgccttaatt attttatgtg attgtattca gtattgtagt
     3901 tctcaaaata agaaactgtt tcttcatcta ggagaataaa atgtagataa atgagaaatt
     3961 aaatttccca agtaaagtag cattatgata agatcattca ttcatttgtg ttgggcacag
     4021 ttggacatgc ctataattcc agtacacaga attgctggga atgtcaggcc agtgtagcta
     4081 catagcaaga ccctgactca aaaagctaaa ttattcattc tcattgttta tttaatttcc
     4141 tgaaaatatt tgaagttttc acattaaaat cacttcatgt cttgtaagtg gagtgtttca
     4201 gtttaagagc tgcttttcct ttctattttg tatcaccctt tgttccagta attacggttt
     4261 ctcctgagtt tcccctgggt gtaactcctg gatcccctga ggatcttccc acactggagg
     4321 tttagccttc tgaagaatca ggtcgctagt gttcaccttt tcttctgtgt gcctagcatc
     4381 gggaaggatg tgaataagcc atttaaatta atagttagat gatgtatcag tatacatatt
     4441 tttagcagca aaccttattt tttaaaatat aaagtattgg cttggcagtc tagctcagca
     4501 tgtctaacat atccagtgct ggctaatttg aacgatagtc taagatttgg ctgccaatta
     4561 atgatgaatg gtaaccaaag ttttattttt aaattttaaa aagaggtttg ggttatgttt
     4621 tgcttgtctg aaattgtatt cttgtgtttt gtgtagtatc tacacatgtt gtaataagcc
     4681 aaataatagt ctgtcttgag tccttgtaca tatttctgtg tagctataac tactgtatca
     4741 ctttcattat taatgtacaa aatataaatg tagatttatc cagtggctat gttaaaaaac
     4801 ttaagtaatg aatttgccaa ttttcaggac tttgtattaa tgtatataaa atagttaata
     4861 aaaattagaa ttttaaaaac taaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
