LOCUS       NM_001039167            4545 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus RNA binding protein, fox-1 homolog (C. elegans) 3
            (Rbfox3), transcript variant 1, mRNA.
ACCESSION   NM_001039167
VERSION     NM_001039167.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4545)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4545)
  AUTHORS   Kawase,K., Nakamura,Y., Wolbeck,L., Takemura,S., Zaitsu,K.,
            Ando,T., Jinnou,H., Sawada,M., Nakajima,C., Rydbirk,R., Gokenya,S.,
            Ito,A., Fujiyama,H., Saito,A., Iguchi,A., Kratimenos,P.,
            Ishibashi,N., Gallo,V., Iwata,O., Saitoh,S., Khodosevich,K. and
            Sawamoto,K.
  TITLE     Significance of birth in the maintenance of quiescent neural stem
            cells
  JOURNAL   Sci Adv 11 (4), eadn6377 (2025)
   PUBMED   39841848
REFERENCE   3  (bases 1 to 4545)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4545)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   5  (bases 1 to 4545)
  AUTHORS   Parvathy,S., Basu,B., Surya,S., Jose,R., Meera,V., Riya,P.A.,
            Jyothi,N.P., Sanalkumar,R., Praz,V., Riggi,N., Nair,B.S.,
            Gulia,K.K., Kumar,M., Binukumar,B.K. and James,J.
  TITLE     TLX3 regulates CGN progenitor proliferation during cerebellum
            development and its dysfunction can lead to autism
  JOURNAL   iScience 27 (12), 111260 (2024)
   PUBMED   39628587
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4545)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   7  (bases 1 to 4545)
  AUTHORS   Keller-Peck,C.R. and Mullen,R.J.
  TITLE     Patterns of neuronal differentiation in neural tube mutant mice:
            curly tail and Pax3 splotch-delayed
  JOURNAL   J Comp Neurol 368 (4), 516-526 (1996)
   PUBMED   8744440
REFERENCE   8  (bases 1 to 4545)
  AUTHORS   Friedman,G.C. and Seeds,N.W.
  TITLE     Tissue plasminogen activator mRNA expression in granule neurons
            coincides with their migration in the developing cerebellum
  JOURNAL   J Comp Neurol 360 (4), 658-670 (1995)
   PUBMED   8801257
REFERENCE   9  (bases 1 to 4545)
  AUTHORS   Mullen,R.J., Buck,C.R. and Smith,A.M.
  TITLE     NeuN, a neuronal specific nuclear protein in vertebrates
  JOURNAL   Development 116 (1), 201-211 (1992)
   PUBMED   1483388
REFERENCE   10 (bases 1 to 4545)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079086.1, AK049926.1, AK160816.1 and AL591075.11.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079086.1, SRR7345562.3528434.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AK079086.1         2-23
            23-757              AK049926.1         1-735
            758-1666            AK160816.1         697-1605
            1667-2341           AK079086.1         1668-2342
            2342-4545           AL591075.11        75554-77757         c
FEATURES             Location/Qualifiers
     source          1..4545
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.22 cM"
     gene            1..4545
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /note="RNA binding protein, fox-1 homolog (C. elegans) 3"
                     /db_xref="GeneID:52897"
                     /db_xref="MGI:MGI:106368"
     exon            1..269
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            270..408
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            409..513
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            514..553
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            554..808
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     CDS             587..1711
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /note="isoform 1 is encoded by transcript variant 1; fox-1
                     homolog C; hexaribonucleotide binding protein 3; neuronal
                     nuclear antigen A60; RNA binding protein fox-1 homolog 3;
                     neuN antigen; neuronal nuclei antigen"
                     /codon_start=1
                     /product="RNA binding protein fox-1 homolog 3 isoform 1"
                     /protein_id="NP_001034256.1"
                     /db_xref="CCDS:CCDS25706.1"
                     /db_xref="GeneID:52897"
                     /db_xref="MGI:MGI:106368"
                     /translation="MAQPYPPAQYPPPPQNGIPAEYAPPPPHPTQDYSGQTPVPPEHG
                     MTLYTPAQTHPEQPGTEASTQPIAGTQTVPQADEAAQTDNQQLHPSDPTEKQQPKRLH
                     VSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFETSSDADRAREKLNG
                     TIVEGRKIEVNNATARVMTNKKPGNPYANGWKLNPVVGTVYGPEFYAVTSFPYPTTGT
                     AVAYRGAHLRGRGRAVYNTFRAAPPPPPIPTYGAALEQTLVKMPVPWAGLAPCPLPPQ
                     QTPEPAYPTSPAFPPLSCPFASRVVYQDGFYGAEIYGGYAAYRYAQPAAATAAAYSDS
                     YGRVYAAADPYHHTIGPTATYSIGTMASLCRGGYSRFTPY"
     exon            809..946
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1000
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1093
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1154
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1208
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1341
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1522
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1587
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1666
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..4545
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /note="hexamer: ATTAAA"
     polyA_site      2311
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /note="major polyA site"
     regulatory      4520..4525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /note="hexamer: AATAAA"
     polyA_site      4541
                     /gene="Rbfox3"
                     /gene_synonym="Fox-3; Hrnbp3; NeuN; Neuna60"
                     /note="major polyA site"
ORIGIN      
        1 gagagagaga gagagagaga gagagagagt cggcgaggca agcggagcgg ggacacggag
       61 ccgttgctcc ggaaccggcg gaaacctcct cggacagcag tcgggcgcct gccccagcag
      121 ctcgcgtggt ctccggagac gccgcggcag ccaccgccgc tccaacccgg cctctcgcgc
      181 cccttgccgc cggctcgccg gggcggccgg gatgcagccg gggcatggcc gccagggccc
      241 cgtcacctgc cgtggggaac gctgaacccg ttgaaaagct gcctgtgaga acctagtgct
      301 tttttgcgat cccactctgc gtgggcacac acacactcca tactgaggaa gcttcatcag
      361 ttcttccacg ggcccctggc tacaggaaag tagacgacac cccaacagtg tgacatcaga
      421 aggaccaggg ggaattccgc cggcctcccc agagctggcc cacaggcctc cttagcggga
      481 acctgtccga ggagtggccc gttctgcaaa cagagagccc agagcgcctc cgggaaaatt
      541 ggctgaataa aagggcaatc aggacgccac ggctccacct gaagcgatgg cccagcccta
      601 cccccctgcc cagtaccctc ctccgcctca gaatggaatc ccagctgaat atgccccacc
      661 tccgcctcat cccacccagg actactccgg ccagacccct gttccccccg agcacggcat
      721 gaccctctac acacccgcac agactcatcc tgagcagcca ggcactgagg ccagcacaca
      781 gcccattgct gggacccaga cggtgccgca ggcagatgaa gcagcacaga cagacaacca
      841 gcaactccac ccttccgacc ccacggagaa gcagcagccc aaacgactac atgtctccaa
      901 catccccttc cggttcaggg accccgacct gcggcaaatg ttcgggcaat tcgggaaaat
      961 tttagacgtg gagatcattt ttaacgagcg gggctccaag ggttttgggt ttgtaacttt
     1021 tgaaactagc tcagatgctg accgagcccg ggagaagctg aatgggacga tcgtagaggg
     1081 acggaaaatt gaggtcaata atgccacagc ccgggtcatg accaataaga agcctgggaa
     1141 cccatatgcc aatggctgga agctaaaccc tgtggtagga acagtctatg ggcctgaatt
     1201 ctatgcagtg accagtttcc cctaccccac cacgggcacc gccgttgcct accggggtgc
     1261 acacctgcgg ggccggggcc gtgctgtgta taatacattt cgagctgcac cacctccacc
     1321 ccccattcca acttatggag cggcactgga gcaaacgctt gttaaaatgc cagtcccgtg
     1381 ggcggggctg gcaccgtgcc ccctccctcc tcagcagaca ccggagccgg cctaccccac
     1441 ctctccagcg ttcccaccac tctcttgtcc gtttgcttcc agggtcgtgt atcaggatgg
     1501 attttatggt gctgagattt atggaggcta tgcagcttac agatatgctc agccagcagc
     1561 cgccaccgca gcagcctaca gtgacagtta tggtagagtc tatgccgctg ctgatcctta
     1621 ccatcacacc atcggcccca cagcaaccta cagcatcgga accatggcta gcctctgccg
     1681 aggagggtac agccgcttca ccccctacta gcaagagacc ccctcacagc attcacacta
     1741 cagcttattc caaaccaaac cctacagtcc caacaccagg cacaaccgcc cggaggacag
     1801 tgcgcccctc ccagtcagcg accagcgagc tgactctctg cgactctaaa gtccatagat
     1861 ttttacctcc agccagctgg tctccccacc ccacccatgc tggtgtgtgt gtctctgacc
     1921 ctggttttcc tgtatgtctg aaccttggtt tcctatcttg acgttgttgt acgagccact
     1981 ccaggtacgg tatgcataca gcgggagcca ggccaggggg acggcaaggt gccctgccag
     2041 ggccatgccc atgcctcagg gcaccacggc ccctcagggc tccagaagtg ccaggccaag
     2101 cctccctcag agccacctca gtcagctccg gcaggtctgg ccatcccggg tttgctggct
     2161 gacagaggag ttccaggcct agtcagtggg gtcctcccag tgggagggac ttccacccac
     2221 ctttcacaga gactgtcaag agtaactgca tgccctctct ggacttccac tcagccgaag
     2281 ttatcgtttc tattaaagtt tactaaccat cttcctgtcc aagtagtcac agcacactgt
     2341 tctgtgtgca atactgccgt ggccaccctg gctctgggat tccttacaga cacggaaatg
     2401 tccctgcccc aaggttaccc tgtattgcct gtggacctag agaccctccc tgagcctgac
     2461 caccctcagg ctcctggagc tgatggctct gggaccattt gttcttgacc tacagagcca
     2521 ccccacccat ccccttttgt agcggtccat accaggaaag gccagggttc cagtagtcag
     2581 gcctgggaca cagtatcacc ttccttcctc tggtctccct gcagccaccc aagcctcagt
     2641 tagcatgtgt gtgcctctgt ggcctgtggg gacccaccta gctccactgc ctagagtccc
     2701 tgaagtcagg ctgaaagcct agagaactag cagatgttaa tccctccact ctgggggttc
     2761 agggccacaa agtgaccaaa gctgtaagtc ccatcaaacc ccatctcctc caccatacac
     2821 catgcccgct acccactctg agccctgccc attgctatga gatggtctac tctaggtcta
     2881 gcttgtggtg tggtcccaga agctgtggtg ggggtatggg taggattggg ggggtgtgtg
     2941 gcctcagggc aggtttaggg gaagtgtggc ttcaggtcgg accccagacc acaagcacgg
     3001 tggccctgca tgctgcagcc gacgctcgga aaccgcaagc cctcatttct gtttctgttg
     3061 tagtgaaacc ttccaccgtc tccttctcgg accatgaagg gcaaaaacaa aaaaacaaaa
     3121 aaaatcacaa aacaaaaaac aaaacaaaaa aagatgttaa gatccaagca acaacagcaa
     3181 caacaacaaa taccaaccaa accaagaggc atccaaccaa gtccaagtcc acgtctggcg
     3241 tacacccgca tcgagggagc tcgtccccca gggggcgccg gagagtggct ttgcctggct
     3301 ggcggtgtag tggggacgcg gccagacact ggggaagacc tggaggggga acgtggccag
     3361 tgggtgtggg gcggggggct ccggtatcta tccagtcttc ctttcccacc ctgctcccca
     3421 gacagggggt tcctagggtg gaccaggccc ctgagaagga gcggccagct gacttgggct
     3481 attgcctgct gagccctgaa ggggctggag cagttagggg ccagcggctt atcactcatc
     3541 ccaggtctgc agcctggcct cattgaatgt tgctgccagt gccgtcagct atccaaccag
     3601 ccgccctggg ttccaactcc caatgcaaag ggctgacacg gctccagaac tctggggcac
     3661 cccatgctcc gctcccctat gtgagaaagc ttccggctac aaagaacaaa gaaagcccag
     3721 ccagcgagga cccagtcctc acgctgtgaa cgtggacagg tgggccctcg ggcacagggt
     3781 tgtttgtcgt ggcagcctcc ctgaaggagg ctccgtgggc ttgaaggcca gcctcagctg
     3841 tcttctagga cccagccctc ctttccactc ccttctgtag gctccgttct gctggggagt
     3901 ggggattgag acgggccagc cctgggctgc acctagatgt tgggagtcaa ggtgctgtgg
     3961 gtctggaggg ccgcagtcag aacaggaccc atgggaaagg caagggatgg ggaaggtctg
     4021 ggctggccct gccacgggga aggccggctg ggctgcagcc cgtttgctcc ctgggcaggt
     4081 aaagtgtggg agtcacggga aagcagcagg cccagtggat ggaacaggga agaggtatca
     4141 agaagcccct gggcaaggca gggataggtg gagtagggtt aacagcaaaa aagaaaaaaa
     4201 aaaaaaaatt aacagaaacc aaggctcccg acgcggcacc actgtctcat gacacctcaa
     4261 aataaatcac ctcactttct atccagcatc agccacagaa gctatggaaa cggaaccctc
     4321 cttttctatt cctgatgtac atagccccgc gcctgcctct ggctctgtcc tctgtacgga
     4381 gccccttgcc ttctgctgtt tcggaccctt ttcccgcagc ccctcccagg actgcagccg
     4441 agccccaggc ttcctttctt accattctgt atgcttccac ggtgtgacca ttcaaattaa
     4501 cagtattatt attaagatta ataaagattt ctttcttcaa accag
//
