LOCUS       NM_001417334            4266 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RNA binding protein, fox-1 homolog (C. elegans) 1
            (Rbfox1), transcript variant 10, mRNA.
ACCESSION   NM_001417334 XM_036159934
VERSION     NM_001417334.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4266)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4266)
  AUTHORS   Gu,L., Kwong,J.M.K., Caprioli,J. and Piri,N.
  TITLE     Visual Function and Survival of Injured Retinal Ganglion Cells in
            Aged Rbfox1 Knockout Animals
  JOURNAL   Cells 11 (21), 3401 (2022)
   PUBMED   36359797
  REMARK    GeneRIF: Visual Function and Survival of Injured Retinal Ganglion
            Cells in Aged Rbfox1 Knockout Animals.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4266)
  AUTHORS   Kadouri,N., Givony,T., Nevo,S., Hey,J., Ben Dor,S., Damari,G.,
            Dassa,B., Dobes,J., Weichenhan,D., Bahr,M., Paulsen,M.,
            Haffner-Krausz,R., Mall,M.A., Plass,C., Goldfarb,Y. and Abramson,J.
  TITLE     Transcriptional regulation of the thymus master regulator Foxn1
  JOURNAL   Sci Immunol 7 (74), eabn8144 (2022)
   PUBMED   36026441
  REMARK    GeneRIF: Transcriptional regulation of the thymus master regulator
            Foxn1.
REFERENCE   4  (bases 1 to 4266)
  AUTHORS   Gu,L., Caprioli,J. and Piri,N.
  TITLE     Rbfox1 expression in amacrine cells is restricted to GABAergic and
            VGlut3 glycinergic cells
  JOURNAL   Biosci Rep 42 (7) (2022)
   PUBMED   35730583
  REMARK    GeneRIF: Rbfox1 expression in amacrine cells is restricted to
            GABAergic and VGlut3 glycinergic cells.
REFERENCE   5  (bases 1 to 4266)
  AUTHORS   Lin,F., Xu,L., Yuan,R., Han,S., Xie,J., Jiang,K., Li,B., Yu,W.,
            Rao,T., Zhou,X. and Cheng,F.
  TITLE     Identification of inflammatory response and alternative splicing in
            acute kidney injury and experimental verification of the
            involvement of RNA-binding protein RBFOX1 in this disease
  JOURNAL   Int J Mol Med 49 (3) (2022)
   PUBMED   35059728
  REMARK    GeneRIF: Identification of inflammatory response and alternative
            splicing in acute kidney injury and experimental verification of
            the involvement of RNAbinding protein RBFOX1 in this disease.
REFERENCE   6  (bases 1 to 4266)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4266)
  AUTHORS   Nakahata,S. and Kawamoto,S.
  TITLE     Tissue-dependent isoforms of mammalian Fox-1 homologs are
            associated with tissue-specific splicing activities
  JOURNAL   Nucleic Acids Res 33 (7), 2078-2089 (2005)
   PUBMED   15824060
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4266)
  AUTHORS   Jin,Y., Suzuki,H., Maegawa,S., Endo,H., Sugano,S., Hashimoto,K.,
            Yasuda,K. and Inoue,K.
  TITLE     A vertebrate RNA-binding protein Fox-1 regulates tissue-specific
            splicing via the pentanucleotide GCAUG
  JOURNAL   EMBO J 22 (4), 905-912 (2003)
   PUBMED   12574126
REFERENCE   9  (bases 1 to 4266)
  AUTHORS   Kiehl,T.R., Shibata,H., Vo,T., Huynh,D.P. and Pulst,S.M.
  TITLE     Identification and expression of a mouse ortholog of A2BP1
  JOURNAL   Mamm Genome 12 (8), 595-601 (2001)
   PUBMED   11471052
REFERENCE   10 (bases 1 to 4266)
  AUTHORS   Shibata,H., Huynh,D.P. and Pulst,S.M.
  TITLE     A novel protein with RNA-binding motifs interacts with ataxin-2
  JOURNAL   Hum Mol Genet 9 (9), 1303-1313 (2000)
   PUBMED   10814712
  REMARK    Erratum:[Hum Mol Genet 2000 Jul 22;9(12):1903]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124551.4, AC125179.4, AC154705.2, AC161378.2, AC124225.13 and
            AC163654.2.
            
            On Mar 2, 2023 this sequence version replaced XM_036159934.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662773.947575.1,
                                           SRR5189670.106857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               AC124551.4         139672-140016
            346-393             AC125179.4         73987-74034
            394-435             AC154705.2         71646-71687         c
            436-675             AC161378.2         183283-183522
            676-819             AC124225.13        103520-103663       c
            820-873             AC124225.13        95157-95210         c
            874-966             AC124225.13        88411-88503         c
            967-1027            AC124225.13        86558-86618         c
            1028-1081           AC124225.13        74227-74280         c
            1082-1162           AC124225.13        50246-50326         c
            1163-1295           AC124225.13        27624-27756         c
            1296-1335           AC124225.13        16784-16823         c
            1336-1400           AC124225.13        4719-4783           c
            1401-1476           AC163654.2         102992-103067       c
            1477-4266           AC163654.2         98551-101340        c
FEATURES             Location/Qualifiers
     source          1..4266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 3.34 cM"
     gene            1..4266
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /note="RNA binding protein, fox-1 homolog (C. elegans) 1"
                     /db_xref="GeneID:268859"
                     /db_xref="MGI:MGI:1926224"
     exon            1..345
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1599
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /note="isoform 6 is encoded by transcript variant 10;
                     ataxin 2 binding protein 1; fox-1 homolog A; RNA binding
                     protein fox-1 homolog 1; hexaribonucleotide binding
                     protein 1"
                     /codon_start=1
                     /product="RNA binding protein fox-1 homolog 1 isoform 6"
                     /protein_id="NP_001404263.1"
                     /db_xref="GeneID:268859"
                     /db_xref="MGI:MGI:1926224"
                     /translation="MKSWQLIAVVGDALQDIKGDSNNCAQTEDRKVLRQQMNCEREQL
                     RGNQEAAAAPDTMAQPYASAQFAPPQNGIPAEYTAPHPHPAPEYTGQTTVPDHTLNLY
                     PPTQTHSEQSADTSAQTVSGTATQTDDAAPTDGQPQTQPSENTESKSQPKRLHVSNIP
                     FRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEG
                     RKIEVNNATARVMTNKKTVNPYTNGWKLNPVVGAVYSPDFYAGTVLLCQANQEGSSMY
                     SGPSSLVYTSAMPGFPYPAATAAAAYRGAHLRGRGRTVYNTFRAAAPPPPIPAYGGVV
                     YQDGFYGADIYGGYAAYRYAQPTPATAAAYSDSYGRVYAADPYHHTLAPAPTYGVGAM
                     NAFAPLTDAKTRSHADDVGLVLSSLQASIYRGGYNRFAPY"
     exon            346..393
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..435
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..675
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..819
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..873
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..966
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1027
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1081
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1162
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1295
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1335
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1400
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1476
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..4266
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4211..4216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /note="hexamer: AATAAA"
     regulatory      4215..4220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /note="hexamer: AAGAAA"
     polyA_site      4221
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /note="major polyA site"
     regulatory      4242..4247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /note="hexamer: AATAAA"
     polyA_site      4248
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
                     /note="major polyA site"
     polyA_site      4266
                     /gene="Rbfox1"
                     /gene_synonym="A2bp; A2bp1; fox-1; Hrnbp1"
ORIGIN      
        1 gtctttgtgt gttcctggag ctttgattac ctccctgcac cgcgcgctcg ctcttgtgcc
       61 tgctggatct ctggccctct cgcttgttca aggccttgaa cacctgctgg tggctggagc
      121 aaaacagccc aggcaggcga aggcgcggcc agcccagcag agagagctag aatcattggc
      181 attgctagca cgtgggtacc attctctgct gctgctgctg ccccggcact tctcccgcct
      241 tgcgtttctc ccaatgcgat gtagcaagag agggagcagg aggcgctttt gcagcgggcg
      301 atgaaatcct ggcagctaat tgcagtcgtg ggagatgccc ttcaggatat caaaggcgac
      361 tccaataact gcgcgcagac agaggacaga aaggttttga ggcaacagat gaattgtgaa
      421 agagagcagc tgaggggtaa tcaggaagca gccgccgccc ctgacacaat ggctcagcct
      481 tatgcctcag cgcagttcgc accaccccag aatggcatcc ctgcagaata cacggcccct
      541 catcctcatc ccgcgccaga gtacaccggc cagaccactg tccctgacca cacattaaac
      601 ctgtatcctc ctacacagac gcactcggag cagagtgctg acaccagtgc gcagaccgtc
      661 tccggcaccg ccacacagac agatgatgca gccccgaccg acggccagcc ccagacacaa
      721 ccttctgaaa acacagaaag caagtcccag cccaagcggc tgcatgtgtc caacatccct
      781 ttccggttcc gggatccaga cctccgacaa atgtttggtc aatttggtaa aatattagat
      841 gttgaaatta tttttaatga gcgaggctcc aagggatttg gtttcgtaac tttcgaaaat
      901 agtgcggatg cggacagggc gagggagaaa ttgcacggta ccgtggtaga gggccgtaaa
      961 atcgaggtta ataatgcgac agcacgcgtg atgacaaata agaagactgt caacccctac
     1021 accaatggct ggaaattaaa tccagttgtg ggcgcggtct acagccccga cttctatgca
     1081 ggcacggtgc tgttgtgcca ggccaaccag gagggatctt ccatgtacag tggccccagt
     1141 tcacttgtat atacttctgc aatgcctggc ttcccatatc cggccgccac tgctgcagct
     1201 gcataccgag gggctcacct tcgaggccgt ggtcgcaccg tgtacaacac cttcagggct
     1261 gcagcgcccc cgcccccaat cccggcctat ggcggtgttg tttaccagga tggattttat
     1321 ggtgcagaca tttatggtgg ttatgctgcg taccgctatg cccagcccac ccctgccact
     1381 gccgctgcct acagtgacag ttacggacga gtttatgctg ccgaccccta ccaccacaca
     1441 cttgctccag cccccaccta cggcgttggt gccatgaatg cttttgcgcc cttgaccgat
     1501 gccaagacta ggagccatgc tgatgatgtg ggtctcgttc tttcttcatt gcaggctagt
     1561 atataccgag ggggatacaa ccgttttgct ccatattaaa tgataaaacc attaaacaaa
     1621 caaacaaata aacaaacaaa cgaacaaaaa aaacccaacc ttccaatgtg gggagagagg
     1681 aagctttccg aggcctgagt gttgcatcac atgcagtagg acatcatgtt agcaactcaa
     1741 agaaacaact aaaaagaaaa aaaaattaaa aaaagaggaa aaattacatt ttttatctta
     1801 tacctcagat attttgttct gtgtatttta atattgtggg tctttggttt ctgaaggttt
     1861 ttgtagttca gttggctgta ggagtttttg tggttgatct agagagaggc tagatatgaa
     1921 taaaaactga tttagggcca tatccagagt gctatattat gtaaatgaat tctatatgcc
     1981 gaacatgaag ctactggggt taagctgttt gggaagactg gaaacggcaa gtcattcttt
     2041 ctgcatccac attattttat tctgtgaaag gggaggctgg ggcgggctta ggggtttggc
     2101 tgaaaggaaa aaaagaaaat atatatatat atatatatat acatatatat agtaactgat
     2161 gaatctaaat gacccactgc accaactatc ataaatctat ggttctaagt tactcctggc
     2221 aaagtcaagc caaaggctgt gttaagaatc cgcttctcat agcacggaga ttgcagttga
     2281 aggaaggaag ctgtgtcggc cagtccaccc tcttatcatt ccacctgcag tactcagctt
     2341 cttacctacc cactagttat ttaagcaaag gctactagtt aggccatcag taagcattct
     2401 ttttatattt cttccagtat gagaaattat tgatatcact gctgactttt atattacggg
     2461 agggaaaaat taacattaat aaaaaggtga ttaaaaaaag cactgtttct atttttttct
     2521 ttttttccaa aaaagaaagt aataaaaact taaattcttt gtaccagtta aaaatatgta
     2581 taaaatttac atctgtgcag tggagttatg ttctagaaca gtctctgagg ctttagttta
     2641 gcttagtaga ttaactgtta gagacagacg tataattttt atggaattac atgataatca
     2701 tatctggatt tatagtcgca ttttacaagt atcgcaatca ttgaatagag ataatcatgg
     2761 tattttcatc agcttgatac tttttgaaaa catgactgcg ctgtgagcaa cttgcaattt
     2821 ttcagtctgt gagagcccgc ccttccctct ccccagtgcc ccagggttat cataaactgg
     2881 tatctttatt tctatcacca aggcccaaca attgtcagaa ggaagcaaac acaagacaaa
     2941 aaacaagaac tagaactatc ccctccaccc ccaaagaaca agatctgccc catccttttt
     3001 cggagcaggg ccagagcaac acagccgaaa aattgcaact tgtgattttc ttctgtttga
     3061 atccccccca tgttgtcctg tttacaagtt aacctaagtt ggggtatctg tcatgggtct
     3121 tcctgttttg tatttaaatt ctaaaatatc agcaagctgt tccctgagta gtgttgctgc
     3181 ctgtgtgtgc ggtgccggcc ccgcggcacg cactttagta agttatcaac tcacgctgtg
     3241 aacctgccaa cctgctgtaa caactctgct ttaaaatcaa aaccaaacga aactttaaaa
     3301 agaaaaaaaa aagtgtgtgt gatccagctt ttcctcgtca tcctacgtgc atgcccgtaa
     3361 gatcggttgg atattaaacc atcaataaag tttcatgaga tttgaaaaca aagtttttgt
     3421 agcttcgata tctaagacag gtgatcatgg tttgggagag aaagaaaagc aaagggcgag
     3481 gaggggaagg gagagaaact gctgaactgg tgagaagaga aactgttctt ctttcaccag
     3541 acccctttct ttgagtaggg agagacaggt ccagagggaa ccatttgaca acatcacgtt
     3601 cccacttccc tggcctgcta cagcgtgcac ctggttgatg ttatccaagg caacaattta
     3661 tcatgatgct gtagcattca accccagatg gggtcaagat agtaatagaa aagggggctg
     3721 caaaaagatc aacagactcc tcccagtcgc cccagatttt caagcccaga acctgcattg
     3781 tgtatgaaat cacaaacatg gaattcttac tgtgctggct aaagtaaaac tcatttgcgg
     3841 ttttgatttc catcaatgaa ctgtactttc ccctacgatc gtatgtagtt ttaataaaaa
     3901 tcatttagag caagtgggtg ccaatcggtg tcgcagaacc ttttgtctag gcactccact
     3961 gagctgccga taagtcgttt taaactgtca tgtcagaggt gtaaacaaac attttggatt
     4021 ttttaaaaca acagtattta tttggaatgt tttcatttat ctaaataact attgctatta
     4081 tgaattatgg aaaaaaagat taatgtggca tatagtgact tcttaacaca catcactcaa
     4141 tctgcaaacc cagaaaatgt gtatatctgt ctttagaaat tagtgtttat atcacttaca
     4201 gtggtttgtg aataaagaaa actggtttgt aatatcaaaa aaataaaagc ttagtctgaa
     4261 aaggta
//
