LOCUS       NM_001083921            2410 bp    mRNA    linear   ROD 23-APR-2023
DEFINITION  Mus musculus RanBP-type and C3HC4-type zinc finger containing 1
            (Rbck1), transcript variant 1, mRNA.
ACCESSION   NM_001083921
VERSION     NM_001083921.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2410)
  AUTHORS   Skordos I, Driege Y, Haegman M, Kreike M, Staal J, Demeyer A and
            Beyaert R.
  TITLE     Normal lymphocyte homeostasis and function in MALT1
            protease-resistant HOIL-1 knock-in mice
  JOURNAL   FEBS J 290 (8), 2032-2048 (2023)
   PUBMED   36479846
  REMARK    GeneRIF: Normal lymphocyte homeostasis and function in MALT1
            protease-resistant HOIL-1 knock-in mice.
REFERENCE   2  (bases 1 to 2410)
  AUTHORS   Nitschke S, Sullivan MA, Mitra S, Marchioni CR, Lee JPY, Smith BH,
            Ahonen S, Wu J, Chown EE, Wang P, Petkovic S, Zhao X, DiGiovanni
            LF, Perri AM, Israelian L, Grossman TR, Kordasiewicz H, Vilaplana
            F, Iwai K, Nitschke F and Minassian BA.
  TITLE     Glycogen synthase downregulation rescues the amylopectinosis of
            murine RBCK1 deficiency
  JOURNAL   Brain 145 (7), 2361-2377 (2022)
   PUBMED   35084461
  REMARK    GeneRIF: Glycogen synthase downregulation rescues the
            amylopectinosis of murine RBCK1 deficiency.
REFERENCE   3  (bases 1 to 2410)
  AUTHORS   Wood MJ, Marshall JN, Hartley VL, Liu TC, Iwai K, Stappenbeck TS
            and MacDuff DA.
  TITLE     HOIL1 regulates group 2 innate lymphoid cell numbers and type 2
            inflammation in the small intestine
  JOURNAL   Mucosal Immunol 15 (4), 642-655 (2022)
   PUBMED   35534698
  REMARK    GeneRIF: HOIL1 regulates group 2 innate lymphoid cell numbers and
            type 2 inflammation in the small intestine.
REFERENCE   4  (bases 1 to 2410)
  AUTHORS   Gomez-Diaz C, Jonsson G, Schodl K, Deszcz L, Bestehorn A, Eislmayr
            K, Almagro J, Kavirayani A, Seida M, Fennell LM, Hagelkruys A,
            Kovarik P, Penninger JM and Ikeda F.
  TITLE     The ubiquitin ligase HOIL-1L regulates immune responses by
            interacting with linear ubiquitin chains
  JOURNAL   iScience 24 (11), 103241 (2021)
   PUBMED   34755089
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2410)
  AUTHORS   Fu Y, Wang H, Dai H, Zhu Q, Cui CP, Sun X, Li Y, Deng Z, Zhou X, Ge
            Y, Peng Z, Yuan C, Wu B, Yang X, Li R, Liu CH, He F, Wei W and
            Zhang L.
  TITLE     OTULIN allies with LUBAC to govern angiogenesis by editing ALK1
            linear polyubiquitin
  JOURNAL   Mol Cell 81 (15), 3187-3204 (2021)
   PUBMED   34157307
REFERENCE   6  (bases 1 to 2410)
  AUTHORS   Zenke-Kawasaki Y, Dohi Y, Katoh Y, Ikura T, Ikura M, Asahara T,
            Tokunaga F, Iwai K and Igarashi K.
  TITLE     Heme induces ubiquitination and degradation of the transcription
            factor Bach1
  JOURNAL   Mol Cell Biol 27 (19), 6962-6971 (2007)
   PUBMED   17682061
REFERENCE   7  (bases 1 to 2410)
  AUTHORS   Nakamura M, Tokunaga F, Sakata S and Iwai K.
  TITLE     Mutual regulation of conventional protein kinase C and a ubiquitin
            ligase complex
  JOURNAL   Biochem Biophys Res Commun 351 (2), 340-347 (2006)
   PUBMED   17069764
REFERENCE   8  (bases 1 to 2410)
  AUTHORS   Farber CR, Corva PM and Medrano JF.
  TITLE     Genome-wide isolation of growth and obesity QTL using mouse speed
            congenic strains
  JOURNAL   BMC Genomics 7, 102 (2006)
   PUBMED   16670015
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2410)
  AUTHORS   Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M,
            Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A and
            Cortese R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2410)
  AUTHORS   Martinez-Noel G, Niedenthal R, Tamura T and Harbers K.
  TITLE     A family of structurally related RING finger proteins interacts
            specifically with the ubiquitin-conjugating enzyme UbcM4
  JOURNAL   FEBS Lett 454 (3), 257-261 (1999)
   PUBMED   10431818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX238505.1, AK085559.1, AK166075.1 and AI853834.1.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_001083921.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085559.1, AK166075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-616               CX238505.1         1-616
            617-1690            AK085559.1         606-1679
            1691-2393           AK166075.1         1659-2361
            2394-2410           AI853834.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2410
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..2410
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /note="RanBP-type and C3HC4-type zinc finger containing 1"
                     /db_xref="GeneID:24105"
                     /db_xref="MGI:MGI:1344372"
     exon            1..392
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..1897
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /EC_number="2.3.2.31"
                     /note="isoform a is encoded by transcript variant 1;
                     ranBP-type and C3HC4-type zinc finger-containing protein
                     1; novel zinc finger, C3HC4 type (RING finger) protein;
                     ubcM4-interacting protein 28; ubiquitin-conjugating enzyme
                     7-interacting protein 3; heme-oxidized IRP2 ubiquitin
                     ligase 1 homolog; RING-type E3 ubiquitin transferase
                     HOIL-1"
                     /codon_start=1
                     /product="ranBP-type and C3HC4-type zinc finger-containing
                     protein 1 isoform a"
                     /protein_id="NP_001077390.1"
                     /db_xref="CCDS:CCDS38273.1"
                     /db_xref="GeneID:24105"
                     /db_xref="MGI:MGI:1344372"
                     /translation="MDEKTKKAEEMALSLARAVAGGDEQAAIKYATWLAEQRVPLRVQ
                     VKPEVSPTQDIRLCVSVEDAYMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPSLQQWV
                     VGQRLARDQETLHSHGIRRNGDGAYLYLLSARNTSLNPQELQRQRQLRMLEDLGFKDL
                     TLQSRGPLEPVLPKPRTNQEPGQPDAAPESPPVGWQCPGCTFINKPTRPGCEMCCRAR
                     PETYQIPASYQPDEEERARLAGEEEALRQYQQRKQQQQEGNYLQHVQLEQRSLVLNTE
                     PTECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVACPFIDSTYSCPGKL
                     LEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDVNEFTCPVC
                     TRVNCLLCKAIHEHMNCREYQDDLALRAQNDVAARQTTEMLKVMLQQGEAMHCPQCRI
                     VVQKKDGCDWIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQNCH
                     "
     exon            393..537
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            538..631
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            632..830
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            831..946
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1120
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1281
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1393
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1573
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1672
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1816
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2397
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2377..2382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /note="putative"
     polyA_site      2393
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; HOIL-1L; Ubce7ip3; UIP28"
                     /note="putative"
ORIGIN      
        1 cgctgctcgc gctgtcttcc gggtagcgcg agcctccggg ctggggttcc ggacgctagg
       61 gcgcccgcgc cggctggctg gccggcctcc ctccgtccct cgcttttggg tcgtggttac
      121 tcatcgccct ttgcagactt ggctcggggc ctccttcgct gtccgtgtcc ctcgcggggc
      181 cccattggtt cccagtgccc ggcctcgggc cctgggcagt gtgatgctgc ccgagtgcgg
      241 actggaacac acgcacgagg ccggctaggg cagagttgct tctaccttcc cgctctctcc
      301 caggttacct caaagtagcg ttttccggaa gcagcagccc tttctgaggg gatgggcgca
      361 gccaggccag atggacgaga agaccaagaa agcagaggag atggccctga gccttgcccg
      421 ggcagtggct ggcggagatg aacaggctgc tatcaagtat gccacctggc tggcagagca
      481 gagggtgccc ctcagggtgc aagtaaaacc cgaggtctcc ccaacacagg acatcaggct
      541 ctgtgtgagt gtggaggatg cgtacatgca caccgtcacc atttggctca cagtacgccc
      601 ggatatgaca gtggcctccc ttaaggacat ggtattcctg gactatggct tcccacctag
      661 cctgcagcag tgggtggttg gacagaggct ggcacgagac caggagacct tgcattcaca
      721 cggcattcgg cggaatggag acggtgccta tctctacctg ctgtcagccc gcaacacgtc
      781 actcaaccca caagagctgc agcggcagcg gcaactgcga atgttggaag atttgggctt
      841 caaggacctc acccttcagt cacgggggcc cttggaacct gtccttccga agcccaggac
      901 caaccaggag ccgggacagc cagatgcagc accggagtca ccaccggtgg gctggcagtg
      961 ccctggctgc actttcatca acaaacccac acggcctggg tgtgagatgt gctgtcgtgc
     1021 aaggcctgag acctaccaga tacctgcttc ataccagcct gacgaggaag agcgagcacg
     1081 cctggccggc gaggaggagg cgctgcgcca gtaccagcag cggaaacagc agcagcagga
     1141 ggggaactac ctgcagcacg tgcagctgga gcagaggagc ctggtgctga acaccgaacc
     1201 tactgagtgc cctgtgtgct actcagtgct ggcacccggc gaggccgtgg tgctgcgtga
     1261 gtgtctgcac accttctgca gggagtgcct gcagggcacc atccgaaaca gccaggaggc
     1321 ggaggtggct tgccccttca ttgacagcac ctactcatgc cccggcaagc tgctggagag
     1381 agagatccgg gcgctcctgt cccctgagga ctaccagcgt ttcctggatc tgggtgtgtc
     1441 catcgcagag aaccgaagca ccttgagcta ccactgcaag acccccgact gcaggggttg
     1501 gtgcttcttt gaggatgatg tcaacgagtt cacctgtcct gtgtgcaccc gtgtcaactg
     1561 cctgctctgc aaggccatcc atgagcacat gaattgcagg gagtaccaag acgacctggc
     1621 cctgcgggct cagaatgatg tggctgcccg gcagacgaca gagatgctaa aggtaatgct
     1681 gcagcagggc gaggccatgc actgcccaca gtgccggatt gtggtgcaga agaaggacgg
     1741 ctgtgactgg atccgctgta cagtctgcca cactgagatc tgctgggtca ccaagggccc
     1801 acgctggggc ccagggggcc caggggacac cagtggtggc tgccgctgcc gggtcaatgg
     1861 gattccatgc cacccaagct gtcaaaactg ccactaagtc gacgatggtg gctctcatac
     1921 tgacccagcc ccacatgtat agcagtgaac agcagggcta ggcaagggac tggcctggtt
     1981 tggccccata cctttaggct tggtaaggga gaaagcccga gctgtactgc agtctgattg
     2041 ctgtgttaca aggacccagc tgagctgatg tcattcgcac tgcctctgtt gcttctggct
     2101 gaccagacct catggccctg cactagacac ccgaccctta ctagccacca gccttaatta
     2161 aacacggcct tggcctaagg cctggctggc tagtgctctg agtgactcta ttttccctga
     2221 gcttgctccc tgaggaccca ccacagcctc atcctttgcc ttgctggctt tctgggcacg
     2281 tcttaaagct gatgtgaatc catccagggc ctaggtagat tggtaagtca ggaaacagcc
     2341 catggggttc agctctgcat cctcctcttt aagtgaatta aagtggtttt cccagaaaaa
     2401 aaaaaaaaaa
//
