LOCUS       NM_001081223            3618 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus retinoblastoma binding protein 8, endonuclease
            (Rbbp8), transcript variant 1, mRNA.
ACCESSION   NM_001081223 XM_484703
VERSION     NM_001081223.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3618)
  AUTHORS   Georgieva,D., Wang,N., Taglialatela,A., Jerabek,S., Reczek,C.R.,
            Lim,P.X., Sung,J., Du,Q., Horiguchi,M., Jasin,M., Ciccia,A.,
            Baer,R. and Egli,D.
  TITLE     BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA
            repair pathway choice at replication-associated double-strand
            breaks
  JOURNAL   Cell Rep 43 (4), 114006 (2024)
   PUBMED   38554279
REFERENCE   2  (bases 1 to 3618)
  AUTHORS   Wu-Baer,F., Wong,M., Tschoe,L., Lin,C.S., Jiang,W., Zha,S. and
            Baer,R.
  TITLE     ATM/ATR Phosphorylation of CtIP on Its Conserved Sae2-like Domain
            Is Required for Genotoxin-Induced DNA Resection but Dispensable for
            Animal Development
  JOURNAL   Cells 12 (23), 2762 (2023)
   PUBMED   38067190
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3618)
  AUTHORS   Iskusnykh,I.Y., Fattakhov,N., Li,Y., Bihannic,L., Kirchner,M.K.,
            Steshina,E.Y., Northcott,P.A. and Chizhikov,V.V.
  TITLE     Lmx1a is a master regulator of the cortical hem
  JOURNAL   Elife 12, e84095 (2023)
   PUBMED   37725078
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3618)
  AUTHORS   Wang,X.S., Menolfi,D., Wu-Baer,F., Fangazio,M., Meyer,S.N.,
            Shao,Z., Wang,Y., Zhu,Y., Lee,B.J., Estes,V.M., Cupo,O.M.,
            Gautier,J., Pasqualucci,L., Dalla-Favera,R., Baer,R. and Zha,S.
  TITLE     DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR
            site T855 promotes lymphomagenesis in mice
  JOURNAL   Proc Natl Acad Sci U S A 118 (38) (2021)
   PUBMED   34521752
REFERENCE   5  (bases 1 to 3618)
  AUTHORS   Wang,X.S., Zhao,J., Wu-Baer,F., Shao,Z., Lee,B.J., Cupo,O.M.,
            Rabadan,R., Gautier,J., Baer,R. and Zha,S.
  TITLE     CtIP-mediated DNA resection is dispensable for IgH class switch
            recombination by alternative end-joining
  JOURNAL   Proc Natl Acad Sci U S A 117 (41), 25700-25711 (2020)
   PUBMED   32989150
  REMARK    GeneRIF: CtIP-mediated DNA resection is dispensable for IgH class
            switch recombination by alternative end-joining.
REFERENCE   6  (bases 1 to 3618)
  AUTHORS   Liu,F. and Lee,W.H.
  TITLE     CtIP activates its own and cyclin D1 promoters via the E2F/RB
            pathway during G1/S progression
  JOURNAL   Mol Cell Biol 26 (8), 3124-3134 (2006)
   PUBMED   16581787
  REMARK    GeneRIF: CtiP activates its own and cyclin D promoters via the
            E2F/RB pathway during G1/S progression.
REFERENCE   7  (bases 1 to 3618)
  AUTHORS   Darakhshan,F., Badie,C., Moody,J., Coster,M., Finnon,R., Finnon,P.,
            Edwards,A.A., Szluinska,M., Skidmore,C.J., Yoshida,K., Ullrich,R.,
            Cox,R. and Bouffler,S.D.
  TITLE     Evidence for complex multigenic inheritance of radiation AML
            susceptibility in mice revealed using a surrogate phenotypic assay
  JOURNAL   Carcinogenesis 27 (2), 311-318 (2006)
   PUBMED   16093251
  REMARK    GeneRIF: Rbbp8 is shown to be upregulated in response to
            X-irradiation in the AML sensitive CBA strain but not AML resistant
            C57BL/6 strain
REFERENCE   8  (bases 1 to 3618)
  AUTHORS   Chinnadurai,G.
  TITLE     CtIP, a candidate tumor susceptibility gene is a team player with
            luminaries
  JOURNAL   Biochim Biophys Acta 1765 (1), 67-73 (2006)
   PUBMED   16249056
  REMARK    Review article
REFERENCE   9  (bases 1 to 3618)
  AUTHORS   Chen,P.L., Liu,F., Cai,S., Lin,X., Li,A., Chen,Y., Gu,B., Lee,E.Y.
            and Lee,W.H.
  TITLE     Inactivation of CtIP leads to early embryonic lethality mediated by
            G1 restraint and to tumorigenesis by haploid insufficiency
  JOURNAL   Mol Cell Biol 25 (9), 3535-3542 (2005)
   PUBMED   15831459
  REMARK    GeneRIF: CtIP counteracts Rb-mediated G(1) restraint.
REFERENCE   10 (bases 1 to 3618)
  AUTHORS   McCarthy,E.E., Celebi,J.T., Baer,R. and Ludwig,T.
  TITLE     Loss of Bard1, the heterodimeric partner of the Brca1 tumor
            suppressor, results in early embryonic lethality and chromosomal
            instability
  JOURNAL   Mol Cell Biol 23 (14), 5056-5063 (2003)
   PUBMED   12832489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090479.6, AK037049.1 and AC115894.6.
            
            On Nov 16, 2011 this sequence version replaced NM_001081223.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037049.1, SRR9219381.344709.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC090479.6         166825-166904
            81-1306             AK037049.1         3-1228
            1307-3289           AK037049.1         1230-3212
            3290-3618           AC115894.6         53242-53570         c
FEATURES             Location/Qualifiers
     source          1..3618
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 5.85 cM"
     gene            1..3618
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /note="retinoblastoma binding protein 8, endonuclease"
                     /db_xref="GeneID:225182"
                     /db_xref="MGI:MGI:2442995"
     exon            1..344
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            345..551
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..3124
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /note="ctBP-interacting protein; sporulation in the
                     absence of SPO11 protein 2 homolog; retinoblastoma-binding
                     protein 8"
                     /codon_start=1
                     /product="DNA endonuclease RBBP8"
                     /protein_id="NP_001074692.1"
                     /db_xref="CCDS:CCDS37738.1"
                     /db_xref="GeneID:225182"
                     /db_xref="MGI:MGI:2442995"
                     /translation="MSISGSGCGSPNSADASNDFKELWTKLKEYHDKEVQGLQVKVTK
                     LKKERILDAQRLEEFFTKNQQLRDQQKVLQETIKILEDRLRAGLCDRCAVTEEHMHKK
                     QQEFENIRQQNLKLITELMNEKNTLQEENKKLSEQLQQKMENGQQDQVAELACEENII
                     PDSPVTSFSFSGINRLRKKENLHVRYVEQTHTKLERSLCTNELRKISKDSAPAPVNSE
                     EHEILVADTCDQNHSPLSKICETSSYPTDKTSFNLDTVVAETLGLNGQEESEPQGPMS
                     PLGSELYHCLKEDHKKHPFMESARSKEDSLRFSDSASKTPPQEFTTRASSPVFGATST
                     VKAHLGLNTSFSPSLLDIGKKNLLKTAPFSNIAVSRSEKVRSKSEDNALFTQHSLGSE
                     VKVISQSFSSKQILTNKTVSDSVDEQCSADHMNTTVADKYLVPLKSLGGKASKRKRTE
                     EESEHAVKCPQACFDKENALPFPMENQFSMNGDHVMDKPLDLSDRFAATQRQEKNHGN
                     ETSKNKLKQATIYEALKPIPKGSSSGRKALSGDCMPAKDSWETYCLQPRSLQSSSKFS
                     PDQKTPLQIKEENPVFKTPPCSQESLETENLFGDVKGTGSLVPTKVKSRAVHGGCELA
                     SVLQLNPCRVAKTKALPSNQDTSFENIQWSVDPGADLSQYKMDVTVIDTKDSSHSRLG
                     GETVDMDCTLVSETVLLKMKKQEQKERSPNGDIKMNDSLEDMFDRTTHEEYESCLADS
                     FSQVPDEEELPDTTKKTNIPADKQDGVKQKAFVGPYFKDKERETSIQNFPHIEVVRKK
                     EERRKLLGHTCKECEIYYADLPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQ
                     TCLERGYIKEDLDLSPRPKRRQPYNAVFSPKGKEQRT"
     exon            552..594
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..690
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..803
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..870
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1046
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1151
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1249
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1362
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..2248
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2375
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2464
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2576
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2717
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2787
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2884
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3026
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3618
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3254..3259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /note="hexamer: ATTAAA"
     polyA_site      3295
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /note="major polyA site"
     polyA_site      3301
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
     regulatory      3394..3399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /note="hexamer: ATTATA"
     polyA_site      3413
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /note="major polyA site"
     regulatory      3593..3598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
                     /note="hexamer: AATATA"
     polyA_site      3618
                     /gene="Rbbp8"
                     /gene_synonym="9930104E21Rik; CtIP; RBBP-8; RIM; SAE2"
ORIGIN      
        1 gggaactccg gcgtgacgtc acgagacggc cgctgcctcc ggggccgggc ggggcgagca
       61 gccctccggc ctgcctccgg gaggttctgg ccgtcccctc cgtgggttcc gccgccagga
      121 gaaggagggg acgcggcgag aggtaggcag tagcgagcgg cggggccttc ccggcccgga
      181 agacgtcgct ctcttctttg agctcccgaa ggctctgctg ggaggctcgg aagctgtgag
      241 tgaagagacg gattctcctt cttcctaccc tgcgtgctgg gtcggagcag ctacttccgg
      301 tcggacgcgg cgctttcgcg gaggcgaaaa aggcacccgc cgaggtattt caacaatcca
      361 aagacaacgt cacacctatg taaggacaca agaaaggtca gggaaacatc agcaaataga
      421 agggtgaagc ctggtaagca agatgagcat ttcaggaagc ggctgtggaa gccctaattc
      481 tgcggatgca tccaatgact tcaaggaact ctggacaaaa ctaaaagagt atcatgataa
      541 ggaagtgcaa ggtttacaag tcaaagtaac caaactgaaa aaggaacgaa ttttagatgc
      601 acagagacta gaagaattct tcaccaaaaa tcaacagctg agagaccagc agaaagtcct
      661 tcaggaaacc attaaaattt tagaagatag gttaagagca ggattgtgtg atcgctgtgc
      721 agtaactgaa gagcatatgc acaaaaagca gcaggagttt gaaaatatcc gacagcagaa
      781 ccttaagctt attacagagc tgatgaatga aaagaatact cttcaagaag aaaacaaaaa
      841 gctttctgaa caactgcagc agaaaatgga aaatggtcaa caggatcaag tagctgagct
      901 tgcatgtgag gaaaacatta ttccagactc accagtaaca tccttttcct tttctggcat
      961 taaccggcta cgaaagaagg agaatctcca tgtccgatac gtggaacaaa cacatactaa
     1021 gttggagcgc tctctatgta caaatgaatt aagaaaaata tctaaggatt cagctcctgc
     1081 accagttaac tctgaggaac atgaaattct cgtagctgac acttgtgatc aaaatcactc
     1141 accactgtca aaaatatgtg aaacaagcag ttaccccact gataagacat cttttaattt
     1201 agacactgtt gttgctgaga cacttggact taatggtcaa gaagaatctg aaccccaagg
     1261 tcccatgagc cctctgggaa gtgaactcta ccactgtctc aaagaagatc acaaaaaaca
     1321 cccttttatg gaatctgcaa gaagtaagga agatagctta agattttcag actctgcttc
     1381 aaagacacct cctcaagaat ttactactcg ggcgtcatct ccggtatttg gagctacctc
     1441 tactgtgaaa gctcatttgg gtttgaatac aagtttctcc ccctctctct tagacattgg
     1501 gaaaaaaaac cttctgaaga cagctccctt tagcaacatt gctgtttcta gatcagagaa
     1561 agttagatcc aaatctgagg ataatgccct tttcacacaa catagtcttg ggtcagaagt
     1621 gaaggtcatt agccagtcat tttctagtaa acagatactt acaaataaaa ctgtaagtga
     1681 ctctgtagat gaacagtgca gtgctgacca catgaatact actgttgctg ataaatattt
     1741 ggtgcctttg aaatccctgg gaggcaaagc atccaaaagg aagaggactg aggaggaaag
     1801 tgagcatgca gtaaagtgcc cccaggcctg ttttgataag gaaaatgccc ttcctttccc
     1861 aatggagaat cagttctcca tgaatggaga ccatgtgatg gataaacctc tggacctgtc
     1921 agatcggttt gcagctactc agcggcaaga gaagaaccac ggaaacgaga cttctaaaaa
     1981 caaacttaag caagccacta tttacgaggc tttgaagccc attccaaagg gctcctcctc
     2041 aggccgtaaa gccttgagtg gggactgcat gccagccaaa gactcttggg agacatactg
     2101 cttacagccg aggagcctcc agtcctctag taaattctct ccagaccaaa aaacaccatt
     2161 acagataaaa gaagaaaatc ctgtcttcaa aacacctcca tgttcacagg aaagtttgga
     2221 gacagagaat ctctttggtg atgtgaaggg tactggttct cttgtgccaa caaaagtaaa
     2281 gagcagagca gtccatggag gatgtgagct tgcatcagtt cttcagttaa acccctgtag
     2341 agttgctaaa acaaaggctc tgccaagcaa ccaagatacg tcctttgaaa atatccagtg
     2401 gagtgtagac ccaggagcag acctttctca gtataaaatg gatgttactg taatagatac
     2461 aaaggatagc agtcactcac gattaggagg agaaacagtg gacatggact gtacattggt
     2521 cagtgaaacc gtgcttttaa aaatgaagaa acaagagcaa aaagaaagaa gtccaaatgg
     2581 agacataaaa atgaatgata gcctagaaga tatgtttgat cggacaacac atgaagagta
     2641 tgagtcctgt ttggcagata gcttctccca ggtaccagat gaggaagaac tgcctgacac
     2701 cacaaagaaa acaaacatac ctgctgataa acaagatgga gtcaaacaga aagcatttgt
     2761 ggggccatat tttaaagata aggagagaga aactagcata cagaattttc ctcatattga
     2821 ggtagttcgg aaaaaagaag agagaaggaa attgcttggg cacacatgta aagaatgtga
     2881 aatttattat gcagatttgc cagcagaaga aagagaaaag aagttggctt cctgctcaag
     2941 acaccgattt cgctacattc cacccaacac accagagaat ttctgggaag ttggttttcc
     3001 ttctactcag acgtgtctgg aaagaggtta tatcaaggaa gatctcgatc ttagtcctcg
     3061 tcccaaaaga cggcagcctt acaacgcggt cttttctcca aaaggcaaag aacagaggac
     3121 ctagacactg gcgtgaaagc aggagagcag acctttctgt gtttcattta gttatttata
     3181 gttaaagttg gaataaacat tgatctttga tattttttga tcctctataa aatgatttat
     3241 aaatgagttt tctattaaaa gtgttttaaa tggcatatac caaccataca aataactaaa
     3301 atgtggatgt gttacttttt ttcttttgta cctttaagca gtagggtgtt tcattttgca
     3361 ctctaaattt agggttattt actttatttg gtaattatag cttttgaaat acggctgttg
     3421 tagtctataa tttattctgt atggatcttc atcatctatt tcctttggtg tttatctgca
     3481 caagagccct cgtggtaatc tttaggggtt ttcagtttat tcattaacct gtagatcata
     3541 ccagcttttg acatgcaagt atgttttttt aaggggtgga agctaacttt tcaatatagt
     3601 ccttctgact gtccagca
//
