LOCUS       NP_001390011            1828 aa            linear   ROD 02-JUN-2024
DEFINITION  E3 ubiquitin-protein ligase RBBP6 isoform 3 [Mus musculus].
ACCESSION   NP_001390011 XP_036008696
VERSION     NP_001390011.1
DBSOURCE    REFSEQ: accession NM_001403082.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1828)
  AUTHORS   Wu,C., Liu,H., Zhan,Z., Zhang,X., Zhang,M., You,J. and Ma,J.
  TITLE     Unveiling dysregulated lncRNAs and networks in non-syndromic cleft
            lip with or without cleft palate pathogenesis
  JOURNAL   Sci Rep 14 (1), 1047 (2024)
   PUBMED   38200098
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1828)
  AUTHORS   Dar,A.A., Sawada,K., Dybas,J.M., Moser,E.K., Lewis,E.L., Park,E.,
            Fazelinia,H., Spruce,L.A., Ding,H., Seeholzer,S.H. and Oliver,P.M.
  TITLE     The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by
            aiding the repair of damaged DNA
  JOURNAL   PLoS Biol 19 (2), e3001041 (2021)
   PUBMED   33524014
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1828)
  AUTHORS   Miotto,B., Chibi,M., Xie,P., Koundrioukoff,S., Moolman-Smook,H.,
            Pugh,D., Debatisse,M., He,F., Zhang,L. and Defossez,P.A.
  TITLE     The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common
            fragile site stability
  JOURNAL   Cell Rep 7 (2), 575-587 (2014)
   PUBMED   24726359
REFERENCE   4  (residues 1 to 1828)
  AUTHORS   Li,L., Deng,B., Xing,G., Teng,Y., Tian,C., Cheng,X., Yin,X.,
            Yang,J., Gao,X., Zhu,Y., Sun,Q., Zhang,L., Yang,X. and He,F.
  TITLE     PACT is a negative regulator of p53 and essential for cell growth
            and embryonic development
  JOURNAL   Proc Natl Acad Sci U S A 104 (19), 7951-7956 (2007)
   PUBMED   17470788
  REMARK    GeneRIF: the PACT-p53 interaction plays a critical role in
            embryonic development and tumorigenesis and identify PACT as a
            member of negative regulators of p53.
REFERENCE   5  (residues 1 to 1828)
  AUTHORS   Scott,R.E., White-Grindley,E., Ruley,H.E., Chesler,E.J. and
            Williams,R.W.
  TITLE     P2P-R expression is genetically coregulated with components of the
            translation machinery and with PUM2, a translational repressor that
            associates with the P2P-R mRNA
  JOURNAL   J Cell Physiol 204 (1), 99-105 (2005)
   PUBMED   15617101
  REMARK    GeneRIF: P2P-R expression may be translationally regulated by PUM2
            and that P2P-R may modulate translation by influencing ribosomal
            protein gene expression
REFERENCE   6  (residues 1 to 1828)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 1828)
  AUTHORS   Gao,S. and Scott,R.E.
  TITLE     P2P-R protein overexpression restricts mitotic progression at
            prometaphase and promotes mitotic apoptosis
  JOURNAL   J Cell Physiol 193 (2), 199-207 (2002)
   PUBMED   12384997
REFERENCE   8  (residues 1 to 1828)
  AUTHORS   Gao,S., Witte,M.M. and Scott,R.E.
  TITLE     P2P-R protein localizes to the nucleolus of interphase cells and
            the periphery of chromosomes in mitotic cells which show maximum
            P2P-R immunoreactivity
  JOURNAL   J Cell Physiol 191 (2), 145-154 (2002)
   PUBMED   12064457
  REMARK    Erratum:[J Cell Physiol 2002 Sep;192(3):359-60]
REFERENCE   9  (residues 1 to 1828)
  AUTHORS   Witte,M.M. and Scott,R.E.
  TITLE     The proliferation potential protein-related (P2P-R) gene with
            domains encoding heterogeneous nuclear ribonucleoprotein
            association and Rb1 binding shows repressed expression during
            terminal differentiation
  JOURNAL   Proc Natl Acad Sci U S A 94 (4), 1212-1217 (1997)
   PUBMED   9037032
REFERENCE   10 (residues 1 to 1828)
  AUTHORS   Simons,A., Melamed-Bessudo,C., Wolkowicz,R., Sperling,J.,
            Sperling,R., Eisenbach,L. and Rotter,V.
  TITLE     PACT: cloning and characterization of a cellular p53 binding
            protein that interacts with Rb
  JOURNAL   Oncogene 14 (2), 145-155 (1997)
   PUBMED   9010216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125221.4.
            
            On Mar 25, 2022 this sequence version replaced XP_036008696.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 67.42 cM"
     Protein         1..1828
                     /product="E3 ubiquitin-protein ligase RBBP6 isoform 3"
                     /EC_number="2.3.2.27"
                     /note="proliferation potential-related protein;
                     p53-associated cellular protein of testis; E3
                     ubiquitin-protein ligase RBBP6; protein P2P-R; RING-type
                     E3 ubiquitin transferase RBBP6; retinoblastoma-binding
                     protein 6"
                     /calculated_mol_wt=203779
     Region          2..458
                     /region_name="COG5222"
                     /note="Uncharacterized conserved protein, contains RING
                     Zn-finger [General function prediction only]"
                     /db_xref="CDD:227547"
     Region          <944..1588
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1828
                     /gene="Rbbp6"
                     /gene_synonym="4933422O15Rik; C030034J04Rik; P2P-R; PACT"
                     /coded_by="NM_001403082.1:1027..6513"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:19647"
                     /db_xref="MGI:MGI:894835"
ORIGIN      
        1 mscvhykfss klnydtvtfd glhislcdlk kqimgreklk aadsdlqitn aqtkeeytdd
       61 nalipknssv ivrripiggv kstsktyvis rtepvmgttk aiddasasis laqltktanl
      121 aeanaseedk ikammsqsgh eydpinymkk tlvgppppsy tcfrcgkpgh yikncptngd
      181 knfesgprik kstgiprsfm mevkdpnmkg amltntgkya iptidagrll fhklgtmghk
      241 qidtylwnrg dvygaaatqi thlreayaig kkekppflpe epsssseedd pipdellcli
      301 ckdimtdavv ipccgnsycd ecirtalles dehtcptchq ndvspdalia nkflrqavnn
      361 fknetgytkr lrkqlppppp pvppprplmq rnlqplmrsp isrqqdplmi pvtsssahsa
      421 psissltsnp salapsvsgn pssapapvpd itatvsisvh seksdgpfrd sdnkllpaaa
      481 ltsehskgas siaitalmee kgyqvpvlgt psllgqsllh gqlipttgpv rinaarpggg
      541 rpgwehsnkl gylvsppqqi rrgerscyrs inrgrhhser sqrtqgpslp atpvfvpvpp
      601 pplyppppht lplppgvppp qfspqfppgq pppagysvpp pgfppapani stpwvssgvq
      661 tahsntiptt qapplsreef yreqrrlkee ekkkskldef tndfakelme ykkiqkerrr
      721 sfsrskspys gssysrssyt ysksrsgstr srsysrsfsr shsrsysrsp pyprrgrgks
      781 rnyrsrsrsh gyhrsrsrsp pyrryhsrsr spqafrgqsp tkrnvpqget ereyfnryre
      841 vpppydikay ygrsvdfrdp fekeryrewe rkyrewyeky ykgyavgaqp rpsanredfs
      901 perllplnir nspftrgrre dyaagqshrn rnlggnypek lstrdshnak dnpkskekes
      961 envpgdgkgn khkkhrkrrk geesesflnp elletsrkcr essgidetkt dtlfvlpsrd
     1021 datpvrdepm daesitfksv sdkdkrekdk pkvksdktkr ksdgsatakk dnvlkpskgp
     1081 qekvdgdrek sprsepplkk akeeatkids vkpssssqkd ekvtgtprka hsksakehqe
     1141 akpakdekvk kdcskdikse kpaskdekak kpeknkllds kgekrkrkte eksvdkdfes
     1201 ssmkiskveg teivkpspkr kmegdvekle rtpekdkias sttpakkikl nretgkkign
     1261 aenasttkep seklestssk ikqekvkgka krkvagsegs sstlvdytst sstggspvrk
     1321 seektdtkrt viktmeeynn dntapaedvi imiqvpqskw dkddfeseee dvkttqpiqs
     1381 vgkpssiikn vttkpsatak ytekeseqpe klqklpkeas helmqhelrs skgsassekg
     1441 rakdrehsgs ekdnpdkrks gaqpdkestv drlseqghfk tlsqssketr tsekhesvrg
     1501 ssnkdftpgr dkkvdydsrd yssskrrder gelarrkdsp prgkeslsgq ksklreerdl
     1561 pkkgaeskks nsspprdkkp hdhkapyetk rpceetkpvd knsgkerekh aaearngkes
     1621 sggklpcipn ppdppmekel aagqveksav kpkpqlshss rlssdltret deaafepdyn
     1681 esdsesnvsv keeeavasis kdlkekttek akesltvata sqpgadrsqs qsspsvspsr
     1741 shspsgsqtr shsssassag sqdskkkkkk kekkkhkkhk khkkhkkhag adgdveksqk
     1801 hkhkkkkakk nkdkekekdd qkvrsvtv
//
