LOCUS       NM_172517               3632 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus retinoblastoma binding protein 5, histone lysine
            methyltransferase complex subunit (Rbbp5), transcript variant 1,
            mRNA.
ACCESSION   NM_172517
VERSION     NM_172517.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3632)
  AUTHORS   Ma,M., Zhou,J., Ma,Z., Chen,H., Li,L., Hou,L., Yin,B., Qiang,B.,
            Shu,P. and Peng,X.
  TITLE     The Ash2l SDI Domain Is Required to Maintain the Stability and
            Binding of DPY30
  JOURNAL   Cells 11 (9), 1450 (2022)
   PUBMED   35563756
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3632)
  AUTHORS   Scoville,D.W., Cyphert,H.A., Liao,L., Xu,J., Reynolds,A., Guo,S.
            and Stein,R.
  TITLE     MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB
            Transcription Factors to Regulate Islet beta-Cell Function
  JOURNAL   Diabetes 64 (11), 3772-3783 (2015)
   PUBMED   26180087
REFERENCE   3  (bases 1 to 3632)
  AUTHORS   Zhang,Y., Mittal,A., Reid,J., Reich,S., Gamblin,S.J. and
            Wilson,J.R.
  TITLE     Evolving Catalytic Properties of the MLL Family SET Domain
  JOURNAL   Structure 23 (10), 1921-1933 (2015)
   PUBMED   26320581
REFERENCE   4  (bases 1 to 3632)
  AUTHORS   Zhang,P., Chaturvedi,C.P., Tremblay,V., Cramet,M., Brunzelle,J.S.,
            Skiniotis,G., Brand,M., Shilatifard,A. and Couture,J.F.
  TITLE     A phosphorylation switch on RbBP5 regulates histone H3 Lys4
            methylation
  JOURNAL   Genes Dev 29 (2), 123-128 (2015)
   PUBMED   25593305
  REMARK    GeneRIF: a phosphorylation switch on RbBP5 stimulates WRAD complex
            formation and significantly increases KMT2 (lysine [K]
            methyltransferase 2) enzyme methylation rates
REFERENCE   5  (bases 1 to 3632)
  AUTHORS   Lee,J.E., Wang,C., Xu,S., Cho,Y.W., Wang,L., Feng,X., Baldridge,A.,
            Sartorelli,V., Zhuang,L., Peng,W. and Ge,K.
  TITLE     H3K4 mono- and di-methyltransferase MLL4 is required for enhancer
            activation during cell differentiation
  JOURNAL   Elife 2, e01503 (2013)
   PUBMED   24368734
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3632)
  AUTHORS   Jiang,H., Shukla,A., Wang,X., Chen,W.Y., Bernstein,B.E. and
            Roeder,R.G.
  TITLE     Role for Dpy-30 in ES cell-fate specification by regulation of H3K4
            methylation within bivalent domains
  JOURNAL   Cell 144 (4), 513-525 (2011)
   PUBMED   21335234
  REMARK    Erratum:[Cell. 2011 Mar 4;144(5):825]
REFERENCE   7  (bases 1 to 3632)
  AUTHORS   Odho,Z., Southall,S.M. and Wilson,J.R.
  TITLE     Characterization of a novel WDR5-binding site that recruits RbBP5
            through a conserved motif to enhance methylation of histone H3
            lysine 4 by mixed lineage leukemia protein-1
  JOURNAL   J Biol Chem 285 (43), 32967-32976 (2010)
   PUBMED   20716525
  REMARK    GeneRIF: Characterization of a novel WDR5-binding site that
            recruits RbBP5 through a conserved motif to enhance methylation of
            histone H3 lysine 4 by mixed lineage leukemia protein-1.
REFERENCE   8  (bases 1 to 3632)
  AUTHORS   De Santa,F., Totaro,M.G., Prosperini,E., Notarbartolo,S., Testa,G.
            and Natoli,G.
  TITLE     The histone H3 lysine-27 demethylase Jmjd3 links inflammation to
            inhibition of polycomb-mediated gene silencing
  JOURNAL   Cell 130 (6), 1083-1094 (2007)
   PUBMED   17825402
REFERENCE   9  (bases 1 to 3632)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
REFERENCE   10 (bases 1 to 3632)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY193756.1, AK049247.1, CV562303.1 and AC107846.5.
            
            On Jan 4, 2008 this sequence version replaced NM_172517.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154782.1, AK049247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               BY193756.1         2-128
            128-868             AK049247.1         115-855
            869-1216            CV562303.1         302-649
            1217-2855           AK049247.1         1204-2842
            2856-3632           AC107846.5         1185-1961           c
FEATURES             Location/Qualifiers
     source          1..3632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.24 cM"
     gene            1..3632
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /note="retinoblastoma binding protein 5, histone lysine
                     methyltransferase complex subunit"
                     /db_xref="GeneID:213464"
                     /db_xref="MGI:MGI:1918367"
     exon            1..161
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1759
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RBBP-5; retinoblastoma-binding protein 5"
                     /codon_start=1
                     /product="retinoblastoma-binding protein 5 isoform 1"
                     /protein_id="NP_766105.2"
                     /db_xref="CCDS:CCDS15286.1"
                     /db_xref="GeneID:213464"
                     /db_xref="MGI:MGI:1918367"
                     /translation="MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCN
                     DGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQ
                     RFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFD
                     RRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTA
                     DRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHAL
                     YIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAP
                     DFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEE
                     LEDSKALLYLPIAPEVEDPEENPYGPPPDAVPSSLMDEGASSEKKRQSSADGSQPPKK
                     KPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDR
                     GLPLEGSTKGKVQAELSQSLAAGGAISELL"
     exon            162..187
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            188..360
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            361..501
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            502..664
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            665..774
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            775..894
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1048
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1120
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1238
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1308
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1538
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1730
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..3632
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2835..2840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /note="hexamer: AATAAA"
     polyA_site      2858
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
     regulatory      3604..3609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /note="hexamer: AATAAA"
     polyA_site      3626
                     /gene="Rbbp5"
                     /gene_synonym="4933411J24Rik; C330016J05"
                     /note="major polyA site"
ORIGIN      
        1 gcggggcctt ctaagtccga aagtctccgg agcttgcgcc aggctcttcg cggcgccccc
       61 cacttagacg cggggcttct gagcgggtgg gggagaagga actgttgccg gtgcggagac
      121 caggcggcca gcgtctgcag ggatgaacct cgagttgctg gagtcctttg gacagaacta
      181 cccagaggaa gctgatggga ctctggactg catcagcatg gccctgacct gcacctttaa
      241 caggtggggc acactgcttg ctgttggctg taacgatggc cggattgtta tttgggattt
      301 cttgaccaga ggcattgcta aaataattag tgcacacatc catccagtct gttctttgtg
      361 ttggagccga gatggtcata agcttgtgag tgcttctaca gataacatag tgtcacagtg
      421 ggatgttctt tcaggagatt gcgaccagag gtttcgattc ccttcaccca tcttaaaagt
      481 ccaatatcat cctcgagatc agaacaaggt tctcgtgtgt cccatgaaat ctgctcctgt
      541 catgttgacc ctttcagatt ccaaacatgt tgttctgccg gtagacgatg actcggattt
      601 gaacgtggtg gcatcttttg ataggcgagg ggaatatatt tatacaggaa atgcaaaagg
      661 caagatcttg gtcctaaaaa cagactctca ggatcttgtt gcttccttca gagtaacaac
      721 tgggacaagc aatactaccg ccattaaatc aattgagttt gcccggaagg ggagttgctt
      781 cctgattaac acagcagatc gaataataag agtctatgac ggcagagaga ttttaacgtg
      841 tggaagggat ggagagccag agcctatgca gaagctgcag gacttggtga ataggactcc
      901 atggaaaaaa tgttgtttct ctggggatgg ggagtacata gtggcgggct ctgcgaggca
      961 gcatgcgctg tatatctggg aaaagagcat tggcaacctg gtgaagatct tacatgggac
     1021 cagaggggaa ctcctgctgg acgtggcttg gcatccagtc cgacccatca tagcttctat
     1081 ctctagtgga gtggtgtcca tttgggccca aaatcaagta gaaaattgga gtgcatttgc
     1141 accagacttc aaagagttgg atgaaaatgt agaatatgag gaaagagaat cagaatttga
     1201 tattgaggat gaagataaga gtgagcctga gcaaacaggg gctgatgctg ctgaagatga
     1261 ggaagtggat gtcaccagcg tggatcccat cgctgccttc tgtagcagtg atgaagagct
     1321 ggaagattca aaggctctat tgtatttacc cattgcccct gaggtagaag accctgaaga
     1381 aaacccgtat ggccctccac cggatgcagt cccaagctcc ttgatggatg aaggggctag
     1441 ttcagagaag aagaggcagt cttcagcaga tggatcccag ccaccaaaga agaaacctaa
     1501 aaccaccaat atagagctcc aaggagtgcc gaatgatgaa gtccatccac tactgggtgt
     1561 gaagggggat ggcaaatcca agaagaagca agcaggccgg cctaaaggat caaaaggtaa
     1621 agagaaagat tctccattta aaccgaaact ctacaaaggg gacagaggtt tacctctgga
     1681 aggatcaacg aagggtaaag tgcaggcgga actcagccag tccttggcag caggaggagc
     1741 catctcagaa ctgctgtgaa gaccgtggaa cccttggttc ttctcactct gtcatcaggt
     1801 agcctttgga cagcgtggcc aatcatctga gattggcttt agttgaaaac aaaggcctct
     1861 gcctcccacc caggaggtga aggagtggat tttgtgtttg aatgaggaag tgaattatgg
     1921 aagaagagca cacggccctg ccttcctttc aagcagaagt ccaaacaggc tctcaggaac
     1981 gcggatgcgc gaagacggca ggaggcttga cccacttcaa cttcacacca ggttgtgttg
     2041 ctggtgaaga gtgcccgtgt tttgttcacc taactgttgg agtcccatct ttggacgtgt
     2101 catttcccat gtcctgcttg ccttccgtcc tccatgcatg tcctcgagtg acttgttctt
     2161 ttctgaaaat ttgctaccag cacctaggaa gactgatgca tcttctgttt ctttcattca
     2221 taactttccc ctcccagtgc ttcctgtagc tccatattgt gtataaaggt tgggcagaga
     2281 agcaagtgct cgaaagattt cagactggca ggaaaggaag gaggaacgaa ggcccctatc
     2341 acgctatctt accatgccct ttgctcagga ggctgggctc tagagaatca ggggttccct
     2401 tgcattgcat gttttccagt attagatccg tttgaataat catggctttt ggatatgatt
     2461 agttttatcc atctccagct aagaatcatc agtagtttgt gtatcgcttt acctgtgttg
     2521 acttccagag ttagaaacaa agcaaggtgt gtttctccac gaggttcttt tttatgggtg
     2581 tggggcacta tgcaaggact gacatgagag acctccaccc ccaaatcaaa gcaacagcag
     2641 cccacttcaa atcaaagatg aggttcgttc cttaaatcct tgcctgtgga gaacctgtcc
     2701 ccggcagcca tagtttgtcc tttcctggag ctacgcccca ttactgtctt cactcacttc
     2761 ctttctgtga aaggttgctt agcttttacc cttctctttc tcaccttggc tctctctgca
     2821 tttgctgttc ttttaataaa aatagcaaat tgaatggatt tgtacaataa gtgtttgaaa
     2881 ttttctgaaa atccaaagtc aggaagccaa gtgtgcgaag ggttagtgac gcctctggca
     2941 atagctttgg cttgccctgg gccatactct gtcagcactg aaaggaggtt taaatactat
     3001 gctaattgtg aaatctctta tcagttggtg gaggctcctt cagacagcca aacccgttga
     3061 ttacattgta ctgtggtaga tgtgacaggg acacgctgga agtttctagt tctgttgctc
     3121 ctgtgctgct tccaagtgtg agtgagacca atggttgtga ttggtaagtg gctcacggga
     3181 tgtttttatt tgtagacatt acctccatgt catgtctctg tacagcacac tgcagtggtg
     3241 tgcaagctga tgcaggggtt tctgccttcc ctgtgtgaag tggcttgatt tccctccatc
     3301 tggatgctaa tgctgtgtcc catttccatt aatgagctac tgagtaaatc agctcaaacc
     3361 ctgccagatt gtctctggca gcagctccta ataattattt atgctttggg aatctttttg
     3421 tcggcttcta gaaccttccg tccactctca gcttaggttt ttgatttgtg taatatatgt
     3481 atattctttt tccttgctgt cgtcctccct gcctctccgt tttgtttctt aaaatgttct
     3541 gtagttttgt acaagatgag acttagcctt gggtacttct tgctaaagct ttaatgcttt
     3601 gtaaataaaa ttggatgttt attaaaccac aa
//
