LOCUS       NM_009030               4407 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus retinoblastoma binding protein 4, chromatin remodeling
            factor (Rbbp4), mRNA.
ACCESSION   NM_009030
VERSION     NM_009030.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4407)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4407)
  AUTHORS   Ping,W., Sheng,Y., Hu,G., Zhong,H., Li,Y., Liu,Y., Luo,W., Yan,C.,
            Wen,Y., Wang,X., Li,Q., Guo,R., Zhang,J., Liu,A., Pan,G. and Yao,H.
  TITLE     RBBP4 is an epigenetic barrier for the induced transition of
            pluripotent stem cells into totipotent 2C-like cells
  JOURNAL   Nucleic Acids Res 51 (11), 5414-5431 (2023)
   PUBMED   37021556
  REMARK    GeneRIF: RBBP4 is an epigenetic barrier for the induced transition
            of pluripotent stem cells into totipotent 2C-like cells.
REFERENCE   3  (bases 1 to 4407)
  AUTHORS   Price,J.D., Lindtner,S., Ypsilanti,A., Binyameen,F., Johnson,J.R.,
            Newton,B.W., Krogan,N.J. and Rubenstein,J.L.R.
  TITLE     DLX1 and the NuRD complex cooperate in enhancer decommissioning and
            transcriptional repression
  JOURNAL   Development 149 (11) (2022)
   PUBMED   35695185
REFERENCE   4  (bases 1 to 4407)
  AUTHORS   Mu,W., Murcia,N.S., Smith,K.N., Menon,D.U., Yee,D. and Magnuson,T.
  TITLE     RBBP4 dysfunction reshapes the genomic landscape of H3K27
            methylation and acetylation and disrupts gene expression
  JOURNAL   G3 (Bethesda) 12 (6) (2022)
   PUBMED   35416979
  REMARK    GeneRIF: RBBP4 dysfunction reshapes the genomic landscape of H3K27
            methylation and acetylation and disrupts gene expression.
REFERENCE   5  (bases 1 to 4407)
  AUTHORS   Yan,L., Jin,W., Zhao,Q., Cui,X., Shi,T., Xu,Y., Li,F., Jin,W.,
            Zhang,Z., Zhang,Z., Tang,Q.Q. and Pan,D.
  TITLE     PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a
            NuRD Subcomplex
  JOURNAL   Adv Sci (Weinh) 8 (16), e2102060 (2021)
   PUBMED   34180153
REFERENCE   6  (bases 1 to 4407)
  AUTHORS   Yuan,S.S., Cox,L.A., Dasika,G.K. and Lee,E.Y.
  TITLE     Cloning and functional studies of a novel gene aberrantly expressed
            in RB-deficient embryos
  JOURNAL   Dev Biol 207 (1), 62-75 (1999)
   PUBMED   10049565
REFERENCE   7  (bases 1 to 4407)
  AUTHORS   Laherty,C.D., Billin,A.N., Lavinsky,R.M., Yochum,G.S., Bush,A.C.,
            Sun,J.M., Mullen,T.M., Davie,J.R., Rose,D.W., Glass,C.K.,
            Rosenfeld,M.G., Ayer,D.E. and Eisenman,R.N.
  TITLE     SAP30, a component of the mSin3 corepressor complex involved in
            N-CoR-mediated repression by specific transcription factors
  JOURNAL   Mol Cell 2 (1), 33-42 (1998)
   PUBMED   9702189
REFERENCE   8  (bases 1 to 4407)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   9  (bases 1 to 4407)
  AUTHORS   Qian,Y.W. and Lee,E.Y.
  TITLE     Dual retinoblastoma-binding proteins with properties related to a
            negative regulator of ras in yeast
  JOURNAL   J Biol Chem 270 (43), 25507-25513 (1995)
   PUBMED   7503932
REFERENCE   10 (bases 1 to 4407)
  AUTHORS   Lee,E.Y., Hu,N., Yuan,S.S., Cox,L.A., Bradley,A., Lee,W.H. and
            Herrup,K.
  TITLE     Dual roles of the retinoblastoma protein in cell cycle regulation
            and neuron differentiation
  JOURNAL   Genes Dev 8 (17), 2008-2021 (1994)
   PUBMED   7958874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607123.22.
            
            On Nov 17, 2006 this sequence version replaced NM_009030.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082419.1, BC138570.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AL607123.22        84203-84355         c
            154-301             AL607123.22        83482-83629         c
            302-447             AL607123.22        77573-77718         c
            448-621             AL607123.22        71681-71854         c
            622-737             AL607123.22        71338-71453         c
            738-898             AL607123.22        71064-71224         c
            899-1025            AL607123.22        70839-70965         c
            1026-1103           AL607123.22        69454-69531         c
            1104-1180           AL607123.22        67429-67505         c
            1181-1238           AL607123.22        66847-66904         c
            1239-1349           AL607123.22        66633-66743         c
            1350-4407           AL607123.22        56085-59142         c
FEATURES             Location/Qualifiers
     source          1..4407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.26 cM"
     gene            1..4407
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /note="retinoblastoma binding protein 4, chromatin
                     remodeling factor"
                     /db_xref="GeneID:19646"
                     /db_xref="MGI:MGI:1194912"
     exon            1..153
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1415
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /note="RBBP-4; CAF-I p48; CAF-1 subunit C; CAF-I 48 kDa
                     subunit; retinoblastoma-binding protein p48; chromatin
                     assembly factor 1 subunit C; chromatin assembly factor I
                     p48 subunit; nucleosome-remodeling factor subunit RBAP48;
                     retinoblastoma-binding protein 4; CAF-1 p48 subunit"
                     /codon_start=1
                     /product="histone-binding protein RBBP4"
                     /protein_id="NP_033056.2"
                     /db_xref="CCDS:CCDS18688.1"
                     /db_xref="GeneID:19646"
                     /db_xref="MGI:MGI:1194912"
                     /translation="MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPS
                     LTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEK
                     GEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSK
                     PDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVD
                     AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV
                     NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA
                     SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICS
                     VSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS"
     exon            154..301
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            302..447
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            448..621
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            622..737
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            738..898
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1025
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1103
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1180
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1238
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1349
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..4407
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1972..1977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /note="hexamer: AATAAA"
     polyA_site      1992
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /note="major polyA site"
     regulatory      2102..2107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
                     /note="hexamer: AATAAA"
     polyA_site      2123
                     /gene="Rbbp4"
                     /gene_synonym="mRbAp48; RBAP48"
ORIGIN      
        1 gcgagccggc cccctacgca cgggccgcag gaaacaatag aggccgcgcg cgcggagtgg
       61 agcgctcgta gcctccccgc ccctcctgca acgcacgacc ccgggatccc ccaacccctc
      121 ccggctctcc tgccgccatg gctgacaagg aagcggcctt tgacgacgca gtggaagaac
      181 gggtgatcaa cgaggagtac aaaatatgga agaagaacac cccttttctt tatgatttgg
      241 tgatgaccca tgccctggag tggcccagct taactgccca gtggcttcca gatgtgacca
      301 ggcctgaagg gaaagatttc agcattcatc ggcttgtcct gggaacacac acatctgatg
      361 aacagaacca cctggtgatt gccagtgtcc agctccctaa tgatgatgct cagtttgatg
      421 catcccatta tgacagtgaa aaaggagaat ttggaggttt tggttctgtc agtgggaaaa
      481 ttgaaataga aatcaagatc aaccatgaag gagaagtgaa cagggcccgg tacatgcctc
      541 agaacccctg catcattgca acaaagactc catccagtga tgttcttgtt tttgactaca
      601 caaagcaccc ttctaaacca gacccttctg gagaatgcaa ccccgatttg cgtctccgtg
      661 gacatcagaa ggaaggttat gggctttctt ggaatccaaa tctcagtggg cacttactta
      721 gtgcttcaga tgaccatacc atctgcctgt gggacatcag tgcagttcca aaagaaggaa
      781 aggtggtgga tgcaaagacc atcttcacgg ggcatacagc agtagtggag gacgtgtcct
      841 ggcatctgct ccacgagtct ctatttggct cagttgctga tgaccagaag cttatgattt
      901 gggacactcg ttcaaacaat acttccaagc caagccactc ggttgatgct cacacagctg
      961 aagtgaattg cttatctttc aatccttata gtgagttcat tcttgccaca ggatcggctg
     1021 acaagactgt tgccttgtgg gatctgagga atctgaaact caagttgcac tcctttgaat
     1081 cccataagga tgaaatattc caagttcagt ggtcacctca caatgagact atcttagctt
     1141 ccagtggtac cgatcgtagg ctgaatgtct gggatctaag taaaattgga gaagagcagt
     1201 ccccagaaga tgcagaggat ggcccaccag aattgttgtt tattcatggt ggtcacactg
     1261 ccaagatatc tgacttctcc tggaatccca atgagccttg ggtgatttgt tctgtatcag
     1321 aagacaatat catgcaagtg tggcagatgg cggagaacat ttacaatgat gaagatcctg
     1381 aaggaagtgt ggatccagag ggacaagggt cctagacgtg tctgcacctg tgatcctaga
     1441 ctctccttgt tttcctctga accccgagat ggatttaaca ttggtttgag gcacagactt
     1501 tgttcagcta cccagctaca ataggtgcca ccaacaatgc tacaagccca aaccaccggt
     1561 gttttctaaa tcttaactgg gggtttaagt cagcaaagcc tcgttggtgg ctccaattgt
     1621 ggctgggtag ctgaacaaag tctggttttt gttgtgtgtg gtttttcctt ccttcctttc
     1681 tttttctttc tttccttttt tctttctttc tttttttaaa cttgggacca ccaagttgta
     1741 aagatgtatg tttttacctg gcagttgttc cactggtgaa ctgtcaagtt gagaaagagt
     1801 ggattgctag tttgtgtttg tttttaagat taaattaatc cttgataaaa gttgcttttt
     1861 taggggttag tctttgacca ctatagtttg atgccatctc cattttggtt gacctgtctc
     1921 accatcaggc ctgttactct ccatgactaa ctgtgtaagt gcttataatg gaataaattg
     1981 cttttctata tagccccatg ctggtgggtt ttatttagta tccatcagac aacagtctat
     2041 ggcttctgga agagtttgtt cgatgacagt tgttttctgt agttttgact atcaagattg
     2101 taataaacat aatagaccaa taaccataga taaaagagag ctttactcca gtcagggaaa
     2161 ttgaagacat tactgaatag agtacacaaa ctagccttgg taaaattaca tattcttgaa
     2221 gtcttctccc gagagctaca taggtttcca agaatctcaa aggcagtgtg atagacagct
     2281 taaggcagag tttaaattta aaacacactt gaactgttta cagagagctt gtatctgatg
     2341 agtgtttttc attggaaccc ctacttttaa agtatagact taagagtcag tgcctttatt
     2401 accacttggt gataactggc gaaaggggaa aaaaaaaaaa aaaaaacaag caaacctgct
     2461 tttgcttgga ctgactagat gactctcacc tcagaaccat ttatggcttt gggaaagttt
     2521 gggtaatgaa gtgtctggtc cagatctgaa gtgatgccta gaacttgtga ttacgctggc
     2581 atgtagtaca aattatcaag ctggatatgg gatgtgcact tttaatccta gagcttgtag
     2641 gtttccgtga gttaggtcca ggacaggagg ggtggggtgt gtcttgggtc atggctgaca
     2701 gtgcacacac acctggagtc tcagcagttg ggaggtagag gcaagaccag aagttcaagg
     2761 tcatcctgac ccacagaagt tagagaccag cctagacgac ttgagacctg gtctcaaaaa
     2821 aaagcatgcc attcctttaa tcccagcaga gttcagggcc aacgttgtct aaagagtgag
     2881 ttctaggcca cttggggcta tatataagtg gggtctggtg gtggtggtgg tagtggtttg
     2941 tttttttggt gttttttaat ttgacactat tttaagagta aaatacgagt gtagacttga
     3001 aggggaagat ggctttgtga gcagagtctt aaaatctaat acctgtagca caaagttgtg
     3061 gatccatata gcagaaattg gctgcccttt gaccccaaca ttttccctca gacgttcttg
     3121 gtttgggtca gcacaaagca ctccataaca ttcttcacga tagttcaggg tatggtgatg
     3181 catccatcac tcagggttct gctggaagat aaaaggctct ttttcccttc catagtacac
     3241 tgaaatcagt accagcagcc tacaaaaaaa gttgactggg attctgcttc cagccaacct
     3301 aaaatatttt taggcaaaac agccagtgtt tgtactttta cagggtgaat tgcttgccag
     3361 tgctggtact cttatctgtt gggggaaagt ccatcctagt gatcctttaa taaatgtttt
     3421 cttgtttctg ggctacaggt ccgaccatat atttctaaac agtccctgta agattgaaag
     3481 aaataacagt taagtttgta ctttctacaa tctgaaatac agcttttata acagtgaact
     3541 tcaaaggttt ttttagaaca atgtggtttt ggttgattac atagctttga ctggactgaa
     3601 gttgactgtg taaaacttgg gcctttaact cccagagatc cacttgcctc ctgagtgttg
     3661 attaagtcat gtgtcaccac acctgcctgt tttcaggcag catgttttca tgggaccaga
     3721 aatgacattc cagtagcaga tacttaagtg gaaagtggat cttgtttgca aaactgaata
     3781 atgacagtga ggcgaaagag tcgagcagac agatatggtg gcatacatac agttagagtt
     3841 aaagcttttg agtttatgat gctcctgcct cagcttccta agtggatttg tgtgatttgg
     3901 ttgaaaggta ctaggctcta tatcctccca actactgaaa ccacagcctt tgtgtttatt
     3961 acccaagaaa atggggacag gagagatggc ttagcagcta aggggatgtc atctccagag
     4021 gacttcagtt tagttccctg tactcacaga cccaccctga cacaggaatg gacaagcttg
     4081 ttcattgttt tatacattga ctaagcagta catttgggct ctattctctt tttttctttt
     4141 tctaatgagt aatttagccc tcttttatca ttctgaagtt ggtgataggg ttgccttttg
     4201 atctttacca agggaacttg agtgcctgag aagtgtgtat gtagaacctg gatttagggt
     4261 gtttaaaata ttttatgggg ctggtgagat ggctcagtgg ttaagagcac tgactgctct
     4321 ccagaagttc tgaattcaat tcccagcaac cacatggtgg ttcacaacca tctgtaatgg
     4381 ggatccatat acataaataa acctttt
//
