LOCUS       NM_009029               4673 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus RB transcriptional corepressor 1 (Rb1), mRNA.
ACCESSION   NM_009029
VERSION     NM_009029.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4673)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
REFERENCE   2  (bases 1 to 4673)
  AUTHORS   Guanizo,A.C., Luong,Q., Jayasekara,W.S.N., de Geus,E.D.,
            Inampudi,C., Xue,V.S., Chen,J., de Weerd,N.A., Matthews,A.Y.,
            Gantier,M.P., Balic,J.J., Arulananda,S., Garama,D.J., Hertzog,P.J.,
            Ganju,V., Watkins,D.N., Cain,J.E. and Gough,D.J.
  TITLE     A STAT3-STING-IFN axis controls the metastatic spread of small cell
            lung cancer
  JOURNAL   Nat Immunol 25 (12), 2259-2269 (2024)
   PUBMED   39572642
REFERENCE   3  (bases 1 to 4673)
  AUTHORS   Rodarte,K.E., Nir Heyman,S., Guo,L., Flores,L., Savage,T.K.,
            Villarreal,J., Deng,S., Xu,L., Shah,R.B., Oliver,T.G. and
            Johnson,J.E.
  TITLE     Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1
  JOURNAL   Cancer Res 84 (21), 3522-3537 (2024)
   PUBMED   39264686
REFERENCE   4  (bases 1 to 4673)
  AUTHORS   Flesken-Nikitin,A., Ralston,C.Q., Fu,D.J., De Micheli,A.J.,
            Phuong,D.J., Harlan,B.A., Ashe,C.S., Armstrong,A.P., McKellar,D.W.,
            Ghuwalewala,S., Ellenson,L.H., Schimenti,J.C., Cosgrove,B.D. and
            Nikitin,A.Y.
  TITLE     Pre-ciliated tubal epithelial cells are prone to initiation of
            high-grade serous ovarian carcinoma
  JOURNAL   Nat Commun 15 (1), 8641 (2024)
   PUBMED   39366996
  REMARK    Erratum:[Nat Commun. 2024 Nov 20;15(1):10053. doi:
            10.1038/s41467-024-54465-x. PMID: 39567528]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4673)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4673)
  AUTHORS   Clarke,A.R., Maandag,E.R., van Roon,M., van der Lugt,N.M., van der
            Valk,M., Hooper,M.L., Berns,A. and te Riele,H.
  TITLE     Requirement for a functional Rb-1 gene in murine development
  JOURNAL   Nature 359 (6393), 328-330 (1992)
   PUBMED   1406937
REFERENCE   7  (bases 1 to 4673)
  AUTHORS   Jacks,T., Fazeli,A., Schmitt,E.M., Bronson,R.T., Goodell,M.A. and
            Weinberg,R.A.
  TITLE     Effects of an Rb mutation in the mouse
  JOURNAL   Nature 359 (6393), 295-300 (1992)
   PUBMED   1406933
REFERENCE   8  (bases 1 to 4673)
  AUTHORS   Lee,E.Y., Chang,C.Y., Hu,N., Wang,Y.C., Lai,C.C., Herrup,K.,
            Lee,W.H. and Bradley,A.
  TITLE     Mice deficient for Rb are nonviable and show defects in
            neurogenesis and haematopoiesis
  JOURNAL   Nature 359 (6393), 288-294 (1992)
   PUBMED   1406932
REFERENCE   9  (bases 1 to 4673)
  AUTHORS   te Riele,H., Maandag,E.R. and Berns,A.
  TITLE     Highly efficient gene targeting in embryonic stem cells through
            homologous recombination with isogenic DNA constructs
  JOURNAL   Proc Natl Acad Sci U S A 89 (11), 5128-5132 (1992)
   PUBMED   1594621
REFERENCE   10 (bases 1 to 4673)
  AUTHORS   Yu,D., Matin,A. and Hung,M.C.
  TITLE     The retinoblastoma gene product suppresses neu oncogene-induced
            transformation via transcriptional repression of neu
  JOURNAL   J Biol Chem 267 (15), 10203-10206 (1992)
   PUBMED   1350277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141028.1 and BC096525.1.
            
            On Apr 17, 2018 this sequence version replaced NM_009029.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096525.1, AK141028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AK141028.1         2-32
            32-4673             BC096525.1         1-4642
FEATURES             Location/Qualifiers
     source          1..4673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 38.73 cM"
     gene            1..4673
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /note="RB transcriptional corepressor 1"
                     /db_xref="GeneID:19645"
                     /db_xref="MGI:MGI:97874"
     exon            1..300
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2947
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /note="retinoblastoma 1"
                     /codon_start=1
                     /product="retinoblastoma-associated protein"
                     /protein_id="NP_033055.2"
                     /db_xref="CCDS:CCDS27267.1"
                     /db_xref="GeneID:19645"
                     /db_xref="MGI:MGI:97874"
                     /translation="MPPKAPRRAAAAEPPPPPPPPPREDDPAQDSGPEELPLARLEFE
                     EIEEPEFIALCQKLKVPDHVRERAWLTWEKVSSVDGILEGYIQKKKELWGICIFIAAV
                     DLDEMPFTFTELQKSIETSVYKFFDLLKEIDTSTKVDNAMSRLLKKYNVLCALYSKLE
                     RTCELIYLTQPSSALSTEINSMLVLKISWITFLLAKGEVLQMEDDLVISFQLMLCVVD
                     YFIKFSPPALLREPYKTAAIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHE
                     CNIDEVKNVYFKNFIPFINSLGIVSSNGLPEVESLSKRYEEVYLKNKDLDARLFLDHD
                     KTLQTDPIDSFETERTPRKNNPDEEANVVTPHTPVRTVMNTIQQLMVILNSASDQPSE
                     NLISYFNNCTVNPKENILKRVKDVGHIFKEKFANAVGQGCVDIGVQRYKLGVRLYYRV
                     MESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTLQHLDSGTDLSF
                     PWILNVLNLKAFDFYKVIESFIKVEANLTREMIKHLERCEHRIMESLAWLSDSPLFDL
                     IKQSKDGEGPDNLEPACPLSLPLQGNHTAADMYLSPLRSPKKRTSTTRVNSAANTETQ
                     AASAFHTQKPLKSTSLALFYKKVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLQ
                     NEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREE
                     EFDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFSSSPLRIPGGNIY
                     ISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSA
                     EGGNPPKPLKKLRFDIEGADEADGSKHLPAESKFQQKLAEMTSTRTRMQKQRMNESKD
                     VSNKEEK"
     exon            301..427
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..543
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..663
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..702
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..770
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..881
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1024
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1102
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1212
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1290
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1378
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1495
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1552
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1584
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1661
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1858
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1974
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2120
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2266
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2371
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2485
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2649
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2680
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2823
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2873
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..4656
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4632..4637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /note="hexamer: AATAAA"
     polyA_site      4656
                     /gene="Rb1"
                     /gene_synonym="p110-RB1; pp105; pRb; Rb; Rb-1"
                     /note="major polyA site"
ORIGIN      
        1 gttttcccgc ggttggcccg ggcgctcggt tgccgggcgc gtccggtttt cctcggggga
       61 cgttcccatt atttttgtaa cgggagtcgg gtgaggacgg ggcgtgcccg gcgtgcgcgc
      121 gcgcccgccc gcctccccgc gcgcctccct cggctgctcg cgccggcccg cgctgcgcgt
      181 catgccgccc aaagccccgc gcagagccgc ggccgccgag cccccgccac cgccgccgcc
      241 gccgcctcgg gaggacgacc ccgcgcagga cagcggcccc gaagagctgc ccctggccag
      301 gcttgagttt gaagaaattg aagaacccga atttattgca ttatgtcaaa agttaaaggt
      361 acccgatcat gtcagagaaa gagcttggct aacttgggag aaagtttcat ccgtggatgg
      421 aatcctggaa ggatatattc aaaagaagaa ggaactctgg ggcatctgca tctttatcgc
      481 agcagttgat ctagatgaga tgccattcac ttttactgag ctacagaaaa gcatagaaac
      541 cagtgtctat aaattctttg acttattaaa agaaatcgat accagtacca aggttgataa
      601 tgctatgtca agactattga agaagtataa tgtgttatgt gcactctaca gcaaattaga
      661 acggacgtgt gaacttatat atttgacaca acccagcagt gcgttatcta ctgaaataaa
      721 ttctatgttg gtgctaaaaa tttcttggat cactttttta ctagctaaag gagaagtatt
      781 acagatggaa gatgacctgg taatctcatt tcagctaatg ttgtgtgtag ttgactattt
      841 tattaagttc tcacctcctg cactactcag agagccatac aaaacagctg caatccccat
      901 taatggttca cctcgaacac ccagaagagg tcagaacagg agcgctcgga tagcaaaaca
      961 actagaaaat gatacgagga ttatcgaggt tctctgtaaa gaacacgagt gtaatataga
     1021 tgaggtgaaa aatgtttatt tcaaaaattt tatccctttt ataaattcac ttggaattgt
     1081 atcatctaat ggacttccag aggttgaaag tctttctaaa cgctatgaag aagtttatct
     1141 taaaaacaaa gatttagatg caagactgtt tttggatcat gataaaacac ttcagactga
     1201 tcctatagac agttttgaaa cagagagaac gccacgaaaa aacaaccctg atgaagaggc
     1261 aaacgtggtt actccacaca ctccagttag gactgttatg aatactattc aacaattaat
     1321 ggtgatttta aattctgcaa gtgatcagcc atcagaaaat ctgatttcct acttcaataa
     1381 ttgcacagtg aatccaaaag aaaatatcct aaagagagta aaggatgttg ggcacatctt
     1441 taaagagaag tttgctaacg ctgtgggcca gggctgtgtt gacatcggag tacagcgata
     1501 taaacttgga gtccgattgt attaccgtgt gatggaatcc atgcttaaat cagaagaaga
     1561 acgtttgtcc attcagaatt ttagcaaact cctaaatgac aacatctttc atatgtcttt
     1621 actggcctgt gctcttgaag ttgtaatggc tacgtatagc agaagtacat tgcagcatct
     1681 tgattctgga acagatttgt ccttcccgtg gattctgaac gtacttaatt taaaagcctt
     1741 tgatttttac aaagtgattg aaagttttat caaagtggaa gccaacttga caagagaaat
     1801 gataaaacat ttagaaagat gtgagcatcg aatcatggaa tcccttgcat ggctttcaga
     1861 ttcaccttta tttgatctca ttaagcagtc caaggatgga gaaggacctg ataaccttga
     1921 acctgcttgt cctctcagcc tgcctctcca gggtaaccat actgcagcag atatgtatct
     1981 ttctcctcta agatctccaa agaaaagaac ttccactaca cgtgtaaatt ctgctgcaaa
     2041 tacagagaca caagcagcct cagccttcca tactcagaag ccattgaaat ctacctccct
     2101 tgccctgttt tacaaaaaag tgtaccgtct agcatatctc cgactaaata cactctgtgc
     2161 acgccttctg tctgaccacc cagagctaga gcacatcatc tggactctgt ttcagcatac
     2221 attgcaaaat gagtatgagc tcatgagaga ccgacatttg gaccagatta tgatgtgctc
     2281 tatgtatggc atctgcaagg tgaagaacat cgacctcaag ttcaaaatca tcgtcactgc
     2341 ctacaaggat cttcctcacg ctgcccagga gacctttaaa cgtgttttga tcagagaaga
     2401 ggagtttgat tccattatag tattctataa ctccgttttc atgcagagac taaaaacaaa
     2461 tattttacag tatgcctcca ccaggcctcc taccttgtca ccaatacctc acattcctcg
     2521 aagcccttac aagttttcta gttcaccctt acggattcct ggaggtaaca tctatatatc
     2581 acccctaaag agtccttata aaatttcaga aggtctgcca acacccacaa aaatgactcc
     2641 gagatcaaga atcttggtct caattggtga atcatttggg acatctgaaa agttccagaa
     2701 aataaaccag atggtgtgta atagtgacag agtgctcaaa agaagtgctg aaggcggcaa
     2761 cccccccaaa ccactgaaaa agctgcgctt tgacatcgag ggagccgatg aagcagatgg
     2821 gagtaaacat ctcccagcgg agtccaaatt ccaacagaaa ctggcagaaa tgacttccac
     2881 tcgaacacga atgcaaaagc agagaatgaa tgagagcaag gatgtctcaa acaaggagga
     2941 aaagtgagga cctcagggcc ctggaccctc agccctgggg acaccagact cctggctcat
     3001 ggttgtgact agttcccagg ttctgctcat gttagagata taaaatgtgc aggtacaagc
     3061 tgaatatttg tgtgggtgat tcgtaagcca cttcaatgtt gtaatcaatg gtagagaatt
     3121 gatagcacac aggattgaga atcttgtgca gatcatgcca tttaaaatat gaaagcaagt
     3181 tgtttgcatt tccaacatga gcctgctgcc ctcagaagtg agggcctctg caggggtcct
     3241 gaccccctac atctggctga ctactttgcc tttcctcatg gcacatgtgt gatgtttgct
     3301 cttggtttta ttaatttata tgtatttttt aatttaacgt gaataccctt agaaaatgtg
     3361 tcttgtcttc caaatgcaag ttgattgact gtccacattc aaccaaatta tcttgaatct
     3421 tctactgaaa cagattgtta caaactggga aaaagtacta atttctacac attggactat
     3481 tttaatatta gaatctaatg tgccgtgtgt ttgtttcaca tattttactt ttgaaataca
     3541 agcaaaaaaa gtataatcat atgatactgt cttactactg acacagattt catacctcag
     3601 accctctaag aaccgattct tttattcacc caacacatgc tttgaactga agactattga
     3661 taatactccg aggttgtttt tttctttcaa tcattcagat cactgaattt ataagtaccc
     3721 atgtagtact tgaaagtcaa gtttggccac aactgtgctt aagaggaccc tagtacagta
     3781 caacccaagt gcacttttta atgtttctgg gtcctgaaga atcaagatac aaattaattg
     3841 tgatttacaa gcagactgtt aactatagaa gccttcagtt tttttccctc atagacgtgt
     3901 ctaattacat ctcaacagtt tactctgttc ttctacatct ggggatgttt gtgttctctc
     3961 tggaatggta catcttccag ggtcttttga acttgcagtt atctattttt taagccaatc
     4021 tggtctaata actctggctt cttcaaagcc acaccatttc tagtccagct gtgcagaaac
     4081 ttcagatgaa aacagctgca ttgaaaatag aggcactccc ttcacccccc acctaaaggt
     4141 gtatttaaat tatcttgtgg gattaactta tttagagatg gtataattta aaatagggga
     4201 tatttaaggt agcatcagct agcatttaag aaaatcactt tttctaaact ccatactttt
     4261 tgaaaagaaa tctggtcttg ttaggaaaca aatttctatt ttgtcctcaa tttagtttca
     4321 gttttactag tttgatagtt atctcaataa caaaagcaat agacagcttc ccccatttct
     4381 tcattaagtt ttgcatgatc atcacacaga ttagttaggt tttaggtcaa gggcttacca
     4441 tacttctagg tcttttgcta gtgagttcaa gttagaatta gtgacagaat cataggaatt
     4501 ttcagagatc ctgcttcgag atttcttaaa gctgcagaca ctgcactatt ggttttgttt
     4561 ttttgtaccg gttgaaacta tacattcaaa ttgctatgtt cctattttct ataatagttt
     4621 gtctatttta aaataaacta gttgttcaga gccttaaaaa aaaaaaaaaa aaa
//
