LOCUS       NM_013833               1687 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus retina and anterior neural fold homeobox (Rax), mRNA.
ACCESSION   NM_013833
VERSION     NM_013833.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1687)
  AUTHORS   Benevento,M., Alpar,A., Gundacker,A., Afjehi,L., Balueva,K.,
            Hevesi,Z., Hanics,J., Rehman,S., Pollak,D.D., Lubec,G., Wulff,P.,
            Prevot,V., Horvath,T.L. and Harkany,T.
  TITLE     A brainstem-hypothalamus neuronal circuit reduces feeding upon heat
            exposure
  JOURNAL   Nature 628 (8009), 826-834 (2024)
   PUBMED   38538787
REFERENCE   2  (bases 1 to 1687)
  AUTHORS   Yoshimoto,T., Chaya,T., Varner,L.R., Ando,M., Tsujii,T.,
            Motooka,D., Kimura,K. and Furukawa,T.
  TITLE     The Rax homeoprotein in Muller glial cells is required for
            homeostasis maintenance of the postnatal mouse retina
  JOURNAL   J Biol Chem 299 (12), 105461 (2023)
   PUBMED   37977220
  REMARK    GeneRIF: The Rax homeoprotein in Muller glial cells is required for
            homeostasis maintenance of the postnatal mouse retina.
REFERENCE   3  (bases 1 to 1687)
  AUTHORS   Ong,A.L.C., Kokaji,T., Kishi,A., Takihara,Y., Shinozuka,T.,
            Shimamoto,R., Isotani,A., Shirai,M. and Sasai,N.
  TITLE     Acquisition of neural fate by combination of BMP blockade and
            chromatin modification
  JOURNAL   iScience 26 (10), 107887 (2023)
   PUBMED   37771660
  REMARK    Erratum:[iScience. 2023 Oct 22;26(11):108257. doi:
            10.1016/j.isci.2023.108257.. PMID: 37920664]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1687)
  AUTHORS   Takata,N., Miska,J.M., Morgan,M.A., Patel,P., Billingham,L.K.,
            Joshi,N., Schipma,M.J., Dumar,Z.J., Joshi,N.R., Misharin,A.V.,
            Embry,R.B., Fiore,L., Gao,P., Diebold,L.P., McElroy,G.S.,
            Shilatifard,A., Chandel,N.S. and Oliver,G.
  TITLE     Lactate-dependent transcriptional regulation controls mammalian eye
            morphogenesis
  JOURNAL   Nat Commun 14 (1), 4129 (2023)
   PUBMED   37452018
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1687)
  AUTHORS   Iwagawa,T., Fukushima,M., Takeuchi,S., Kawamura,Y., Aihara,Y.,
            Ozawa,M., Yakushiji-Kaminatsui,N., Aihara,M., Koseki,H., Suzuki,Y.
            and Watanabe,S.
  TITLE     The histone H3K36 demethylase Fbxl11 plays pivotal roles in the
            development of retinal late-born cell types
  JOURNAL   Genes Cells 28 (7), 482-495 (2023)
   PUBMED   37073980
REFERENCE   6  (bases 1 to 1687)
  AUTHORS   Laemle,L.K. and Rusa,R.
  TITLE     VIP-like immunoreactivity in the suprachiasmatic nuclei of a mutant
            anophthalmic mouse
  JOURNAL   Brain Res 589 (1), 124-128 (1992)
   PUBMED   1422812
REFERENCE   7  (bases 1 to 1687)
  AUTHORS   Faradji-Prevautel,H., Cespuglio,R. and Jouvet,M.
  TITLE     Circadian rest-activity rhythms in the anophthalmic, monocular and
            binocular ZRDCT/An mice. Retinal and serotoninergic (raphe)
            influences
  JOURNAL   Brain Res 526 (2), 207-216 (1990)
   PUBMED   2147868
REFERENCE   8  (bases 1 to 1687)
  AUTHORS   Harch,C., Chase,H.B. and Gonsalves,N.I.
  TITLE     Studies on an anophthalmic strain of mice. VI. Lens and cup
            interaction
  JOURNAL   Dev Biol 63 (2), 352-357 (1978)
   PUBMED   640224
REFERENCE   9  (bases 1 to 1687)
  AUTHORS   Silver,J.
  TITLE     Abnormal development of the suprachiasmatic nuclei of the
            hypothalamus in a strain of genetically anophthalmic mice
  JOURNAL   J Comp Neurol 176 (4), 589-606 (1977)
   PUBMED   925203
REFERENCE   10 (bases 1 to 1687)
  AUTHORS   Cullen,M.J. and Kaiserman-Abramof,I.R.
  TITLE     Cytological organization of the dorsal lateral geniculate nuclei in
            mutant anophthalmic and postnatally enucleated mice
  JOURNAL   J Neurocytol 5 (4), 407-424 (1976)
   PUBMED   993820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC024731.1.
            
            On Mar 9, 2006 this sequence version replaced NM_013833.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024731.1, U73177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1687              BC024731.1         1-1687
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 39.03 cM"
     gene            1..1687
                     /gene="Rax"
                     /gene_synonym="7530406A22Rik; E130303K03Rik; ey-1; ey1;
                     Rx"
                     /note="retina and anterior neural fold homeobox"
                     /db_xref="GeneID:19434"
                     /db_xref="MGI:MGI:109632"
     exon            1..564
                     /gene="Rax"
                     /gene_synonym="7530406A22Rik; E130303K03Rik; ey-1; ey1;
                     Rx"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1304
                     /gene="Rax"
                     /gene_synonym="7530406A22Rik; E130303K03Rik; ey-1; ey1;
                     Rx"
                     /note="Rx/rax homeoprotein; retina and anterior neural
                     fold homeobox protein; eyeless 1"
                     /codon_start=1
                     /product="retinal homeobox protein Rx"
                     /protein_id="NP_038861.2"
                     /db_xref="CCDS:CCDS29311.1"
                     /db_xref="GeneID:19434"
                     /db_xref="MGI:MGI:109632"
                     /translation="MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKE
                     DGILDTFPAERSSRSSKERDPRLGAQPACPKAPAGGSESSPPAAPGFVPEYEATRPCY
                     PKEQGEARPSPGLSVGPAAGDSKLSEEEPPKKKHRRNRTTFTTYQLHELERAFEKSHY
                     PDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPPS
                     SALAPLGTGPGSGSGPPGSALPLEPWLGPPLPGGGATALQSLPGFGPPGQGLPASYTP
                     PPPFLNSAPLGPGLQQLGPPPAYPCAPAFGDKFSLEEAYPRNSSIAALRLKAKEHIQA
                     IGKPWQAL"
     exon            565..818
                     /gene="Rax"
                     /gene_synonym="7530406A22Rik; E130303K03Rik; ey-1; ey1;
                     Rx"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1669
                     /gene="Rax"
                     /gene_synonym="7530406A22Rik; E130303K03Rik; ey-1; ey1;
                     Rx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctttagca ccaaagctcc agttaccctg aggctaaact tgcagctcca gcagcgggtc
       61 cgttaatcgc tggcccagcg cttgcccacc tcctgagccg ttgcccaagc cggttgcccg
      121 ccgagtttag ctttggacag accgatccac cgagtttagc tttggaccga cccatccatt
      181 tgctcacgtt ctagaagtgc acacttgagg gggtggagga ggagaaggga accgggcatc
      241 gagctccagt ttgcaaagtg cactccctcc tctccatgca cctgccgggc tgcgcgccag
      301 ccatggcgga cgggagcttc tcgctcgctg gccacctgct ccgcagcccg ggcgggagca
      361 cgtcgcgttt gcacagcatc gaagccatcc tgggctttac caaggaagac ggcatcctag
      421 acacctttcc tgcagagagg agctccagga gctcgaaaga gcgggatccc aggctgggcg
      481 cgcagcctgc ctgccccaag gcgccagccg gaggctccga gtcttcccca ccagcagccc
      541 cgggattcgt cccggagtac gaagctacta ggccctgcta ccccaaggag caaggagaag
      601 cacgtccgag cccaggactc tcggttgggc cagcagcagg cgactcgaag ctgtcggagg
      661 aggaacctcc caagaagaag catcgacgca accgcacgac gttcaccact taccaactgc
      721 acgagctgga gcgcgccttc gagaagtccc actaccccga cgtgtacagc cgcgaagagc
      781 tggccggcaa ggttaaccta cccgaggttc gggtccaggt atggttccag aaccgacggg
      841 ctaagtggag gcgccaggag aaactggaag tgtcgtccat gaagctgcag gattctcccc
      901 tcctctcctt cagccgctcc ccgccttcct cggcactggc cccgctggga accggcccgg
      961 gcagcgggag cggacctccg gggagcgccc tgccgctgga gccgtggctt gggccaccgc
     1021 tgcccggagg aggcgccaca gcgctgcaga gcctgccggg attcgggccg ccggggcagg
     1081 gtctcccggc cagctacacg ccaccaccgc ccttcctgaa ctccgcgccc ctgggtccag
     1141 gtctgcagca gctcgggcca ccgcccgcgt acccctgcgc gccggcattc ggggacaagt
     1201 tctcgctgga agaggcgtac ccgcgcaaca gcagcatcgc cgctctgcgc ctgaaggcca
     1261 aagagcacat ccaggccatc ggaaagccct ggcaagccct ctagaggcgc tgcggagttg
     1321 ctgcgagccc tgtgtgcacc cagcccagcc tggtggccga acttttcttt gctagccctg
     1381 ctgcaagccg ccagccagcc ttgggcggga cactcgcgcc tactcttcga aagaggccaa
     1441 acggaaattc agcctcgctg tcagagggac aaactgcggg tcccgctgtc cacaccgctc
     1501 ctagctgctc ccataagcat cagcgcctat catcgggaag gaccaaggat cttgacctgg
     1561 gatgttccgg acggcaggaa tggggagtga gaaaaatagg ttgaagaaac tttgtaaagt
     1621 tagtttaaag tattttggag gaaaattaaa gatttgtttg ttgcccggca aaaaaaaaaa
     1681 aaaaaaa
//
