LOCUS       NM_027760               5407 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Ras association (RalGDS/AF-6) domain family
            (N-terminal) member 8 (Rassf8), mRNA.
ACCESSION   NM_027760 XM_011241598
VERSION     NM_027760.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5407)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5407)
  AUTHORS   Urbanek,M.E. and Zuo,J.
  TITLE     Genetic predisposition to tinnitus in the UK Biobank population
  JOURNAL   Sci Rep 11 (1), 18150 (2021)
   PUBMED   34518561
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5407)
  AUTHORS   Lock,F.E., Underhill-Day,N., Dunwell,T., Matallanas,D., Cooper,W.,
            Hesson,L., Recino,A., Ward,A., Pavlova,T., Zabarovsky,E.,
            Grant,M.M., Maher,E.R., Chalmers,A.D., Kolch,W. and Latif,F.
  TITLE     The RASSF8 candidate tumor suppressor inhibits cell growth and
            regulates the Wnt and NF-kappaB signaling pathways
  JOURNAL   Oncogene 29 (30), 4307-4316 (2010)
   PUBMED   20514026
REFERENCE   4  (bases 1 to 5407)
  AUTHORS   Schilling,K. and Oberdick,J.
  TITLE     The treasury of the commons: making use of public gene expression
            resources to better characterize the molecular diversity of
            inhibitory interneurons in the cerebellar cortex
  JOURNAL   Cerebellum 8 (4), 477-489 (2009)
   PUBMED   19554387
REFERENCE   5  (bases 1 to 5407)
  AUTHORS   Giallourakis,C., Cao,Z., Green,T., Wachtel,H., Xie,X.,
            Lopez-Illasaca,M., Daly,M., Rioux,J. and Xavier,R.
  TITLE     A molecular-properties-based approach to understanding PDZ domain
            proteins and PDZ ligands
  JOURNAL   Genome Res 16 (8), 1056-1072 (2006)
   PUBMED   16825666
REFERENCE   6  (bases 1 to 5407)
  AUTHORS   Wang,M., Lemon,W.J., Liu,G., Wang,Y., Iraqi,F.A., Malkinson,A.M.
            and You,M.
  TITLE     Fine mapping and identification of candidate pulmonary adenoma
            susceptibility 1 genes using advanced intercross lines
  JOURNAL   Cancer Res 63 (12), 3317-3324 (2003)
   PUBMED   12810665
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ062665.1, BC115779.1 and AC138117.4.
            
            On or before May 30, 2018 this sequence version replaced
            XM_011241598.1, NM_027760.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.7144.1,
                                           SRR10223971.7323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               CJ062665.1         41-248
            209-1635            BC115779.1         1-1427
            1636-5407           AC138117.4         195242-199013
FEATURES             Location/Qualifiers
     source          1..5407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.68 cM"
     gene            1..5407
                     /gene="Rassf8"
                     /gene_synonym="5133400D11Rik; Hoj1; mHoj-1"
                     /note="Ras association (RalGDS/AF-6) domain family
                     (N-terminal) member 8"
                     /db_xref="GeneID:71323"
                     /db_xref="MGI:MGI:1918573"
     exon            1..180
                     /gene="Rassf8"
                     /gene_synonym="5133400D11Rik; Hoj1; mHoj-1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..359
                     /gene="Rassf8"
                     /gene_synonym="5133400D11Rik; Hoj1; mHoj-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1516
                     /gene="Rassf8"
                     /gene_synonym="5133400D11Rik; Hoj1; mHoj-1"
                     /note="carcinoma-associated protein HOJ-1 homolog"
                     /codon_start=1
                     /product="ras association domain-containing protein 8"
                     /protein_id="NP_082036.1"
                     /db_xref="CCDS:CCDS20696.1"
                     /db_xref="GeneID:71323"
                     /db_xref="MGI:MGI:1918573"
                     /translation="MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIE
                     KWRDTERHLAPHENPIVSLNKWGQYASDVQLILRRTGPSLSERPTSDSVARIPERTLY
                     RQSLPPLAKLRPQADKSIRRREPKRKSLTFTGGAKGLTDIFGKGKETEFRQKVLSNCR
                     ATAEELKRLIRLQTGKLQAIEKQLESSEAEIRFWEQKYSCSLEEEIVRLEQRIKRNDV
                     EIEEEEFWENELQIEQENEKQLQDQLEEIRQKVTDCEGRLKDYLAQIHTMESGLQAEK
                     LHREVQEAQVNEEEVKGKIEKVKGEMDLQGQQSLRLENGIRAVERSLGQATKRLQDKE
                     QELEQLTKELRQVNLQQFIQQTGTKVTVLPAEPTEIEASQADIETEAPFQSGSLKRPG
                     SSRQLPSNLRILQNPVSSGFNPEGIYV"
     exon            360..1249
                     /gene="Rassf8"
                     /gene_synonym="5133400D11Rik; Hoj1; mHoj-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1394
                     /gene="Rassf8"
                     /gene_synonym="5133400D11Rik; Hoj1; mHoj-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..5407
                     /gene="Rassf8"
                     /gene_synonym="5133400D11Rik; Hoj1; mHoj-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5380..5385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rassf8"
                     /gene_synonym="5133400D11Rik; Hoj1; mHoj-1"
                     /note="hexamer: AATAAA"
     polyA_site      5407
                     /gene="Rassf8"
                     /gene_synonym="5133400D11Rik; Hoj1; mHoj-1"
                     /note="major polyA site"
ORIGIN      
        1 gtctctctgc cggctcagcc ctccgcgcgc cgccctgcgg cccggcctcc tcagccccgg
       61 cccgccgctc gccctccgcc gccgccggcc gcggccgtct cagccgccgc ctcagcctgg
      121 gcgggccggg cctccgccga gggccgtgca ccgggactac gaggacgggc tgcgagcgca
      181 tgtttctgaa gccagagcca tgacctgaca ccctgatgcc tactgccagg gcctttgtgg
      241 gactggcaca tgcaccatgg aacttaaagt gtgggtggat ggcgttcaga ggatcgtctg
      301 tggcgtcacg gaagtcacaa cttgccagga ggttgtaata gccttagccc aagctatagg
      361 tcgaactgga aggtacaccc tgatagagaa atggagagac actgagcggc acttggcacc
      421 gcatgaaaac cccatcgtgt ctttgaacaa gtgggggcag tatgctagtg acgtgcagct
      481 catcttgcgt cggactgggc catctctcag tgagcgaccc acctcggaca gtgtggcccg
      541 aattcctgaa agaactttgt atcgacagag ccttcccccc ttagccaagc tccggcctca
      601 ggcggacaag tccatcagaa ggagggagcc taagcgaaag tctctcacct tcacaggggg
      661 cgccaaaggg ctgacggaca tttttggaaa aggcaaagag actgagttca ggcagaaggt
      721 gctgagtaac tgcagggcaa cagcagagga gctgaaaagg ctgatccggc tgcagacggg
      781 gaagctgcag gccatcgaga agcagctgga gtccagtgag gcagagatcc ggttctggga
      841 gcagaagtac agctgtagcc tggaggagga gattgtccgc ctggagcaga ggatcaagag
      901 aaacgacgtg gagatcgagg aggaagagtt ctgggaaaac gaattacaga tcgaacaaga
      961 gaacgagaag cagctgcagg atcagctgga ggagatacgg cagaaggtga cagactgtga
     1021 aggcaggctg aaggactacc tggcccagat ccacaccatg gagagcggtc tccaggcaga
     1081 aaaactgcac cgggaagttc aggaggcaca ggtcaatgag gaggaggtga aaggaaagat
     1141 cgaaaaggtc aagggggaga tggaccttca agggcagcag agcctgaggc tggagaacgg
     1201 cattagagct gtggagaggt ctctggggca ggccaccaag cggctacagg acaaggagca
     1261 ggagctagag cagttgacca aagagctgcg gcaggtcaac ctccagcagt tcatccagca
     1321 gacagggacc aaagtcaccg tgctgccggc cgagcccacg gagatcgagg cctcgcaggc
     1381 agacatagag acagaggcgc cattccagtc tgggtccctg aagcgacctg gttcatcccg
     1441 gcagctcccc agtaatcttc gtattctaca gaaccctgtc tcctcgggtt ttaatcctga
     1501 aggcatctat gtataacact gtctttggga aaggatccag caaaggtacc atggacagta
     1561 aaatcctcca gtttgtgcca actgaacaga gggtctgttc ccacgccgga tcctctccca
     1621 accacacacc actcggagcc atgccctgtg cactgatgct gaacatggag cctttcactc
     1681 ttcgcagtat tgacatgttg tccagcagct ggaatgcaaa gcctttgttt gtatttgtag
     1741 cattttgaga ccattaggaa agcattgatc tacgtttata catgaataca ccctgaatta
     1801 agagcaaaga agttatgtga ctgcttagtt taatttattc catgtaattg attaatgtat
     1861 gaatgttgct ctctaatgtt ttattaatac ttatcctgtg acttaattct gttaagtgtt
     1921 gtgggactct gactgtgtgc atgttggcag actccatctg agctttgctc atgtacagct
     1981 tcggagcctc ctggggcgct ccaccatcca gactgactcc acggaactcg ccacacttat
     2041 ctggagcctc tcttagccct tgcttaagtg agataattca gcttgctttc tagtctggaa
     2101 gttaattgtt cctttacagt attccaaaca tgacatcaca gaaatatcgt aaaggaagta
     2161 aattgttcgt gtaaaatgtt tgtgatctca gacggtcctg gtgcactctg tgaggctctc
     2221 ctgccttcct gcctcctcct gtgggtcccc atgagaaggt cccacgagaa ggagaggtcc
     2281 ctgggggtct gattgctgtg ctttgggaat cacgcgcagg tgatatactt gagaacaacc
     2341 cacttccttt ttggacttta tgccatgcac agcagggtga atgttgcttg ccaagacgtc
     2401 gacgtggaca gagtgcttgt tctagacata gagacagagg agagagcacc caggtcaggc
     2461 attttttacc aaggaataaa attaaattca gagtatgttt tttattttta agtttgactt
     2521 tataggatat tagtctccat ttatatttgt atcatttgtg tataaagcca aaaatgagtc
     2581 agtactttgc tctcgagcag tgacttcact gcagtcaaca gtaatattta gacaggagct
     2641 gccaggtgcc tcagcccttc ccattctcca gtaaatttgg tacagtataa ctaagacttt
     2701 aatctgaaat ttaaagtagc ttttaatcct gaagagaatg catcctctgt attatttaca
     2761 tgcaataata tgaaagtggg ttagcatagt gatgccgcaa ccacactcaa ggtgagctga
     2821 ggtgggtgac cacacccaac ttacttctgg tttgatgaat gttcgatgaa gccgagaatg
     2881 ctgctttatt ttagtttcca atgaaaagat ttaagactgg ctgtgaagta gtagacactt
     2941 gtagagaact gaaatttgtg tagtgttgcc ttctacccaa gtgaattgca gacctcagct
     3001 gaacgccgac tcacccagtg ggtcttgctg tcactgcctc gcaggtgact tgagaagtaa
     3061 attattcttt ctgaaataac cattgcctga acacatttgc tccagatttg tagcaactgt
     3121 ttcatatctc tatatattta aaaagaataa ttcaaagtcc gagtaacttg cagctttcgg
     3181 tggcacgggt gagtccacag gcccagggcc tgccttactc tcagactctt cctctgttga
     3241 gtcattgcat tgatcagata aattgaaacc ttgctcataa aggaagacac tgtacaaatg
     3301 gattatcttc catttaaacc aaaatgttgg tggtaggtag gttacactct atgaaaaaaa
     3361 tgaaagatga agctgggcgt ggtggctcat gaccgtgatt ccagcactct ggaggttgag
     3421 gcaggacagt tgccaggaag cccaggctat cctaagttac aggggaagtt ctaggatagc
     3481 ctggggtctg gtgtgagacc ctgtggaaag aaagagaatt gcacagatcc cctgacacac
     3541 tcagttgtga actgtctggc ttactgagga acctaaagaa gggcggcttc ccaccagctc
     3601 gcagcagtcc tggctctcca ccaccgtcac ctctgaacct ggaagctgcc agctactctc
     3661 ccggcctccc ggcctccccg actggtgggg tgcagccttg agagttgaca agcacgttga
     3721 gaagctgtgc tgtgtcacga gtcacagggc cttcacaggc tcatcactgt ccagtgtttt
     3781 ctaaagcttt tttagctcgg ggtgggggtg ggggggggaa acaactaatt tgtgtaggaa
     3841 catctgaaaa tattttagtc tgctgtcaca gtttttacct attgtgacta taaatgaatt
     3901 ggcttatgaa ccctaccttt ggctacatgt cagaggggta cagccaatgg tattaaaaaa
     3961 ctaccaaatg caaaattttg catatggaga agtatacagg ttctaaataa taaattagat
     4021 cacaaatttt tgtgtctttt taattagtac tacaggttac attatgtggt ttttctacag
     4081 gtattaaata tattacaagt ttttttctta ccaatgaata atttgagtat cattggtcta
     4141 tttgacctat agagtatcct ctttctcaga gaatcaccca cagtgggtta cctcactttg
     4201 tgtgtttatt ttttttcatt tcctttacat tttggctgtt agtgttcctt ttttgtctcc
     4261 gtgaacaggg aattttatat gtgaggcttc agttggtatt gatagaagtt gccctctgac
     4321 tgtgcagatt gacataacta tcagggggca gttgggcata gctccgccca gcagagcctg
     4381 cacagtgaag atgcagctca tggtactcgc tgtggagtgt ggcagcacgg accgacagat
     4441 cagcactcct ccacagctaa gacagcccag tcctgcggca acacagctgc ttgtaagtgc
     4501 aaaaaggtct gcagagacaa gaagtcttca cctagagcaa catctgggaa catctttgca
     4561 agtaaggacc ttgatagatt gaggaaatca tgtgaaaaag acaaaggcct gatggcaggc
     4621 gggcacagga agatgggcag ttagcattgg acattgcctt tgacaggtta ggccttaatg
     4681 tatattaaac gatgctctgt gtgcttccca aacacaagcc tgtcttgatc ggtagatact
     4741 gtggcgaggc tagctcgtga gtattccttt tgtatcacgc cagtgtttta aagttgtgtg
     4801 ttcgtatgtc tgctgtggta tttttaagtt ctgggagaag cctgctggcc gtgtcagctc
     4861 acggccatca gtagttactc agtattgctg ctccacgttt cccagtgcac cttccatgcc
     4921 agggcagtgg ctgcgtgcgt gcaagccgcg ggagcgcctt cccgctcatt ttatatgtat
     4981 ttatagaaac caaatgaccg cagatggcta tatggtgtgg tgttaaacca gtggaactct
     5041 aatggcaata aatatatgca tatgtgtggg agaggggaaa agtggaaata caggtttaca
     5101 gccagacatg gtgggtgata gcccttcagt gtatttctct gtcccttcac tgacctagaa
     5161 ggatttgagc tgctgcagct ttagacagaa aatgtccaca tttgctgatt gtgggccata
     5221 aatatgcttt tagtactgct ttgctgatgt ataaataaga aatctgtaat atgtactata
     5281 tgtaattatt ttcttttgac tttatttcaa aatgtatatt ttctgattat tatcatgagc
     5341 tataaagcaa aaagatcaat atctgatatt ctcccaaata ataaattttc aagattcatt
     5401 ggagcaa
//
